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Select item 100101751.

LTA4H extensively associates with mRNAs and lncRNAs indicative of its novel regulatory targets

Tianjiao Ren, Song Wang, Bo Zhang, Wei Zhou, Cansi Wang, Xiaorui Zhao, Juan Feng

PeerJ. 2023; 11: e14875. Published online 2023 Mar 10. doi: 10.7717/peerj.14875

PMCID:: PMC10010175

Article PDF–2.4M

Select item 99888312.

Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis

Selwyn Selva Kumar, Raja Solomon, Priyanka Gautam, Leeberk Raja Inbaraj, Ajith Sivadasan, Joy Sarojini Michael, Rajiv Karthik, George M. Varghese, Christhunesa S. Christudass, Prasanna Samuel, Abi Manesh

Sci Rep. 2023; 13: 3746. Published online 2023 Mar 6. doi: 10.1038/s41598-023-30923-2

PMCID:: PMC9988831

Article PDF–892K

Select item 77324483.

Leukotriene A₄ Hydrolase Is a Candidate Predictive Biomarker for Successful Allergen Immunotherapy

Ting-Ting Ma, Meng-Da Cao, Rui-Li Yu, Hai-Yun Shi, Wei-Jun Yan, Jian-Guo Liu, Chen Pan, Jinlyu Sun, Qing-Yu Wei, De-Yun Wang, Ji-Fu Wei, Xue-Yan Wang, Jin-Shu Yin

Front Immunol. 2020; 11: 559746. Published online 2020 Nov 24. doi: 10.3389/fimmu.2020.559746

PMCID:: PMC7732448

Article PDF–1.7M

Select item 73565934.

Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking

Suaad A. Audat, Nizar A. Al-Shar’i, Buthina A. Al-Oudat, Amanda Bryant-Friedrich, Mel F. Bedi, Aref L. Zayed, Qosay A. Al-Balas

Molecules. 2020 Jun; 25(12): 2871. Published online 2020 Jun 22. doi: 10.3390/molecules25122871

PMCID:: PMC7356593

Article PDF–4.7M

Select item 64811085.

The Polymorphism rs17525495 of LTA4H Is Associated with Susceptibility of Crohn's Disease instead of Intestinal Tuberculosis in a Chinese Han Population

Zi-qi Yu, Wen-fei Wang, Chuan-zhi Zhu, Ke-hong Zhang, Xin-chun Chen, Jian-yong Chen

Biomed Res Int. 2019; 2019: 9537050. Published online 2019 Apr 10. doi: 10.1155/2019/9537050

PMCID:: PMC6481108

Article PDF–718K

Select item 64446306.

Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma

Kavita Pal, Xin Feng, John W. Steinke, Marie D. Burdick, Yun M. Shim, Sun-Sang Sung, W. Gerald Teague, Larry Borish

Am J Respir Cell Mol Biol. 2019 Apr; 60(4): 413–419. doi: 10.1165/rcmb.2018-0175OC

PMCID:: PMC6444630

Article PDF–1.0M

Select item 55946977.

Capturing LTA₄ hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB₄ synthesis

Alena Stsiapanava, Bengt Samuelsson, Jesper Z. Haeggström

Proc Natl Acad Sci U S A. 2017 Sep 5; 114(36): 9689–9694. Published online 2017 Aug 21. doi: 10.1073/pnas.1710850114

PMCID:: PMC5594697

Article PDF–1.8M

Select item 54263738.

Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis

Nguyen T. T. Thuong, Dorothee Heemskerk, Trinh T. B. Tram, Le T. P. Thao, Lalita Ramakrishnan, Vu T. N. Ha, Nguyen D. Bang, Tran T. H. Chau, Nguyen H. Lan, Maxine Caws, Sarah J. Dunstan, Nguyen V. V. Chau, Marcel Wolbers, Nguyen T. H. Mai, Guy E. Thwaites

J Infect Dis. 2017 Apr 1; 215(7): 1020–1028. Published online 2017 Apr 17. doi: 10.1093/infdis/jix050

PMCID:: PMC5426373

Article PDF–2.8M

Select item 50280729.

Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV

Gopalan Narendran, Dhanasekaran Kavitha, Ramesh Karunaianantham, Leonardo Gil-Santana, Jilson L. Almeida-Junior, Sirasanambatti Devarajulu Reddy, Marimuthu Makesh Kumar, Haribabu Hemalatha, Nagesh Nalini Jayanthi, Narayanan Ravichandran, Raja Krishnaraja, Angamuthu Prabhakar, Tamizhselvan Manoharan, Lokeswaran Nithyananthan, Gunasundari Arjunan, Mohan Natrajan, Soumya Swaminathan, Bruno B. Andrade

PLoS One. 2016; 11(9): e0163298. Published online 2016 Sep 19. doi: 10.1371/journal.pone.0163298

PMCID:: PMC5028072

Article PDF–1.2M

Select item 464221010.

