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Select item 106653391.

NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma

Naixue Wang, Dantong Zhu, Yao Liu, Jingran Wu, Meiling Wang, Shanxiu Jin, Fangwei Fu, Baolei Li, Hongjuan Ji, Cheng Du, Zhendong Zheng

Sci Rep. 2023; 13: 20430. Published online 2023 Nov 22. doi: 10.1038/s41598-023-47782-6

PMCID:: PMC10665339

Article PDF–8.7M

Select item 73631122.

Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma

Hirofumi Yoshino, Yasutoshi Yamada, Hideki Enokida, Yoichi Osako, Masafumi Tsuruda, Kazuki Kuroshima, Takashi Sakaguchi, Satoshi Sugita, Shuichi Tatarano, Masayuki Nakagawa

PLoS One. 2020; 15(7): e0236119. Published online 2020 Jul 15. doi: 10.1371/journal.pone.0236119

PMCID:: PMC7363112

Article PDF–1.7M

Select item 65436713.

Upregulation of NPL4 promotes bladder cancer cell proliferation by inhibiting DXO destabilization of cyclin D1 mRNA

Bao-Sai Lu, Yue-Wei Yin, Yan-Ping Zhang, Ping-Ying Guo, Wei Li, Kai-Long Liu

Cancer Cell Int. 2019; 19: 149. Published online 2019 May 30. doi: 10.1186/s12935-019-0874-2

PMCID:: PMC6543671

Article PDF–1.6M

Select item 77857364.

Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative

Man Pan, Qingyun Zheng, Yuanyuan Yu, Huasong Ai, Yuan Xie, Xin Zeng, Chu Wang, Lei Liu, Minglei Zhao

Nat Commun. 2021; 12: 121. Published online 2021 Jan 5. doi: 10.1038/s41467-020-20359-x

PMCID:: PMC7785736

Article PDF–2.0M

Select item 69293235.

Multisystem proteinopathy (MSP) mutations in VCP/p97 increase NPLOC4·UFD1L binding and substrate processing

Emily E. Blythe, Stephanie N. Gates, Raymond J. Deshaies, Andreas Martin

Structure. Author manuscript; available in PMC 2020 Dec 3.

Published in final edited form as: Structure. 2019 Dec 3; 27(12): 1820–1829.e4. Published online 2019 Oct 14. doi: 10.1016/j.str.2019.09.011

PMCID:: PMC6929323

Article PDF–1.0M

Select item 54659066.

Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy

Emily E. Blythe, Kristine C. Olson, Vincent Chau, Raymond J. Deshaies

Proc Natl Acad Sci U S A. 2017 May 30; 114(22): E4380–E4388. Published online 2017 May 16. doi: 10.1073/pnas.1706205114

PMCID:: PMC5465906

Article PDF–1.1M

Select item 33661197.

Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4

Bin Wang, Steven L. Alam, Hemmo H. Meyer, Marielle Payne, Timothy L. Stemmler, Darrell R. Davis, Wesley I. Sundquist

J Biol Chem. Author manuscript; available in PMC 2012 Jun 3.

Published in final edited form as: J Biol Chem. 2003 May 30; 278(22): 20225–20234. Published online 2003 Mar 18. doi: 10.1074/jbc.M300459200

PMCID:: PMC3366119

Article PDF–3.5M

Select item 96739308.

WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP

Guang Lu, Hayden Weng Siong Tan, Tomas Schmauck-Medina, Liming Wang, Jiaqing Chen, Yik-Lam Cho, Kelie Chen, Jing-Zi Zhang, Weifeng He, Yihua Wu, Dajing Xia, Jing Zhou, Evandro F. Fang, Lei Fang, Wei Liu, Han-Ming Shen

Autophagy. 2022; 18(12): 2865–2879. Published online 2022 Apr 7. doi: 10.1080/15548627.2022.2052461

PMCID:: PMC9673930

Article PDF–3.5M

Select item 29522369.

