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Select item 104635451.

ACLY as a modulator of liver cell functions and its role in Metabolic Dysfunction-Associated Steatohepatitis

Paolo Convertini, Anna Santarsiero, Simona Todisco, Michele Gilio, Donatella Palazzo, Ilaria Pappalardo, Dominga Iacobazzi, Maria Frontuto, Vittoria Infantino

J Transl Med. 2023; 21: 568. Published online 2023 Aug 24. doi: 10.1186/s12967-023-04431-w

PMCID:: PMC10463545

Abstract Article PDF–4.7M

Select item 102818862.

ACLY-induced reprogramming of glycolytic metabolism plays an important role in the progression of breast cancer: Role of ACLY in breast cancer

Yu Lu, Liping Tian, Chengcheng Peng, Jienan Kong, Pengpeng Xiao, Nan Li

Acta Biochim Biophys Sin (Shanghai) 2023 May; 55(5): 878–881. Published online 2023 Apr 28. doi: 10.3724/abbs.2023084

PMCID:: PMC10281886

Article PDF–861K

Select item 101157953.

Allosteric role of the citrate synthase homology domain of ATP citrate lyase

Xuepeng Wei, Kollin Schultz, Hannah L. Pepper, Emily Megill, Austin Vogt, Nathaniel W. Snyder, Ronen Marmorstein

Nat Commun. 2023; 14: 2247. Published online 2023 Apr 19. doi: 10.1038/s41467-023-37986-9

PMCID:: PMC10115795

Abstract Article PDF–4.6M

Select item 98099674.

Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation

Hainan He, Junling Wang, Xingmei Mou, Xin Liu, Qiao Li, Mingyue Zhong, Bingbing Luo, Zhisheng Yu, Jingjing Zhang, Tian Xu, Chengli Dou, Danya Wu, Wei Qing, Linhui Wu, Kai Zhou, Zhengang Fan, Tingting Wang, Taotao Hu, Xia Zhang, Jilong Zhou, Yi-Liang Miao

Autophagy. 2023; 19(1): 163–179. Published online 2022 Apr 25. doi: 10.1080/15548627.2022.2063005

PMCID:: PMC9809967

Abstract Article PDF–4.4M

Select item 93052655.

Targeting ACLY efficiently inhibits SARS-CoV-2 replication

Terrence Tsz-Tai Yuen, Jasper Fuk-Woo Chan, Bingpeng Yan, Cynthia Cheuk-Ying Shum, Yuanchen Liu, Huiping Shuai, Yuxin Hou, Xiner Huang, Bingjie Hu, Yue Chai, Chaemin Yoon, Tianrenzheng Zhu, Huan Liu, Jialu Shi, Jinjin Zhang, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Feifei Yin, Shuofeng Yuan, Bao-Zhong Zhang, Hin Chu

Int J Biol Sci. 2022; 18(12): 4714–4730. Published online 2022 Jul 11. doi: 10.7150/ijbs.72709

PMCID:: PMC9305265

Abstract Article PDF–3.4M

Select item 91170186.

Deletion of ACLY Disrupts Histone Acetylation and IL-10 Secretion in Trophoblasts, Which Inhibits M2 Polarization of Macrophages: A Possible Role in Recurrent Spontaneous Abortion

Xin Chen, Qian Lin Song, Ze Hong Li, Rui Ji, Jia Yu Wang, Chang Ge, Zhuo Ni Xiao, Duan Ying Guo, Jing Yang

Oxid Med Cell Longev. 2022; 2022: 5216786. Published online 2022 May 11. doi: 10.1155/2022/5216786

PMCID:: PMC9117018

Abstract Article PDF–3.2M

Select item 86165377.

ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation

Anna Santarsiero, Paolo Convertini, Simona Todisco, Ciro L. Pierri, Anna De Grassi, Niamh C. Williams, Dominga Iacobazzi, Giulio De Stefano, Luke A. J. O’Neill, Vittoria Infantino

Cells. 2021 Nov; 10(11): 2962. Published online 2021 Oct 30. doi: 10.3390/cells10112962

PMCID:: PMC8616537

Abstract Article PDF–5.3M

Select item 84362508.

Molecular Basis for Acetyl-CoA Production by ATP-Citrate Lyase

Xuepeng Wei, Kollin Schultz, Gleb A. Bazilevsky, Austin Vogt, Ronen Marmorstein

Nat Struct Mol Biol. Author manuscript; available in PMC 2021 Sep 13.

Published in final edited form as: Nat Struct Mol Biol. 2020 Jan; 27(1): 33–41. Published online 2019 Dec 23. doi: 10.1038/s41594-019-0351-6

Correction in:: Nat Struct Mol Biol. 2020 May; 27(5): 511–513.

PMCID:: PMC8436250

Abstract Article PDF–4.5M

Select item 81275659.

Serum proteome‐wide identified ATP citrate lyase as a novel informative diagnostic and prognostic biomarker in pediatric sepsis: A pilot study

Chunxia Wang, Xiaodong Zhu, Yun Cui, Huijie Miao, Yaya Xu, Xi Xiong, Xiaomeng Tang, Lujing Shao, Yucai Zhang

Immun Inflamm Dis. 2021 Jun; 9(2): 389–397. Published online 2020 Dec 30. doi: 10.1002/iid3.399

PMCID:: PMC8127565

Abstract Article PDF–1.0M

Select item 761292710.

