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Select item 104607111.

Knock-out of the critical nitric oxide synthase regulator DDAH1 in mice impacts amphetamine sensitivity and dopamine metabolism

Alena A. Kozlova, Elena Rubets, Magdalini R. Vareltzoglou, Natalia Jarzebska, Vinitha N. Ragavan, Yingjie Chen, Jens Martens-Lobenhoffer, Stefanie M. Bode-Böger, Raul R. Gainetdinov, Roman N. Rodionov, Nadine Bernhardt

J Neural Transm (Vienna) 2023; 130(9): 1097–1112. Published online 2023 Feb 16. doi: 10.1007/s00702-023-02597-7

PMCID:: PMC10460711

Article PDF–1.4M

Select item 95691142.

Dimethylarginine dimethylaminohydrolase 1 protects PM_2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress

Junling Gao, Tong Lei, Hongyun Wang, Kai Luo, Yuanli Wang, Bingqing Cui, Zhuoran Yu, Xiaoqi Hu, Fang Zhang, Yingjie Chen, Wenjun Ding, Zhongbing Lu

Part Fibre Toxicol. 2022; 19: 64. Published online 2022 Oct 14. doi: 10.1186/s12989-022-00505-7

PMCID:: PMC9569114

Article PDF–16M

Select item 76893603.

Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice

Juliane Hannemann, Antonia Glatzel, Jonas Hillig, Julia Zummack, Udo Schumacher, Nicole Lüneburg, Lars Harbaum, Rainer Böger

Front Physiol. 2020; 11: 597559. Published online 2020 Nov 12. doi: 10.3389/fphys.2020.597559

PMCID:: PMC7689360

Article PDF–2.1M

Select item 38948604.

Overexpression of Dimethylarginine Dimethylaminohydrolase 1 Attenuates Airway Inflammation in a Mouse Model of Asthma

Kayla G. Kinker, Aaron M. Gibson, Stacey A. Bass, Brandy P. Day, Jingyuan Deng, Mario Medvedovic, Julio A. Landero Figueroa, Gurjit K. Khurana Hershey, Weiguo Chen

PLoS One. 2014; 9(1): e85148. Published online 2014 Jan 10. doi: 10.1371/journal.pone.0085148

PMCID:: PMC3894860

Article PDF–1.4M

Select item 38240495.

Effects of Dimethylarginine Dimethylaminohydrolase–1 Overexpression on the Response of the Pulmonary Vasculature to Hypoxia

Adel Bakr, Oleg Pak, Ashraf Taye, Farid Hamada, Ramadan Hemeida, Wiebke Janssen, Mareike Gierhardt, Hossein A. Ghofrani, Werner Seeger, Friedrich Grimminger, Ralph T. Schermuly, Martin Witzenrath, Ralf P. Brandes, Ngan Huang, John P. Cooke, Norbert Weissmann, Natascha Sommer

Am J Respir Cell Mol Biol. 2013 Sep; 49(3): 491–500. doi: 10.1165/rcmb.2012-0330OC

PMCID:: PMC3824049

Article PDF–1.0M

Select item 28043996.

Vascular endothelial specific dimethylarginine dimethylaminohydrolase-1 deficient mice reveal vascular endothelium plays an important role in removing asymmetric dimethylarginine

Xinli Hu, Xin Xu, Guangshuo Zhu, Doro Atzler, Masumi Kimoto, Ju Chen, Edzard Schwedhelm, Nicole Lüneburg, Rainer H. Böger, Ping Zhang, Yingjie Chen

Circulation. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Circulation. 2009 Dec 1; 120(22): 2222–2229. Published online 2009 Nov 16. doi: 10.1161/CIRCULATIONAHA.108.819912

PMCID:: PMC2804399

Article PDF–1.2M

Select item 27536637.

Dimethylarginine Dimethylaminohydrolase-1 Transgenic Mice Are Not Protected from Ischemic Stroke

Frank Leypoldt, Chi-Un Choe, Mathias Gelderblom, Eike-Christin von Leitner, Dorothee Atzler, Edzard Schwedhelm, Christian Gerloff, Karsten Sydow, Rainer H. Böger, Tim Magnus

PLoS One. 2009; 4(10): e7337. Published online 2009 Oct 7. doi: 10.1371/journal.pone.0007337

PMCID:: PMC2753663

Article PDF–339K

Select item 99080228.

Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis

Yizheng Wu, Shuying Shen, Jiaxin Chen, Weiyu Ni, Qinxin Wang, Hongyi Zhou, Junxin Chen, Haitao Zhang, Zixuan Mei, Xuewu Sun, Panyang Shen, Zhiwei Jie, Wenbin Xu, Zhenghua Hong, Yan Ma, Kefan Wang, Shuanglin Wan, Hongfei Wu, Ziang Xie, An Qin, Shunwu Fan

Sci Adv. 2023 Feb; 9(6): eade5584. Published online 2023 Feb 8. doi: 10.1126/sciadv.ade5584

PMCID:: PMC9908022

Article PDF–1.8M

Select item 87487819.

Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation

Ziang Xie, Lei Hou, Shuying Shen, Yizheng Wu, Jian Wang, Zhiwei Jie, Xiangde Zhao, Xiang Li, Xuyang Zhang, Junxin Chen, Wenbin Xu, Lei Ning, Qingliang Ma, Shiyu Wang, Haoming Wang, Putao Yuan, Xiangqian Fang, An Qin, Shunwu Fan

Nat Commun. 2022; 13: 50. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27629-2

PMCID:: PMC8748781

Article PDF–3.2M

Select item 650263710.

Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction

Xin Xu, Ping Zhang, Dongmin Kwak, John Fassett, Wenhui Yue, Dorothee Atzler, Xinli Hu, Xiaohong Liu, Huan Wang, Zhongbing Lu, Haipeng Guo, Edzard Schwedhelm, Rainer H. Böger, Peijie Chen, Yingjie Chen

Basic Res Cardiol. Author manuscript; available in PMC 2019 May 6.

Published in final edited form as: Basic Res Cardiol. 2017 Aug 17; 112(5): 55. Published online 2017 Aug 17. doi: 10.1007/s00395-017-0644-z

PMCID:: PMC6502637

Article PDF–1.3M

Select item 608778711.

Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase 1

Tracy Bell, Magali Araujo, Zaiming Luo, James Tomlinson, James Leiper, William J. Welch, Christopher S. Wilcox

Am J Physiol Renal Physiol. 2018 Jul 1; 315(1): F74–F78. Published online 2018 Mar 7. doi: 10.1152/ajprenal.00560.2017

PMCID:: PMC6087787

Article

Select item 491201012.

Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis

Clemens Lange, Freya Mowat, Haroon Sayed, Manjit Mehad, Lucie Duluc, Sophie Piper, Ulrich Luhmann, Manasi Nandi, Peter Kelly, Alexander Smith, Robin Ali, James Leiper, James Bainbridge

Exp Eye Res. 2016 Jun; 147: 148–155. doi: 10.1016/j.exer.2016.05.007

PMCID:: PMC4912010

Article PDF–2.5M

Select item 401357913.

Effect of Lowering Asymmetric Dimethylarginine (ADMA) on Vascular Pathology in Atherosclerotic ApoE-Deficient Mice with Reduced Renal Mass

Johannes Jacobi, Renke Maas, Michaela Arend, Nada Cordasic, Karl F. Hilgers

Int J Mol Sci. 2014 Apr; 15(4): 5522–5535. Published online 2014 Mar 31. doi: 10.3390/ijms15045522

PMCID:: PMC4013579

Article PDF–551K

Select item 383254814.

DDAH1 Deficiency Attenuates Endothelial Cell Cycle Progression and Angiogenesis

Ping Zhang, Xin Xu, Xinli Hu, Huan Wang, John Fassett, Yuqing Huo, Yingjie Chen, Robert J. Bache

PLoS One. 2013; 8(11): e79444. Published online 2013 Nov 18. doi: 10.1371/journal.pone.0079444

PMCID:: PMC3832548

Article PDF–1.9M

Select item 306445815.

Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through NO and Akt

Ping Zhang, Xinli Hu, Xin Xu, Yingjie Chen, Robert J. Bache

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2012 Apr 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4): 890–897. Published online 2011 Jan 6. doi: 10.1161/ATVBAHA.110.215640

PMCID:: PMC3064458

Article PDF–634K

Select item 1087690916.

DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis

Juntao Yuan, Zhuoran Yu, Ping Zhang, Kai Luo, Ying Xu, Ting Lan, Min Zhang, Yingjie Chen, Zhongbing Lu

Redox Biol. 2024 Apr; 70: 103080. Published online 2024 Feb 8. doi: 10.1016/j.redox.2024.103080

PMCID:: PMC10876909

Article PDF–18M

Select item 286112017.

Dimethylarginine Dimethylaminohydrolase Overexpression Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Lowering Asymmetric Dimethylarginine

Johannes Jacobi, Renke Maas, Arturo J. Cardounel, Michaela Arend, Arthur J. Pope, Nada Cordasic, Juliane Heusinger-Ribeiro, Dorothee Atzler, Joachim Strobel, Edzard Schwedhelm, Rainer H. Böger, Karl F. Hilgers

Am J Pathol. 2010 May; 176(5): 2559–2570. doi: 10.2353/ajpath.2010.090614

PMCID:: PMC2861120

Article PDF–1.4M

Select item 261309518.

Modulation of Rac1 Activity by ADMA/DDAH Regulates Pulmonary Endothelial Barrier Function

Beata Wojciak-Stothard, Belen Torondel, Lan Zhao, Thomas Renné, James M. Leiper

Mol Biol Cell. 2009 Jan 1; 20(1): 33–42. doi: 10.1091/mbc.E08-04-0395

PMCID:: PMC2613095

Article PDF–683K

Select item 251922819.

Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia

Sanjana Dayal, Roman N. Rodionov, Erland Arning, Teodoro Bottiglieri, Masumi Kimoto, Daryl J. Murry, John P. Cooke, Frank M. Faraci, Steven R. Lentz

Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2): H816–H825. Published online 2008 Jun 20. doi: 10.1152/ajpheart.01348.2007

PMCID:: PMC2519228

Article

Select item 1025680120.

A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase

Vinitha N. Ragavan, Pramod C. Nair, Natalia Jarzebska, Ramcharan Singh Angom, Luana Ruta, Elisa Bianconi, Silvia Grottelli, Natalia D. Tararova, Daniel Ryazanskiy, Steven R. Lentz, Sara Tommasi, Jens Martens-Lobenhoffer, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Elena Rubets, Sarah Chau, Yingjie Chen, Xinli Hu, Nadine Bernhardt, Peter M. Spieth, Norbert Weiss, Stefan R. Bornstein, Debabrata Mukhopadhyay, Stefanie M. Bode-Böger, Renke Maas, Ying Wang, Antonio Macchiarulo, Arduino A. Mangoni, Barbara Cellini, Roman N. Rodionov

Nat Commun. 2023; 14: 3392. Published online 2023 Jun 9. doi: 10.1038/s41467-023-38467-9

PMCID:: PMC10256801

Article PDF–2.8M

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