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Select item 101059521.

Overexpression of KCNJ2 enhances maturation of human-induced pluripotent stem cell-derived cardiomyocytes

Jingjun Zhou, Baiping Cui, Xiaochen Wang, Hongkun Wang, Junnan Zheng, Fengfeng Guo, Yaxun Sun, Hangping Fan, Jiaxi Shen, Jun Su, Jue Wang, Haige Zhao, Yiquan Tang, Tingyu Gong, Ning Sun, Ping Liang

Stem Cell Res Ther. 2023; 14: 92. Published online 2023 Apr 15. doi: 10.1186/s13287-023-03312-9

PMCID:: PMC10105952

Article PDF–7.7M

Select item 95067302.

Cryo–electron microscopy unveils unique structural features of the human Kir2.1 channel

Carlos A. H. Fernandes, Dania Zuniga, Charline Fagnen, Valérie Kugler, Rosa Scala, Gérard Péhau-Arnaudet, Renaud Wagner, David Perahia, Saïd Bendahhou, Catherine Vénien-Bryan

Sci Adv. 2022 Sep; 8(38): eabq8489. Published online 2022 Sep 23. doi: 10.1126/sciadv.abq8489

PMCID:: PMC9506730

Article PDF–7.3M

Select item 92135383.

Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters

Weiwei Yu, Zhen Wang, Xiafei Yu, Yonghui Zhao, Zili Xie, Kailian Zhang, Zhexu Chi, Sheng Chen, Ting Xu, Danlu Jiang, Xingchen Guo, Mobai Li, Jian Zhang, Hui Fang, Dehang Yang, Yuxian Guo, Xuyan Yang, Xue Zhang, Yingliang Wu, Wei Yang, Di Wang

Nat Commun. 2022; 13: 3544. Published online 2022 Jun 21. doi: 10.1038/s41467-022-31149-y

PMCID:: PMC9213538

Article PDF–4.2M

Select item 89136864.

Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas

Yan-Xia Wang, Haibo Wu, Yong Ren, Shengqing Lv, Chengdong Ji, Dongfang Xiang, Mengsi Zhang, Huimin Lu, Wenjuan Fu, Qing Liu, Zexuan Yan, Qinghua Ma, Jingya Miao, Ruili Cai, Xi Lan, Bin Wu, Wenying Wang, Yinhua Liu, Dai-Zhong Wang, Mianfu Cao, Zhicheng He, Yu Shi, Yifang Ping, Xiaohong Yao, Xia Zhang, Peng Zhang, Ji Ming Wang, Yan Wang, Youhong Cui, Xiu-Wu Bian

Signal Transduct Target Ther. 2022; 7: 72. Published online 2022 Mar 11. doi: 10.1038/s41392-022-00890-7

PMCID:: PMC8913686

Article PDF–6.4M

Select item 87427235.

Differential effects of obesity on visceral versus subcutaneous adipose arteries: role of shear-activated Kir2.1 and alterations to the glycocalyx

Sang Joon Ahn, Elizabeth Le Master, James C. Lee, Shane A. Phillips, Irena Levitan, Ibra S. Fancher

Am J Physiol Heart Circ Physiol. 2022 Feb 1; 322(2): H156–H166. Published online 2021 Dec 10. doi: 10.1152/ajpheart.00399.2021

PMCID:: PMC8742723

Article

Select item 84974946.

Monitoring of compound resting membrane potentials of cell cultures with ratiometric genetically encoded voltage indicators

Philipp Rühl, Johanna M. Langner, Jasmin Reidel, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann

Commun Biol. 2021; 4: 1164. Published online 2021 Oct 7. doi: 10.1038/s42003-021-02675-0

PMCID:: PMC8497494

Article PDF–3.1M

Select item 82353717.

Electrophysiology of hiPSC-Cardiomyocytes Co-Cultured with HEK Cells Expressing the Inward Rectifier Channel

Ana Da Silva Costa, Peter Mortensen, Maria P. Hortigon-Vinagre, Marcel A. G. van der Heyden, Francis L. Burton, Hao Gao, Radostin D. Simitev, Godfrey L. Smith

Int J Mol Sci. 2021 Jun; 22(12): 6621. Published online 2021 Jun 21. doi: 10.3390/ijms22126621

PMCID:: PMC8235371

Article PDF–5.8M

Select item 79963268.

