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Select item 101329741.

Age-associated microenvironmental changes highlight the role of PDGF-C in ER⁺ breast cancer metastatic relapse

Frances K. Turrell, Rebecca Orha, Naomi J. Guppy, Andrea Gillespie, Matthew Guelbert, Chris Starling, Syed Haider, Clare M. Isacke

Nat Cancer. 2023; 4(4): 468–484. Published online 2023 Mar 13. doi: 10.1038/s43018-023-00525-y

PMCID:: PMC10132974

Article PDF–28M

Select item 77595792.

Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood–brain barrier

Manuel Zeitelhofer, Milena Z. Adzemovic, Christine Moessinger, Christina Stefanitsch, Carina Strell, Lars Muhl, Lou Brundin, Linda Fredriksson, Tomas Olsson, Ulf Eriksson, Ingrid Nilsson

Sci Rep. 2020; 10: 22383. Published online 2020 Dec 24. doi: 10.1038/s41598-020-79598-z

PMCID:: PMC7759579

Article PDF–7.7M

Select item 60516353.

Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CC^hum mice

Manuel Zeitelhofer, Hong Li, Milena Z. Adzemovic, Ingrid Nilsson, Lars Muhl, Andrew M. Scott, Ulf Eriksson

PLoS One. 2018; 13(7): e0200649. Published online 2018 Jul 18. doi: 10.1371/journal.pone.0200649

PMCID:: PMC6051635

Article PDF–11M

Select item 55876284.

Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke

Enming Joseph Su, Chunzhang Cao, Linda Fredriksson, Ingrid Nilsson, Christina Stefanitsch, Tamara K. Stevenson, Juanjuan Zhao, Margret Ragsdale, Yu-Yo Sun, Manuel Yepes, Chia-Yi Kuan, Ulf Eriksson, Dudley K. Strickland, Daniel A. Lawrence, Li Zhang

Acta Neuropathol. 2017; 134(4): 585–604. Published online 2017 Jul 19. doi: 10.1007/s00401-017-1749-z

PMCID:: PMC5587628

Article PDF–7.3M

Select item 29014285.

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets

Xu Hou, Anil Kumar, Chunsik Lee, Bin Wang, Pachiappan Arjunan, Lijin Dong, Arvydas Maminishkis, Zhongshu Tang, Yang Li, Fan Zhang, Shi-Zhuang Zhang, Piotr Wardega, Sagarika Chakrabarty, Baoying Liu, Zhijian Wu, Peter Colosi, Robert N. Fariss, Johan Lennartsson, Robert Nussenblatt, J. Silvio Gutkind, Yihai Cao, Xuri Li

Proc Natl Acad Sci U S A. 2010 Jul 6; 107(27): 12216–12221. Published online 2010 Jun 21. doi: 10.1073/pnas.1004143107

PMCID:: PMC2901428

Article PDF–1.1M

Select item 28936516.

PDGF-C Mediates Glomerular Capillary Repair

Peter Boor, Claudia R.C. van Roeyen, Uta Kunter, Luigi Villa, Eva Bücher, Bernd Hohenstein, Christian P.M. Hugo, Ulf Eriksson, Simon C. Satchell, Peter W. Mathieson, Frank Eitner, Jürgen Floege, Tammo Ostendorf

Am J Pathol. 2010 Jul; 177(1): 58–69. doi: 10.2353/ajpath.2010.091008

PMCID:: PMC2893651

Article PDF–1.2M

Select item 27127267.

Focus on Molecules: Platelet-derived Growth Factor C, PDGF-C

Hetian Lei, Andrius Kazlauskas

Exp Eye Res. Author manuscript; available in PMC 2009 Jul 20.

Published in final edited form as: Exp Eye Res. 2008 May; 86(5): 711–712. Published online 2007 Aug 19. doi: 10.1016/j.exer.2007.08.007

PMCID:: PMC2712726

Article PDF–63K

Select item 23967468.

