PMC Links for Gene (Select 90) - PMC

Links from Gene

Items: 1 to 20 of 95

<< First< Prev

Page of 5

Select item 109665181.

BMP‐ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B‐Cell Lymphoma

Dongdong Liu, Zhen Li, Dongxia Tan, Yang An, Liping Chu, Tiancheng Chen, Weijia Li, Ailin Zhou, Ruijie Xiang, Liye Zhang, Yuxiu Qu, Wei Qi

Adv Sci (Weinh) 2024 Mar; 11(12): 2306499. Published online 2024 Jan 16. doi: 10.1002/advs.202306499

PMCID:: PMC10966518

Article PDF–14M

Select item 102129222.

A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders

Takenobu Katagiri, Sho Tsukamoto, Mai Kuratani, Shinnosuke Tsuji, Kensuke Nakamura, Satoshi Ohte, Yoshiro Kawaguchi, Kiyosumi Takaishi

Nat Commun. 2023; 14: 2960. Published online 2023 May 25. doi: 10.1038/s41467-023-38746-5

Correction in:: Nat Commun. 2023; 14: 6054.

PMCID:: PMC10212922

Article PDF–5.4M

Select item 94948703.

Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs

Hirotsugu Maekawa, Yonghui Jin, Megumi Nishio, Shunsuke Kawai, Sanae Nagata, Takeshi Kamakura, Hiroyuki Yoshitomi, Akira Niwa, Megumu K. Saito, Shuichi Matsuda, Junya Toguchida

Orphanet J Rare Dis. 2022; 17: 364. Published online 2022 Sep 21. doi: 10.1186/s13023-022-02506-3

PMCID:: PMC9494870

Article PDF–9.6M

Select item 88032614.

ACVR1^R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages

Koji Matsuo, Abigail Lepinski, Robert D. Chavez, Emilie Barruet, Ashley Pereira, Tania A. Moody, Amy N. Ton, Aditi Sharma, Judith Hellman, Kiichiro Tomoda, Mary C. Nakamura, Edward C. Hsiao

Bone. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Bone. 2021 Dec; 153: 116129. Published online 2021 Jul 24. doi: 10.1016/j.bone.2021.116129

Correction in:: Bone. 2022 Feb 28 : 116325.

PMCID:: PMC8803261

Article PDF–2.5M

Select item 86918325.

Modeling the ACVR1^R206H mutation in human skeletal muscle stem cells

Emilie Barruet, Steven M Garcia, Jake Wu, Blanca M Morales, Stanley Tamaki, Tania Moody, Jason H Pomerantz, Edward C Hsiao

eLife. 2021; 10: e66107. Published online 2021 Nov 10. doi: 10.7554/eLife.66107

PMCID:: PMC8691832

Article PDF–16M

Select item 82807956.

Pathogenic ACVR1^R206H activation by Activin A‐induced receptor clustering and autophosphorylation

Anassuya Ramachandran, Merima Mehić, Laabiah Wasim, Dessislava Malinova, Ilaria Gori, Beata K Blaszczyk, Diana M Carvalho, Eileen M Shore, Chris Jones, Marko Hyvönen, Pavel Tolar, Caroline S Hill

EMBO J. 2021 Jul 15; 40(14): e106317. Published online 2021 May 18. doi: 10.15252/embj.2020106317

PMCID:: PMC8280795

Article PDF–3.2M

Select item 72457887.

Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1

Hirotsugu Maekawa, Shunsuke Kawai, Megumi Nishio, Sanae Nagata, Yonghui Jin, Hiroyuki Yoshitomi, Shuichi Matsuda, Junya Toguchida

Orphanet J Rare Dis. 2020; 15: 122. Published online 2020 May 24. doi: 10.1186/s13023-020-01406-8

PMCID:: PMC7245788

Article PDF–5.4M

Select item 72259898.

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors

Oddrun Elise Olsen, Hanne Hella, Samah Elsaadi, Carsten Jacobi, Erik Martinez-Hackert, Toril Holien

Biomolecules. 2020 Apr; 10(4): 519. Published online 2020 Mar 29. doi: 10.3390/biom10040519

PMCID:: PMC7225989

Article PDF–2.8M

Select item 71458579.

Differential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma

Hongnan Cao, Miao Jin, Mu Gao, Hongyi Zhou, Yizhi Jane Tao, Jeffrey Skolnick

Sci Rep. 2020; 10: 6140. Published online 2020 Apr 9. doi: 10.1038/s41598-020-63061-0

PMCID:: PMC7145857

Article PDF–2.7M

Select item 675518310.

Targeting heterotopic ossification by inhibiting activin receptor-like kinase 2 function

Fuli Shi, Jiayu Gao, Junrong Zou, Ying Ying, Hui Lin

Mol Med Rep. 2019 Oct; 20(4): 2979–2989. Published online 2019 Aug 6. doi: 10.3892/mmr.2019.10556

PMCID:: PMC6755183

Article PDF–575K

Select item 597930911.

The Horizon of a Therapy for Rare Genetic Diseases: A “Druggable” Future for Fibrodysplasia Ossificans Progressiva

Serena Cappato, Francesca Giacopelli, Roberto Ravazzolo, Renata Bocciardi

Int J Mol Sci. 2018 Apr; 19(4): 989. Published online 2018 Mar 26. doi: 10.3390/ijms19040989

PMCID:: PMC5979309

Article PDF–723K

Select item 498805212.

