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Select item 67569281.

Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome.

Ashish K Solanki, Eugen Widmeier, Ehtesham Arif, Shailza Sharma, Ankana Daga, Pankaj Srivastava, Sang-Ho Kwon, Hannah Hugo, Makiko Nakayama, Nina Mann, Amar J. Majmundar, Wei Tan, Heon Yung Gee, Caroline E. Sadowski, Choni Rinat, Rachel Becker-Cohen, Carsten Bergmann, Seymour Rosen, Michael Somers, Shirlee Shril, Tobias B. Huber, Shrikant Mane, Friedhelm Hildebrandt, Deepak Nihalani

Kidney Int. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Kidney Int. 2019 Oct; 96(4): 883–889. Published online 2019 Jul 10. doi: 10.1016/j.kint.2019.06.016

PMCID:: PMC6756928

Article PDF–845K

Select item 49593102.

Structural Analysis of the Myo1c and Neph1 Complex Provides Insight into the Intracellular Movement of Neph1

Ehtesham Arif, Pankaj Sharma, Ashish Solanki, Leena Mallik, Yogendra S. Rathore, Waleed O. Twal, Samir K. Nath, Darpan Gandhi, Lawrence B. Holzman, E. Michael Ostap, Ashish, Deepak Nihalani

Mol Cell Biol. 2016 Jun 1; 36(11): 1639–1654. Prepublished online 2016 Apr 4. Published online 2016 May 16. doi: 10.1128/MCB.00020-16

PMCID:: PMC4959310

Article PDF–4.2M

Select item 39750023.

Slit Diaphragm Protein Neph1 and Its Signaling: A NOVEL THERAPEUTIC TARGET FOR PROTECTION OF PODOCYTES AGAINST GLOMERULAR INJURY

Ehtesham Arif, Yogendra S. Rathore, Babita Kumari, Fnu Ashish, Hetty N. Wong, Lawrence B. Holzman, Deepak Nihalani

J Biol Chem. 2014 Apr 4; 289(14): 9502–9518. Published online 2014 Feb 19. doi: 10.1074/jbc.M113.505743

PMCID:: PMC3975002

Article PDF–5.5M

Select item 33088194.

Solution Structure Analysis of Cytoplasmic Domain of Podocyte Protein Neph1 Using Small/Wide Angle X-ray Scattering (SWAXS)

Leena Mallik, Ehtesham Arif, Pankaj Sharma, Yogendra S. Rathore, Hetty N. Wong, Lawrence B. Holzman, Ashish, Deepak Nihalani

J Biol Chem. 2012 Mar 16; 287(12): 9441–9453. Published online 2012 Jan 17. doi: 10.1074/jbc.M111.284927

PMCID:: PMC3308819

Article PDF–2.9M

Select item 88544065.

Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites

Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong

Nat Commun. 2022; 13: 930. Published online 2022 Feb 17. doi: 10.1038/s41467-022-28567-3

PMCID:: PMC8854406

Article PDF–3.9M

Select item 871766.

Proteinuria and Perinatal Lethality in Mice Lacking NEPH1, a Novel Protein with Homology to NEPHRIN

Dorit B. Donoviel, Deon D. Freed, Hannes Vogel, David G. Potter, Edith Hawkins, James P. Barrish, Brian N. Mathur, C. Alexander Turner, Robert Geske, Charles A. Montgomery, Michael Starbuck, Mary Brandt, Anupma Gupta, Ramiro Ramirez-Solis, Brian P. Zambrowicz, David R. Powell

Mol Cell Biol. 2001 Jul; 21(14): 4829–4836. doi: 10.1128/MCB.21.14.4829-4836.2001

PMCID:: PMC87176

Article PDF–2.6M

Select item 108055017.

KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway

Tao Wang, Shuo Chen, Ziliang Wang, Siyu Li, Xichang Fei, Tong Wang, Mingjun Zhang

J Cell Mol Med. 2024 Jan; 28(1): e18020. Published online 2023 Nov 1. doi: 10.1111/jcmm.18020

PMCID:: PMC10805501

Article PDF–36M

Select item 31333538.

Motor Protein Myo1c Is a Podocyte Protein That Facilitates the Transport of Slit Diaphragm Protein Neph1 to the Podocyte Membrane

E. Arif, M. C. Wagner, D. B. Johnstone, H. N. Wong, B. George, P. A. Pruthi, M. J. Lazzara, D. Nihalani

Mol Cell Biol. 2011 May; 31(10): 2134–2150. doi: 10.1128/MCB.05051-11

PMCID:: PMC3133353

Article PDF–6.1M

Select item 26028829.

Ischemic Injury to Kidney Induces Glomerular Podocyte Effacement and Dissociation of Slit Diaphragm Proteins Neph1 and ZO-1

Mark C. Wagner, George Rhodes, Exing Wang, Vikas Pruthi, Ehtesham Arif, Moin A. Saleem, Sarah E. Wean, Puneet Garg, Rakesh Verma, Lawrence B. Holzman, Vince Gattone, Bruce A. Molitoris, Deepak Nihalani

J Biol Chem. 2008 Dec 19; 283(51): 35579–35589. doi: 10.1074/jbc.M805507200

PMCID:: PMC2602882

Article PDF–955K

Select item 16429310.

Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability

Gang Liu, Beenu Kaw, Jayson Kurfis, Syed Rahmanuddin, Yashpal S. Kanwar, Sumant S. Chugh

J Clin Invest. 2003 Jul 15; 112(2): 209–221. doi: 10.1172/JCI18242

PMCID:: PMC164293

Article PDF–3.4M

Select item 315222511.

Genotype–Phenotype Correlations in Non-Finnish Congenital Nephrotic Syndrome

Eduardo Machuca, Geneviève Benoit, Fabien Nevo, Marie-Josèphe Tête, Olivier Gribouval, Audrey Pawtowski, Per Brandström, Chantal Loirat, Patrick Niaudet, Marie-Claire Gubler, Corinne Antignac

J Am Soc Nephrol. 2010 Jul; 21(7): 1209–1217. doi: 10.1681/ASN.2009121309

PMCID:: PMC3152225

Article

Select item 243103712.

Neph1, a Component of the Kidney Slit Diaphragm, Is Tyrosine-phosphorylated by the Src Family Tyrosine Kinase and Modulates Intracellular Signaling by Binding to Grb2

Yutaka Harita, Hidetake Kurihara, Hidetaka Kosako, Tohru Tezuka, Takashi Sekine, Takashi Igarashi, Seisuke Hattori

J Biol Chem. 2008 Apr 4; 283(14): 9177–9186. doi: 10.1074/jbc.M707247200

PMCID:: PMC2431037

Article PDF–548K

Select item 251698113.

Neph-Nephrin Proteins Bind the Par3-Par6-Atypical Protein Kinase C (aPKC) Complex to Regulate Podocyte Cell Polarity

Björn Hartleben, Heiko Schweizer, Pauline Lübben, Malte P. Bartram, Clemens C. Möller, Ronja Herr, Changli Wei, Elke Neumann-Haefelin, Bernhard Schermer, Hanswalter Zentgraf, Dontscho Kerjaschki, Jochen Reiser, Gerd Walz, Thomas Benzing, Tobias B. Huber

J Biol Chem. 2008 Aug 22; 283(34): 23033–23038. doi: 10.1074/jbc.M803143200

PMCID:: PMC2516981

Article PDF–427K

Select item 955211814.

Claudin-4 localization in epithelial ovarian cancer

Margaret C. Neville, Patricia G. Webb, Heidi K. Baumgartner, Benjamin G. Bitler

Heliyon. 2022 Oct; 8(10): e10862. Published online 2022 Oct 4. doi: 10.1016/j.heliyon.2022.e10862

PMCID:: PMC9552118

Article PDF–4.5M

Select item 589142915.

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics

Thomas O'Loughlin, Thomas A Masters, Folma Buss

EMBO Rep. 2018 Apr; 19(4): e44884. Published online 2018 Feb 21. doi: 10.15252/embr.201744884

PMCID:: PMC5891429

Article PDF–9.1M

Select item 694423816.

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion

Antoine Méant, Beichen Gao, Geneviève Lavoie, Sami Nourreddine, Flora Jung, Léo Aubert, Joseph Tcherkezian, Anne-Claude Gingras, Philippe P. Roux

Mol Cell Proteomics. 2020 Jan; 19(1): 50–64. Published online 2019 Nov 2. doi: 10.1074/mcp.RA119.001811

PMCID:: PMC6944238

Article PDF–5.7M

Select item 884482717.

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase

Zhifen Zhou, Yujing Li, Huimin Xu, Xiaowei Xie, Zibin He, Song Lin, Ruofei Li, Shouheng Jin, Jun Cui, Hai Hu, Feng Liu, Su Wu, Wenbin Ma, Zhou Songyang

iScience. 2022 Feb 18; 25(2): 103813. Published online 2022 Jan 25. doi: 10.1016/j.isci.2022.103813

PMCID:: PMC8844827

Article PDF–6.0M

Select item 855075918.

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

Tomasz Radaszkiewicz, Michaela Nosková, Kristína Gömöryová, Olga Vondálová Blanářová, Katarzyna Anna Radaszkiewicz, Markéta Picková, Ráchel Víchová, Tomáš Gybeľ, Karol Kaiser, Lucia Demková, Lucia Kučerová, Tomáš Bárta, David Potěšil, Zbyněk Zdráhal, Karel Souček, Vítězslav Bryja

eLife. 2021; 10: e65759. Published online 2021 Oct 27. doi: 10.7554/eLife.65759

PMCID:: PMC8550759

Article PDF–7.4M

Select item 1032325219.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468

PMCID:: PMC10323252

Article

Select item 1091686620.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Article PDF–4.7M

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