LOCUS NP_000688 663 aa linear PRI 22-OCT-2008
DEFINITION arachidonate 12-lipoxygenase [Homo sapiens].
ACCESSION NP_000688
VERSION NP_000688.2 GI:154426292
DBSOURCE REFSEQ: accession NM_000697.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 663)
AUTHORS Hosgood,H.D. III, Menashe,I., Shen,M., Yeager,M., Yuenger,J.,
Rajaraman,P., He,X., Chatterjee,N., Caporaso,N.E., Zhu,Y.,
Chanock,S.J., Zheng,T. and Lan,Q.
TITLE Pathway-based evaluation of 380 candidate genes and lung cancer
susceptibility suggests the importance of the cell cycle pathway
JOURNAL Carcinogenesis 29 (10), 1938-1943 (2008)
PUBMED 18676680
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 2 (residues 1 to 663)
AUTHORS Liu,Y., Freedman,B.I., Burdon,K.P., Langefeld,C.D., Howard,T.,
Herrington,D., Goff,D.C. Jr., Bowden,D.W., Wagenknecht,L.E.,
Hedrick,C.C. and Rich,S.S.
TITLE Association of arachidonate 12-lipoxygenase genotype variation and
glycemic control with albuminuria in type 2 diabetes
JOURNAL Am. J. Kidney Dis. 52 (2), 242-250 (2008)
PUBMED 18640486
REMARK GeneRIF: Compared with 261Arg allele carriers, adjusted mean ACR
was 42% greater in the 189 carriers of two 261Gln alleles (95%
confidence interval, 10 to 83; P = 0.007).
GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (residues 1 to 663)
AUTHORS Jacquot,C., Wecksler,A.T., McGinley,C.M., Segraves,E.N.,
Holman,T.R. and van der Donk,W.A.
TITLE Isotope sensitive branching and kinetic isotope effects in the
reaction of deuterated arachidonic acids with human 12- and
15-lipoxygenases
JOURNAL Biochemistry 47 (27), 7295-7303 (2008)
PUBMED 18547056
REMARK GeneRIF: Kinetic isotope effects (KIEs) in the reactions of three
human LOs (platelet 12-hLO, reticulocyte 15-hLO-1, and epithelial
15-hLO-2) with arachidonic acid (AA).
REFERENCE 4 (residues 1 to 663)
AUTHORS Guimaraes,P.E., Fridman,C., Gregorio,S.P., Kalil,E.M.,
Cristante,A.F., Teixeira,W.G., Rodrigues,C.J., Costa,M.C.,
Gattaz,W.F., Barros,T.E., Oliveira,P.S. and Dias-Neto,E.
TITLE DNA polymorphisms as tools for spinal cord injury research
JOURNAL Spinal Cord (2008) In press
PUBMED 18504448
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 5 (residues 1 to 663)
AUTHORS Somjen,D., Tordjman,K., Katzburg,S., Knoll,E., Sharon,O., Limor,R.,
Naidich,M., Naor,Z., Hendel,D. and Stern,N.
TITLE Lipoxygenase metabolites are mediators of PTH-dependent human
osteoblast growth
JOURNAL Bone 42 (3), 491-497 (2008)
PUBMED 18187376
REMARK GeneRIF: These results demonstrate a novel mechanism of parathyroid
hormone-induced human bone cell proliferation operating through 12-
and 15-lipoxygenase enzymes.
REFERENCE 6 (residues 1 to 663)
AUTHORS Yoshimoto,T., Arakawa,T., Hada,T., Yamamoto,S. and Takahashi,E.
TITLE Structure and chromosomal localization of human arachidonate
12-lipoxygenase gene
JOURNAL J. Biol. Chem. 267 (34), 24805-24809 (1992)
PUBMED 1447217
REFERENCE 7 (residues 1 to 663)
AUTHORS Funk,C.D., Funk,L.B., FitzGerald,G.A. and Samuelsson,B.
TITLE Characterization of human 12-lipoxygenase genes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (9), 3962-3966 (1992)
PUBMED 1570320
REFERENCE 8 (residues 1 to 663)
AUTHORS Yoshimoto,T., Yamamoto,Y., Arakawa,T., Suzuki,H., Yamamoto,S.,
Yokoyama,C., Tanabe,T. and Toh,H.
TITLE Molecular cloning and expression of human arachidonate
12-lipoxygenase
JOURNAL Biochem. Biophys. Res. Commun. 172 (3), 1230-1235 (1990)
PUBMED 2244907
REFERENCE 9 (residues 1 to 663)
AUTHORS Izumi,T., Hoshiko,S., Radmark,O. and Samuelsson,B.
TITLE Cloning of the cDNA for human 12-lipoxygenase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (19), 7477-7481 (1990)
PUBMED 2217179
REFERENCE 10 (residues 1 to 663)
AUTHORS Funk,C.D., Furci,L. and FitzGerald,G.A.
TITLE Molecular cloning, primary structure, and expression of the human
platelet/erythroleukemia cell 12-lipoxygenase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (15), 5638-5642 (1990)
PUBMED 2377602
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC040977.10 and M58704.1.
On Aug 2, 2007 this sequence version replaced gi:4502051.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..663
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p13.1"
Protein 1..663
/product="arachidonate 12-lipoxygenase"
/EC_number="1.13.11.31"
/note="12(S)-lipoxygenase; platelet-type 12-lipoxygenase"
/calculated_mol_wt=75563
CDS 1..663
/gene="ALOX12"
/gene_synonym="LOG12"
/gene_synonym="12-LOX"
/gene_synonym="12S-LOX"
/coded_by="NM_000697.2:54..2045"
/db_xref="CCDS:CCDS11084.1"
/db_xref="GeneID:239"
/db_xref="HGNC:429"
/db_xref="HPRD:01066"
/db_xref="MIM:152391"
ORIGIN
1 mgryrirvat gawlfsgsyn rvqlwlvgtr geaelelqlr pargeeeefd hdvaedlgll
61 qfvrlrkhhw lvddawfcdr itvqgpgaca evafpcyrwv qgedilslpe gtarlpgdna
121 ldmfqkhrek elkdrqqiyc watwkeglpl tiaadrkddl ppnmrfheek rldfewtlka
181 galemalkrv ytllsswncl edfdqifwgq ksalaekvrq cwqddelfsy qflnganpml
241 lrrstslpsr lvlpsgmeel qaqlekelqn gslfeadfil ldgipanvir gekqylaapl
301 vmlkmepngk lqpmviqiqp pnpssptptl flpsdpplaw llakswvrns dfqlheiqyh
361 llnthlvaev iavatmrclp glhpifkfli phirytmein trartqlisd ggifdkavst
421 gggghvqllr raaaqltycs lcppddladr gllglpgaly ahdalrlwei iaryvegivh
481 lfyqrddivk gdpelqawcr eitevglcqa qdrgfpvsfq sqsqlchflt mcvftctaqh
541 aainqgqldw yawvpnapct mrmpppttke dvtmatvmgs lpdvrqaclq maiswhlsrr
601 qpdmvplghh kekyfsgpkp kavlnqfrtd leklekeita rneqldwpye ylkpsciens
661 vti
//