The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling

Emilie Barruet, Blanca M. Morales, Wint Lwin, Mark P. White, Christina V. Theodoris, Hannah Kim, Ashley Urrutia, Sarah Anne Wong, Deepak Srivastava, Edward C. Hsiao

Stem Cell Res Ther. 2016; 7: 115. Published online 2016 Aug 17. doi: 10.1186/s13287-016-0372-6

PMCID:: PMC4988052

Article PDF–3.7M

Select item 496458713.

Fibrodysplasia Ossificans Progressiva (FOP): Watch the great toes!

Mutlu Kartal, Eileen M. Shore, Meiqi Xu, Ludwig Schwering, Markus Uhl, Rudolf Korinthenberg, Charlotte Niemeyer, Frederick S. Kaplan, Melchior Lauten

Eur J Pediatr. Author manuscript; available in PMC 2016 Jul 28.

Published in final edited form as: Eur J Pediatr. 2010 Nov; 169(11): 1417–1421. Published online 2010 Jun 26. doi: 10.1007/s00431-010-1232-5

PMCID:: PMC4964587

Article PDF–149K

Select item 492969314.

Concurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC

Bu-Yeo Kim, SangKyun Jeong, Seo-Young Lee, So Min Lee, Eun Jeong Gweon, Hyunjun Ahn, Janghwan Kim, Sun-Ku Chung

Exp Mol Med. 2016 Jun; 48(6): e237. Published online 2016 Jun 3. doi: 10.1038/emm.2016.43

PMCID:: PMC4929693

Article PDF–3.3M

Select item 475313715.

Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders

Maurizio Pacifici, Eileen M. Shore

Cytokine Growth Factor Rev. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Cytokine Growth Factor Rev. 2016 Feb; 27: 93–104. Published online 2015 Dec 28. doi: 10.1016/j.cytogfr.2015.12.007

PMCID:: PMC4753137

Article PDF–456K

Select item 468758716.

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

Kyosuke Hino, Makoto Ikeya, Kazuhiko Horigome, Yoshihisa Matsumoto, Hayao Ebise, Megumi Nishio, Kazuya Sekiguchi, Mitsuaki Shibata, Sanae Nagata, Shuichi Matsuda, Junya Toguchida

Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50): 15438–15443. Published online 2015 Nov 30. doi: 10.1073/pnas.1510540112

PMCID:: PMC4687587

Article PDF–1.5M

Select item 448987017.

Uncovering Molecular Bases Underlying Bone Morphogenetic Protein Receptor Inhibitor Selectivity

Abdelaziz Alsamarah, Alecander E. LaCuran, Peter Oelschlaeger, Jijun Hao, Yun Luo

PLoS One. 2015; 10(7): e0132221. Published online 2015 Jul 2. doi: 10.1371/journal.pone.0132221

PMCID:: PMC4489870

Article PDF–2.9M

Select item 428299418.

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

Adam M. Fontebasso, Simon Papillon-Cavanagh, Jeremy Schwartzentruber, Hamid Nikbakht, Noha Gerges, Pierre-Olivier Fiset, Denise Bechet, Damien Faury, Nicolas De Jay, Lori Ramkissoon, Aoife Corcoran, David T W Jones, Dominik Sturm, Pascal Johann, Tadanori Tomita, Stewart Goldman, Mahmoud Nagib, Anne Bendel, Liliana Goumnerova, Daniel C. Bowers, Jeffrey R. Leonard, Joshua B. Rubin, Tord Alden, Samuel Browd, J. Russell Geyer, Sarah Leary, George Jallo, Kenneth Cohen, Nalin Gupta, Michael D. Prados, Anne-Sophie Carret, Benjamin Ellezam, Louis Crevier, Almos Klekner, Laszlo Bognar, Peter Hauser, Miklos Garami, John Myseros, Zhifeng Dong, Peter M. Siegel, Hayley Malkin, Azra Ligon, Steffen Albrecht, Stefan M. Pfister, Keith L. Ligon, Jacek Majewski, Nada Jabado, Mark W Kieran

Nat Genet. Author manuscript; available in PMC 2015 Jan 5.

Published in final edited form as: Nat Genet. 2014 May; 46(5): 462–466. Published online 2014 Apr 6. doi: 10.1038/ng.2950

PMCID:: PMC4282994

Article PDF–933K

Select item 419159619.

Structure–Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants

Agustin H. Mohedas, You Wang, Caroline E. Sanvitale, Peter Canning, Sungwoon Choi, Xuechao Xing, Alex N. Bullock, Gregory D. Cuny, Paul B. Yu

J Med Chem. 2014 Oct 9; 57(19): 7900–7915. Published online 2014 Aug 7. doi: 10.1021/jm501177w

PMCID:: PMC4191596

Article PDF–3.8M

Select item 405913920.

Fibrodysplasia Ossificans Progressiva-related Activated Activin-like Kinase Signaling Enhances Osteoclast Formation during Heterotopic Ossification in Muscle Tissues

Masato Yano, Naoyuki Kawao, Katsumi Okumoto, Yukinori Tamura, Kiyotaka Okada, Hiroshi Kaji

J Biol Chem. 2014 Jun 13; 289(24): 16966–16977. Published online 2014 May 5. doi: 10.1074/jbc.M113.526038

PMCID:: PMC4059139

Article PDF–1.7M

PMC

Result Filters

Article attributes

Text availability

Publication date

Custom date range

Research Funder

Additional filters

Display Settings:

Send to:

Links from Gene

Items: 1 to 20 of 95

Display Settings:

Send to:

Supplemental Content

Find related data

Recent activity