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Select item 105293621.

ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

Wendy Leung, Antoine Simoneau, Sneha Saxena, Jessica Jackson, Parasvi S. Patel, Mangsi Limbu, Alessandro Vindigni, Lee Zou

Cell Rep. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112792. Published online 2023 Jul 16. doi: 10.1016/j.celrep.2023.112792

PMCID:: PMC10529362

Article PDF–2.8M

Select item 104682042.

A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

Sana Ahmed-Seghir, Manisha Jalan, Helen E Grimsley, Aman Sharma, Shyam Twayana, Settapong T Kosiyatrakul, Christopher Thompson, Carl L Schildkraut, Simon N Powell

eLife. 2023; 12: RP87357. Published online 2023 Aug 30. doi: 10.7554/eLife.87357

PMCID:: PMC10468204

Article PDF–5.3M

Select item 104501863.

Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase

Yujin Kang, Ye Gi Han, Keon Woo Khim, Woo Gyun Choi, Min Kyung Ju, Kibeom Park, Kyeong Jin Shin, Young Chan Chae, Jang Hyun Choi, Hongtae Kim, Ja Yil Lee

Nucleic Acids Res. 2023 Aug 25; 51(15): 7936–7950. Published online 2023 Jun 28. doi: 10.1093/nar/gkad543

PMCID:: PMC10450186

Article PDF–1.6M

Select item 99043234.

The “extreme phenotype approach” applied to male breast cancer allows the identification of rare variants of ATR as potential breast cancer susceptibility alleles

Martin Chevarin, Diana Alcantara, Juliette Albuisson, Marie-Agnès Collonge-Rame, Céline Populaire, Zohair Selmani, Amandine Baurand, Caroline Sawka, Geoffrey Bertolone, Patrick Callier, Yannis Duffourd, Philippe Jonveaux, Yves-Jean Bignon, Isabelle Coupier, François Cornelis, Christophe Cordier, Monique Mozelle-Nivoix, Jean-Baptiste Rivière, Paul Kuentz, Christel Thauvin, Romain Boidot, François Ghiringhelli, Marc O'Driscoll, Laurence Faivre, Sophie Nambot

Oncotarget. 2023; 14: 111–125. Published online 2023 Feb 7. doi: 10.18632/oncotarget.28358

PMCID:: PMC9904323

Article PDF–1.5M

Select item 89714165.

A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress

Tom Egger, Benoît Bordignon, Arnaud Coquelle

Sci Rep. 2022; 12: 5422. Published online 2022 Mar 31. doi: 10.1038/s41598-022-09308-4

PMCID:: PMC8971416

Article PDF–9.5M

Select item 85419126.

A Basal-Level Activity of ATR Links Replication Fork Surveillance and Stress Response

Yandong Yin, Wei Ting Chelsea Lee, Gupta Dipika, Huijun Xue, Peter Tonzi, James A. Borowiec, Tony T. Huang, Mauro Modesti, Eli Rothenberg

Mol Cell. Author manuscript; available in PMC 2022 Oct 21.

Published in final edited form as: Mol Cell. 2021 Oct 21; 81(20): 4243–4257.e6. Published online 2021 Sep 1. doi: 10.1016/j.molcel.2021.08.009

PMCID:: PMC8541912

Article PDF–3.2M

Select item 81874257.

PB01 suppresses radio-resistance by regulating ATR signaling in human non-small-cell lung cancer cells

Tae Woo Kim, Da-Won Hong, Sung Hee Hong

Sci Rep. 2021; 11: 12093. Published online 2021 Jun 8. doi: 10.1038/s41598-021-91716-z

PMCID:: PMC8187425

Article PDF–2.5M

Select item 80758758.

Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model

Jose Ichisima, Naoya M. Suzuki, Bumpei Samata, Tomonari Awaya, Jun Takahashi, Masatoshi Hagiwara, Tatsutoshi Nakahata, Megumu K. Saito

J Hum Genet. 2019; 64(5): 445–458. Published online 2019 Mar 8. doi: 10.1038/s10038-019-0574-8

PMCID:: PMC8075875

Article PDF–3.3M

Select item 79131349.

Effect of ATR Inhibition in RT Response of HPV-Negative and HPV-Positive Head and Neck Cancers

Rüveyda Dok, Mary Glorieux, Marieke Bamps, Sandra Nuyts

Int J Mol Sci. 2021 Feb; 22(4): 1504. Published online 2021 Feb 3. doi: 10.3390/ijms22041504

PMCID:: PMC7913134

Article PDF–15M

Select item 761575710.

Analysis of novel missense ATR mutations reveals new splicing defects underlying Seckel syndrome

Marta Llorens-Agost, Janna Luessing, Amandine van Beneden, John Eykelenboom, Dawn O’Reilly, Louise S Bicknell, John J Reynolds, Marianne van Koegelenberg, Matthew E Hurles, Angela F Brady, Andrew P Jackson, Grant S Stewart, Noel F Lowndes

Hum Mutat. Author manuscript; available in PMC 2024 Mar 20.

Published in final edited form as: Hum Mutat. 2018 Dec 1; 39(12): 1847–1853. Published online 2018 Sep 24. doi: 10.1002/humu.23648

PMCID:: PMC7615757

Article PDF–1.0M

Select item 748991011.

Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways

Soichiro S. Ito, Yosuke Nakagawa, Masaya Matsubayashi, Yoshihiko M. Sakaguchi, Shinko Kobashigawa, Takeshi K. Matsui, Hitoki Nanaura, Mari Nakanishi, Fumika Kitayoshi, Sotaro Kikuchi, Atsuhisa Kajihara, Shigehiro Tamaki, Kazuma Sugie, Genro Kashino, Akihisa Takahashi, Masatoshi Hasegawa, Eiichiro Mori, Tadaaki Kirita

J Biol Chem. 2020 Sep 11; 295(37): 12946–12961. Published online 2020 Jul 16. doi: 10.1074/jbc.RA120.013726

PMCID:: PMC7489910

Article PDF–3.7M

Select item 736128612.

ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways

Xu Feng, Anthony Tubbs, Chunchao Zhang, Mengfan Tang, Sriram Sridharan, Chao Wang, Dadi Jiang, Dan Su, Huimin Zhang, Zhen Chen, Litong Nie, Yun Xiong, Min Huang, André Nussenzweig, Junjie Chen

EMBO J. 2020 Jul 15; 39(14): e104036. Published online 2020 Jun 2. doi: 10.15252/embj.2019104036

PMCID:: PMC7361286

Article PDF–2.0M

Select item 727919513.

ATR-16 syndrome: mechanisms linking monosomy to phenotype

Christian Babbs, Jill Brown, Sharon W Horsley, Joanne Slater, Evie Maifoshie, Shiwangini Kumar, Paul Ooijevaar, Marjolein Kriek, Amanda Dixon-McIver, Cornelis L Harteveld, Jan Traeger-Synodinos, Andrew O M Wilkie, Douglas R Higgs, Veronica J Buckle

J Med Genet. 2020 Jun; 57(6): 414–421. Published online 2020 Jan 31. doi: 10.1136/jmedgenet-2019-106528

PMCID:: PMC7279195

Article PDF–2.1M

Select item 722963514.

Clinical and functional significance of tumor/stromal ATR expression in breast cancer patients

Mysoon M. Al-Ansari, Maher Al-Saif, Maria Arafah, Abdelmonneim M. Eldali, Asma Tulbah, Taher Al-Tweigeri, Abdelhabib Semlali, Khalid S. Khabar, Abdelilah Aboussekhra

Breast Cancer Res. 2020; 22: 49. Published online 2020 May 15. doi: 10.1186/s13058-020-01289-4

PMCID:: PMC7229635

Article PDF–3.9M

Select item 719849615.

ATR Inhibition Broadly Sensitizes Soft-Tissue Sarcoma Cells to Chemotherapy Independent of Alternative Lengthening Telomere (ALT) Status

Audrey Laroche-Clary, Vanessa Chaire, Stéphanie Verbeke, Marie-Paule Algéo, Andrei Malykh, François Le Loarer, Antoine Italiano

Sci Rep. 2020; 10: 7488. Published online 2020 May 4. doi: 10.1038/s41598-020-63294-z

PMCID:: PMC7198496

Article PDF–2.4M

Select item 692546616.

The Ataxia telangiectasia-mutated and Rad3-related Protein Kinase Regulates Cellular Hydrogen Sulfide Concentrations

Jie Chen, Xinggui Shen, Sibile Pardue, Andrew T Meram, Saranya Rajendran, Ghali E. Ghali, Christopher G. Kevil, Rodney E. Shackelford

DNA Repair (Amst) Author manuscript; available in PMC 2020 Jan 1.

Published in final edited form as: DNA Repair (Amst). 2019 Jan; 73: 55–63. Published online 2018 Nov 13. doi: 10.1016/j.dnarep.2018.11.002

PMCID:: PMC6925466

Article PDF–2.0M

Select item 691881817.

Inhibition of ATR potentiates the cytotoxic effect of gemcitabine on pancreatic cancer cells through enhancement of DNA damage and abrogation of ribonucleotide reductase induction by gemcitabine

Shuang Liu, Yubin Ge, Tingting Wang, Holly Edwards, Qihang Ren, Yiqun Jiang, Chengshi Quan, Guan Wang

Oncol Rep. 2017 Jun; 37(6): 3377–3386. Published online 2017 Apr 19. doi: 10.3892/or.2017.5580

PMCID:: PMC6918818

Article PDF–934K

Select item 690546818.

ATR kinase inhibition sensitizes quiescent human cells to the lethal effects of cisplatin but increases mutagenesis

Rebekah J. Hutcherson, Michael G. Kemp

Mutat Res. Author manuscript; available in PMC 2020 Nov 1.

Published in final edited form as: Mutat Res. 2019 Nov; 816-818: 111678. Published online 2019 Sep 17. doi: 10.1016/j.mrfmmm.2019.111678

PMCID:: PMC6905468

Article PDF–1.9M

Select item 615548819.

ATR is a therapeutic target in synovial sarcoma

Samuel E. Jones, Emmy D.G. Fleuren, Jessica Frankum, Asha Konde, Chris T. Williamson, Dragomir B. Krastev, Helen N. Pemberton, James Campbell, Aditi Gulati, Richard Elliott, Malini Menon, Joanna L. Selfe, Rachel Brough, Stephen J. Pettitt, Wojciech Niedzwiedz, Winette T.A. van der Graaf, Janet Shipley, Alan Ashworth, Christopher J. Lord

Cancer Res. Author manuscript; available in PMC 2018 Sep 25.

Published in final edited form as: Cancer Res. 2017 Dec 15; 77(24): 7014–7026. Published online 2017 Oct 16. doi: 10.1158/0008-5472.CAN-17-2056

PMCID:: PMC6155488

Article PDF–1.8M

Select item 614478420.

ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells

Dongsung Kim, Yi Liu, Susannah Oberly, Raimundo Freire, Marcus B Smolka

Nucleic Acids Res. 2018 Sep 19; 46(16): 8311–8325. Published online 2018 Jul 12. doi: 10.1093/nar/gky625

PMCID:: PMC6144784

Article PDF–5.3M

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