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Select item 77976831.

NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation

Guofang Lu, Siyuan Tian, Yi Sun, Jiaqiang Dong, Na Wang, Jiaoxia Zeng, Yongzhan Nie, Kaichun Wu, Ying Han, Bin Feng, Yulong Shang

Theranostics. 2021; 11(5): 2460–2474. Published online 2021 Jan 1. doi: 10.7150/thno.53169

PMCID:: PMC7797683

Article PDF–4.6M

Select item 48636612.

Somatic Mutations in NEK9 Cause Nevus Comedonicus

Jonathan L. Levinsohn, Jeffrey L. Sugarman, Yale Center for Mendelian Genomics, Jennifer M. McNiff, Richard J. Antaya, Keith A. Choate

Am J Hum Genet. 2016 May 5; 98(5): 1030–1037. Published online 2016 May 5. doi: 10.1016/j.ajhg.2016.03.019

PMCID:: PMC4863661

Article PDF–1.7M

Select item 47340013.

The Dual Nature of Nek9 in Adenovirus Replication

Richard Jung, Sandi Radko, Peter Pelka

J Virol. 2016 Feb 15; 90(4): 1931–1943. Prepublished online 2015 Dec 16. Published online 2016 Jan 28. doi: 10.1128/JVI.02392-15

PMCID:: PMC4734001

Article PDF–2.4M

Select item 41353304.

NEK9-dependent proliferation of cancer cells lacking functional p53

Daisuke Kurioka, Fumitaka Takeshita, Koji Tsuta, Hiromi Sakamoto, Shun-ichi Watanabe, Kenji Matsumoto, Masatoshi Watanabe, Hitoshi Nakagama, Takahiro Ochiya, Jun Yokota, Takashi Kohno, Naoto Tsuchiya

Sci Rep. 2014; 4: 6111. Published online 2014 Aug 18. doi: 10.1038/srep06111

PMCID:: PMC4135330

Article PDF–1.6M

Select item 93141845.

Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q-PCR Technology and Its Relationship with the Disease

Zhu Zhaoyu, Xiong Huanyu, Zhao Yajie, Dong Ziyu, Liu Hui, Shi Feng

Contrast Media Mol Imaging. 2022; 2022: 2634080. Published online 2022 Jul 14. doi: 10.1155/2022/2634080

PMCID:: PMC9314184

Article PDF–465K

Select item 79143416.

The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer

Huizhen Nie, Pei-Qi Huang, Shu-Heng Jiang, Qin Yang, Li-Peng Hu, Xiao-Mei Yang, Jun Li, Ya-Hui Wang, Qing Li, Yi-Fan Zhang, Lei Zhu, Yan-Li Zhang, Yanqiu Yu, Gary Guishan Xiao, Yong-Wei Sun, Jianguang Ji, Zhi-Gang Zhang

Theranostics. 2021; 11(8): 3898–3915. Published online 2021 Feb 6. doi: 10.7150/thno.51712

PMCID:: PMC7914341

Article PDF–4.7M

Select item 59558147.

Mass spectrometry-based proteomics reveals potential roles of NEK9 and MAP2K4 in resistance to PI3K inhibitors in triple negative breast cancers

Filip Mundt, Sandeep Rajput, Shunqiang Li, Kelly Ruggles, Arshag D. Mooradian, Philipp Mertins, Michael A. Gillette, Karsten Krug, Zhanfang Guo, Jeremy Hoog, Petra Erdmann-Gilmore, Tina Primeau, Shixia Huang, Dean P. Edwards, Xiaowei Wang, Xuya Wang, Emily Kawaler, D R. Mani, Karl R. Clauser, Feng Gao, Jingqin Luo, Sherri R. Davies, Gary L. Johnson, Kuan-lin Huang, Christopher J. Yoon, Li Ding, David Fenyö, Matthew J. Ellis, R. Reid Townsend, Jason M. Held, Steven A. Carr, Cynthia X. Ma

Cancer Res. Author manuscript; available in PMC 2019 May 15.

Published in final edited form as: Cancer Res. 2018 May 15; 78(10): 2732–2746. Published online 2018 Feb 22. doi: 10.1158/0008-5472.CAN-17-1990

PMCID:: PMC5955814

Article PDF–1.2M

Select item 46321858.