PDGF-C Is a Proinflammatory Cytokine that Mediates Renal Interstitial Fibrosis

Frank Eitner, Eva Bücher, Claudia van Roeyen, Uta Kunter, Song Rong, Claudia Seikrit, Luigi Villa, Peter Boor, Linda Fredriksson, Gudrun Bäckström, Ulf Eriksson, Arne Östman, Jürgen Floege, Tammo Ostendorf

J Am Soc Nephrol. 2008 Feb; 19(2): 281–289. doi: 10.1681/ASN.2007030290

PMCID:: PMC2396746

Article

Select item 18682119.

Transgenic Overexpression of Platelet-Derived Growth Factor-C in the Mouse Heart Induces Cardiac Fibrosis, Hypertrophy, and Dilated Cardiomyopathy

Annica Pontén, Xuri Li, Peter Thorén, Karin Aase, Tobias Sjöblom, Arne Östman, Ulf Eriksson

Am J Pathol. 2003 Aug; 163(2): 673–682. doi: 10.1016/S0002-9440(10)63694-2

PMCID:: PMC1868211

Article PDF–902K

Select item 863378310.

Expression and function of PDGF-C in development and stem cells

Yi Tian, Ying Zhan, Qin Jiang, Weisi Lu, Xuri Li

Open Biol. 2021 Dec; 11(12): 210268. Published online December 1, 2021. doi: 10.1098/rsob.210268

PMCID:: PMC8633783

Article PDF–982K

Select item 596589911.

Metabolic benefits of inhibition of p38α in white adipose tissue in obesity

Shengjie Zhang, Hongchao Cao, Yan Li, Yanyan Jing, Shengnan Liu, Cheng Ye, Hui Wang, Shuxian Yu, Chengyuan Peng, Lijian Hui, Yu-cheng Wang, Haibing Zhang, Feifan Guo, Qiwei Zhai, Hui Wang, Ruimin Huang, Ling Zhang, Jingjing Jiang, Wei Liu, Hao Ying

PLoS Biol. 2018 May; 16(5): e2004225. Published online 2018 May 11. doi: 10.1371/journal.pbio.2004225

PMCID:: PMC5965899

Article PDF–13M

Select item 589672912.

Microenvironmental control of breast cancer subtype elicited by paracrine platelet derived growth factor-CC signaling

Pernilla Roswall, Matteo Bocci, Michael Bartoschek, Hong Li, Glen Kristiansen, Sara Jansson, Sophie Lehn, Jonas Sjölund, Steven Reid, Christer Larsson, Pontus Eriksson, Charlotte Anderberg, Eliane Cortez, Lao H Saal, Christina Orsmark-Pietras, Eugenia Cordero, B Kristian Haller, Jari Häkkinen, Ingrid JG Burvenich, Elgene Lim, Akira Orimo, Mattias Höglund, Lisa Rydén, Holger Moch, Andrew M Scott, Ulf Eriksson, Kristian Pietras

Nat Med. Author manuscript; available in PMC 2018 Sep 12.

Published in final edited form as: Nat Med. 2018 May; 24(4): 463–473. Published online 2018 Mar 12. doi: 10.1038/nm.4494

PMCID:: PMC5896729

Article PDF–2.7M

Select item 420561013.

Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration

Chang He, Chen Zhao, Anil Kumar, Chunsik Lee, Mingquan Chen, Lijuan Huang, Jing Wang, Xiangrong Ren, Yida Jiang, Wei Chen, Bin Wang, Zhiqin Gao, Zheng Zhong, Zijing Huang, Fan Zhang, Bing Huang, Hao Ding, Rong Ju, Zhongshu Tang, Yizhi Liu, Yihai Cao, Xuri Li, Xialin Liu

Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41): 14806–14811. Published online 2014 Sep 29. doi: 10.1073/pnas.1404140111

PMCID:: PMC4205610

Article PDF–2.6M

Select item 334989014.

