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Select item 90104291.

Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects

Sara Canovas Nunes, Serena De Vita, Andrew Anighoro, François Autelitano, Edward Beaumont, Pamela Klingbeil, Meaghan McGuinness, Beatrice Duvert, Chad Harris, Lu Yang, Sheela Pangeni Pokharel, Chun-Wei Chen, Monika Ermann, David A. Williams, Haiming Xu

Blood Cancer J. 2022 Apr; 12(4): 64. Published online 2022 Apr 14. doi: 10.1038/s41408-022-00663-z

PMCID:: PMC9010429

Article PDF–6.9M

Select item 98573542.

PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to Primary Cilia

Siebren Faber, Stef J. F. Letteboer, Katrin Junger, Rossano Butcher, Trinadh V. Satish Tammana, Sylvia E. C. van Beersum, Marius Ueffing, Rob W. J. Collin, Qin Liu, Karsten Boldt, Ronald Roepman

Cells. 2023 Jan; 12(2): 312. Published online 2023 Jan 13. doi: 10.3390/cells12020312

PMCID:: PMC9857354

Article PDF–43M

Select item 39463723.

A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium

Sophie Thomas, Kevin J. Wright, Stéphanie Le Corre, Alessia Micalizzi, Marta Romani, Avinash Abhyankar, Julien Saada, Isabelle Perrault, Jeanne Amiel, Julie Litzler, Emilie Filhol, Nadia Elkhartoufi, Mandy Kwong, Jean-Laurent Casanova, Nathalie Boddaert, Wolfgang Baehr, Stanislas Lyonnet, Arnold Munnich, Lydie Burglen, Nicolas Chassaing, Ferechté Encha-Ravazi, Michel Vekemans, Joseph G. Gleeson, Enza Maria Valente, Peter K. Jackson, Iain A. Drummond, Sophie Saunier, Tania Attié-Bitach

Hum Mutat. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Hum Mutat. 2014 Jan; 35(1): 137–146. doi: 10.1002/humu.22470

PMCID:: PMC3946372

Article PDF–2.2M

Select item 60785984.

Prenylated retinal ciliopathy protein RPGR interacts with PDE6δ and regulates ciliary localization of Joubert syndrome-associated protein INPP5E

Kollu N. Rao, Wei Zhang, Linjing Li, Manisha Anand, Hemant Khanna

Hum Mol Genet. 2016 Oct 15; 25(20): 4533–4545. Published online 2016 Aug 22. doi: 10.1093/hmg/ddw281

PMCID:: PMC6078598

Article PDF–1.3M

Select item 35117695.

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

Melissa C. Humbert, Katie Weihbrecht, Charles C. Searby, Yalan Li, Robert M. Pope, Val C. Sheffield, Seongjin Seo

Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48): 19691–19696. Published online 2012 Nov 12. doi: 10.1073/pnas.1210916109

PMCID:: PMC3511769

Article PDF–905K

Select item 154606.

The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase

Marco Linari, Marius Ueffing, Forbes Manson, Alan Wright, Thomas Meitinger, Jörg Becker

Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4): 1315–1320. doi: 10.1073/pnas.96.4.1315

PMCID:: PMC15460

Article PDF–267K

Select item 61589157.

Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Michael Dumbacher, Tom Van Dooren, Katrien Princen, Koen De Witte, Mélissa Farinelli, Sam Lievens, Jan Tavernier, Wim Dehaen, Stefaan Wera, Joris Winderickx, Sara Allasia, Amuri Kilonda, Stéphane Spieser, Arnaud Marchand, Patrick Chaltin, Casper C. Hoogenraad, Gerard Griffioen

Mol Neurodegener. 2018; 13: 50. Published online 2018 Sep 26. doi: 10.1186/s13024-018-0283-3

PMCID:: PMC6158915

Article PDF–3.0M

Select item 36423778.

The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo

Denise Wätzlich, Ingrid Vetter, Katja Gotthardt, Mandy Miertzschke, Yong-Xiang Chen, Alfred Wittinghofer, Shehab Ismail

EMBO Rep. 2013 May; 14(5): 465–472. Published online 2013 Apr 5. doi: 10.1038/embor.2013.37

PMCID:: PMC3642377

Article PDF–1.3M

Select item 99883759.

Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation

David Liang, Liping Jiang, Sameer Ahmed Bhat, Sonia Missiroli, Mariasole Perrone, Angela Lauriola, Ritika Adhikari, Anish Gudur, Zahra Vasi, Ian Ahearn, Daniele Guardavaccaro, Carlotta Giorgi, Mark Philips, Shafi Kuchay

Cell Rep. Author manuscript; available in PMC 2023 Mar 6.

Published in final edited form as: Cell Rep. 2023 Jan 31; 42(1): 111999. Published online 2023 Jan 19. doi: 10.1016/j.celrep.2023.111999

PMCID:: PMC9988375

Article PDF–2.1M

Select item 426988110.

The EHEC-host interactome reveals novel targets for the translocated intimin receptor

Sonja Blasche, Stefan Arens, Arnaud Ceol, Gabriella Siszler, M. Alexander Schmidt, Roman Häuser, Frank Schwarz, Stefan Wuchty, Patrick Aloy, Peter Uetz, Theresia Stradal, Manfred Koegl

Sci Rep. 2014; 4: 7531. Published online 2014 Dec 18. doi: 10.1038/srep07531

PMCID:: PMC4269881

Article PDF–1.8M

Select item 12598111.

