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Select item 103302991.

Ubiquitin ligases Siah1a/2 control alveolar macrophage functions to limit carcinogen-induced lung adenocarcinoma

Marzia Scortegagna, Yuanning Du, Linda M. Bradley, Kun Wang, Alfredo Molinolo, Eytan Ruppin, Rabi Murad, Ze’ev A. Ronai

Cancer Res. Author manuscript; available in PMC 2023 Dec 15.

Published in final edited form as: Cancer Res. 2023 Jun 15; 83(12): 2016–2033. doi: 10.1158/0008-5472.CAN-23-0258

PMCID:: PMC10330299

Abstract Article PDF–2.6M

Select item 98172802.

LINC00963 promotes the malignancy and metastasis of lung adenocarcinoma by stabilizing Zeb1 and exosomes-induced M2 macrophage polarization

Ronghang Hu, Baobin Xu, Jiajun Ma, Linfeng Li, Liming Zhang, Li Wang, Jiebo Zhu, Tao Guo, Heng Zhang, Shaoqiang Wang

Mol Med. 2023; 29: 1. Published online 2023 Jan 5. doi: 10.1186/s10020-022-00598-y

PMCID:: PMC9817280

Abstract Article PDF–14M

Select item 97415053.

SIAH proteins regulate the degradation and intra‐mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease

Fatimah Abd Elghani, Hazem Safory, Haya Hamza, Mor Savyon, Malik Farhoud, Michal Toren‐Hershoviz, Zagorka Vitic, Kirsten Ebanks, Vered Shani, Sleman Bisharat, Lihi Shaulov, Claude Brodski, Zhiyin Song, Rina Bandopadhyay, Simone Engelender

Aging Cell. 2022 Dec; 21(12): e13731. Published online 2022 Oct 28. doi: 10.1111/acel.13731

PMCID:: PMC9741505

Abstract Article PDF–5.1M

Select item 97135214.

FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1

Yan Wang, Kai Wang, Jiale Fu, Yu Zhang, Yufei Mao, Xu Wang, Xiang Wang, Rutong Yu, Xiuping Zhou

Neuro Oncol. 2022 Dec; 24(12): 2107–2120. Published online 2022 Jun 20. doi: 10.1093/neuonc/noac156

PMCID:: PMC9713521

Abstract Article PDF–51M

Select item 94449775.

MAB21L4 deficiency drives squamous cell carcinoma via activation of RET

Ankit Srivastava, Cristina Tommasi, Dane Sessions, Angela Mah, Tomas Bencomo, Jasmine M. Garcia, Tiffany Jiang, Michael Lee, Joseph Y. Shen, Lek Wei Seow, Audrey Nguyen, Kimal Rajapakshe, Cristian Coarfa, Kenneth Y. Tsai, Vanessa Lopez-Pajares, Carolyn S. Lee

Cancer Res. Author manuscript; available in PMC 2023 Mar 2.

Published in final edited form as: Cancer Res. 2022 Sep 2; 82(17): 3143–3157. doi: 10.1158/0008-5472.CAN-22-0047

PMCID:: PMC9444977

Abstract Article PDF–3.8M

Select item 93485766.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 91225297.

P-TEFb is degraded by Siah1/2 in quiescent cells

Fang Huang, Yongmei Feng, B Matija Peterlin, Koh Fujinaga

Nucleic Acids Res. 2022 May 20; 50(9): 5000–5013. Published online 2022 May 7. doi: 10.1093/nar/gkac291

PMCID:: PMC9122529

Abstract Article PDF–6.1M

Select item 91052358.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 89954439.

Reactive oxygen species‐induced SIAH1 promotes granulosa cells' senescence in premature ovarian failure

Li Lin, Wujiang Gao, Yumei Chen, Taoqiong Li, Chunli Sha, Lu Chen, Meiling Yang, Hong Wei, Yunpeng Chen, Xiaolan Zhu

J Cell Mol Med. 2022 Apr; 26(8): 2417–2427. Published online 2022 Mar 9. doi: 10.1111/jcmm.17264

PMCID:: PMC8995443

Abstract Article PDF–1.6M

Select item 896577010.

m⁶A-induced repression of SIAH1 facilitates alternative splicing of androgen receptor variant 7 by regulating CPSF1

Lei Xia, Qing Han, Xuehui Duan, Yinjie Zhu, Jiahua Pan, Baijun Dong, Weiliang Xia, Wei Xue, Jianjun Sha

Mol Ther Nucleic Acids. 2022 Jun 14; 28: 219–230. Published online 2022 Mar 15. doi: 10.1016/j.omtn.2022.03.008

PMCID:: PMC8965770

Abstract Article PDF–2.7M

Select item 891366311.

SIAH1 reverses chemoresistance in epithelial ovarian cancer via ubiquitination of YBX-1

Wujiang Gao, Lu Chen, Li Lin, Meiling Yang, Taoqiong Li, Hong Wei, Chunli Sha, Jie Xing, Mengxue Zhang, Shijie Zhao, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu

Oncogenesis. 2022 Dec; 11(1): 13. Published online 2022 Mar 10. doi: 10.1038/s41389-022-00387-6

PMCID:: PMC8913663

Abstract Article PDF–6.0M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 796902313.

DAZAP2 acts as specifier of the p53 response to DNA damage

Magdalena C Liebl, Jutta Moehlenbrink, Huong Becker, Günter Raddatz, Suhaib K Abdeen, Rami I Aqeilan, Frank Lyko, Thomas G Hofmann

Nucleic Acids Res. 2021 Mar 18; 49(5): 2759–2776. Published online 2021 Feb 16. doi: 10.1093/nar/gkab084

PMCID:: PMC7969023

Abstract Article PDF–3.5M

Select item 736718414.

Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2

Jun Wu, Yuhua Xue, Xiang Gao, Qiang Zhou

Nucleic Acids Res. 2020 Jul 27; 48(13): 7321–7332. Published online 2020 Jun 1. doi: 10.1093/nar/gkaa461

PMCID:: PMC7367184

Abstract Article PDF–3.8M

Select item 732206715.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 716998316.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x