LOCUS NP_000558 224 aa linear PRI 16-NOV-2008
DEFINITION C-reactive protein, pentraxin-related [Homo sapiens].
ACCESSION NP_000558
VERSION NP_000558.2 GI:55770842
DBSOURCE REFSEQ: accession NM_000567.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 224)
AUTHORS Rafiq,S., Melzer,D., Weedon,M.N., Lango,H., Saxena,R., Scott,L.J.,
Palmer,C.N., Morris,A.D., McCarthy,M.I., Ferrucci,L.,
Hattersley,A.T., Zeggini,E. and Frayling,T.M.
CONSRTM the DIAGRAM Consortium
TITLE Gene variants influencing measures of inflammation or predisposing
to autoimmune and inflammatory diseases are not associated with the
risk of type 2 diabetes
JOURNAL Diabetologia 51 (12), 2205-2213 (2008)
PUBMED 18853133
REMARK GeneRIF: Observational study and meta-analysis of gene-disease
association. (HuGE Navigator)
REFERENCE 2 (residues 1 to 224)
AUTHORS Haarala,A., Eklund,C., Pessi,T., Lehtimaki,T., Huupponen,R.,
Jula,A., Viikari,J., Raitakari,O. and Hurme,M.
TITLE Use of combined oral contraceptives alters metabolic determinants
and genetic regulation of C-reactive protein. The Cardiovascular
Risk in Young Finns Study
JOURNAL Scand. J. Clin. Lab. Invest., 1-7 (2008) In press
PUBMED 18937150
REMARK GeneRIF: Observational study of gene-disease association and
gene-environment interaction. (HuGE Navigator)
Publication Status: Available-Online prior to print
REFERENCE 3 (residues 1 to 224)
AUTHORS Ennis,S., Jomary,C., Mullins,R., Cree,A., Chen,X., Macleod,A.,
Jones,S., Collins,A., Stone,E. and Lotery,A.
TITLE Association between the SERPING1 gene and age-related macular
degeneration: a two-stage case-control study
JOURNAL Lancet (2008) In press
PUBMED 18842294
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 4 (residues 1 to 224)
AUTHORS Badger,S.A., Soong,C.V., O' Donnell,M.E., Mercer,C., Young,I.S. and
Hughes,A.E.
TITLE C-reactive protein (CRP) elevation in patients with abdominal
aortic aneurysm is independent of the most important CRP genetic
polymorphism
JOURNAL J. Vasc. Surg. (2008) In press
PUBMED 18829218
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Available-Online prior to print
REFERENCE 5 (residues 1 to 224)
AUTHORS Velez,D.R., Fortunato,S.J., Thorsen,P., Lombardi,S.J.,
Williams,S.M. and Menon,R.
TITLE Preterm birth in Caucasians is associated with coagulation and
inflammation pathway gene variants
JOURNAL PLoS ONE 3 (9), E3283 (2008)
PUBMED 18818748
REMARK GeneRIF: Observational study of gene-disease association and
gene-gene interaction. (HuGE Navigator)
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 224)
AUTHORS Swanson,S.J., Christner,R.B. and Mortensen,R.F.
TITLE Human serum amyloid P-component (SAP) selectively binds to
immobilized or bound forms of C-reactive protein (CRP)
JOURNAL Biochim. Biophys. Acta 1160 (3), 309-316 (1992)
PUBMED 1477104
REFERENCE 7 (residues 1 to 224)
AUTHORS Du Clos,T.W., Zlock,L.T. and Marnell,L.
TITLE Definition of a C-reactive protein binding determinant on histones
JOURNAL J. Biol. Chem. 266 (4), 2167-2171 (1991)
PUBMED 1989977
REFERENCE 8 (residues 1 to 224)
AUTHORS Oliveira,E.B., Gotschlich,C. and Liu,T.Y.
TITLE Primary structure of human C-reactive protein
JOURNAL J. Biol. Chem. 254 (2), 489-502 (1979)
PUBMED 762075
REFERENCE 9 (residues 1 to 224)
AUTHORS Osmand,A.P., Gerwurz,H. and Friedenson,B.
TITLE Partial amino-acid sequences of human and rabbit C-reactive
proteins: homology with immunoglobulins and histocompatibility
antigens
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 74 (3), 1214-1218 (1977)
PUBMED 403526
REFERENCE 10 (residues 1 to 224)
AUTHORS Osmand,A.P., Friedenson,B., Gewurz,H., Painter,R.H., Hofmann,T. and
Shelton,E.
TITLE Characterization of C-reactive protein and the complement
subcomponent C1t as homologous proteins displaying cyclic
pentameric symmetry (pentraxins)
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 74 (2), 739-743 (1977)
PUBMED 265538
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BG533281.1, X56214.1, X56692.1, BG618967.1 and AI609949.1.
On Nov 15, 2004 this sequence version replaced gi:10835135.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Entrez Gene record to access additional publications.
FEATURES Location/Qualifiers
source 1..224
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21-q23"
Protein 1..224
/product="C-reactive protein, pentraxin-related"
/calculated_mol_wt=24908
CDS 1..224
/gene="CRP"
/gene_synonym="PTX1"
/gene_synonym="MGC88244"
/gene_synonym="MGC149895"
/coded_by="NM_000567.2:105..779"
/db_xref="CCDS:CCDS30911.1"
/db_xref="GeneID:1401"
/db_xref="HGNC:2367"
/db_xref="HPRD:00422"
/db_xref="MIM:123260"
ORIGIN
1 mekllcflvl tslshafgqt dmsrkafvfp kesdtsyvsl kapltkplka ftvclhfyte
61 lsstrgysif syatkrqdne ilifwskdig ysftvggsei lfevpevtva pvhictswes
121 asgivefwvd gkprvrkslk kgytvgaeas iilgqeqdsf ggnfegsqsl vgdignvnmw
181 dfvlspdein tiylggpfsp nvlnwralky evqgevftkp qlwp
//