Mendelian Randomization Study of ACLY and Cardiovascular Disease

Brian A. Ference, Kausik K. Ray, Alberico L. Catapano, Thatcher B. Ference, Stephen Burgess, David R. Neff, Clare Oliver-Williams, Angela M. Wood, Adam S. Butterworth, Emanuele Di Angelantonio, John Danesh, John J.P. Kastelein, Stephen J. Nicholls

N Engl J Med. Author manuscript; available in PMC 2022 Jun 30.

Published in final edited form as: N Engl J Med. 2019 Mar 14; 380(11): 1033–1042. doi: 10.1056/NEJMoa1806747

PMCID:: PMC7612927

Abstract Article PDF–1.0M

Select item 707281111.

In Steatotic Cells, ATP-Citrate Lyase mRNA Is Efficiently Translated through a Cap-Independent Mechanism, Contributing to the Stimulation of De Novo Lipogenesis

Luisa Siculella, Laura Giannotti, Mariangela Testini, Gabriele V. Gnoni, Fabrizio Damiano

Int J Mol Sci. 2020 Feb; 21(4): 1206. Published online 2020 Feb 11. doi: 10.3390/ijms21041206

PMCID:: PMC7072811

Abstract Article PDF–2.1M

Select item 650977712.

Low expression of ACLY associates with favorable prognosis in acute myeloid leukemia

Jinghan Wang, Wenle Ye, Xiao Yan, Qi Guo, Qiuling Ma, Fang Lin, Jiansong Huang, Jie Jin

J Transl Med. 2019; 17: 149. Published online 2019 May 10. doi: 10.1186/s12967-019-1884-5

PMCID:: PMC6509777

Abstract Article PDF–1.0M

Select item 629034213.

Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase

Dmitry Namgaladze, Sven Zukunft, Frank Schnütgen, Nina Kurrle, Ingrid Fleming, Dominik Fuhrmann, Bernhard Brüne

Front Immunol. 2018; 9: 2858. Published online 2018 Dec 4. doi: 10.3389/fimmu.2018.02858

PMCID:: PMC6290342

Abstract Article PDF–1.5M

Select item 558039814.

Nuclear acetyl-CoA production by ACLY promotes homologous recombination

Sharanya Sivanand, Seth Rhoades, Qinqin Jiang, Joyce V. Lee, Joseph Benci, Jingwen Zhang, Salina Yuan, Isabella Viney, Steven Zhao, Alessandro Carrer, Michael J. Bennett, Andy J Minn, Aalim M Weljie, Roger A. Greenberg, Kathryn E. Wellen

Mol Cell. Author manuscript; available in PMC 2018 Jul 20.

Published in final edited form as: Mol Cell. 2017 Jul 20; 67(2): 252–265.e6. Published online 2017 Jul 6. doi: 10.1016/j.molcel.2017.06.008

PMCID:: PMC5580398

Abstract Article PDF–1.7M

Select item 508308515.

Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4⁺ T lymphocytes

Nerea Osinalde, Jone Mitxelena, Virginia Sánchez-Quiles, Vyacheslav Akimov, Kerman Aloria, Jesus M. Arizmendi, Ana M. Zubiaga, Blagoy Blagoev, Irina Kratchmarova

Mol Cell Proteomics. 2016 Jun; 15(6): 2076–2092. Published online 2016 Apr 11. doi: 10.1074/mcp.M115.057158

PMCID:: PMC5083085

Abstract Article PDF–2.8M

Select item 487346916.

Cyclin E associates with the lipogenic enzyme ATP-citrate lyase to enable malignant growth of breast cancer cells

Kimberly S. Lucenay, Iman Doostan, Cansu Karakas, Tuyen Bui, Zhiyong Ding, Gordon B. Mills, Kelly K Hunt, Khandan Keyomarsi

Cancer Res. Author manuscript; available in PMC 2017 Apr 15.

Published in final edited form as: Cancer Res. 2016 Apr 15; 76(8): 2406–2418. Published online 2016 Feb 29. doi: 10.1158/0008-5472.CAN-15-1646

PMCID:: PMC4873469

Abstract Article PDF–3.0M

Select item 435953817.

Functional polymorphisms of ATP citrate lyase gene predicts clinical outcome of patients with advanced colorectal cancer

Shuang Xie, Feng Zhou, Jiaojiao Wang, Haiyan Cao, Yibing Chen, Xiaonan Liu, Zhaohui Zhang, Jingyao Dai, Xianli He

World J Surg Oncol. 2015; 13: 42. Published online 2015 Feb 12. doi: 10.1186/s12957-015-0440-x

PMCID:: PMC4359538

Abstract Article PDF–788K

Select item 430227518.

ATP Citrate Lyase Mediates Resistance of Colorectal Cancer Cells to SN38

Yunfei Zhou, Lakshmi Reddy Bollu, Federico Tozzi, Xiangcang Ye, Rajat Bhattacharya, Guang Gao, Elizabeth Dupre, Ling Xia, Jia Lu, Fan Fan, Seth Bellister, Lee M Ellis, Zhang Weihua

Mol Cancer Ther. Author manuscript; available in PMC 2015 Jan 22.

Published in final edited form as: Mol Cancer Ther. 2013 Dec; 12(12): 2782–2791. Published online 2013 Oct 16. doi: 10.1158/1535-7163.MCT-13-0098