LOCUS NP_000796 101 aa linear PRI 12-OCT-2008
DEFINITION gastrin preproprotein [Homo sapiens].
ACCESSION NP_000796
VERSION NP_000796.1 GI:4503923
DBSOURCE REFSEQ: accession NM_000805.3
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 101)
AUTHORS Zhang,Z.H., Wu,S.D., Wang,B., Su,Y., Jin,J.Z., Kong,J. and
Wang,H.L.
TITLE Sphincter of Oddi hypomotility and its relationship with
duodenal-biliary reflux, plasma motilin and serum gastrin
JOURNAL World J. Gastroenterol. 14 (25), 4077-4081 (2008)
PUBMED 18609694
REMARK GeneRIF: About 35.9% of the patients with a T tube after
cholecystectomy and choledochotomy have duodenal-biliary reflux.
Most of them have sphincter of Oddi hypomotility and the decreased
level of plasma motilin and serum gastrin.
REFERENCE 2 (residues 1 to 101)
AUTHORS Mao,J.D., Wu,P., Yang,Y.L., Wu,J. and Huang,H.
TITLE Relationship between expression of gastrin, somatostatin, Fas/FasL
and caspases in large intestinal carcinoma
JOURNAL World J. Gastroenterol. 14 (18), 2802-2809 (2008)
PUBMED 18473402
REMARK GeneRIF: Gastrin and somatostatin play important roles in the
regulation and control of cell apoptosis in large intestinal
carcinoma, and the mechanism may be directly related to the
aberrant expression of Fas and Fas ligand.
REFERENCE 3 (residues 1 to 101)
AUTHORS Bundgaard,J.R. and Rehfeld,J.F.
TITLE Distinct linkage between post-translational processing and
differential secretion of progastrin derivatives in endocrine cells
JOURNAL J. Biol. Chem. 283 (7), 4014-4021 (2008)
PUBMED 18057001
REMARK GeneRIF: differences in post-translational modifications are
attributable to differential intracellular sorting of precursors;a
two-step sorting mechanism for progastrin leading to differential
secretion of processed fragments
REFERENCE 4 (residues 1 to 101)
AUTHORS Zhang,Z.H., Wu,S.D., Su,Y., Jin,J.Z., Fan,Y., Yu,H. and Zhang,L.K.
TITLE Differences and significance of motilin, vasoactive intestinal
peptide and gastrin in blood and gallbladder tissues of patients
with gallstones
JOURNAL HBPD INT 7 (1), 58-64 (2008)
PUBMED 18234640
REMARK GeneRIF: The abnormal excretion of hormonal factors is closely
related to gallstone formation
REFERENCE 5 (residues 1 to 101)
AUTHORS Stephens,M.R., Hopper,A.N., Lewis,W.G., Blackshaw,G., Edwards,P.,
Osborne,B. and Thompson,I.W.
TITLE Prognostic significance of gastrin expression in patients
undergoing R0 gastrectomy for adenocarcinoma
JOURNAL Gastric Cancer 10 (3), 159-166 (2007)
PUBMED 17922093
REMARK GeneRIF: The duration of survival of patients whose tumors
exhibited well-differentiated gastrin-positive tumor (GPT) cells (n
= 12) was significantly poorer than that of patients whose tumors
were GPT-negative (5-year survival, 30% vs 54%; P = 0.037).
REFERENCE 6 (sites)
AUTHORS Bertenshaw,G.P., Turk,B.E., Hubbard,S.J., Matters,G.L.,
Bylander,J.E., Crisman,J.M., Cantley,L.C. and Bond,J.S.
TITLE Marked differences between metalloproteases meprin A and B in
substrate and peptide bond specificity
JOURNAL J. Biol. Chem. 276 (16), 13248-13255 (2001)
PUBMED 11278902
REFERENCE 7 (sites)
AUTHORS Sawada,M., Finniss,S. and Dickinson,C.J.
TITLE Diminished prohormone convertase 3 expression (PC1/PC3) inhibits
progastrin post-translational processing
JOURNAL Regul. Pept. 89 (1-3), 19-28 (2000)
PUBMED 10771309
REFERENCE 8 (sites)
AUTHORS Bishop,L., Dimaline,R., Blackmore,C., Deavall,D., Dockray,G.J. and
Varro,A.
TITLE Modulation of the cleavage of the gastrin precursor by prohormone
phosphorylation
JOURNAL Gastroenterology 115 (5), 1154-1162 (1998)
PUBMED 9797370
REFERENCE 9 (sites)
AUTHORS Lacourse,K.A., Friis-Hansen,L., Rehfeld,J.F. and Samuelson,L.C.
TITLE Disturbed progastrin processing in carboxypeptidase E-deficient fat
mice
JOURNAL FEBS Lett. 416 (1), 45-50 (1997)
PUBMED 9369230
REFERENCE 10 (sites)
AUTHORS Varro,A. and Dockray,G.J.
