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Select item 109818231.

FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury

Mi Zhou, Yang-Wu-Yue Liu, Yu-Hang He, Jing-Yu Zhang, Hao Guo, Hao Wang, Jia-Kui Ren, Yi-Xun Su, Teng Yang, Jia-Bo Li, Wen-Hui He, Peng-Jiao Ma, Man-Tian Mi, Shuang-Shuang Dai

Mil Med Res. 2024; 11: 20. Published online 2024 Mar 31. doi: 10.1186/s40779-024-00523-w

PMCID:: PMC10981823

Article PDF–14M

Select item 109327422.

Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning

Limin Shi, Jinying Yang, Zhipeng Tao, Louise Zheng, Tyler F. Bui, Ramon L. Alonso, Feng Yue, Zhiyong Cheng

Clin Sci (Lond) 2024 Mar; 138(6): 371–385. Published online 2024 Mar 12. doi: 10.1042/CS20230973

PMCID:: PMC10932742

Article PDF–6.5M

Select item 108971803.

Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice

Aurélie Durand, Nelly Bonilla, Théo Level, Zoé Ginestet, Amélie Lombès, Vincent Guichard, Mathieu Germain, Sébastien Jacques, Franck Letourneur, Marcio Do Cruzeiro, Carmen Marchiol, Gilles Renault, Morgane Le Gall, Céline Charvet, Agnès Le Bon, Bruno Martin, Cédric Auffray, Bruno Lucas

Nat Commun. 2024; 15: 1718. Published online 2024 Feb 26. doi: 10.1038/s41467-024-45984-8

PMCID:: PMC10897180

Article PDF–8.4M

Select item 108667084.

FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy

Vera A. van der Weijden, Maximilian Stötzel, Dhanur P. Iyer, Beatrix Fauler, Elzbieta Gralinska, Mohammed Shahraz, David Meierhofer, Martin Vingron, Steffen Rulands, Theodore Alexandrov, Thorsten Mielke, Aydan Bulut-Karslioglu

Nat Cell Biol. 2024; 26(2): 181–193. Published online 2024 Jan 4. doi: 10.1038/s41556-023-01325-3

PMCID:: PMC10866708

Article PDF–8.5M

Select item 105775495.

Suppression of FOXO1 attenuates inflamm‐aging and improves liver function during aging

Wanbao Yang, Da Mi Kim, Wen Jiang, Weiqi Ai, Quan Pan, Shahina Rahman, James J. Cai, Wesley A. Brashear, Yuxiang Sun, Shaodong Guo

Aging Cell. 2023 Oct; 22(10): e13968. Published online 2023 Aug 21. doi: 10.1111/acel.13968

PMCID:: PMC10577549

Article PDF–48M

Select item 104217476.

FOXO 1 deletion in chondrocytes rescues diabetes-impaired fracture healing by restoring angiogenesis and reducing apoptosis

Mohammed A. Alharbi, Dana T. Graves

Front Endocrinol (Lausanne) 2023; 14: 1136117. Published online 2023 Aug 2. doi: 10.3389/fendo.2023.1136117

PMCID:: PMC10421747

Article PDF–1.6M

Select item 102768247.

FOXO1 regulates Th17 cell-mediated hepatocellular carcinoma recurrence after hepatic ischemia-reperfusion injury

Haozhen Ren, Yuyan Chen, Zhengyi Zhu, Jinkun Xia, Shujun Liu, Yingzhe Hu, Xueqian Qin, Lu Zhang, Yitao Ding, Senzhe Xia, Jinglin Wang

Cell Death Dis. 2023 Jun; 14(6): 367. Published online 2023 Jun 17. doi: 10.1038/s41419-023-05879-w

PMCID:: PMC10276824

Article PDF–7.4M

Select item 100268678.

The role of FOXO1-mediated autophagy in the regulation of bone formation

Yixuan Jiang, Wenqiong Luo, Feng Zhou, Ping Gong, Yi Xiong

Cell Cycle. 2023; 22(7): 829–840. Published online 2022 Dec 12. doi: 10.1080/15384101.2022.2155443

PMCID:: PMC10026867

Article PDF–2.2M

Select item 86096419.

iNKT subsets differ in their developmental and functional requirements on Foxo1

Huimin Zhang, Yuwei Zhang, Jun Pan, Qielan Wu, Yuanyuan Huang, Shiyu Bai, Chenxi Tian, Mingzhao Zhu, Zhexiong Lian, Fengyin Li, Zhigang Tian, Li Bai

Proc Natl Acad Sci U S A. 2021 Nov 16; 118(46): e2105950118. Published online 2021 Nov 11. doi: 10.1073/pnas.2105950118

PMCID:: PMC8609641

Article PDF–3.3M

Select item 860933310.

