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Select item 94964001.

Structural Comparison of hMDH2 Complexed with Natural Substrates and Cofactors: The Importance of Phosphate Binding for Active Conformation and Catalysis

Yumi Eo, Men Thi Hoai Duong, Hee-Chul Ahn

Biomolecules. 2022 Sep; 12(9): 1175. Published online 2022 Aug 25. doi: 10.3390/biom12091175

PMCID:: PMC9496400

Article PDF–2.5M

Select item 94952592.

Integrated genomic, transcriptomic and metabolomic analysis reveals MDH2 mutation-induced metabolic disorder in recurrent focal segmental glomerulosclerosis

Qixia Shen, Lisha Teng, Yucheng Wang, Luying Guo, Feng Xu, Hongfeng Huang, Wenqing Xie, Qin Zhou, Ying Chen, Junwen Wang, Youying Mao, Jianghua Chen, Hong Jiang

Front Immunol. 2022; 13: 962986. Published online 2022 Sep 8. doi: 10.3389/fimmu.2022.962986

PMCID:: PMC9495259

Article PDF–6.9M

Select item 81777903.

Urinary malate dehydrogenase 2 is a new biomarker for early detection of non‐small‐cell lung cancer

Yu‐Chen Ma, Peng‐Fei Tian, Zhi‐Peng Chen, Dong‐Sheng Yue, Cui‐Cui Liu, Chen‐Guang Li, Chen Chen, Hua Zhang, Hai‐Lin Liu, Zhen‐Fa Zhang, Liang Chen, Bin Zhang, Chang‐Li Wang

Cancer Sci. 2021 Jun; 112(6): 2349–2360. Published online 2021 May 1. doi: 10.1111/cas.14845

PMCID:: PMC8177790

Article PDF–1.3M

Select item 74565384.

Role of MDH2 pathogenic variant in pheochromocytoma and paraganglioma patients

Bruna Calsina, Maria Currás-Freixes, Alexandre Buffet, Tirso Pons, Laura Contreras, Rocío Letón, Iñaki Comino Méndez, Laura Remacha, María Calatayud, Berta Obispo, Antoine Martin, Regis Cohen, Susan Richter, Judith Balmaña, Esther Korpershoek, Elena Rapizzi, Timo Deutschbein, Laurent Vroonen, Judith Favier, Ronald R. de Krijger, Martin Fassnacht, Felix Beuschlein, Henri J. Timmers, Graeme Eisenhofer, Massimo Mannelli, Karel Pacak, Jorgina Satrústegui, Cristina Rodríguez-Antona, Laurence Amar, Alberto Cascón, Nicole Dölker, Anne-Paule Gimenez-Roqueplo, Mercedes Robledo

Genet Med. Author manuscript; available in PMC 2020 Aug 30.

Published in final edited form as: Genet Med. 2018 Dec; 20(12): 1652–1662. Published online 2018 Jul 16. doi: 10.1038/s41436-018-0068-7

PMCID:: PMC7456538

Article PDF–1.7M

Select item 21438405.

Aggregation states of mitochondrial malate dehydrogenase.

S. A. Sánchez, T. L. Hazlett, J. E. Brunet, D. M. Jameson

Protein Sci. 1998 Oct; 7(10): 2184–2189. doi: 10.1002/pro.5560071016

PMCID:: PMC2143840

Summary PDF–564K

Select item 88522276.

Gain of Function of Malate Dehydrogenase 2 and Familial Hyperglycemia

Prapaporn Jungtrakoon Thamtarana, Antonella Marucci, Luca Pannone, Amélie Bonnefond, Serena Pezzilli, Tommaso Biagini, Patinut Buranasupkajorn, Timothy Hastings, Christine Mendonca, Lorella Marselli, Rosa Di Paola, Zuroida Abubakar, Luana Mercuri, Federica Alberico, Elisabetta Flex, Julian Ceròn, Montserrat Porta-de-la-Riva, Ornella Ludovico, Massimo Carella, Simone Martinelli, Piero Marchetti, Tommaso Mazza, Philippe Froguel, Vincenzo Trischitta, Alessandro Doria, Sabrina Prudente

J Clin Endocrinol Metab. 2022 Mar; 107(3): 668–684. Published online 2021 Oct 30. doi: 10.1210/clinem/dgab790

PMCID:: PMC8852227

Article

Select item 43951897.