The complex of Arl2-GTP and PDEδ: from structure to function

Michael Hanzal-Bayer, Louis Renault, Pietro Roversi, Alfred Wittinghofer, Roman C. Hillig

EMBO J. 2002 May 1; 21(9): 2095–2106. doi: 10.1093/emboj/21.9.2095

PMCID:: PMC125981

Article PDF–549K

Select item 463531512.

The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function

Mandy Lokaj, Stefanie K. Kösling, Carolin Koerner, Sven M. Lange, Sylvia E.C. van Beersum, Jeroen van Reeuwijk, Ronald Roepman, Nicola Horn, Marius Ueffing, Karsten Boldt, Alfred Wittinghofer

Structure. 2015 Nov 3; 23(11): 2122–2132. doi: 10.1016/j.str.2015.08.016

PMCID:: PMC4635315

Article

Select item 377587413.

Genetic variants associated with disordered eating

Tracey D Wade, Scott Gordon, Sarah Medland, Cynthia M. Bulik, Andrew C Heath, Grant W Montgomery, Nicholas G Martin

Int J Eat Disord. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Int J Eat Disord. 2013 Sep; 46(6): 594–608. Published online 2013 Apr 9. doi: 10.1002/eat.22133

PMCID:: PMC3775874

Article PDF–2.1M

Select item 484876214.

Pooled‐matrix protein interaction screens using Barcode Fusion Genetics

Nozomu Yachie, Evangelia Petsalaki, Joseph C Mellor, Jochen Weile, Yves Jacob, Marta Verby, Sedide B Ozturk, Siyang Li, Atina G Cote, Roberto Mosca, Jennifer J Knapp, Minjeong Ko, Analyn Yu, Marinella Gebbia, Nidhi Sahni, Song Yi, Tanya Tyagi, Dayag Sheykhkarimli, Jonathan F Roth, Cassandra Wong, Louai Musa, Jamie Snider, Yi‐Chun Liu, Haiyuan Yu, Pascal Braun, Igor Stagljar, Tong Hao, Michael A Calderwood, Laurence Pelletier, Patrick Aloy, David E Hill, Marc Vidal, Frederick P Roth

Mol Syst Biol. 2016 Apr; 12(4): 863. Published online 2016 Apr 23. doi: 10.15252/msb.20156660

PMCID:: PMC4848762

Article PDF–2.8M

Select item 318838815.

Leveraging the power of next-generation sequencing to generate interactome datasets

Haiyuan Yu, Leah Tardivo, Stanley Tam, Evan Weiner, Fana Gebreab, Changyu Fan, Nenad Svrzikapa, Tomoko Hirozane-Kishikawa, Edward Rietman, Xinping Yang, Julie Sahalie, Kourosh Salehi-Ashtiani, Tong Hao, Michael E. Cusick, David E. Hill, Frederick P. Roth, Pascal Braun, Marc Vidal

Nat Methods. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Nat Methods. 2011 Jun; 8(6): 478–480. Published online 2011 Apr 24. doi: 10.1038/nmeth.1597

PMCID:: PMC3188388

Article PDF–932K

Select item 486917016.

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, Konstantinos Koutroumpas, Thanh-Minh T. Nguyen, Yves Texier, Sylvia E. C. van Beersum, Nicola Horn, Jason R. Willer, Dorus A. Mans, Gerard Dougherty, Ideke J. C. Lamers, Karlien L. M. Coene, Heleen H. Arts, Matthew J. Betts, Tina Beyer, Emine Bolat, Christian Johannes Gloeckner, Khatera Haidari, Lisette Hetterschijt, Daniela Iaconis, Dagan Jenkins, Franziska Klose, Barbara Knapp, Brooke Latour, Stef J. F. Letteboer, Carlo L. Marcelis, Dragana Mitic, Manuela Morleo, Machteld M. Oud, Moniek Riemersma, Susan Rix, Paulien A. Terhal, Grischa Toedt, Teunis J. P. van Dam, Erik de Vrieze, Yasmin Wissinger, Ka Man Wu, Gordana Apic, Philip L. Beales, Oliver E. Blacque, Toby J. Gibson, Martijn A. Huynen, Nicholas Katsanis, Hannie Kremer, Heymut Omran, Erwin van Wijk, Uwe Wolfrum, François Kepes, Erica E. Davis, Brunella Franco, Rachel H. Giles, Marius Ueffing, Robert B. Russell, Ronald Roepman, UK10K Rare Diseases Group

Nat Commun. 2016; 7: 11491. Published online 2016 May 13. doi: 10.1038/ncomms11491

PMCID:: PMC4869170

Article PDF–2.0M

Select item 674264617.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Article PDF–1.2M

Select item 300858618.

Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics

Eric J. Bennett, John Rush, Steven P. Gygi, J. Wade Harper

Cell. Author manuscript; available in PMC 2011 Dec 10.

Published in final edited form as: Cell. 2010 Dec 10; 143(6): 951–965. doi: 10.1016/j.cell.2010.11.017

PMCID:: PMC3008586

Article PDF–3.0M

Select item 742732719.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Article

Select item 927928520.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Article PDF–2.5M

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