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Select item 107280221.

Dual role of autotaxin as novel biomarker and therapeutic target in pancreatic neuroendocrine neoplasms

Tadashi Toyohara, Michihiro Yoshida, Katsuyuki Miyabe, Kazuki Hayashi, Itaru Naitoh, Hiromu Kondo, Yasuki Hori, Akihisa Kato, Kenta Kachi, Go Asano, Hidenori Sahashi, Akihisa Adachi, Kayoko Kuno, Yusuke Kito, Yoichi Matsuo, Hiromi Kataoka

Cancer Sci. 2023 Dec; 114(12): 4571–4582. Published online 2023 Sep 28. doi: 10.1111/cas.15980

PMCID:: PMC10728022

Article PDF–2.5M

Select item 101795332.

The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer

Christiana Magkrioti, Eleanna Kaffe, Vassilis Aidinis

Int J Mol Sci. 2023 May; 24(9): 8325. Published online 2023 May 5. doi: 10.3390/ijms24098325

PMCID:: PMC10179533

Article PDF–272K

Select item 94092723.

Role of Autotaxin in High Glucose-Induced Human ARPE-19 Cells

Yang Liu, Reiko Yamagishi, Megumi Honjo, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Makoto Aihara

Int J Mol Sci. 2022 Aug; 23(16): 9181. Published online 2022 Aug 16. doi: 10.3390/ijms23169181

PMCID:: PMC9409272

Article PDF–4.7M

Select item 89989924.

ENPP2 Promoter Methylation Correlates with Decreased Gene Expression in Breast Cancer: Implementation as a Liquid Biopsy Biomarker

Maria Panagopoulou, Andrianna Drosouni, Dionysiοs Fanidis, Makrina Karaglani, Ioanna Balgkouranidou, Nikolaos Xenidis, Vassilis Aidinis, Ekaterini Chatzaki

Int J Mol Sci. 2022 Apr; 23(7): 3717. Published online 2022 Mar 28. doi: 10.3390/ijms23073717

PMCID:: PMC8998992

Article PDF–2.2M

Select item 87613595.

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8⁺ T cells

Elisa Matas-Rico, Elselien Frijlink, Irene van der Haar Àvila, Apostolos Menegakis, Maaike van Zon, Andrew J. Morris, Jan Koster, Fernando Salgado-Polo, Sander de Kivit, Telma Lança, Antonio Mazzocca, Zoë Johnson, John Haanen, Ton N. Schumacher, Anastassis Perrakis, Inge Verbrugge, Joost H. van den Berg, Jannie Borst, Wouter H. Moolenaar

Cell Rep. Author manuscript; available in PMC 2022 Jan 16.

Published in final edited form as: Cell Rep. 2021 Nov 16; 37(7): 110013. doi: 10.1016/j.celrep.2021.110013

PMCID:: PMC8761359

Article PDF–2.7M

Select item 85850136.

ENPP2 Methylation in Health and Cancer

Maria Panagopoulou, Dionysios Fanidis, Vassilis Aidinis, Ekaterini Chatzaki

Int J Mol Sci. 2021 Nov; 22(21): 11958. Published online 2021 Nov 4. doi: 10.3390/ijms222111958

PMCID:: PMC8585013

Article PDF–2.4M

Select item 84692797.

Increased Autotaxin Levels in Severe COVID-19, Correlating with IL-6 Levels, Endothelial Dysfunction Biomarkers, and Impaired Functions of Dendritic Cells

Ioanna Nikitopoulou, Dionysios Fanidis, Konstantinos Ntatsoulis, Panagiotis Moulos, George Mpekoulis, Maria Evangelidou, Alice G. Vassiliou, Vasiliki Dimakopoulou, Edison Jahaj, Stamatios Tsipilis, Stylianos E. Orfanos, Ioanna Dimopoulou, Emmanouil Angelakis, Karolina Akinosoglou, Niki Vassilaki, Argyrios Tzouvelekis, Anastasia Kotanidou, Vassilis Aidinis

Int J Mol Sci. 2021 Sep; 22(18): 10006. Published online 2021 Sep 16. doi: 10.3390/ijms221810006

PMCID:: PMC8469279

Article PDF–1.6M

Select item 75827058.

Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors

Christiana Magkrioti, Eleanna Kaffe, Elli-Anna Stylianaki, Camelia Sidahmet, Georgia Melagraki, Antreas Afantitis, Alexios N. Matralis, Vassilis Aidinis

Int J Mol Sci. 2020 Oct; 21(19): 7002. Published online 2020 Sep 23. doi: 10.3390/ijms21197002

PMCID:: PMC7582705

Article PDF–3.2M

Select item 72992269.

Metabolic Dysregulation of the Lysophospholipid/Autotaxin Axis in the Chromosome 9p21 Gene SNP rs10757274

Sven W. Meckelmann, Jade I. Hawksworth, Daniel White, Robert Andrews, Patricia Rodrigues, Anne O’Connor, Jorge Alvarez-Jarreta, Victoria J. Tyrrell, Christine Hinz, You Zhou, Julie Williams, Maceler Aldrovandi, William J. Watkins, Adam J. Engler, Valentina Lo Sardo, David A. Slatter, Stuart M. Allen, Jay Acharya, Jacquie Mitchell, Jackie Cooper, Junken Aoki, Kuniyuki Kano, Steve E. Humphries, Valerie B. O’Donnell

Circ Genom Precis Med. 2020 Jun; 13(3): e002806. Published online 2020 May 12. doi: 10.1161/CIRCGEN.119.002806

PMCID:: PMC7299226

Article PDF–4.5M

Select item 715666810.