Mitochondrial proteomics with siRNA knockdown to reveal ACAT1 and MDH2 in the development of doxorubicin-resistant uterine cancer

Yi-Wen Lo, Szu-Ting Lin, Shing-Jyh Chang, Chia-Hao Chan, Kevin W Lyu, Jo-Fan Chang, Eugenie Wong Soon May, Dai-Ying Lin, Hsiu-Chuan Chou, Hong-Lin Chan

J Cell Mol Med. 2015 Apr; 19(4): 744–759. Published online 2015 Jan 30. doi: 10.1111/jcmm.12388

PMCID:: PMC4395189

Article PDF–1.3M

Select item 54650288.

Chaperone activity of human small heat shock protein-GST fusion proteins

Hannah Arbach, Caley Butler, Kathryn A. McMenimen

Cell Stress Chaperones. 2017 Jul; 22(4): 503–515. Published online 2017 Jan 27. doi: 10.1007/s12192-017-0764-2

PMCID:: PMC5465028

Article PDF–3.3M

Select item 52230299.

Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy

Samira Ait-El-Mkadem, Manal Dayem-Quere, Mirjana Gusic, Annabelle Chaussenot, Sylvie Bannwarth, Bérengère François, Emmanuelle C. Genin, Konstantina Fragaki, Catharina L.M. Volker-Touw, Christelle Vasnier, Valérie Serre, Koen L.I. van Gassen, Françoise Lespinasse, Susan Richter, Graeme Eisenhofer, Cécile Rouzier, Fanny Mochel, Anne De Saint-Martin, Marie-Thérèse Abi Warde, Monique G.M. de Sain-van der Velde, Judith J.M. Jans, Jeanne Amiel, Ziga Avsec, Christian Mertes, Tobias B. Haack, Tim Strom, Thomas Meitinger, Penelope E. Bonnen, Robert W. Taylor, Julien Gagneur, Peter M. van Hasselt, Agnès Rötig, Agnès Delahodde, Holger Prokisch, Sabine A. Fuchs, Véronique Paquis-Flucklinger

Am J Hum Genet. 2017 Jan 5; 100(1): 151–159. Published online 2016 Dec 15. doi: 10.1016/j.ajhg.2016.11.014

PMCID:: PMC5223029

Article PDF–1.1M

Select item 299871510.

The interaction of unfolding α-lactalbumin and malate dehydrogenase with the molecular chaperone αB-crystallin: a light and X-ray scattering investigation

Justyn W. Regini, Heath Ecroyd, Sarah Meehan, Kristen Bremmell, Matthew J. Clarke, Donna Lammie, Tim Wess, John A. Carver

Mol Vis. 2010; 16: 2446–2456. Published online 2010 Nov 18.

PMCID:: PMC2998715

Article PDF–2.2M

Select item 323267511.

Regulation of Cellular Metabolism by Protein Lysine Acetylation

Shimin Zhao, Wei Xu, Wenqing Jiang, Wei Yu, Yan Lin, Tengfei Zhang, Jun Yao, Li Zhou, Yaxue Zeng, Hong Li, Yixue Li, Jiong Shi, Wenlin An, Susan M. Hancock, Fuchu He, Lunxiu Qin, Jason Chin, Pengyuan Yang, Xian Chen, Qunying Lei, Yue Xiong, Kun-Liang Guan

Science. Author manuscript; available in PMC 2011 Dec 7.

Published in final edited form as: Science. 2010 Feb 19; 327(5968): 1000–1004. doi: 10.1126/science.1179689

PMCID:: PMC3232675

Article PDF–2.4M

Select item 359321112.

GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules

Alexis A. Jourdain, Mirko Koppen, Mateusz Wydro, Chris D. Rodley, Robert N. Lightowlers, Zofia M. Chrzanowska-Lightowlers, Jean-Claude Martinou

Cell Metab. 2013 Mar 5; 17(3): 399–410. doi: 10.1016/j.cmet.2013.02.005

PMCID:: PMC3593211

Article PDF–2.1M

Select item 975894913.