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization

Tamanna Haq, Mark W. Richards, Selena G. Burgess, Pablo Gallego, Sharon Yeoh, Laura O'Regan, David Reverter, Joan Roig, Andrew M. Fry, Richard Bayliss

Nat Commun. 2015; 6: 8771. Published online 2015 Nov 2. doi: 10.1038/ncomms9771

PMCID:: PMC4632185

Article PDF–1.6M

Select item 36369129.

Structural Analysis of the Regulation of the DYNLL/LC8 Binding to Nek9 by Phosphorylation

Pablo Gallego, Adrian Velazquez-Campoy, Laura Regué, Joan Roig, David Reverter

J Biol Chem. 2013 Apr 26; 288(17): 12283–12294. Published online 2013 Mar 12. doi: 10.1074/jbc.M113.459149

PMCID:: PMC3636912

Article PDF–2.1M

Select item 280703410.

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

Mark W. Richards, Laura O'Regan, Corine Mas-Droux, Joelle M.Y. Blot, Jack Cheung, Swen Hoelder, Andrew M. Fry, Richard Bayliss

Mol Cell. 2009 Nov 25; 36(4): 560–570. doi: 10.1016/j.molcel.2009.09.038

PMCID:: PMC2807034

Article

Select item 309388411.

DYNLL/LC8 Protein Controls Signal Transduction through the Nek9/Nek6 Signaling Module by Regulating Nek6 Binding to Nek9

Laura Regué, Sara Sdelci, M. Teresa Bertran, Carme Caelles, David Reverter, Joan Roig

J Biol Chem. 2011 May 20; 286(20): 18118–18129. Published online 2011 Mar 22. doi: 10.1074/jbc.M110.209080

PMCID:: PMC3093884

Article PDF–1.9M

Select item 724030012.

EML4–ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7

Laura O'Regan, Giancarlo Barone, Rozita Adib, Chang Gok Woo, Hui Jeong Jeong, Emily L. Richardson, Mark W. Richards, Patricia A. J. Muller, Spencer J. Collis, Dean A. Fennell, Jene Choi, Richard Bayliss, Andrew M. Fry

J Cell Sci. 2020 May 1; 133(9): jcs241505. Published online 2020 May 11. doi: 10.1242/jcs.241505

PMCID:: PMC7240300

Article

Select item 592765013.

Chk1 modulates the interaction between myosin phosphatase targeting protein 1 (MYPT1) and protein phosphatase 1cβ (PP1cβ)

Xiaomei Hu, Zhe Li, Yuehe Ding, Qizhi Geng, Zhikai Xiahou, Huanwei Ru, Meng-Qiu Dong, Xingzhi Xu, Jing Li

Cell Cycle. 2018; 17(4): 421–427. Published online 2018 Mar 19. doi: 10.1080/15384101.2017.1418235

PMCID:: PMC5927650

Article PDF–775K

Select item 555169514.

A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase

Sierra N. Cullati, Lilian Kabeche, Arminja N. Kettenbach, Scott A. Gerber

J Cell Biol. 2017 Aug 7; 216(8): 2339–2354. doi: 10.1083/jcb.201512055

PMCID:: PMC5551695

Article PDF–2.7M

Select item 315531015.

Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5

M Teresa Bertran, Sara Sdelci, Laura Regué, Joseph Avruch, Carme Caelles, Joan Roig

EMBO J. 2011 Jul 6; 30(13): 2634–2647. Published online 2011 Jun 3. doi: 10.1038/emboj.2011.179

PMCID:: PMC3155310

Article PDF–1.4M

Select item 958507416.

Marion Müller, Rose Eghbalian, Jes-Niels Boeckel, Karen S. Frese, Jan Haas, Elham Kayvanpour, Farbod Sedaghat-Hamedani, Maximilian K. Lackner, Oguz F. Tugrul, Thomas Ruppert, Rewati Tappu, Diana Martins Bordalo, Jasmin M. Kneuer, Annika Piekarek, Sabine Herch, Sarah Schudy, Andreas Keller, Nadja Grammes, Cornelius Bischof, Anna Klinke, Margarida Cardoso-Moreira, Henrik Kaessmann, Hugo A. Katus, Norbert Frey, Lars M. Steinmetz, Benjamin Meder

Nat Commun. 2022; 13: 6209. Published online 2022 Oct 20. doi: 10.1038/s41467-022-33658-2