LOCUS NP_000660 375 aa linear PRI 16-NOV-2008
DEFINITION class I alcohol dehydrogenase, gamma subunit [Homo sapiens].
ACCESSION NP_000660
VERSION NP_000660.1 GI:4501933
DBSOURCE REFSEQ: accession NM_000669.3
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 375)
AUTHORS Chang,M.H., Lindegren,M.L., Butler,M.A., Chanock,S.J.,
Dowling,N.F., Gallagher,M., Moonesinghe,R., Moore,C.A., Ned,R.M.,
Reichler,M.R., Sanders,C.L., Welch,R., Yesupriya,A. and Khoury,M.J.
CONSRTM for the CDC/NCI NHANES III Genomics Working Group
TITLE Prevalence in the United States of Selected Candidate Gene
Variants: Third National Health and Nutrition Examination Survey,
1991-1994
JOURNAL Am. J. Epidemiol. (2008) In press
PUBMED 18936436
REMARK GeneRIF: Observational study of genotype prevalence. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 2 (residues 1 to 375)
AUTHORS Hosgood,H.D. III, Menashe,I., Shen,M., Yeager,M., Yuenger,J.,
Rajaraman,P., He,X., Chatterjee,N., Caporaso,N.E., Zhu,Y.,
Chanock,S.J., Zheng,T. and Lan,Q.
TITLE Pathway-based evaluation of 380 candidate genes and lung cancer
susceptibility suggests the importance of the cell cycle pathway
JOURNAL Carcinogenesis 29 (10), 1938-1943 (2008)
PUBMED 18676680
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (residues 1 to 375)
AUTHORS Tolstrup,J.S., Nordestgaard,B.G., Rasmussen,S., Tybjaerg-Hansen,A.
and Gronbaek,M.
TITLE [Genetic variations in alcohol dehydrogenase, drinking habits and
alcoholism]
JOURNAL Ugeskr. Laeg. 170 (35), 2672-2675 (2008)
PUBMED 18761854
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (residues 1 to 375)
AUTHORS Velez,D.R., Fortunato,S.J., Thorsen,P., Lombardi,S.J.,
Williams,S.M. and Menon,R.
TITLE Preterm birth in Caucasians is associated with coagulation and
inflammation pathway gene variants
JOURNAL PLoS ONE 3 (9), E3283 (2008)
PUBMED 18818748
REMARK GeneRIF: Observational study of gene-disease association and
gene-gene interaction. (HuGE Navigator)
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 375)
AUTHORS Cichoz-Lach,H., Celinski,K. and Slomka,M.
TITLE Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic
pancreatitis among Polish individuals
JOURNAL HPB (Oxford) 10 (2), 138-143 (2008)
PUBMED 18773092
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (residues 1 to 375)
AUTHORS Yokoyama,S., Matsuo,Y., Rajasekharan,S. and Yokoyama,R.
TITLE Molecular structure of the human alcohol dehydrogenase 3 gene
JOURNAL Jpn. J. Genet. 67 (2), 167-171 (1992)
PUBMED 1524834
REFERENCE 7 (residues 1 to 375)
AUTHORS Hurley,T.D., Bosron,W.F., Hamilton,J.A. and Amzel,L.M.
TITLE Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic
effects of non-active-site substitutions
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (18), 8149-8153 (1991)
PUBMED 1896463
REFERENCE 8 (residues 1 to 375)
AUTHORS Stewart,M.J., McBride,M.S., Winter,L.A. and Duester,G.
TITLE Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and
ADH3: interaction of CCAAT/enhancer-binding protein with elements
flanking the ADH2 TATA box
JOURNAL Gene 90 (2), 271-279 (1990)
PUBMED 2169444
REFERENCE 9 (residues 1 to 375)
AUTHORS Yasunami,M., Kikuchi,I., Sarapata,D. and Yoshida,A.
TITLE The human class I alcohol dehydrogenase gene cluster: three genes
are tandemly organized in an 80-kb-long segment of the genome
JOURNAL Genomics 7 (2), 152-158 (1990)
PUBMED 2347582
REFERENCE 10 (residues 1 to 375)
AUTHORS Lange,L.G., Sytkowski,A.J. and Vallee,B.L.
TITLE Human liver alcohol dehydrogenase: purification, composition, and
catalytic features
JOURNAL Biochemistry 15 (21), 4687-4693 (1976)
PUBMED 9982
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CB114902.1, X04350.1 and
BC062476.1.
Summary: This gene encodes class I alcohol dehydrogenase, gamma
subunit, which is a member of the alcohol dehydrogenase family.
Members of this enzyme family metabolize a wide variety of
substrates, including ethanol, retinol, other aliphatic alcohols,
hydroxysteroids, and lipid peroxidation products. Class I alcohol
dehydrogenase, consisting of several homo- and heterodimers of
alpha, beta, and gamma subunits, exhibits high activity for ethanol
oxidation and plays a major role in ethanol catabolism. Three genes
encoding alpha, beta and gamma subunits are tandemly organized in a
genomic segment as a gene cluster. [provided by RefSeq].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..375
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q21-q23"
Protein 1..375
/product="class I alcohol dehydrogenase, gamma subunit"
/EC_number="1.1.1.1"
/note="ADH, gamma subunit; alcohol dehydrogenase 3 (class
I), gamma polypeptide; aldehyde reductase"
/calculated_mol_wt=39737
CDS 1..375
/gene="ADH1C"
/gene_synonym="ADH3"
/coded_by="NM_000669.3:86..1213"
/db_xref="GeneID:126"
/db_xref="HGNC:251"
/db_xref="HPRD:00066"
/db_xref="MIM:103730"
ORIGIN
1 mstagkvikc kaavlwelkk pfsieeveva ppkahevrik mvaagicrsd ehvvsgnlvt
61 plpvilghea agivesvgeg vttvkpgdkv iplftpqcgk cricknpesn yclkndlgnp
121 rgtlqdgtrr ftcsgkpihh fvgvstfsqy tvvdenavak idaasplekv cligcgfstg
181 ygsavkvakv tpgstcavfg lggvglsvvm gckaagaari iavdinkdkf akakelgate
241 cinpqdykkp iqevlkemtd ggvdfsfevi grldtmmasl lccheacgts vivgvppdsq
301 nlsinpmlll tgrtwkgaif ggfkskesvp klvadfmakk fsldalitni lpfekinegf
361 dllrsgksir tvltf
//