A novel lncRNA MDHDH suppresses glioblastoma multiforme by acting as a scaffold for MDH2 and PSMA1 to regulate NAD+ metabolism and autophagy

Dong He, Tao Xin, Bo Pang, Jun Sun, Zi Hao Liu, Zhen Qin, Xiao Shuai Ji, Fan Yang, Yan Bang Wei, Zi Xiao Wang, Jia Jia Gao, Qi Pang, Qian Liu

J Exp Clin Cancer Res. 2022; 41: 349. Published online 2022 Dec 17. doi: 10.1186/s13046-022-02543-7

PMCID:: PMC9758949

Article PDF–18M

Select item 860506814.

14-3-3ζ negatively regulates mitochondrial biogenesis in GBM residual cells

Jacinth Rajendra, Atanu Ghorai, Shilpee Dutt

Heliyon. 2021 Nov; 7(11): e08371. Published online 2021 Nov 12. doi: 10.1016/j.heliyon.2021.e08371

PMCID:: PMC8605068

Article PDF–1.5M

Select item 476262215.

Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein–Protein Interaction Data

Yuba Raj Pokharel, Jani Saarela, Agnieszka Szwajda, Christian Rupp, Anne Rokka, Shibendra Kumar Lal Karna, Kaisa Teittinen, Garry Corthals, Olli Kallioniemi, Krister Wennerberg, Tero Aittokallio, Jukka Westermarck

Mol Cell Proteomics. 2015 Dec; 14(12): 3274–3283. Published online 2015 Oct 23. doi: 10.1074/mcp.M115.050773

PMCID:: PMC4762622

Article PDF–1.4M

Select item 804475516.

TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination

Yiming Zhu, Chihao Zhang, Mingzhe Huang, Jiayun Lin, Xiao Fan, Tao Ni

Front Cell Dev Biol. 2021; 9: 644901. Published online 2021 Mar 25. doi: 10.3389/fcell.2021.644901

PMCID:: PMC8044755

Article PDF–3.7M

Select item 629714117.

The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage

Ryotaro Nishi, Paul W. G. Wijnhoven, Yusuke Kimura, Misaki Matsui, Rebecca Konietzny, Qian Wu, Keisuke Nakamura, Tom L. Blundell, Benedikt M. Kessler

Sci Rep. 2018; 8: 17891. Published online 2018 Dec 17. doi: 10.1038/s41598-018-36235-0

PMCID:: PMC6297141

Article PDF–2.6M

Select item 364181918.

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

Shireen A. Sarraf, Malavika Raman, Virginia Guarani-Pereira, Mathew E. Sowa, Edward L. Huttlin, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2013 Oct 18.

Published in final edited form as: Nature. 2013 Apr 18; 496(7445): 372–376. Published online 2013 Mar 17. doi: 10.1038/nature12043

PMCID:: PMC3641819

Article PDF–1.7M

Select item 979335919.

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

Saisai Guo, Xiaobo Lei, Yan Chang, Jianyuan Zhao, Jing Wang, Xiaojing Dong, Qian Liu, Zixiong Zhang, Lidan Wang, Dongrong Yi, Ling Ma, Quanjie Li, Yongxin Zhang, Jiwei Ding, Chen Liang, Xiaoyu Li, Fei Guo, Jianwei Wang, Shan Cen

Signal Transduct Target Ther. 2022; 7: 400. Published online 2022 Dec 27. doi: 10.1038/s41392-022-01239-w

PMCID:: PMC9793359

Article PDF–3.7M

Select item 263802120.

Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis

Grzegorz Sumara, Ivan Formentini, Stephan Collins, Izabela Sumara, Renata Windak, Bernd Bodenmiller, Reshma Ramracheya, Dorothée Caille, Huiping Jiang, Kenneth A. Platt, Paolo Meda, Rudolf Aebersold, Patrik Rorsman, Romeo Ricci

Cell. 2009 Jan 23; 136(2): 235–248. doi: 10.1016/j.cell.2008.11.018

PMCID:: PMC2638021

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