LOCUS       NP_000066                303 aa            linear   PRI 24-OCT-2008
DEFINITION  cyclin-dependent kinase 4 [Homo sapiens].
ACCESSION   NP_000066 NP_116302
VERSION     NP_000066.1  GI:4502735
DBSOURCE    REFSEQ: accession NM_000075.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 303)
  AUTHORS   Hosgood,H.D. III, Menashe,I., Shen,M., Yeager,M., Yuenger,J.,
            Rajaraman,P., He,X., Chatterjee,N., Caporaso,N.E., Zhu,Y.,
            Chanock,S.J., Zheng,T. and Lan,Q.
  TITLE     Pathway-based evaluation of 380 candidate genes and lung cancer
            susceptibility suggests the importance of the cell cycle pathway
  JOURNAL   Carcinogenesis 29 (10), 1938-1943 (2008)
   PUBMED   18676680
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (residues 1 to 303)
  AUTHORS   Ye,Y., Lippman,S.M., Lee,J.J., Chen,M., Frazier,M.L., Spitz,M.R.
            and Wu,X.
  TITLE     Genetic variations in cell-cycle pathway and the risk of oral
            premalignant lesions
  JOURNAL   Cancer 113 (9), 2488-2495 (2008)
   PUBMED   18823025
  REMARK    GeneRIF: Observational study of gene-disease association, gene-gene
            interaction, and gene-environment interaction. (HuGE Navigator)
            Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 303)
  AUTHORS   Smalley,K.S., Contractor,R., Nguyen,T.K., Xiao,M., Edwards,R.,
            Muthusamy,V., King,A.J., Flaherty,K.T., Bosenberg,M., Herlyn,M. and
            Nathanson,K.L.
  TITLE     Identification of a novel subgroup of melanomas with
            KIT/cyclin-dependent kinase-4 overexpression
  JOURNAL   Cancer Res. 68 (14), 5743-5752 (2008)
   PUBMED   18632627
  REMARK    GeneRIF: co-overexpression of KIT/CDK4 is a potential mechanism of
            oncogenic transformation in some BRAF/NRAS wild-type melanomas
REFERENCE   4  (residues 1 to 303)
  AUTHORS   Peric,B., Cerkovnik,P., Novakovic,S., Zgajnar,J., Besic,N. and
            Hocevar,M.
  TITLE     Prevalence of variations in melanoma susceptibility genes among
            Slovenian melanoma families
  JOURNAL   BMC Med. Genet. 9, 86 (2008)
   PUBMED   18803811
  REMARK    GeneRIF: The present study has shown an absence of CDK4 mutations
            in Slovenian population of familial melanoma patients (37%)
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 303)
  AUTHORS   Skibola,C.F., Bracci,P.M., Halperin,E., Nieters,A., Hubbard,A.,
            Paynter,R.A., Skibola,D.R., Agana,L., Becker,N., Tressler,P.,
            Forrest,M.S., Sankararaman,S., Conde,L., Holly,E.A. and Smith,M.T.
  TITLE     Polymorphisms in the estrogen receptor 1 and vitamin C and matrix
            metalloproteinase gene families are associated with susceptibility
            to lymphoma
  JOURNAL   PLoS ONE 3 (7), E2816 (2008)
   PUBMED   18636124
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 303)
  AUTHORS   Hall,M., Bates,S. and Peters,G.
  TITLE     Evidence for different modes of action of cyclin-dependent kinase
            inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to
            cyclins
  JOURNAL   Oncogene 11 (8), 1581-1588 (1995)
   PUBMED   7478582
REFERENCE   7  (residues 1 to 303)
  AUTHORS   Tassan,J.P., Jaquenoud,M., Leopold,P., Schultz,S.J. and Nigg,E.A.
  TITLE     Identification of human cyclin-dependent kinase 8, a putative
            protein kinase partner for cyclin C
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (19), 8871-8875 (1995)
   PUBMED   7568034
REFERENCE   8  (residues 1 to 303)
  AUTHORS   Medema,R.H., Herrera,R.E., Lam,F. and Weinberg,R.A.
  TITLE     Growth suppression by p16ink4 requires functional retinoblastoma
            protein
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (14), 6289-6293 (1995)
   PUBMED   7603984
REFERENCE   9  (residues 1 to 303)
  AUTHORS   Mitchell,E.L., White,G.R., Santibanez-Koref,M.F., Varley,J.M. and
            Heighway,J.
  TITLE     Mapping of gene loci in the Q13-Q15 region of chromosome 12
  JOURNAL   Chromosome Res. 3 (4), 261-262 (1995)
   PUBMED   7606365
REFERENCE   10 (sites)
  AUTHORS   Kato,J.Y., Matsuoka,M., Strom,D.K. and Sherr,C.J.
  TITLE     Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating
            kinase
  JOURNAL   Mol. Cell. Biol. 14 (4), 2713-2721 (1994)
   PUBMED   8139570
REFERENCE   11 (residues 1 to 303)
  AUTHORS   Hanks,S.K.
  TITLE     Homology probing: identification of cDNA clones encoding members of
            the protein-serine kinase family
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (2), 388-392 (1987)
   PUBMED   2948189
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M14505.1 and BC003644.2.
            On Nov 4, 2002 this sequence version replaced gi:14249694.
            
            Summary: The protein encoded by this gene is a member of the
            Ser/Thr protein kinase family. This protein is highly similar to
            the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a
            catalytic subunit of the protein kinase complex that is important
            for cell cycle G1 phase progression. The activity of this kinase is
            restricted to the G1-S phase, which is controlled by the regulatory
            subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase
            was shown to be responsible for the phosphorylation of
            retinoblastoma gene product (Rb). Mutations in this gene as well as
            in its related proteins including D-type cyclins, p16(INK4a) and Rb
            were all found to be associated with tumorigenesis of a variety of
            cancers. Multiple polyadenylation sites of this gene have been
            reported. [provided by RefSeq].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14"
     Protein         1..303
                     /product="cyclin-dependent kinase 4"
                     /EC_number="2.7.11.22"
                     /note="cell division kinase 4; melanoma cutaneous
                     malignant, 3"
                     /calculated_mol_wt=33599
     Site            172
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[10]
     CDS             1..303
                     /gene="CDK4"
                     /gene_synonym="CMM3"
                     /gene_synonym="PSK-J3"
                     /gene_synonym="MGC14458"
                     /coded_by="NM_000075.2:228..1139"
                     /db_xref="CCDS:CCDS8953.1"
                     /db_xref="GeneID:1019"
                     /db_xref="HGNC:1773"
                     /db_xref="HPRD:00447"
                     /db_xref="MIM:123829"
ORIGIN      
        1 matsryepva eigvgaygtv ykardphsgh fvalksvrvp nggggggglp istvrevall
       61 rrleafehpn vvrlmdvcat srtdreikvt lvfehvdqdl rtyldkappp glpaetikdl
      121 mrqflrgldf lhancivhrd lkpenilvts ggtvkladfg lariysyqma ltpvvvtlwy
      181 rapevllqst yatpvdmwsv gcifaemfrr kplfcgnsea dqlgkifdli glppeddwpr
      241 dvslprgafp prgprpvqsv vpemeesgaq lllemltfnp hkrisafral qhsylhkdeg
      301 npe
//