LOCUS NP_000895 231 aa linear PRI 24-OCT-2008
DEFINITION NAD(P)H dehydrogenase, quinone 2 [Homo sapiens].
ACCESSION NP_000895
VERSION NP_000895.2 GI:156564357
DBSOURCE REFSEQ: accession NM_000904.3
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 231)
AUTHORS Boutin,J.A., Saunier,C., Guenin,S.P., Berger,S., Moulharat,N.,
Gohier,A., Delagrange,P., Coge,F. and Ferry,G.
TITLE Studies of the melatonin binding site location onto quinone
reductase 2 by directed mutagenesis
JOURNAL Arch. Biochem. Biophys. 477 (1), 12-19 (2008)
PUBMED 18502195
REMARK GeneRIF: This first structural analysis of hQR2 should enable to
better understand the biological role of melatonin on this enzyme .
REFERENCE 2 (residues 1 to 231)
AUTHORS Fu,Y., Buryanovskyy,L. and Zhang,Z.
TITLE Quinone reductase 2 is a catechol quinone reductase
JOURNAL J. Biol. Chem. 283 (35), 23829-23835 (2008)
PUBMED 18579530
REMARK GeneRIF: Quinone reductase 2 is a catechol quinone reductase.
quinone reductase 2 could play important roles in the regulation of
catecholamine oxidation processes that may be involved in the
etiology of Parkinson disease.
REFERENCE 3 (residues 1 to 231)
AUTHORS Payton,A., Miyajima,F., Ollier,W., Rabbitt,P., Pickles,A.,
Weiss,V., Pendleton,N. and Horan,M.
TITLE Investigation of a functional quinine oxidoreductase (NQO2)
polymorphism and cognitive decline
JOURNAL Neurobiol. Aging (2008) In press
PUBMED 18538895
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 4 (residues 1 to 231)
AUTHORS Maruyama,K., Harada,S., Yokoyama,A., Naruse,S., Hirota,M.,
Nishimori,I. and Otsuki,M.
TITLE Association analysis among polymorphisms of the various genes and
chronic alcoholic pancreatitis
JOURNAL J. Gastroenterol. Hepatol. 23 SUPPL 1, S69-S72 (2008)
PUBMED 18336668
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (residues 1 to 231)
AUTHORS Wang,W., Le,W.D., Pan,T., Stringer,J.L. and Jaiswal,A.K.
TITLE Association of NRH:quinone oxidoreductase 2 gene promoter
polymorphism with higher gene expression and increased
susceptibility to Parkinson's disease
JOURNAL J. Gerontol. A Biol. Sci. Med. Sci. 63 (2), 127-134 (2008)
PUBMED 18314446
REMARK GeneRIF: Parkinson's disease patients were analyzed for NQO2 gene
promoter polymorphisms. Three allelic variants were I-29, I-16 and
D. The association of the D promoter with Parkinson's disease may
be due to an increase in expression of the NQO2 gene.
GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (residues 1 to 231)
AUTHORS Foster,C.E., Bianchet,M.A., Talalay,P., Zhao,Q. and Amzel,L.M.
TITLE Crystal structure of human quinone reductase type 2, a
metalloflavoprotein
JOURNAL Biochemistry 38 (31), 9881-9886 (1999)
PUBMED 10433694
REFERENCE 7 (residues 1 to 231)
AUTHORS Wu,K., Knox,R., Sun,X.Z., Joseph,P., Jaiswal,A.K., Zhang,D.,
Deng,P.S. and Chen,S.
TITLE Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a
dihydronicotinamide riboside dependent oxidoreductase
JOURNAL Arch. Biochem. Biophys. 347 (2), 221-228 (1997)
PUBMED 9367528
REFERENCE 8 (residues 1 to 231)
AUTHORS Zhao,Q., Yang,X.L., Holtzclaw,W.D. and Talalay,P.
TITLE Unexpected genetic and structural relationships of a long-forgotten
flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (5), 1669-1674 (1997)
PUBMED 9050836
REMARK Erratum:[Proc Natl Acad Sci U S A 1997 May 27;94(11):5979]
REFERENCE 9 (residues 1 to 231)
AUTHORS Jaiswal,A.K.
TITLE Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity,
and tissue-specific expression
JOURNAL J. Biol. Chem. 269 (20), 14502-14508 (1994)
PUBMED 8182056
REFERENCE 10 (residues 1 to 231)
AUTHORS Jaiswal,A.K., Burnett,P., Adesnik,M. and McBride,O.W.
TITLE Nucleotide and deduced amino acid sequence of a human cDNA (NQO2)
corresponding to a second member of the NAD(P)H:quinone
oxidoreductase gene family. Extensive polymorphism at the NQO2 gene
locus on chromosome 6
JOURNAL Biochemistry 29 (7), 1899-1906 (1990)
PUBMED 1691923
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BI670476.1, CR600371.1 and J02888.1.
On Aug 29, 2007 this sequence version replaced gi:4505417.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..231
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="6"
/map="6pter-q12"
Protein 1..231
/product="NAD(P)H dehydrogenase, quinone 2"
/EC_number="1.10.99.2"
/note="NAD(P)H menadione oxidoreductase-1,
dioxin-inducible-2; NAD(P)H menadione oxidoreductase 2,
dioxin-inducible"
/calculated_mol_wt=25788
CDS 1..231
/gene="NQO2"
/gene_synonym="QR2"
/gene_synonym="DHQV"
/gene_synonym="DIA6"
/gene_synonym="NMOR2"
/coded_by="NM_000904.3:339..1034"
/db_xref="CCDS:CCDS4481.1"
/db_xref="GeneID:4835"
/db_xref="HGNC:7856"
/db_xref="HPRD:01190"
/db_xref="MIM:160998"
ORIGIN
1 magkkvlivy ahqepksfng slknvavdel srqgctvtvs dlyamnlepr atdkditgtl
61 snpevfnygv etheaykqrs lasditdeqk kvreadlvif qfplywfsvp ailkgwmdrv
121 lcqgfafdip gfydsgllqg klallsvttg gtaemytktg vngdsryflw plqhgtlhfc
181 gfkvlapqis fapeiaseee rkgmvaawsq rlqtiwkeep ipctahwhfg q
//