An integrative transcriptional logic model of hepatic insulin resistance

Takumi Kitamoto, Taiyi Kuo, Atsushi Okabe, Atsushi Kaneda, Domenico Accili

Proc Natl Acad Sci U S A. 2021 Nov 9; 118(45): e2102222118. Published online 2021 Nov 3. doi: 10.1073/pnas.2102222118

PMCID:: PMC8609333

Article PDF–2.7M

Select item 841905311.

Angiotensin IV attenuates diabetic cardiomyopathy via suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis

Meng Zhang, Wenhai Sui, Yanqiu Xing, Jing Cheng, Cheng Cheng, Fei Xue, Jie Zhang, Xiaohong Wang, Cheng Zhang, Panpan Hao, Yun Zhang

Theranostics. 2021; 11(18): 8624–8639. Published online 2021 Jul 25. doi: 10.7150/thno.48561

PMCID:: PMC8419053

Article PDF–3.7M

Select item 823115212.

Metformin Targets Foxo1 to Control Glucose Homeostasis

Xiaoqin Guo, Xiaopeng Li, Wanbao Yang, Wang Liao, James Zheng Shen, Weiqi Ai, Quan Pan, Yuxiang Sun, Kebin Zhang, Rui Zhang, Yuyang Qiu, Qian Dai, Hongting Zheng, Shaodong Guo

Biomolecules. 2021 Jun; 11(6): 873. Published online 2021 Jun 11. doi: 10.3390/biom11060873

PMCID:: PMC8231152

Article PDF–3.0M

Select item 810687413.

FOXO1 expression in chondrocytes modulates cartilage production and removal in fracture healing

Zhenjiang Ding, Min Qiu, Mohammed A. Alharbi, Tiffany Huang, Xiyan Pei, Tatyana N. Milovanova, Hongli Jiao, Chanyi Lu, Min Liu, Ling Qin, Dana T. Graves

Bone. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Bone. 2021 Jul; 148: 115905. Published online 2021 Mar 1. doi: 10.1016/j.bone.2021.115905

PMCID:: PMC8106874

Article PDF–1.7M

Select item 794895914.

1α,25-Dihydroxyvitamin D3 ameliorates diabetes-induced bone loss by attenuating FoxO1-mediated autophagy

Yixuan Jiang, Wenqiong Luo, Bin Wang, Zumu Yi, Ping Gong, Yi Xiong

J Biol Chem. 2021 Jan-Jun; 296: 100287. Published online 2021 Jan 13. doi: 10.1016/j.jbc.2021.100287

PMCID:: PMC7948959

Article PDF–4.2M

Select item 772013515.

Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice

Carlos Castaño, Mercedes Mirasierra, Mario Vallejo, Anna Novials, Marcelina Párrizas

Proc Natl Acad Sci U S A. 2020 Dec 1; 117(48): 30335–30343. Published online 2020 Nov 16. doi: 10.1073/pnas.2016112117

PMCID:: PMC7720135

Article PDF–1.7M

Select item 768779416.

Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway

Rahul Khatri, Sybille Mazurek, Sebastian Friedrich Petry, Thomas Linn

Stem Cell Res Ther. 2020; 11: 497. Published online 2020 Nov 25. doi: 10.1186/s13287-020-02007-9

PMCID:: PMC7687794

Article PDF–4.5M

Select item 724269717.

Depletion of hepatic forkhead box O1 does not affect cholelithiasis in male and female mice

Xiaoyun Feng, Cuiling Zhu, Sojin Lee, Jingyang Gao, Ping Zhu, Jun Yamauchi, Chenglin Pan, Sucha Singh, Shen Qu, Rita Miller, Satdarshan P. Monga, Yongde Peng, H. Henry Dong

J Biol Chem. 2020 May 15; 295(20): 7003–7017. Published online 2020 Apr 9. doi: 10.1074/jbc.RA119.012272