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Select item 85900111.

WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells

Arindam Datta, Kajal Biswas, Joshua A. Sommers, Haley Thompson, Sanket Awate, Claudia M. Nicolae, Tanay Thakar, George-Lucian Moldovan, Robert H. Shoemaker, Shyam K. Sharan, Robert M. Brosh, Jr

Nat Commun. 2021; 12: 6561. Published online 2021 Nov 12. doi: 10.1038/s41467-021-26811-w

PMCID:: PMC8590011

Abstract Article PDF–6.8M

Select item 80797062.

Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

So-mi Kang, Min-Ho Yoon, Su-Jin Lee, Jinsook Ahn, Sang Ah Yi, Ki Hong Nam, Soyoung Park, Tae-Gyun Woo, Jung-Hyun Cho, Jaecheol Lee, Nam-Chul Ha, Bum-Joon Park

Sci Rep. 2021; 11: 9122. Published online 2021 Apr 27. doi: 10.1038/s41598-021-88325-1

Correction in:: Sci Rep. 2021; 11: 17776.

PMCID:: PMC8079706

Abstract Article PDF–3.6M

Select item 79387703.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 74159914.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 59989705.

Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein

Lucie Aumailley, Marie Julie Dubois, Tracy A. Brennan, Chantal Garand, Eric R. Paquet, Robert J. Pignolo, André Marette, Michel Lebel

FASEB J. 2018 Jul; 32(7): 3623–3640. Published online 2018 Feb 8. doi: 10.1096/fj.201701176R

PMCID:: PMC5998970

Abstract Article

Select item 58322286.

Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein

Lucie Aumailley, Florence Roux-Dalvai, Isabelle Kelly, Arnaud Droit, Michel Lebel

PLoS One. 2018; 13(3): e0193170. Published online 2018 Mar 1. doi: 10.1371/journal.pone.0193170

PMCID:: PMC5832228

Abstract Article PDF–5.4M

Select item 46175407.

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

You Li, Nikolai T. Klena, George C Gabriel, Xiaoqin Liu, Andrew J. Kim, Kristi Lemke, Yu Chen, Bishwanath Chatterjee, William Devine, Rama Rao Damerla, Chien-fu Chang, Hisato Yagi, Jovenal T. San Agustin, Mohamed Thahir, Shane Anderton, Caroline Lawhead, Anita Vescovi, Herbert Pratt, Judy Morgan, Leslie Haynes, Cynthia L. Smith, Janan T. Eppig, Laura Reinholdt, Richard Francis, Linda Leatherbury, Madhavi K. Ganapathiraju, Kimimasa Tobita, Gregory J. Pazour, Cecilia W. Lo

Nature. Author manuscript; available in PMC 2015 Nov 28.

Published in final edited form as: Nature. 2015 May 28; 521(7553): 520–524. Published online 2015 Mar 25. doi: 10.1038/nature14269

PMCID:: PMC4617540

Abstract Article PDF–518K

Select item 45980858.

Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

Lucie Aumailley, Chantal Garand, Marie Julie Dubois, F. Brad Johnson, André Marette, Michel Lebel

PLoS One. 2015; 10(10): e0140292. Published online 2015 Oct 8. doi: 10.1371/journal.pone.0140292

PMCID:: PMC4598085

Abstract Article PDF–3.1M

Select item 45088919.

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

William C. Drosopoulos, Settapong T. Kosiyatrakul, Carl L. Schildkraut

J Cell Biol. 2015 Jul 20; 210(2): 191–208. doi: 10.1083/jcb.201410061

PMCID:: PMC4508891

Abstract Article PDF–3.9M

Select item 442603110.

DNA damage-induced type I interferon promotes senescence and inhibits stem cell function

Qiujing Yu, Yuliya V. Katlinskaya, Christopher J. Carbone, Bin Zhao, Kanstantsin V. Katlinski, Hui Zheng, Manti Guha, Ning Li, Qijun Chen, Ting Yang, Christopher J. Lengner, Roger A. Greenberg, F. Brad Johnson, Serge Y. Fuchs

Cell Rep. Author manuscript; available in PMC 2016 May 5.

Published in final edited form as: Cell Rep. 2015 May 5; 11(5): 785–797. Published online 2015 Apr 23. doi: 10.1016/j.celrep.2015.03.069

PMCID:: PMC4426031

Abstract Article PDF–1.6M

Select item 416042811.

