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Select item 91088851.

The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins

Chengan Huang, Jinxia Lu, Xiaojuan Ma, Jiali Qiang, Chuchu Wang, Cong Liu, Yanshan Fang, Yaoyang Zhang, Lin Jiang, Dan Li, Shengnan Zhang

J Biol Chem. 2022 May; 298(5): 101912. Published online 2022 Apr 7. doi: 10.1016/j.jbc.2022.101912

PMCID:: PMC9108885

Article PDF–3.3M

Select item 87544322.

Nuclear NAD⁺-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons

David Sokolov, Emily R Sechrest, Yekai Wang, Connor Nevin, Jianhai Du, Saravanan Kolandaivelu

eLife. 2021; 10: e71185. Published online 2021 Dec 8. doi: 10.7554/eLife.71185

PMCID:: PMC8754432

Article PDF–9.2M

Select item 81274073.

Mutant Nmnat1 leads to a retina-specific decrease of NAD⁺ accompanied by increased poly(ADP-ribose) in a mouse model of NMNAT1-associated retinal degeneration

Scott H Greenwald, Emily E Brown, Michael J Scandura, Erin Hennessey, Raymond Farmer, Jianhai Du, Yekai Wang, Eric A Pierce

Hum Mol Genet. 2021 Apr 15; 30(8): 644–657. Published online 2021 Mar 11. doi: 10.1093/hmg/ddab070

PMCID:: PMC8127407

Article PDF–1.0M

Select item 49294024.

Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human Disease

Scott H. Greenwald, Jeremy R. Charette, Magdalena Staniszewska, Lan Ying Shi, Steve D.M. Brown, Lisa Stone, Qin Liu, Wanda L. Hicks, Gayle B. Collin, Michael R. Bowl, Mark P. Krebs, Patsy M. Nishina, Eric A. Pierce

Am J Pathol. 2016 Jul; 186(7): 1925–1938. doi: 10.1016/j.ajpath.2016.03.013

PMCID:: PMC4929402

Article PDF–3.2M

Select item 35419475.

Protection of Mouse Retinal Ganglion Cell Axons and Soma from Glaucomatous and Ischemic Injury by Cytoplasmic Overexpression of Nmnat1

Yanli Zhu, Lihong Zhang, Yo Sasaki, Jeffrey Milbrandt, Jeffrey M. Gidday

Invest Ophthalmol Vis Sci. 2013 Jan; 54(1): 25–36. Published online 2013 Jan 2. doi: 10.1167/iovs.12-10861

PMCID:: PMC3541947

Article PDF–1.6M

Select item 82947646.

Nuclear NAD⁺ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells

Xiangguo Shi, Yajian Jiang, Ayumi Kitano, Tianyuan Hu, Rebecca L. Murdaugh, Yuan Li, Kevin A. Hoegenauer, Rui Chen, Koichi Takahashi, Daisuke Nakada

Sci Adv. 2021 Jul; 7(30): eabf3895. Published online 2021 Jul 21. doi: 10.1126/sciadv.abf3895

PMCID:: PMC8294764

Article PDF–691K

Select item 66654897.

Nicotinamide Mononucleotide Adenylyltransferase Expression in Mitochondrial Matrix Delays Wallerian Degeneration

Naoki Yahata, Shigeki Yuasa, Toshiyuki Araki

J Neurosci. 2009 May 13; 29(19): 6276–6284. doi: 10.1523/JNEUROSCI.4304-08.2009

PMCID:: PMC6665489

Article PDF–517K

Select item 64655348.

Metabolic Regulation of Transcription Through Compartmentalized NAD⁺ Biosynthesis

Keun Woo Ryu, Tulip Nandu, Jiyeon Kim, Sridevi Challa, Ralph J. DeBerardinis, W. Lee Kraus

Science. Author manuscript; available in PMC 2019 May 11.

Published in final edited form as: Science. 2018 May 11; 360(6389): eaan5780. doi: 10.1126/science.aan5780

PMCID:: PMC6465534

Article PDF–1.0M

Select item 57695209.

NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy

Francesca Rossi, Philippine C. Geiszler, Weina Meng, Matthew R. Barron, Malcolm Prior, Anna Herd-Smith, Andrea Loreto, Maria Yanez Lopez, Henryk Faas, Marie-Christine Pardon, Laura Conforti

Behav Brain Res. 2018 Feb 26; 339: 140–152. doi: 10.1016/j.bbr.2017.11.030

PMCID:: PMC5769520

Article

Select item 322346610.

Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

Philip B. Verghese, Yo Sasaki, Donghan Yang, Floy Stewart, Fatima Sabar, Mary Beth Finn, Christine M. Wroge, Steven Mennerick, Jeffrey J. Neil, Jeffrey Milbrandt, David M. Holtzman

Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47): 19054–19059. Published online 2011 Nov 4. doi: 10.1073/pnas.1107325108

PMCID:: PMC3223466

Article PDF–989K

Select item 300984611.

Axonal Degeneration Is Blocked by Nicotinamide Mononucleotide Adenylyltransferase (Nmnat) Protein Transduction into Transected Axons

Yo Sasaki, Jeffrey Milbrandt

J Biol Chem. 2010 Dec 31; 285(53): 41211–41215. Published online 2010 Nov 11. doi: 10.1074/jbc.C110.193904

PMCID:: PMC3009846

Article PDF–2.1M

Select item 269706612.

Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration In Vivo

Yo Sasaki, Bhupinder P. S. Vohra, Robert H. Baloh, Jeffrey Milbrandt

J Neurosci. 2009 May 20; 29(20): 6526–6534. doi: 10.1523/JNEUROSCI.1429-09.2009

PMCID:: PMC2697066

Article PDF–1.3M

Select item 759124713.

SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration

Yo Sasaki, Hiroki Kakita, Shunsuke Kubota, Abdoulaye Sene, Tae Jun Lee, Norimitsu Ban, Zhenyu Dong, Joseph B Lin, Sanford L Boye, Aaron DiAntonio, Shannon E Boye, Rajendra S Apte, Jeffrey Milbrandt

eLife. 2020; 9: e62027. Published online 2020 Oct 27. doi: 10.7554/eLife.62027

PMCID:: PMC7591247

Article PDF–2.6M

Select item 666516214.

Non-Nuclear Wld^S Determines Its Neuroprotective Efficacy for Axons and Synapses In Vivo

Bogdan Beirowski, Elisabetta Babetto, Jon Gilley, Francesca Mazzola, Laura Conforti, Lucie Janeckova, Giulio Magni, Richard R. Ribchester, Michael P. Coleman

J Neurosci. 2009 Jan 21; 29(3): 653–668. doi: 10.1523/JNEUROSCI.3814-08.2009