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Items: 1 to 20 of 211

1.
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR
Dali Zong, Natasha C. Koussa, James A. Cornwell, Ajith V. Pankajam, Michael J. Kruhlak, Nancy Wong, Raj Chari, Steven D. Cappell, André Nussenzweig
Genes Dev. 2023 Oct 1; 37(19-20): 913–928. doi: 10.1101/gad.351085.123
PMCID:
PMC10691471
ArticlePDF–4.0M
2.
Werner syndrome protein works as a dimer for unwinding and replication fork regression
Soochul Shin, Kwangbeom Hyun, Jinwoo Lee, Dongwon Joo, Tomasz Kulikowicz, Vilhelm A Bohr, Jaehoon Kim, Sungchul Hohng
Nucleic Acids Res. 2023 Jan 11; 51(1): 337–348. Published online 2022 Dec 30. doi: 10.1093/nar/gkac1200
PMCID:
PMC9841404
ArticlePDF–2.2M
3.
Repeat expansions confer WRN dependence in microsatellite-unstable cancers
Niek van Wietmarschen, Sriram Sridharan, William J. Nathan, Anthony Tubbs, Edmond M. Chan, Elsa Callen, Wei Wu, Frida Belinky, Veenu Tripathi, Nancy Wong, Kyla Foster, Javad Noorbakhsh, Kiran Garimella, Abimael Cruz-Migoni, Joshua A. Sommers, Yongqing Huang, Ashir A. Borah, Jonathan T. Smith, Jeremie Kalfon, Nikolas Kesten, Kasper Fugger, Robert L. Walker, Egor Dolzhenko, Michael A. Eberle, Bruce E. Hayward, Karen Usdin, Catherine H. Freudenreich, Robert M. Brosh, Jr, Stephen C. West, Peter J. McHugh, Paul S. Meltzer, Adam J. Bass, André Nussenzweig
Nature. Author manuscript; available in PMC 2022 Mar 11.
Published in final edited form as: Nature. 2020 Oct; 586(7828): 292–298. Published online 2020 Sep 30. doi: 10.1038/s41586-020-2769-8
PMCID:
PMC8916167
ArticlePDF–4.2M
4.
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers
Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, Jark Böttcher, John R Engen, Klaus Rumpel, Matthias Samwer, Mark Petronczki, Opher Gileadi
Life Sci Alliance. 2021 Jan; 4(1): e202000795. Published online 2020 Nov 16. doi: 10.26508/lsa.202000795
PMCID:
PMC7671478
ArticlePDF–2.4M
5.
WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells
Juan Manuel Iglesias-Pedraz, Diego Matia Fossatti-Jara, Valeria Valle-Riestra-Felice, Sergio Rafael Cruz-Visalaya, Jose Antonio Ayala Felix, Lucio Comai
BMC Mol Cell Biol. 2020; 21: 71. Published online 2020 Oct 14. doi: 10.1186/s12860-020-00315-9
PMCID:
PMC7557079
ArticlePDF–5.7M
6.
Acetylation of Werner protein at K1127 and K1117 is important for nuclear trafficking and DNA repair
Deblina Ghosh, Vilhelm A. Bohr, Parimal Karmakar
DNA Repair (Amst) Author manuscript; available in PMC 2020 Oct 7.
Published in final edited form as: DNA Repair (Amst). 2019 Jul; 79: 22–31. Published online 2019 May 3. doi: 10.1016/j.dnarep.2019.04.010
Correction in:
DNA Repair (Amst). 2019 Nov; 83: 102671.
PMCID:
PMC7539646
ArticlePDF–1.4M
7.
Werner Syndrome Protein (WRN) Regulates Cell Proliferation and the Human Papillomavirus 16 Life Cycle during Epithelial Differentiation
Claire D. James, Dipon Das, Ethan L. Morgan, Raymonde Otoa, Andrew Macdonald, Iain M. Morgan
mSphere. 2020 Sep-Oct; 5(5): e00858-20. Published online 2020 Sep 16. doi: 10.1128/mSphere.00858-20
PMCID:
PMC7494838
ArticlePDF–2.5M
8.
WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers
Edmond M. Chan, Tsukasa Shibue, James M. McFarland, Benjamin Gaeta, Mahmoud Ghandi, Nancy Dumont, Alfredo Gonzalez, Justine S. McPartlan, Tianxia Li, Yanxi Zhang, Jie Bin Liu, Jean-Bernard Lazaro, Peili Gu, Cortt G. Piett, Annie Apffel, Syed O. Ali, Rebecca Deasy, Paula Keskula, Raymond W.S. Ng, Emma A. Roberts, Elizaveta Reznichenko, Lisa Leung, Maria Alimova, Monica Schenone, Mirazul Islam, Yosef E. Maruvka, Yang Liu, Jatin Roper, Srivatsan Raghavan, Marios Giannakis, Yuen-Yi Tseng, Zachary D. Nagel, Alan D’Andrea, David E. Root, Jesse S. Boehm, Gad Getz, Sandy Chang, Todd R. Golub, Aviad Tsherniak, Francisca Vazquez, Adam J. Bass
Nature. Author manuscript; available in PMC 2019 Oct 10.
Published in final edited form as: Nature. 2019 Apr; 568(7753): 551–556. Published online 2019 Apr 10. doi: 10.1038/s41586-019-1102-x
PMCID:
PMC6580861
ArticlePDF–5.0M
9.
Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins
Jyotirindra Maity, Biswadip Das, Vilhelm A. Bohr, Parimal Karmakar
DNA Repair (Amst) Author manuscript; available in PMC 2019 Feb 1.
Published in final edited form as: DNA Repair (Amst). 2018 Aug; 68: 1–11. Published online 2018 May 18. doi: 10.1016/j.dnarep.2018.05.003
PMCID:
PMC6338341
ArticlePDF–2.2M
10.
Multiple RPAs make WRN syndrome protein a superhelicase
Mina Lee, Soochul Shin, Heesoo Uhm, Heesun Hong, Jaewon Kirk, Kwangbeom Hyun, Tomasz Kulikowicz, Jaehoon Kim, Byungchan Ahn, Vilhelm A Bohr, Sungchul Hohng
Nucleic Acids Res. 2018 May 18; 46(9): 4689–4698. Published online 2018 Apr 14. doi: 10.1093/nar/gky272
PMCID:
PMC5961295
ArticlePDF–2.8M
11.
Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells
Jyotirindra Maity, Vilhelm A. Bohr, Aparna Laskar, Parimal Karmakar
Biochim Biophys Acta. Author manuscript; available in PMC 2017 Sep 4.
Published in final edited form as: Biochim Biophys Acta. 2014 Dec; 1842(12 Pt A): 2387–2394. Published online 2014 Sep 23. doi: 10.1016/j.bbadis.2014.09.007
PMCID:
PMC5582615
ArticlePDF–725K
12.
Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype
Ashwini S. Kamath-Loeb, Diego G. Zavala-van Rankin, Jeny Flores-Morales, Mary J. Emond, Julia M. Sidorova, Alessandra Carnevale, Maria del Carmen Cárdenas-Cortés, Thomas H. Norwood, Raymond J. Monnat, Lawrence A. Loeb, Gabriela E. Mercado-Celis
Sci Rep. 2017; 7: 44081. Published online 2017 Mar 9. doi: 10.1038/srep44081
PMCID:
PMC5343477
ArticlePDF–943K
13.
Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA
Amit Ketkar, Markus Voehler, Tresor Mukiza, Robert L. Eoff
J Biol Chem. 2017 Feb 24; 292(8): 3154–3163. Published online 2017 Jan 9. doi: 10.1074/jbc.M116.767699
PMCID:
PMC5336152
ArticlePDF–1.7M
14.