The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers

Lin Chung, David Onyango, Zhigang Guo, Pingping Jia, Huifang Dai, Songbai Liu, Mian Zhou, Weiqiang Lin, Insun Pang, Hongzhi Li, Yate-Ching Yuan, Qin Huang, Li Zheng, Judith Lopes, Alain Nicolas, Weihang Chai, Dan Raz, Karen L. Reckamp, Binghui Shen

Oncogene. Author manuscript; available in PMC 2015 Aug 12.

Published in final edited form as: Oncogene. 2015 Feb 12; 34(7): 902–911. Published online 2014 Mar 10. doi: 10.1038/onc.2014.19

PMCID:: PMC4160428

Abstract Article PDF–1.9M

Select item 400740912.

Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis

Tracy A. Brennan, Kevin P. Egan, Carter M. Lindborg, Qijun Chen, Mariya T. Sweetwyne, Kurt D. Hankenson, Sharon X. Xie, Frederick B. Johnson, Robert J. Pignolo

Dis Model Mech. 2014 May; 7(5): 583–592. Published online 2014 Mar 13. doi: 10.1242/dmm.014928

PMCID:: PMC4007409

Abstract Article

Select item 383417213.

R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis

Haitao Wang, Tracy A. Brennan, Elizabeth Russell, Jung-Hoon Kim, Kevin P. Egan, Qijun Chen, Craig Israelite, David C. Schultz, Frederick B. Johnson, Robert J. Pignolo

J Mol Med (Berl) Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: J Mol Med (Berl). 2013 Dec; 91(12): 10.1007/s00109-013-1068-3. Published online 2013 Aug 24. doi: 10.1007/s00109-013-1068-3

PMCID:: PMC3834172

Abstract Article PDF–1.5M

Select item 370780214.

MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency

Russell Moser, Masafumi Toyoshima, Kristin Robinson, Kay E. Gurley, Heather L. Howie, Jerry Davison, Martin Morgan, Christopher J. Kemp, Carla Grandori

Mol Cancer Res. Author manuscript; available in PMC 2013 Jul 10.

Published in final edited form as: Mol Cancer Res. 2012 Apr; 10(4): 535–545. Published online 2012 Feb 1. doi: 10.1158/1541-7786.MCR-11-0508

PMCID:: PMC3707802

Abstract Article PDF–2.0M

Select item 345857715.

Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage

Radhakrishnan Kanagaraj, Prasanna Parasuraman, Boris Mihaljevic, Barbara van Loon, Kamila Burdova, Christiane König, Antonia Furrer, Vilhelm A. Bohr, Ulrich Hübscher, Pavel Janscak

Nucleic Acids Res. 2012 Sep; 40(17): 8449–8459. Published online 2012 Jun 29. doi: 10.1093/nar/gks648

PMCID:: PMC3458577

Abstract Article PDF–5.8M

Select item 340002516.

Impairment of Osteoblast Differentiation Due to Proliferation-independent Telomere Dysfunction in Mouse Models of Accelerated Aging

Haitao Wang, Qijun Chen, Seoung-Hoon Lee, Yongwon Choi, F. Brad Johnson, Robert J. Pignolo

Aging Cell. Author manuscript; available in PMC 2013 Aug 1.

Published in final edited form as: Aging Cell. 2012 Aug; 11(4): 704–713. Published online 2012 Jun 11. doi: 10.1111/j.1474-9726.2012.00838.x

PMCID:: PMC3400025

Abstract Article PDF–2.2M

Select item 338278517.

Loss of p16^Ink4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction

Xiufeng Zhang, Xiaoming Wu, Wenru Tang, Ying Luo

Int J Mol Sci. 2012; 13(5): 5866–5877. Published online 2012 May 16. doi: 10.3390/ijms13055866

PMCID:: PMC3382785

Abstract Article PDF–465K

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 309152119.

The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice

Sophie Lachapelle, Steffi Oesterreich, Michel Lebel

Aging (Albany NY) 2011 Mar; 3(3): 277–290. Published online 2011 Mar 20. doi: 10.18632/aging.100300

PMCID:: PMC3091521

Abstract Article PDF–4.6M

Select item 303281420.

BCR/ABL stimulates WRN to promote survival and genomic instability

Artur Slupianek, Tomasz Poplawski, Stanislaw K. Jozwiakowski, Kimberly Cramer, Dariusz Pytel, Ewelina Stoczynska, Michal O. Nowicki, Janusz Blasiak, Tomasz Skorski

Cancer Res. Author manuscript; available in PMC 2012 Feb 1.

Published in final edited form as: Cancer Res. 2011 Feb 1; 71(3): 842–851. Published online 2010 Dec 1. doi: 10.1158/0008-5472.CAN-10-1066

PMCID:: PMC3032814

Abstract Article PDF–1.4M

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