LOCUS NP_000856 365 aa linear PRI 16-NOV-2008
DEFINITION 5-hydroxytryptamine (serotonin) receptor 1E [Homo sapiens].
ACCESSION NP_000856
VERSION NP_000856.1 GI:4504537
DBSOURCE REFSEQ: accession NM_000865.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 365)
AUTHORS Lasky-Su,J., Neale,B.M., Franke,B., Anney,R.J., Zhou,K.,
Maller,J.B., Vasquez,A.A., Chen,W., Asherson,P., Buitelaar,J.,
Banaschewski,T., Ebstein,R., Gill,M., Miranda,A., Mulas,F.,
Oades,R.D., Roeyers,H., Rothenberger,A., Sergeant,J.,
Sonuga-Barke,E., Steinhausen,H.C., Taylor,E., Daly,M., Laird,N.,
Lange,C. and Faraone,S.V.
TITLE Genome-wide association scan of quantitative traits for attention
deficit hyperactivity disorder identifies novel associations and
confirms candidate gene associations
JOURNAL Am. J. Med. Genet. B Neuropsychiatr. Genet. (2008) In press
PUBMED 18821565
REMARK GeneRIF: Observational study and genome-wide association study of
gene-disease association. (HuGE Navigator)
Publication Status: Available-Online prior to print
REFERENCE 2 (residues 1 to 365)
AUTHORS Smith,A.K., Dimulescu,I., Falkenberg,V.R., Narasimhan,S., Heim,C.,
Vernon,S.D. and Rajeevan,M.S.
TITLE Genetic evaluation of the serotonergic system in chronic fatigue
syndrome
JOURNAL Psychoneuroendocrinology 33 (2), 188-197 (2008)
PUBMED 18079067
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (residues 1 to 365)
AUTHORS Oades,R.D., Lasky-Su,J., Christiansen,H., Faraone,S.V.,
Sonuga-Barke,E.J., Banaschewski,T., Chen,W., Anney,R.J.,
Buitelaar,J.K., Ebstein,R.P., Franke,B., Gill,M., Miranda,A.,
Roeyers,H., Rothenberger,A., Sergeant,J.A., Steinhausen,H.C.,
Taylor,E.A., Thompson,M. and Asherson,P.
TITLE The influence of serotonin- and other genes on impulsive behavioral
aggression and cognitive impulsivity in children with
attention-deficit/hyperactivity disorder (ADHD): Findings from a
family-based association test (FBAT) analysis
JOURNAL Behav Brain Funct 4, 48 (2008)
PUBMED 18937842
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 365)
AUTHORS Ewing,R.M., Chu,P., Elisma,F., Li,H., Taylor,P., Climie,S.,
McBroom-Cerajewski,L., Robinson,M.D., O'Connor,L., Li,M.,
Taylor,R., Dharsee,M., Ho,Y., Heilbut,A., Moore,L., Zhang,S.,
Ornatsky,O., Bukhman,Y.V., Ethier,M., Sheng,Y., Vasilescu,J.,
Abu-Farha,M., Lambert,J.P., Duewel,H.S., Stewart,I.I., Kuehl,B.,
Hogue,K., Colwill,K., Gladwish,K., Muskat,B., Kinach,R.,
Adams,S.L., Moran,M.F., Morin,G.B., Topaloglou,T. and Figeys,D.
TITLE Large-scale mapping of human protein-protein interactions by mass
spectrometry
JOURNAL Mol. Syst. Biol. 3, 89 (2007)
PUBMED 17353931
REFERENCE 5 (residues 1 to 365)
AUTHORS Turecki,G., Sequeira,A., Gingras,Y., Seguin,M., Lesage,A.,
Tousignant,M., Chawky,N., Vanier,C., Lipp,O., Benkelfat,C. and
Rouleau,G.A.
TITLE Suicide and serotonin: study of variation at seven serotonin
receptor genes in suicide completers
JOURNAL Am. J. Med. Genet. B Neuropsychiatr. Genet. 118B (1), 36-40 (2003)
PUBMED 12627464
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (residues 1 to 365)
AUTHORS Pierce,P.A., Xie,G.X., Meuser,T. and Peroutka,S.J.
TITLE 5-Hydroxytryptamine receptor subtype messenger RNAs in human dorsal
root ganglia: a polymerase chain reaction study
JOURNAL Neuroscience 81 (3), 813-819 (1997)
PUBMED 9316030
REFERENCE 7 (residues 1 to 365)
AUTHORS Levy,F.O., Holtgreve-Grez,H., Tasken,K., Solberg,R., Ried,T. and
Gudermann,T.
TITLE Assignment of the gene encoding the 5-HT1E serotonin receptor (S31)
(locus HTR1E) to human chromosome 6q14-q15
JOURNAL Genomics 22 (3), 637-640 (1994)
PUBMED 8001977
REFERENCE 8 (residues 1 to 365)
AUTHORS Zgombick,J.M., Schechter,L.E., Macchi,M., Hartig,P.R.,
Branchek,T.A. and Weinshank,R.L.
TITLE Human gene S31 encodes the pharmacologically defined serotonin
5-hydroxytryptamine1E receptor
JOURNAL Mol. Pharmacol. 42 (2), 180-185 (1992)
PUBMED 1513320
REFERENCE 9 (residues 1 to 365)
AUTHORS McAllister,G., Charlesworth,A., Snodin,C., Beer,M.S., Noble,A.J.,
Middlemiss,D.N., Iversen,L.L. and Whiting,P.
TITLE Molecular cloning of a serotonin receptor from human brain (5HT1E):
a fifth 5HT1-like subtype
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (12), 5517-5521 (1992)
PUBMED 1608964
REFERENCE 10 (residues 1 to 365)
AUTHORS Levy,F.O., Gudermann,T., Birnbaumer,M., Kaumann,A.J. and
Birnbaumer,L.
TITLE Molecular cloning of a human gene (S31) encoding a novel serotonin
receptor mediating inhibition of adenylyl cyclase
JOURNAL FEBS Lett. 296 (2), 201-206 (1992)
PUBMED 1733778
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL521170.3, CR618239.1, BC069751.1 and M91467.1.
FEATURES Location/Qualifiers
source 1..365
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q14-q15"
Protein 1..365
/product="5-hydroxytryptamine (serotonin) receptor 1E"
/calculated_mol_wt=41551
CDS 1..365
/gene="HTR1E"
/gene_synonym="5-HT1E"
/coded_by="NM_000865.2:704..1801"
/db_xref="CCDS:CCDS5006.1"
/db_xref="GeneID:3354"
/db_xref="HGNC:5291"
/db_xref="HPRD:01635"
/db_xref="MIM:182132"
ORIGIN
1 mnitncttea smairpktit ekmlicmtlv vittlttlln lavimaigtt kklhqpanyl
61 icslavtdll vavlvmplsi iyivmdrwkl gyflcevwls vdmtcctcsi lhlcvialdr
121 ywaitnaiey arkrtakraa lmiltvwtis ifismpplfw rshrrlsppp sqctiqhdhv
181 iytiystlga fyipltlili lyyriyhaak slyqkrgssr hlsnrstdsq nsfasckltq
241 tfcvsdfsts dpttefekfh asirippfdn dldhpgerqq isstrerkaa rilglilgaf
301 ilswlpffik elivglsiyt vssevadflt wlgyvnslin pllytsfned fklafkklir
361 creht
//