Active Control of Repetitive Structural Transitions between Replication Forks and Holliday Junctions by Werner Syndrome Helicase
Soochul Shin, Jinwoo Lee, Sangwoon Yoo, Tomasz Kulikowicz, Vilhelm A. Bohr, Byungchan Ahn, Sungchul Hohng
Structure. Author manuscript; available in PMC 2016 Dec 19.
Published in final edited form as: Structure. 2016 Aug 2; 24(8): 1292–1300. Published online 2016 Jul 14. doi: 10.1016/j.str.2016.06.004
PMCID:
PMC5167498
ArticlePDF–1.8M
15.
WRN regulates pathway choice between classical and alternative non-homologous end joining
Raghavendra A. Shamanna, Huiming Lu, Jessica K. de Freitas, Jane Tian, Deborah L. Croteau, Vilhelm A. Bohr
Nat Commun. 2016; 7: 13785. Published online 2016 Dec 6. doi: 10.1038/ncomms13785
PMCID:
PMC5150655
ArticlePDF–2.8M
16.
WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells
R. Moles, X. T. Bai, H. Chaib-Mezrag, C. Nicot
J Hematol Oncol. 2016; 9: 121. Published online 2016 Nov 9. doi: 10.1186/s13045-016-0352-4
PMCID:
PMC5103433
ArticlePDF–2.6M
17.
The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription
Weiliang Tang, Ana I. Robles, Richard P. Beyer, Lucas T. Gray, Giang H. Nguyen, Junko Oshima, Nancy Maizels, Curtis C. Harris, Raymond J. Monnat, Jr
Hum Mol Genet. 2016 May 15; 25(10): 2060–2069. Published online 2016 Mar 16. doi: 10.1093/hmg/ddw079
PMCID:
PMC5062591
ArticlePDF–549K
18.
WRN promoter CpG island hypermethylation does not predict more favorable outcomes for metastatic colorectal cancer patients treated with irinotecan-based therapy
Linda J.W. Bosch, Yanxin Luo, Victoria Valinluck Lao, Petur Snaebjornsson, Geert Trooskens, Ilse Vlassenbroeck, Sandra Mongera, Weiliang Tang, Piri Welcsh, James G Herman, Miriam Koopman, Iris D. Nagtegaal, Cornelis JA Punt, Wim van Criekinge, Gerrit A. Meijer, Raymond J. Monnat, Jr., Beatriz Carvalho, William M. Grady
Clin Cancer Res. Author manuscript; available in PMC 2017 Sep 15.
Published in final edited form as: Clin Cancer Res. 2016 Sep 15; 22(18): 4612–4622. Published online 2016 Apr 27. doi: 10.1158/1078-0432.CCR-15-2703
PMCID:
PMC5026547
ArticlePDF–1.3M
19.
Werner Syndrome: Clinical Features, Pathogenesis and Potential Therapeutic Interventions
Junko Oshima, Julia M. Sidorova, Raymond J. Monnat, Jr
Ageing Res Rev. Author manuscript; available in PMC 2018 Jan 1.
Published in final edited form as: Ageing Res Rev. 2017 Jan; 33: 105–114. Published online 2016 Mar 15. doi: 10.1016/j.arr.2016.03.002
PMCID:
PMC5025328
ArticlePDF–995K
20.
Polymorphisms in DNA repair genes, hair dye use, and the risk of non-Hodgkin lymphoma
Huan Guo, Bryan A. Bassig, Qing Lan, Yong Zhu, Yawei Zhang, Theodore R. Holford, Brian Leaderer, Peter Boyle, Qin Qin, Cairong Zhu, Ni Li, Nathaniel Rothman, Tongzhang Zheng
Cancer Causes Control. Author manuscript; available in PMC 2016 Apr 25.
Published in final edited form as: Cancer Causes Control. 2014 Oct; 25(10): 1261–1270. Published online 2014 Sep 2. doi: 10.1007/s10552-014-0423-1
PMCID:
PMC4843788
ArticlePDF–164K

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