The p97 ATPase Dislocates MHC Class I Heavy Chain in US2-expressing Cells via a Ufd1-Npl4-independent Mechanism

Nia Soetandyo, Yihong Ye

J Biol Chem. 2010 Oct 15; 285(42): 32352–32359. Published online 2010 Aug 11. doi: 10.1074/jbc.M110.131649

PMCID:: PMC2952236

Article PDF–1.2M

Select item 538930410.

p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates

Thang Van Nguyen, Jing Li, Chin-Chun (Jean) Lu, Jennifer L. Mamrosh, Gang Lu, Brian E. Cathers, Raymond J. Deshaies

Proc Natl Acad Sci U S A. 2017 Apr 4; 114(14): 3565–3571. Published online 2017 Mar 20. doi: 10.1073/pnas.1700949114

PMCID:: PMC5389304

Article PDF–1.1M

Select item 398431511.

The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G₂/M checkpoint by facilitating CDC25A degradation

Anne Riemer, Grzegorz Dobrynin, Alina Dressler, Sebastian Bremer, Aashish Soni, George Iliakis, Hemmo Meyer

Cell Cycle. 2014 Mar 15; 13(6): 919–927. Published online 2014 Jan 15. doi: 10.4161/cc.27779

PMCID:: PMC3984315

Article PDF–7.1M

Select item 382944612.

NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Promotes Transfer of NEDD8 to Proteasome for Degradation through the P97^UFD1/NPL4 Complex

Shuai Liu, Hui Yang, Jian Zhao, Yu-Hang Zhang, Ai-Xin Song, Hong-Yu Hu

J Biol Chem. 2013 Oct 25; 288(43): 31339–31349. Published online 2013 Sep 9. doi: 10.1074/jbc.M113.484816

PMCID:: PMC3829446

Article PDF–4.4M

Select item 493319013.

Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response

Tao Wang, Wangchao Xu, Meiling Qin, Yi Yang, Puhua Bao, Fuxiao Shen, Zhenlin Zhang, Jin Xu

J Biol Chem. 2016 Jul 1; 291(27): 14373–14384. Published online 2016 May 13. doi: 10.1074/jbc.M116.729343

PMCID:: PMC4933190

Article PDF–2.9M

Select item 359161014.

Complex of Fas-associated Factor 1 (FAF1) with Valosin-containing Protein (VCP)-Npl4-Ufd1 and Polyubiquitinated Proteins Promotes Endoplasmic Reticulum-associated Degradation (ERAD)

Jae-Jin Lee, Joon Kyu Park, Jaeho Jeong, Hyesung Jeon, Jong-Bok Yoon, Eunice EunKyeong Kim, Kong-Joo Lee

J Biol Chem. 2013 Mar 8; 288(10): 6998–7011. Published online 2013 Jan 4. doi: 10.1074/jbc.M112.417576

PMCID:: PMC3591610

Article PDF–3.3M

Select item 286550915.

Digital Quantification of Human Eye Color Highlights Genetic Association of Three New Loci

Fan Liu, Andreas Wollstein, Pirro G. Hysi, Georgina A. Ankra-Badu, Timothy D. Spector, Daniel Park, Gu Zhu, Mats Larsson, David L. Duffy, Grant W. Montgomery, David A. Mackey, Susan Walsh, Oscar Lao, Albert Hofman, Fernando Rivadeneira, Johannes R. Vingerling, André G. Uitterlinden, Nicholas G. Martin, Christopher J. Hammond, Manfred Kayser

PLoS Genet. 2010 May; 6(5): e1000934. Published online 2010 May 6. doi: 10.1371/journal.pgen.1000934

PMCID:: PMC2865509

Article PDF–2.0M

Select item 286168816.

Multilayered Mechanism of CD4 Downregulation by HIV-1 Vpu Involving Distinct ER Retention and ERAD Targeting Steps

Javier G. Magadán, F. Javier Pérez-Victoria, Rachid Sougrat, Yihong Ye, Klaus Strebel, Juan S. Bonifacino

PLoS Pathog. 2010 Apr; 6(4): e1000869. Published online 2010 Apr 29. doi: 10.1371/journal.ppat.1000869

PMCID:: PMC2861688

Article PDF–4.7M

Select item 821322517.

ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication

Dejie Wang, Jian Ma, Maria Victoria Botuyan, Gaofeng Cui, Yuqian Yan, Donglin Ding, Yingke Zhou, Eugene W. Krueger, Jiang Pei, Xiaosheng Wu, Liguo Wang, Huadong Pei, Mark A. McNiven, Dingwei Ye, Georges Mer, Haojie Huang

Sci Adv. 2021 Jun; 7(25): eabd9208. Published online 2021 Jun 18. doi: 10.1126/sciadv.abd9208