LOCUS NP_000752 516 aa linear PRI 16-NOV-2008
DEFINITION cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo
sapiens].
ACCESSION NP_000752
VERSION NP_000752.2 GI:73915100
DBSOURCE REFSEQ: accession NM_000761.3
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 516)
AUTHORS Kotsopoulos,J., Vitonis,A.F., Terry,K.L., De Vivo,I., Cramer,D.W.,
Hankinson,S.E. and Tworoger,S.S.
TITLE Coffee intake, variants in genes involved in caffeine metabolism,
and the risk of epithelial ovarian cancer
JOURNAL Cancer Causes Control (2008) In press
PUBMED 18941913
REMARK GeneRIF: Observational study of gene-disease association and
gene-environment interaction. (HuGE Navigator)
Publication Status: Available-Online prior to print
REFERENCE 2 (residues 1 to 516)
AUTHORS Chang,M.H., Lindegren,M.L., Butler,M.A., Chanock,S.J.,
Dowling,N.F., Gallagher,M., Moonesinghe,R., Moore,C.A., Ned,R.M.,
Reichler,M.R., Sanders,C.L., Welch,R., Yesupriya,A. and Khoury,M.J.
CONSRTM for the CDC/NCI NHANES III Genomics Working Group
TITLE Prevalence in the United States of Selected Candidate Gene
Variants: Third National Health and Nutrition Examination Survey,
1991-1994
JOURNAL Am. J. Epidemiol. (2008) In press
PUBMED 18936436
REMARK GeneRIF: Observational study of genotype prevalence. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 3 (residues 1 to 516)
AUTHORS Bilgen,T., Tosun,O., Luleci,G. and Keser,I.
TITLE Frequencies of four genetic polymorphisms in the CYP1A2 gene in
Turkish population
JOURNAL Genetika 44 (8), 1133-1136 (2008)
PUBMED 18825963
REMARK GeneRIF: Observational study of genotype prevalence. (HuGE
Navigator)
REFERENCE 4 (residues 1 to 516)
AUTHORS El-Sohemy,A., Cornelis,M.C., Kabagambe,E.K. and Campos,H.
TITLE Coffee, CYP1A2 genotype and risk of myocardial infarction
JOURNAL Genes Nutr 2 (1), 155-156 (2007)
PUBMED 18850169
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (residues 1 to 516)
AUTHORS Jiang,Z., Dragin,N., Jorge-Nebert,L.F., Martin,M.V.,
Guengerich,F.P., Aklillu,E., Ingelman-Sundberg,M., Hammons,G.J.,
Lyn-Cook,B.D., Kadlubar,F.F., Saldana,S.N., Sorter,M., Vinks,A.A.,
Nassr,N., von Richter,O., Jin,L. and Nebert,D.W.
TITLE Search for an association between the human CYP1A2 genotype and
CYP1A2 metabolic phenotype
JOURNAL Pharmacogenet. Genomics 16 (5), 359-367 (2006)
PUBMED 16609368
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (residues 1 to 516)
AUTHORS Jiang,Z., Dalton,T.P., Jin,L., Wang,B., Tsuneoka,Y., Shertzer,H.G.,
Deka,R. and Nebert,D.W.
TITLE Toward the evaluation of function in genetic variability:
characterizing human SNP frequencies and establishing
BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus
JOURNAL Hum. Mutat. 25 (2), 196-206 (2005)
PUBMED 15643613
REMARK GeneRIF: Determination of SNP frequencies in the CYP1A1_CYP1A2
locus.
REFERENCE 7 (residues 1 to 516)
AUTHORS Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
Nebert,D.W.
TITLE Comparison of cytochrome P450 (CYP) genes from the mouse and human
genomes, including nomenclature recommendations for genes,
pseudogenes and alternative-splice variants
JOURNAL Pharmacogenetics 14 (1), 1-18 (2004)
PUBMED 15128046
REMARK Review article
REFERENCE 8 (residues 1 to 516)
AUTHORS Butler,M.A., Iwasaki,M., Guengerich,F.P. and Kadlubar,F.F.
