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Select item 75662111.

WTAP Function in Sertoli Cells Is Essential for Sustaining the Spermatogonial Stem Cell Niche

Gong-Xue Jia, Zhen Lin, Rong-Ge Yan, Guo-Wen Wang, Xiao-Na Zhang, Cen Li, Ming-Han Tong, Qi-En Yang

Stem Cell Reports. 2020 Oct 13; 15(4): 968–982. Published online 2020 Oct 13. doi: 10.1016/j.stemcr.2020.09.001

PMCID:: PMC7566211

Article PDF–7.0M

Select item 106306362.

Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2–ERK depending on downregulation of proteasome-related genes

Xinzhi Li, Chunhong Liu, Zhimin Zhang, Xueying Li, Zhicheng Yao, Yanbin Dong, Xin Wang, Zheng Chen

J Biol Chem. 2023 Nov; 299(11): 105301. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105301

PMCID:: PMC10630636

Article PDF–2.9M

Select item 98452393.

WTAP-mediated m⁶A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis

Yunhao You, Jincheng Liu, Lu Zhang, Xiang Li, Zhenqian Sun, Zihan Dai, Jinlong Ma, Guangjun Jiao, Yunzhen Chen

Cell Death Dis. 2023 Jan; 14(1): 33. Published online 2023 Jan 17. doi: 10.1038/s41419-023-05565-x

PMCID:: PMC9845239

Article PDF–7.2M

Select item 93526994.

Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH)

Xinzhi Li, Kaixin Ding, Xueying Li, Bingchuan Yuan, Yuqin Wang, Zhicheng Yao, Shuaikang Wang, He Huang, Bolin Xu, Liwei Xie, Tuo Deng, Xiao-wei Chen, Zheng Chen

Nat Commun. 2022; 13: 4549. Published online 2022 Aug 4. doi: 10.1038/s41467-022-32163-w

PMCID:: PMC9352699

Article PDF–5.0M

Select item 16348385.

Wilms' tumor 1-associating protein regulates G₂/M transition through stabilization of cyclin A2 mRNA

Keiko Horiuchi, Michihisa Umetani, Takashi Minami, Hiroto Okayama, Shinji Takada, Masayuki Yamamoto, Hiroyuki Aburatani, Patrick C. Reid, David E. Housman, Takao Hamakubo, Tatsuhiko Kodama

Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46): 17278–17283. Published online 2006 Nov 6. doi: 10.1073/pnas.0608357103

PMCID:: PMC1634838

Article PDF–510K

Select item 85172686.

Dynamic m⁶A mRNA Methylation Reveals the Role of METTL3/14-m⁶A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration

Shu-Juan Xie, Hang Lei, Bing Yang, Li-Ting Diao, Jian-You Liao, Jie-Hua He, Shuang Tao, Yan-Xia Hu, Ya-Rui Hou, Yu-Jia Sun, Yan-Wen Peng, Qi Zhang, Zhen-Dong Xiao

Front Cell Dev Biol. 2021; 9: 744171. Published online 2021 Oct 1. doi: 10.3389/fcell.2021.744171

PMCID:: PMC8517268

Article PDF–6.4M

Select item 45348227.

A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing

Benoit Moindrot, Andrea Cerase, Heather Coker, Osamu Masui, Anne Grijzenhout, Greta Pintacuda, Lothar Schermelleh, Tatyana B. Nesterova, Neil Brockdorff

Cell Rep. 2015 Jul 28; 12(4): 562–572. Published online 2015 Jul 16. doi: 10.1016/j.celrep.2015.06.053

PMCID:: PMC4534822

Article PDF–4.2M

Select item 101847038.

WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis

Jincheng Liu, Yunhao You, Zhenqian Sun, Lu Zhang, Xiang Li, Zihan Dai, Jinlong Ma, Yunzhen Chen, Guangjun Jiao

Stem Cells Transl Med. 2023 May; 12(5): 307–321. Published online 2023 Apr 3. doi: 10.1093/stcltm/szad020

PMCID:: PMC10184703

Article PDF–61M

Select item 93795459.

PGE₂‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase

Xixi Tao, Ronglu Du, Shumin Guo, Xiangling Feng, Tingting Yu, Qian OuYang, Qiaoli Chen, Xutong Fan, Xueqi Wang, Chen Guo, Xiaozhou Li, Fengxia Xue, Shuai Chen, Minghan Tong, Michael Lazarus, Shengkai Zuo, Ying Yu, Yujun Shen

EMBO J. 2022 Aug; 41(16): e110439. Published online 2022 Jul 4. doi: 10.15252/embj.2021110439

PMCID:: PMC9379545

Article PDF–20M

Select item 606675110.

