LOCUS NP_000572 203 aa linear PRI 16-NOV-2008
DEFINITION glutathione peroxidase 1 isoform 1 [Homo sapiens].
ACCESSION NP_000572
VERSION NP_000572.2 GI:41406084
DBSOURCE REFSEQ: accession NM_000581.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 203)
AUTHORS Lei,C., Niu,X., Wei,J., Zhu,J. and Zhu,Y.
TITLE Interaction of glutathione peroxidase-1 and selenium in endemic
dilated cardiomyopathy
JOURNAL Clin. Chim. Acta (2008) In press
PUBMED 18940188
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 2 (residues 1 to 203)
AUTHORS Hosgood,H.D. III, Menashe,I., Shen,M., Yeager,M., Yuenger,J.,
Rajaraman,P., He,X., Chatterjee,N., Caporaso,N.E., Zhu,Y.,
Chanock,S.J., Zheng,T. and Lan,Q.
TITLE Pathway-based evaluation of 380 candidate genes and lung cancer
susceptibility suggests the importance of the cell cycle pathway
JOURNAL Carcinogenesis 29 (10), 1938-1943 (2008)
PUBMED 18676680
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (residues 1 to 203)
AUTHORS Kato,K., Oguri,M., Kato,N., Hibino,T., Yajima,K., Yoshida,T.,
Metoki,N., Yoshida,H., Satoh,K., Watanabe,S., Yokoi,K., Murohara,T.
and Yamada,Y.
TITLE Assessment of genetic risk factors for thoracic aortic aneurysm in
hypertensive patients
JOURNAL Am. J. Hypertens. 21 (9), 1023-1027 (2008)
PUBMED 18600213
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (residues 1 to 203)
AUTHORS Arsova-Sarafinovska,Z., Matevska,N., Eken,A., Petrovski,D.,
Banev,S., Dzikova,S., Georgiev,V., Sikole,A., Erdem,O., Sayal,A.,
Aydin,A. and Dimovski,A.J.
TITLE Glutathione peroxidase 1 (GPX1) genetic polymorphism, erythrocyte
GPX activity, and prostate cancer risk
JOURNAL Int Urol Nephrol (2008) In press
PUBMED 18563616
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 5 (residues 1 to 203)
AUTHORS Kuzuya,M., Ando,F., Iguchi,A. and Shimokata,H.
TITLE Glutathione peroxidase 1 Pro198Leu variant contributes to the
metabolic syndrome in men in a large Japanese cohort
JOURNAL Am. J. Clin. Nutr. 87 (6), 1939-1944 (2008)
PUBMED 18541588
REMARK GeneRIF: GPX1 Pro198Leu variants are associated with the prevalence
of metabolic syndrome in Japanese men but not in women.
GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (sites)
AUTHORS Cao,C., Leng,Y., Huang,W., Liu,X. and Kufe,D.
TITLE Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine
kinases
JOURNAL J. Biol. Chem. 278 (41), 39609-39614 (2003)
PUBMED 12893824
REFERENCE 7 (residues 1 to 203)
AUTHORS Moscow,J.A., Morrow,C.S., He,R., Mullenbach,G.T. and Cowan,K.H.
TITLE Structure and function of the 5'-flanking sequence of the human
cytosolic selenium-dependent glutathione peroxidase gene (hgpx1)
JOURNAL J. Biol. Chem. 267 (9), 5949-5958 (1992)
PUBMED 1556108
REFERENCE 8 (residues 1 to 203)
AUTHORS Chada,S., Le Beau,M.M., Casey,L. and Newburger,P.E.
TITLE Isolation and chromosomal localization of the human glutathione
peroxidase gene
JOURNAL Genomics 6 (2), 268-271 (1990)
PUBMED 2307470
REFERENCE 9 (residues 1 to 203)
AUTHORS Mullenbach,G.T., Tabrizi,A., Irvine,B.D., Bell,G.I., Tainer,J.A.
and Hallewell,R.A.
TITLE Selenocysteine's mechanism of incorporation and evolution revealed
in cDNAs of three glutathione peroxidases
JOURNAL Protein Eng. 2 (3), 239-246 (1988)
PUBMED 2976939
REFERENCE 10 (residues 1 to 203)
AUTHORS Sukenaga,Y., Ishida,K., Takeda,T. and Takagi,K.
TITLE cDNA sequence coding for human glutathione peroxidase
JOURNAL Nucleic Acids Res. 15 (17), 7178 (1987)
PUBMED 3658677
REFERENCE 11 (residues 1 to 203)
AUTHORS Mullenbach,G.T., Tabrizi,A., Irvine,B.D., Bell,G.I. and
Hallewell,R.A.
TITLE Sequence of a cDNA coding for human glutathione peroxidase confirms
TGA encodes active site selenocysteine
JOURNAL Nucleic Acids Res. 15 (13), 5484 (1987)
PUBMED 2955287
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from Y00433.1 and BC007865.2.
On Jan 30, 2004 this sequence version replaced gi:10834976.
Summary: This gene encodes a member of the glutathione peroxidase
family. Glutathione peroxidase functions in the detoxification of
hydrogen peroxide, and is one of the most important antioxidant
enzymes in humans. This protein is one of only a few proteins known
in higher vertebrates to contain selenocysteine, which occurs at
the active site of glutathione peroxidase and is coded by UGA, that
normally functions as a translation termination codon. In addition,
this protein is characterized in a polyalanine sequence
polymorphism in the N-terminal region, which includes three alleles
with five, six or seven alanine (ALA) repeats in this sequence. The
allele with five ALA repeats is significantly associated with
breast cancer risk. Two alternatively spliced transcript variants
encoding distinct isoforms have been found for this gene. [provided
by RefSeq].
Transcript Variant: This variant (1) represents the shorter
transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..203
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21.3"
Protein 1..203
/product="glutathione peroxidase 1 isoform 1"
/EC_number="1.11.1.9"
/note="cellular glutathione peroxidase"
/calculated_mol_wt=21957
Site 98
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
/db_xref="HPRD:01809"
Site 98
/site_type="phosphorylation"
/experiment="experimental evidence, no additional details
recorded"
/citation=[6]
/db_xref="HPRD:01259"
CDS 1..203
/gene="GPX1"
/gene_synonym="GSHPX1"
/gene_synonym="MGC14399"
/gene_synonym="MGC88245"
/coded_by="NM_000581.2:81..692"
/note="isoform 1 is encoded by transcript variant 1"
/selenocysteine
/db_xref="CCDS:CCDS43091.1"
/db_xref="GeneID:2876"
/db_xref="HGNC:4553"
/db_xref="HPRD:11749"
/db_xref="MIM:138320"
ORIGIN
1 mcaarlaaaa aaaqsvyafs arplaggepv slgslrgkvl lienvaslug ttvrdytqmn
61 elqrrlgprg lvvlgfpcnq fghqenakne eilnslkyvr pgggfepnfm lfekcevnga
121 gahplfaflr ealpapsdda talmtdpkli twspvcrndv awnfekflvg pdgvplrrys
181 rrfqtidiep dieallsqgp sca
//