Involvement of autotaxin in the pathophysiology of elevated intraocular pressure in Posner-Schlossman syndrome

Nozomi Igarashi, Megumi Honjo, Reiko Yamagishi, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Toshikatsu Kaburaki, Makoto Aihara

Sci Rep. 2020; 10: 6265. Published online 2020 Apr 14. doi: 10.1038/s41598-020-63284-1

PMCID:: PMC7156668

Article PDF–5.3M

Select item 686361111.

Role of the Autotaxin-Lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity

Leona T. Y. Ho, Anja Osterwald, Iris Ruf, Daniel Hunziker, Patrizio Mattei, Pratap Challa, Robin Vann, Christoph Ullmer, Ponugoti Vasanth Rao

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1; 1866(1): 165560. Published online 2019 Oct 21. doi: 10.1016/j.bbadis.2019.165560

PMCID:: PMC6863611

Article PDF–2.3M

Select item 655999412.

Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis

Amandeep K. Dhillon, Andreas E. Kremer, Martin Kummen, Kirsten M. Boberg, Ronald P. Oude Elferink, Tom H. Karlsen, Ulrich Beuers, Mette Vesterhus, Johannes R. Hov

Sci Rep. 2019; 9: 8450. Published online 2019 Jun 11. doi: 10.1038/s41598-019-44762-7

PMCID:: PMC6559994

Article PDF–1.9M

Select item 653982613.

Expression of Autotaxin–Lysophosphatidate Signaling-Related Proteins in Breast Cancer with Adipose Stroma

Yoon Jin Cha, Ja Seung Koo

Int J Mol Sci. 2019 May; 20(9): 2102. Published online 2019 Apr 29. doi: 10.3390/ijms20092102

PMCID:: PMC6539826

Article PDF–2.6M

Select item 644385814.

Autotaxin is a novel target of microRNA‐101‐3p

Yuqin Wang, Lin Lyu, Xiaotian Zhang, Junjie Zhang

FEBS Open Bio. 2019 Apr; 9(4): 707–716. Published online 2019 Mar 1. doi: 10.1002/2211-5463.12608

PMCID:: PMC6443858

Article PDF–770K

Select item 643348015.

Regulation of tumor cell – Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis

Gabor J. Tigyi, Junming Yue, Derek D. Norman, Erzsebet Szabo, Andrea Balogh, Louisa Balazs, Guannan Zhao, Sue Chin Lee

Adv Biol Regul. Author manuscript; available in PMC 2019 Mar 25.

Published in final edited form as: Adv Biol Regul. 2019 Jan; 71: 183–193. Published online 2018 Sep 16. doi: 10.1016/j.jbior.2018.09.008

PMCID:: PMC6433480

Article PDF–1.2M

Select item 634921116.

Autotaxin/lysophosphatidic acid signaling mediates obesity‐related cardiomyopathy in mice and human subjects

Jiakan Weng, Sheng Jiang, Lu Ding, Yi Xu, Xiongfei Zhu, Peifeng Jin

J Cell Mol Med. 2019 Feb; 23(2): 1050–1058. Published online 2018 Nov 18. doi: 10.1111/jcmm.14005

PMCID:: PMC6349211

Article PDF–714K

Select item 628137217.

During Hepatitis C Virus (HCV) Infection and HCV-HIV Coinfection, an Elevated Plasma Level of Autotaxin Is Associated With Lysophosphatidic Acid and Markers of Immune Activation That Normalize During Interferon-Free HCV Therapy

Lenche Kostadinova, Carey L. Shive, Chelsey Judge, Elizabeth Zebrowski, Anita Compan, Kelsey Rife, Amy Hirsch, Yngve Falck-Ytter, Daniela M. Schlatzer, Xiaolin Li, Mark R. Chance, Benigno Rodriguez, Daniel L Popkin, Donald D. Anthony

J Infect Dis. 2016 Nov 1; 214(9): 1438–1448. Published online 2016 Aug 17. doi: 10.1093/infdis/jiw372

PMCID:: PMC6281372

Article PDF–775K

Select item 607567518.

Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p

Sudeepti S. Kuppa, Wei Jia, Shuying Liu, Ha Nguyen, Susan S. Smyth, Gordon B. Mills, Kevin K. Dobbin, William J. Hardman, Mandi M. Murph

Cancer Lett. Author manuscript; available in PMC 2019 Sep 28.

Published in final edited form as: Cancer Lett. 2018 Sep 28; 432: 84–92. Published online 2018 May 31. doi: 10.1016/j.canlet.2018.05.037

PMCID:: PMC6075675

Article PDF–1.9M

Select item 606395519.

Increased aqueous autotaxin and lysophosphatidic acid levels are potential prognostic factors after trabeculectomy in different types of glaucoma

Nozomi Igarashi, Megumi Honjo, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Kuniyuki Kano, Junken Aoki, Makoto Aihara

Sci Rep. 2018; 8: 11304. Published online 2018 Jul 27. doi: 10.1038/s41598-018-29649-3

PMCID:: PMC6063955

Article PDF–2.3M

Select item 597015520.

Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis

Satoru Joshita, Takeji Umemura, Yoko Usami, Yuki Yamashita, Gary L. Norman, Ayumi Sugiura, Tomoo Yamazaki, Naoyuki Fujimori, Takefumi Kimura, Akihiro Matsumoto, Koji Igarashi, Kaname Yoshizawa, Masao Ota, Eiji Tanaka

Sci Rep. 2018; 8: 8159. Published online 2018 May 25. doi: 10.1038/s41598-018-26531-0

PMCID:: PMC5970155

Article PDF–1.9M

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