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis

Masatoshi Kobayashi, Mitsuru Ohsugi, Takayoshi Sasako, Motoharu Awazawa, Toshihiro Umehara, Aya Iwane, Naoki Kobayashi, Yukiko Okazaki, Naoto Kubota, Ryo Suzuki, Hironori Waki, Keiko Horiuchi, Takao Hamakubo, Tatsuhiko Kodama, Seiichiro Aoe, Kazuyuki Tobe, Takashi Kadowaki, Kohjiro Ueki

Mol Cell Biol. 2018 Aug 15; 38(16): e00116-18. Prepublished online 2018 Jun 4. Published online 2018 Jul 30. doi: 10.1128/MCB.00116-18

PMCID:: PMC6066751

Article PDF–6.2M

Select item 979113211.

N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis

Furong Xie, Xueqin Zhu, Xiao Liu, Hui Chen, Jun Wang

J Biol Chem. 2022 Dec; 298(12): 102715. Published online 2022 Nov 17. doi: 10.1016/j.jbc.2022.102715

PMCID:: PMC9791132

Article PDF–5.5M

Select item 841076112.

Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation

Kai P. Hoefig, Alexander Reim, Christian Gallus, Elaine H. Wong, Gesine Behrens, Christine Conrad, Meng Xu, Lisa Kifinger, Taku Ito-Kureha, Kyra A. Y. Defourny, Arie Geerlof, Josef Mautner, Stefanie M. Hauck, Dirk Baumjohann, Regina Feederle, Matthias Mann, Michael Wierer, Elke Glasmacher, Vigo Heissmeyer

Nat Commun. 2021; 12: 5208. Published online 2021 Sep 1. doi: 10.1038/s41467-021-25345-5

PMCID:: PMC8410761

Article PDF–16M

Select item 585822613.

Zc3h13 regulates nuclear RNA m⁶A methylation and mouse embryonic stem cell self-renewal

Jing Wen, Ruitu Lv, Honghui Ma, Hongjie Shen, Chenxi He, Jiahua Wang, Fangfang Jiao, Hang Liu, Pengyuan Yang, Li Tan, Fei Lan, Yujiang Geno Shi, Chuan He, Yang Shi, Jianbo Diao

Mol Cell. Author manuscript; available in PMC 2019 Mar 15.

Published in final edited form as: Mol Cell. 2018 Mar 15; 69(6): 1028–1038.e6. doi: 10.1016/j.molcel.2018.02.015

PMCID:: PMC5858226

Article PDF–1.6M

Select item 1054364314.

Mettl14-mediated m⁶A modification ensures the cell-cycle progression of late-born retinal progenitor cells

Liang Li, Yue Sun, Alexander E. Davis, Sahil H. Shah, Lobna K. Hamed, Man-Ru Wu, Cheng-Hui Lin, Jun B. Ding, Sui Wang

Cell Rep. Author manuscript; available in PMC 2023 Oct 2.

Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112596. Published online 2023 Jun 1. doi: 10.1016/j.celrep.2023.112596

PMCID:: PMC10543643

Article PDF–3.9M

Select item 451183315.

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPa N-terminal leukemia

Florian Grebien, Masoud Vedadi, Matthäus Getlik, Roberto Giambruno, Amit Grover, Roberto Avellino, Anna Skucha, Sarah Vittori, Ekaterina Kuznetsova, David Smil, Dalia Barsyte-Lovejoy, Fengling Li, Gennadiy Poda, Matthieu Schapira, Hong Wu, Aiping Dong, Guillermo Senisterra, Alexey Stukalov, Kilian V. M. Huber, Andreas Schönegger, Richard Marcellus, Martin Bilban, Christoph Bock, Peter J. Brown, Johannes Zuber, Keiryn L. Bennett, Rima Al-awar, Ruud Delwel, Claus Nerlov, Cheryl H. Arrowsmith, Giulio Superti-Furga

Nat Chem Biol. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Nat Chem Biol. 2015 Aug; 11(8): 571–578. Published online 2015 Jul 13. doi: 10.1038/nchembio.1859

PMCID:: PMC4511833

Article PDF–2.2M

Select item 874425716.

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins

Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo

BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y

PMCID:: PMC8744257

Article PDF–6.0M

Select item 260547917.

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives

Owen J Tamplin, Doris Kinzel, Brian J Cox, Christine E Bell, Janet Rossant, Heiko Lickert

BMC Genomics. 2008; 9: 511. Published online 2008 Oct 30. doi: 10.1186/1471-2164-9-511

PMCID:: PMC2605479

Article PDF–1.7M

Select item 633346018.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Article PDF–2.7M

Select item 407349419.

The Central Role of EED in the Orchestration of Polycomb Group Complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan

Nat Commun. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Nat Commun. 2014; 5: 3127. doi: 10.1038/ncomms4127

PMCID:: PMC4073494

Article PDF–2.1M

Select item 18788520.

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome

Jens Hansen, Thomas Floss, Petra Van Sloun, Ernst-Martin Füchtbauer, Franz Vauti, Hans-Hennig Arnold, Frank Schnütgen, Wolfgang Wurst, Harald von Melchner, Patricia Ruiz

Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17): 9918–9922. Published online 2003 Aug 6. doi: 10.1073/pnas.1633296100

PMCID:: PMC187885

Article PDF–287K

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