TITLE Post-translational processing of progastrin: inhibition of
cleavage, phosphorylation and sulphation by brefeldin A
JOURNAL Biochem. J. 295 (PT 3), 813-819 (1993)
PUBMED 8240296
REFERENCE 11 (residues 1 to 101)
AUTHORS Pauwels,S., Najdovski,T., Dimaline,R., Lee,C.M. and
Deschodt-Lanckman,M.
TITLE Degradation of human gastrin and CCK by endopeptidase 24.11:
differential behaviour of the sulphated and unsulphated peptides
JOURNAL Biochim. Biophys. Acta 996 (1-2), 82-88 (1989)
PUBMED 2736261
REFERENCE 12 (sites)
AUTHORS Pauwels,S., Najdovski,T., Dimaline,R., Lee,C.M. and
Deschodt-Lanckman,M.
TITLE Degradation of human gastrin and CCK by endopeptidase 24.11:
differential behaviour of the sulphated and unsulphated peptides
JOURNAL Biochim. Biophys. Acta 996 (1-2), 82-88 (1989)
PUBMED 2736261
REFERENCE 13 (residues 1 to 101)
AUTHORS Higashimoto,Y., Himeno,S., Shinomura,Y., Nagao,K., Tamura,T. and
Tarui,S.
TITLE Purification and structural determination of urinary NH2-terminal
big gastrin fragments
JOURNAL Biochem. Biophys. Res. Commun. 160 (3), 1364-1370 (1989)
PUBMED 2730647
REFERENCE 14 (residues 1 to 101)
AUTHORS Lund,T., Geurts van Kessel,A.H., Haun,S. and Dixon,J.E.
TITLE The genes for human gastrin and cholecystokinin are located on
different chromosomes
JOURNAL Hum. Genet. 73 (1), 77-80 (1986)
PUBMED 3011648
REFERENCE 15 (residues 1 to 101)
AUTHORS Polosatov,M.V., Klimov,P.K., Masevich,C.G., Samartsev,M.A. and
Wunsch,E.
TITLE Interaction of synthetic human big gastrin with blood proteins of
man and animals
JOURNAL Acta Hepatogastroenterol (Stuttg) 26 (2), 154-159 (1979)
PUBMED 463490
REFERENCE 16 (residues 1 to 101)
AUTHORS Fritsch,W.P., Hausamen,T.U. and Scholten,T.
TITLE [Gastrointestinal hormones. I. Hormones of the gastrin group]
JOURNAL Z Gastroenterol 15 (4), 264-276 (1977)
PUBMED 871064
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC069724.1 and BM768483.1.
Summary: Gastrin is a hormone whose main function is to stimulate
secretion of hydrochloric acid by the gastric mucosa, which results
in gastrin formation inhibition. This hormone also acts as a
mitogenic factor for gastrointestinal epithelial cells. Gastrin has
two biologically active peptide forms, G34 and G17. [provided by
RefSeq].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..101
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21"
Protein 1..101
/product="gastrin preproprotein"
sig_peptide 1..19
/calculated_mol_wt=2130
proprotein 20..101
/product="gastrin proprotein"
/calculated_mol_wt=9282
mat_peptide 59..92
/product="gastrin G34"
/calculated_mol_wt=3867
mat_peptide 76..92
/product="gastrin G17"
/calculated_mol_wt=2116
Site 79
/site_type="modified"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site"
/citation=[11]
/db_xref="HPRD:00392"
Site 80
/site_type="modified"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site"
/citation=[6]
/db_xref="HPRD:02667"
Site 81
/site_type="modified"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site"
/citation=[6]
/db_xref="HPRD:02667"
Site 82
/site_type="modified"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site"
/citation=[6]
/db_xref="HPRD:02667"
Site 83
/site_type="modified"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site"
/citation=[6]
/db_xref="HPRD:02667"
Site 86
/site_type="modified"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site"
/citation=[11]
/db_xref="HPRD:00392"
Site 88
/site_type="modified"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site"
/citation=[11]
/db_xref="HPRD:00392"
Site 91
/site_type="modified"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site"
/citation=[11]
/db_xref="HPRD:00392"
Site 93
/site_type="modified"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site"
/citation=[9]
/db_xref="HPRD:00272"
Site 96
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[8]
/citation=[10]
CDS 1..101
/gene="GAST"
/gene_synonym="GAS"
/coded_by="NM_000805.3:33..338"
/db_xref="CCDS:CCDS11404.1"
/db_xref="GeneID:2520"
/db_xref="HGNC:4164"
/db_xref="HPRD:00671"
/db_xref="MIM:137250"
ORIGIN
1 mqrlcvyvli falalaafse aswkprsqqp daplgtganr dlelpwleqq gpashhrrql
61 gpqgpphlva dpskkqgpwl eeeeeaygwm dfgrrsaede n
//