Platelet-Derived Growth Factor C Deficiency in C57BL/6 Mice Leads to Abnormal Cerebral Vascularization, Loss of Neuroependymal Integrity, and Ventricular Abnormalities

Linda Fredriksson, Ingrid Nilsson, Enming J. Su, Johanna Andrae, Hao Ding, Christer Betsholtz, Ulf Eriksson, Daniel A. Lawrence

Am J Pathol. 2012 Mar; 180(3): 1136–1144. doi: 10.1016/j.ajpath.2011.12.006

PMCID:: PMC3349890

Article PDF–3.1M

Select item 285602915.

Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation

Zhongshu Tang, Pachiappan Arjunan, Chunsik Lee, Yang Li, Anil Kumar, Xu Hou, Bin Wang, Piotr Wardega, Fan Zhang, Lijin Dong, Yongqing Zhang, Shi-Zhuang Zhang, Hao Ding, Robert N. Fariss, Kevin G. Becker, Johan Lennartsson, Nobuo Nagai, Yihai Cao, Xuri Li

J Exp Med. 2010 Apr 12; 207(4): 867–880. doi: 10.1084/jem.20091704

PMCID:: PMC2856029

Article PDF–6.9M

Select item 55294016.

Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

Jean S. Campbell, Steven D. Hughes, Debra G. Gilbertson, Thomas E. Palmer, Matthew S. Holdren, Aaron C. Haran, Melissa M. Odell, Renay L. Bauer, Hong-Ping Ren, Harald S. Haugen, Matthew M. Yeh, Nelson Fausto

Proc Natl Acad Sci U S A. 2005 Mar 1; 102(9): 3389–3394. Published online 2005 Feb 22. doi: 10.1073/pnas.0409722102

PMCID:: PMC552940

Article PDF–701K

Select item 387696617.

Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice; evidence for stromal induction of hepatocellular carcinoma

Jocelyn H Wright, Melissa M. Johnson, Masami Shimizu-Albergine, Renay L. Bauer, Brian J. Hayes, James Surapisitchat, Kelly L. Hudkins, Kimberly J. Riehle, Simon Johnson, Matthew M. Yeh, Theodor K. Bammler, Richard P. Beyer, Deb G. Gilbertson, Charles C. Alpers, Nelson Fausto, Jean S. Campbell

Int J Cancer. Author manuscript; available in PMC 2015 Feb 15.

Published in final edited form as: Int J Cancer. 2014 Feb 15; 134(4): 778–788. Published online 2013 Sep 16. doi: 10.1002/ijc.28421

PMCID:: PMC3876966

Article PDF–8.3M

Select item 481488718.

High glucose induces platelet‐derived growth factor‐C via carbohydrate response element‐binding protein in glomerular mesangial cells

Hiroya Kitsunai, Yuichi Makino, Hidemitsu Sakagami, Katsutoshi Mizumoto, Tsuyoshi Yanagimachi, Kuralay Atageldiyeva, Yasutaka Takeda, Yukihiro Fujita, Atsuko Abiko, Yumi Takiyama, Masakazu Haneda

Physiol Rep. 2016 Mar; 4(6): e12730. Published online 2016 Mar 31. doi: 10.14814/phy2.12730

PMCID:: PMC4814887

Article PDF–2.3M

Select item 403957419.

Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration

Yujuan Wang, Mones S. Abu-Asab, Cheng-Rong Yu, Zhongshu Tang, Defen Shen, Jingsheng Tuo, Xuri Li, Chi-Chao Chan

Lab Invest. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Lab Invest. 2014 Jun; 94(6): 674–682. Published online 2014 Apr 7. doi: 10.1038/labinvest.2014.60

PMCID:: PMC4039574

Article PDF–582K

Select item 393270520.

Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation

Kimberly J. Riehle, Melissa M. Johnson, Fredrik Johansson, Renay L. Bauer, Brian J. Hayes, Debra G. Gilbertson, Aaron C. Haran, Nelson Fausto, Jean S. Campbell

Biochim Biophys Acta. Author manuscript; available in PMC 2015 Feb 1.

Published in final edited form as: Biochim Biophys Acta. 2014 Feb; 1842(2): 318–325. Published online 2013 Nov 19. doi: 10.1016/j.bbadis.2013.11.013

PMCID:: PMC3932705

Article PDF–2.2M

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