A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease

J. Michael Wells, Patricia L. Jackson, Liliana Viera, Surya P. Bhatt, Joshua Gautney, Guy Handley, R. Wilson King, Xin Xu, Amit Gaggar, William C. Bailey, Mark T. Dransfield, J. Edwin Blalock

Am J Respir Crit Care Med. 2015 Oct 15; 192(8): 934–942. Published online 2015 Oct 15. doi: 10.1164/rccm.201503-0543OC

PMCID:: PMC4642210

Article PDF–1002K

Select item 437066611.

LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome

Sarah J. Dunstan, Trinh Thi Bich Tram, Guy E. Thwaites, Tran Thi Hong Chau, Nguyen Hoan Phu, Tran Tinh Hien, Jeremy J. Farrar, Marcel Wolbers, Nguyen Thi Hoang Mai

PLoS One. 2015; 10(3): e0118789. Published online 2015 Mar 23. doi: 10.1371/journal.pone.0118789

PMCID:: PMC4370666

Article PDF–471K

Select item 398441212.

A remarkable activity of human leukotriene A₄ hydrolase (LTA4H) toward unnatural amino acids

Anna Byzia, Jesper Z. Haeggström, Guy S. Salvesen, Marcin Drag

Amino Acids. 2014; 46(5): 1313–1320. Published online 2014 Feb 27. doi: 10.1007/s00726-014-1694-2

PMCID:: PMC3984412

Article PDF–568K

Select item 396411913.

Binding of Pro-Gly-Pro at the active site of leukotriene A₄ hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor

Alena Stsiapanava, Ulrika Olsson, Min Wan, Thea Kleinschmidt, Dorothea Rutishauser, Roman A. Zubarev, Bengt Samuelsson, Agnes Rinaldo-Matthis, Jesper Z. Haeggström

Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11): 4227–4232. Published online 2014 Mar 3. doi: 10.1073/pnas.1402136111

PMCID:: PMC3964119

Article PDF–1.4M

Select item 363050714.

Leukotriene A4 Hydrolase Haplotype, Diet and Atherosclerosis: A Twin Study

Jinying Zhao, Jack Goldberg, Viola Vaccarino

Atherosclerosis. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Atherosclerosis. 2013 Jan; 226(1): 238–244. Published online 2012 Oct 31. doi: 10.1016/j.atherosclerosis.2012.10.048

PMCID:: PMC3630507

Article PDF–659K

Select item 361609315.

Can Certain Genotypes Predispose to Poor Asthma Control in Children? A Pharmacogenetic Study of 9 Candidate Genes in Children with Difficult Asthma

Basima Almomani, Ahmed F. Hawwa, Jeffrey S. Millership, Liam Heaney, Isabella Douglas, James C. McElnay, Michael D. Shields

PLoS One. 2013; 8(4): e60592. Published online 2013 Apr 3. doi: 10.1371/journal.pone.0060592

PMCID:: PMC3616093

Article PDF–222K

Select item 340506916.

Structural Origins for the Loss of Catalytic Activities of Bifunctional Human LTA4H Revealed through Molecular Dynamics Simulations

Sundarapandian Thangapandian, Shalini John, Prettina Lazar, Sun Choi, Keun Woo Lee

PLoS One. 2012; 7(7): e41063. Published online 2012 Jul 25. doi: 10.1371/journal.pone.0041063

PMCID:: PMC3405069

Article PDF–1.4M

Select item 304079017.

Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects

James Curtis, Liliya Kopanitsa, Emma Stebbings, Arran Speirs, Olga Ignatyeva, Yanina Balabanova, Vladyslav Nikolayevskyy, Sven Hoffner, Rolf Horstmann, Francis Drobniewski, Sergey Nejentsev

Tuberculosis (Edinb) 2011 Jan; 91(1): 22–25. doi: 10.1016/j.tube.2010.11.001

PMCID:: PMC3040790

Article

Select item 121711818.

The human leukotriene A4 hydrolase gene is expressed in two alternatively spliced mRNA forms.

E Jendraschak, W E Kaminski, R Kiefl, C von Schacky

Biochem J. 1996 Mar 15; 314(Pt 3): 733–737. doi: 10.1042/bj3140733

PMCID:: PMC1217118

Summary PDF–346K

Select item 29914619.

Molecular cloning and amino acid sequence of leukotriene A4 hydrolase.

C D Funk, O Rådmark, J Y Fu, T Matsumoto, H Jörnvall, T Shimizu, B Samuelsson

Proc Natl Acad Sci U S A. 1987 Oct; 84(19): 6677–6681. doi: 10.1073/pnas.84.19.6677

PMCID:: PMC299146

Summary Page Browse PDF–1.0M

Select item 5008120.

Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.

A Wetterholm, J F Medina, O Rådmark, R Shapiro, J Z Haeggström, B L Vallee, B Samuelsson

Proc Natl Acad Sci U S A. 1992 Oct 1; 89(19): 9141–9145. doi: 10.1073/pnas.89.19.9141

PMCID:: PMC50081

Summary Page Browse PDF–1.0M

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