LOCUS NP_000889 520 aa linear PRI 22-OCT-2008
DEFINITION monoamine oxidase B [Homo sapiens].
ACCESSION NP_000889
VERSION NP_000889.3 GI:38202207
DBSOURCE REFSEQ: accession NM_000898.4
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 520)
AUTHORS Gasso,P., Bernardo,M., Mas,S., Crescenti,A., Garcia,C.,
Parellada,E. and Lafuente,A.
TITLE Association of A/G Polymorphism in Intron 13 of the Monoamine
Oxidase B Gene with Schizophrenia in a Spanish Population
JOURNAL Neuropsychobiology 58 (2), 65-70 (2008)
PUBMED 18832861
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 2 (residues 1 to 520)
AUTHORS Carrera,N., Sanjuan,J., Molto,M.D., Carracedo,A. and Costas,J.
TITLE Recent adaptive selection at MAOB and ancestral susceptibility to
schizophrenia
JOURNAL Am. J. Med. Genet. B Neuropsychiatr. Genet. (2008) In press
PUBMED 18553363
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 3 (residues 1 to 520)
AUTHORS Singh,M., Khan,A.J., Shah,P.P., Shukla,R., Khanna,V.K. and
Parmar,D.
TITLE Polymorphism in environment responsive genes and association with
Parkinson disease
JOURNAL Mol. Cell. Biochem. 312 (1-2), 131-138 (2008)
PUBMED 18327668
REMARK GeneRIF: Observational study of gene-disease association and
gene-gene interaction. (HuGE Navigator)
REFERENCE 4 (residues 1 to 520)
AUTHORS Mokrovic,G., Matosic,A., Hranilovic,D., Stefulj,J., Novokmet,M.,
Oreskovic,D., Balija,M., Marusic,S. and Cicin-Sain,L.
TITLE Alcohol dependence and polymorphisms of serotonin-related genes:
association studies
JOURNAL Coll Antropol 32 SUPPL 1, 127-131 (2008)
PUBMED 18405071
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (residues 1 to 520)
AUTHORS Malmberg,K., Wargelius,H.L., Lichtenstein,P., Oreland,L. and
Larsson,J.O.
TITLE ADHD and Disruptive Behavior scores - associations with MAO-A and
5-HTT genes and with platelet MAO-B activity in adolescents
JOURNAL BMC Psychiatry 8, 28 (2008)
PUBMED 18430257
REMARK GeneRIF: an association in girls between low platelet MAO-B
activity and symptoms of Oppositional Defiant Disorder.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 520)
AUTHORS Zhu,Q.S., Grimsby,J., Chen,K. and Shih,J.C.
TITLE Promoter organization and activity of human monoamine oxidase (MAO)
A and B genes
JOURNAL J. Neurosci. 12 (11), 4437-4446 (1992)
PUBMED 1432104
REFERENCE 7 (residues 1 to 520)
AUTHORS Grimsby,J., Chen,K., Wang,L.J., Lan,N.C. and Shih,J.C.
TITLE Human monoamine oxidase A and B genes exhibit identical exon-intron
organization
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (9), 3637-3641 (1991)
PUBMED 2023912
REFERENCE 8 (residues 1 to 520)
AUTHORS Bach,A.W., Lan,N.C., Johnson,D.L., Abell,C.W., Bembenek,M.E.,
Kwan,S.W., Seeburg,P.H. and Shih,J.C.
TITLE cDNA cloning of human liver monoamine oxidase A and B: molecular
basis of differences in enzymatic properties
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (13), 4934-4938 (1988)
PUBMED 3387449
REFERENCE 9 (residues 1 to 520)
AUTHORS Kochersperger,L.M., Parker,E.L., Siciliano,M., Darlington,G.J. and
Denney,R.M.
TITLE Assignment of genes for human monoamine oxidases A and B to the X
chromosome
JOURNAL J. Neurosci. Res. 16 (4), 601-616 (1986)
PUBMED 3540317
REFERENCE 10 (residues 1 to 520)
AUTHORS Wyatt,R.J., Murphy,D.L., Belmaker,R., Cohen,S., Donnelly,C.H. and
Pollin,W.
TITLE Reduced monoamine oxidase activity in platelets: a possible genetic
marker for vulnerability to schizophrenia
JOURNAL Science 179 (76), 916-918 (1973)
PUBMED 4687789
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC326844.1, M69177.1,
BM726427.1 and AL133791.1.
On Nov 7, 2003 this sequence version replaced gi:31543137.
Summary: The protein encoded by this gene belongs to the flavin
monoamine oxidase family. It is a enzyme located in the
mitochondrial outer membrane. It catalyzes the oxidative
deamination of biogenic and xenobiotic amines and plays an
important role in the metabolism of neuroactive and vasoactive
amines in the central nervous sysytem and peripheral tissues. This
protein preferentially degrades benzylamine and phenylethylamine.
[provided by RefSeq].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..520
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp11.23"
Protein 1..520
/product="monoamine oxidase B"
/EC_number="1.4.3.4"
/note="MAO, platelet; MAO, brain; tyramine oxidase;
adrenalin oxidase"
/calculated_mol_wt=58632
CDS 1..520
/gene="MAOB"
/gene_synonym="MGC26382"
/coded_by="NM_000898.4:177..1739"
/db_xref="CCDS:CCDS14261.1"
/db_xref="GeneID:4129"
/db_xref="HGNC:6834"
/db_xref="HPRD:02401"
/db_xref="MIM:309860"
ORIGIN
1 msnkcdvvvv gggisgmaaa kllhdsglnv vvleardrvg grtytlrnqk vkyvdlggsy
61 vgptqnrilr lakelglety kvneverlih hvkgksypfr gpfppvwnpi tyldhnnfwr
121 tmddmgreip sdapwkapla eewdnmtmke lldklcwtes akqlatlfvn lcvtaethev
181 salwflwyvk qcggttriis ttnggqerkf vggsgqvser imdllgdrvk lerpviyidq
241 trenvlvetl nhemyeakyv isaipptlgm kihfnpplpm mrnqmitrvp lgsvikcivy
301 ykepfwrkkd ycgtmiidge eapvaytldd tkpegnyaai mgfilahkar klarltkeer
361 lkklcelyak vlgslealep vhyeeknwce eqysggcytt yfppgiltqy grvlrqpvdr
421 iyfagtetat hwsgymegav eageraarei lhamgkiped eiwqsepesv dvpaqpittt
481 flerhlpsvp gllrligltt ifsatalgfl ahkrgllvrv
//