LOCUS NP_000919 148 aa linear PRI 22-OCT-2008
DEFINITION phospholipase A2, group IB [Homo sapiens].
ACCESSION NP_000919
VERSION NP_000919.1 GI:4505847
DBSOURCE REFSEQ: accession NM_000928.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 148)
AUTHORS Kao,W.T., Yen,Y.C. and Lung,F.W.
TITLE The effects of beta2 adrenergic receptor gene polymorphism in lipid
profiles
JOURNAL Lipids Health Dis 7, 20 (2008)
PUBMED 18492292
REMARK GeneRIF: Observational study of gene-disease association and
gene-environment interaction. (HuGE Navigator)
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 148)
AUTHORS Gorovetz,M., Schwob,O., Krimsky,M., Yedgar,S. and Reich,R.
TITLE MMP production in human fibrosarcoma cells and their invasiveness
are regulated by group IB secretory phospholipase A2
receptor-mediated activation of cytosolic phospholipase A2
JOURNAL Front. Biosci. 13, 1917-1925 (2008)
PUBMED 17981679
REMARK GeneRIF: MMP-2/9 production is regulated by sPLA2-IB acting as a
receptor ligand to activate cPLA2
Review article
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 148)
AUTHORS Pan,Y.H. and Bahnson,B.J.
TITLE Structural basis for bile salt inhibition of pancreatic
phospholipase A2
JOURNAL J. Mol. Biol. 369 (2), 439-450 (2007)
PUBMED 17434532
REMARK GeneRIF: Results describe the structural basis for bile salt
inhibition of pancreatic phospholipase A2.
REFERENCE 4 (residues 1 to 148)
AUTHORS Zarini,S., Gijon,M.A., Folco,G. and Murphy,R.C.
TITLE Effect of arachidonic acid reacylation on leukotriene biosynthesis
in human neutrophils stimulated with granulocyte-macrophage
colony-stimulating factor and formyl-methionyl-leucyl-phenylalanine
JOURNAL J. Biol. Chem. 281 (15), 10134-10142 (2006)
PUBMED 16495221
REMARK GeneRIF: a critical regulatory role of arachidonate reacylation
that limits leukotriene biosynthesis in concert with 5-lipoxygenase
and cytosolic phospholipase A(2)alpha activation
REFERENCE 5 (residues 1 to 148)
AUTHORS Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
Eaves,K.A., Egan,A., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
CONSRTM Baylor College of Medicine Human Genome Sequencing Center Sequence
Production Team
TITLE The finished DNA sequence of human chromosome 12
JOURNAL Nature 440 (7082), 346-351 (2006)
PUBMED 16541075
REFERENCE 6 (residues 1 to 148)
AUTHORS Arita,H., Hanasaki,K., Nakano,T., Oka,S., Teraoka,H. and
Matsumoto,K.
TITLE Novel proliferative effect of phospholipase A2 in Swiss 3T3 cells
via specific binding site
JOURNAL J. Biol. Chem. 266 (29), 19139-19141 (1991)
PUBMED 1918029
REFERENCE 7 (residues 1 to 148)
AUTHORS Clark,M.A., Ozgur,L.E., Conway,T.M., Dispoto,J., Crooke,S.T. and
Bomalaski,J.S.
TITLE Cloning of a phospholipase A2-activating protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (12), 5418-5422 (1991)
PUBMED 2052621
REFERENCE 8 (residues 1 to 148)
AUTHORS Seilhamer,J.J., Randall,T.L., Yamanaka,M. and Johnson,L.K.
TITLE Pancreatic phospholipase A2: isolation of the human gene and cDNAs
from porcine pancreas and human lung
JOURNAL DNA 5 (6), 519-527 (1986)
PUBMED 3028739
REFERENCE 9 (residues 1 to 148)
AUTHORS Sternby,B. and Akerstrom,B.
TITLE Immunoreactive pancreatic colipase, lipase and phospholipase A2 in
human plasma and urine from healthy individuals
JOURNAL Biochim. Biophys. Acta 789 (2), 164-169 (1984)
PUBMED 6477929
REFERENCE 10 (residues 1 to 148)
AUTHORS Verheij,H.M., Westerman,J., Sternby,B. and De Haas,G.H.
TITLE The complete primary structure of phospholipase A2 from human
pancreas
JOURNAL Biochim. Biophys. Acta 747 (1-2), 93-99 (1983)
PUBMED 6349696
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
M21054.1, AA844927.1, CA867923.1, BX113838.1 and BE969737.1.
Summary: Phospholipase A2 (EC 3.1.1.4) catalyzes the release of
fatty acids from glycero-3-phosphocholines. The best known
varieties are the digestive enzymes secreted as zymogens by the
pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a
variety of mammals have been reported. One striking feature of
these enzymes is their close homology to venom phospholipases of
snakes. Other forms of PLA2 have been isolated from brain, liver,
lung, spleen, intestine, macrophages, leukocytes, erythrocytes,
inflammatory exudates, chondrocytes, and platelets (Seilhamer et
al., 1986 [PubMed 3028739]) .[supplied by OMIM].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..148
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q23-q24.1"
Protein 1..148
/product="phospholipase A2, group IB"
/EC_number="3.1.1.4"
/calculated_mol_wt=16229
CDS 1..148
/gene="PLA2G1B"
/gene_synonym="PLA2"
/gene_synonym="PLA2A"
/gene_synonym="PPLA2"
/gene_synonym="MGC119834"
/gene_synonym="MGC119835"
/coded_by="NM_000928.2:37..483"
/db_xref="CCDS:CCDS9195.1"
/db_xref="GeneID:5319"
/db_xref="HGNC:9030"
/db_xref="HPRD:01396"
/db_xref="MIM:172410"
ORIGIN
1 mkllvlavll tvaaadsgis pravwqfrkm ikcvipgsdp fleynnygcy cglggsgtpv
61 deldkccqth dncydqakkl dsckflldnp ythtysyscs gsaitcsskn keceaficnc
121 drnaaicfsk apynkahknl dtkkycqs
//