TITLE Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase,
is primarily responsible for the hepatic 3-demethylation of
caffeine and N-oxidation of carcinogenic arylamines
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (20), 7696-7700 (1989)
PUBMED 2813353
REFERENCE 9 (residues 1 to 516)
AUTHORS Ikeya,K., Jaiswal,A.K., Owens,R.A., Jones,J.E., Nebert,D.W. and
Kimura,S.
TITLE Human CYP1A2: sequence, gene structure, comparison with the mouse
and rat orthologous gene, and differences in liver 1A2 mRNA
expression
JOURNAL Mol. Endocrinol. 3 (9), 1399-1408 (1989)
PUBMED 2575218
REFERENCE 10 (residues 1 to 516)
AUTHORS Quattrochi,L.C., Okino,S.T., Pendurthi,U.R. and Tukey,R.H.
TITLE Cloning and isolation of human cytochrome P-450 cDNAs homologous to
dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6
JOURNAL DNA 4 (5), 395-400 (1985)
PUBMED 3000715
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC091230.23, BC067424.1 and
M55053.1.
On Aug 30, 2005 this sequence version replaced gi:4503201.
Summary: This gene encodes a member of the cytochrome P450
superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug
metabolism and synthesis of cholesterol, steroids and other lipids.
The protein encoded by this gene localizes to the endoplasmic
reticulum and its expression is induced by some polycyclic aromatic
hydrocarbons (PAHs), some of which are found in cigarette smoke.
The enzyme's endogenous substrate is unknown; however, it is able
to metabolize some PAHs to carcinogenic intermediates. Other
xenobiotic substrates for this enzyme include caffeine, aflatoxin
B1, and acetaminophen. The transcript from this gene contains four
Alu sequences flanked by direct repeats in the 3' untranslated
region. [provided by RefSeq].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..516
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q24.1"
Protein 1..516
/product="cytochrome P450, family 1, subfamily A,
polypeptide 2"
/EC_number="1.14.14.1"
/note="P450 form 4; xenobiotic monooxygenase; aryl
hydrocarbon hydroxylase; microsomal monooxygenase;
flavoprotein-linked monooxygenase; cytochrome P450,
subfamily I (aromatic compound-inducible), polypeptide 2;
dioxin-inducible P3-450"
/calculated_mol_wt=58277
CDS 1..516
/gene="CYP1A2"
/gene_synonym="CP12"
/gene_synonym="P3-450"
/gene_synonym="P450(PA)"
/coded_by="NM_000761.3:65..1615"
/db_xref="CCDS:CCDS32293.1"
/db_xref="GeneID:1544"
/db_xref="HGNC:2596"
/db_xref="HPRD:00489"
/db_xref="MIM:124060"
ORIGIN
1 malsqsvpfs atelllasai fclvfwvlkg lrprvpkglk sppepwgwpl lghvltlgkn
61 phlalsrmsq rygdvlqiri gstpvlvlsr ldtirqalvr qgddfkgrpd lytstlitdg
121 qsltfstdsg pvwaarrrla qnalntfsia sdpasssscy leehvskeak alisrlqelm
181 agpghfdpyn qvvvsvanvi gamcfgqhfp essdemlslv knthefveta ssgnpldffp
241 ilrylpnpal qrfkafnqrf lwflqktvqe hyqdfdknsv rditgalfkh skkgprasgn
301 lipqekivnl vndifgagfd tvttaiswsl mylvtkpeiq rkiqkeldtv igrerrprls
361 drpqlpylea filetfrhss flpftiphst trdttlngfy ipkkccvfvn qwqvnhdpel
421 wedpsefrpe rfltadgtai nkplsekmml fgmgkrrcig evlakweifl flaillqqle
481 fsvppgvkvd ltpiygltmk harcehvqar lrfsin
//