Association between Sour Taste SNP KCNJ2-rs236514, Diet Quality and Mild Cognitive Impairment in an Elderly Cohort

Celeste Ferraris, Alexandria Turner, Christopher Scarlett, Martin Veysey, Mark Lucock, Tamara Bucher, Emma L. Beckett

Nutrients. 2021 Mar; 13(3): 719. Published online 2021 Feb 24. doi: 10.3390/nu13030719

PMCID:: PMC7996326

Article PDF–311K

Select item 77899719.

Syncytium cell growth increases Kir2.1 contribution in human iPSC-cardiomyocytes

Weizhen Li, Julie L. Han, Emilia Entcheva

Am J Physiol Heart Circ Physiol. 2020 Nov 1; 319(5): H1112–H1122. Published online 2020 Sep 28. doi: 10.1152/ajpheart.00148.2020

PMCID:: PMC7789971

Article

Select item 735888810.

Multivariate analysis of TU wave complex on electrocardiogram in Andersen–Tawil syndrome with KCNJ2 mutations

Hitoshi Horigome, Yasuhiro Ishikawa, Norito Kokubun, Masao Yoshinaga, Naokata Sumitomo, Lisheng Lin, Yoshiaki Kato, Yuri Tanabe‐Kameda, Seiko Ohno, Masami Nagashima, Minoru Horie

Ann Noninvasive Electrocardiol. 2020 May; 25(3): e12721. Published online 2019 Nov 14. doi: 10.1111/anec.12721

PMCID:: PMC7358888

Article PDF–1.1M

Select item 715072011.

Computational Study to Identify the Effects of the KCNJ2 E299V Mutation in Cardiac Pumping Capacity

Da Un Jeong, Jiyeong Lee, Ki Moo Lim

Comput Math Methods Med. 2020; 2020: 7194275. Published online 2020 Mar 31. doi: 10.1155/2020/7194275

PMCID:: PMC7150720

Article PDF–2.4M

Select item 706112512.

Upregulation of Potassium Voltage-Gated Channel Subfamily J Member 2 Levels in the Lungs of Patients with Idiopathic Pulmonary Fibrosis

Jong-Uk Lee, Hun Soo Chang, Chang An Jung, Ryun Hee Kim, Choon-Sik Park, Jong-Sook Park

Can Respir J. 2020; 2020: 3406530. Published online 2020 Feb 25. doi: 10.1155/2020/3406530

PMCID:: PMC7061125

Article PDF–647K

Select item 693229313.

Novel Mutation in the KCNJ2 Gene Is Associated with a Malignant Arrhythmic Phenotype of Andersen‐Tawil Syndrome

E. Fernlund, C. Lundin, E. Hertervig, O. Kongstad, M. Alders, P. Platonov

Ann Noninvasive Electrocardiol. 2013 Sep; 18(5): 471–478. Published online 2013 Sep 16. doi: 10.1111/anec.12074

PMCID:: PMC6932293

Article PDF–1.1M

Select item 563486714.

Characterization of a novel KCNJ2 sequence variant detected in Andersen-Tawil syndrome patients

Stefanie Scheiper, Brigitte Hertel, Britt-Maria Beckmann, Stefan Kääb, Gerhard Thiel, Silke Kauferstein

BMC Med Genet. 2017; 18: 113. Published online 2017 Oct 10. doi: 10.1186/s12881-017-0472-x

PMCID:: PMC5634867

Article PDF–2.6M

Select item 548707115.

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

Dominic G. Whittaker, Haibo Ni, Aziza El Harchi, Jules C. Hancox, Henggui Zhang

PLoS Comput Biol. 2017 Jun; 13(6): e1005593. Published online 2017 Jun 13. doi: 10.1371/journal.pcbi.1005593

Correction in:: PLoS Comput Biol. 2019 Jun; 15(6): e1007145.

PMCID:: PMC5487071

Article PDF–11M

Select item 547321516.

Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating

Shizhen Wang, William F. Borschel, Sarah Heyman, Phillip Hsu, Colin G. Nichols

J Biol Chem. 2017 Jun 16; 292(24): 10087–10096. Published online 2017 Apr 26. doi: 10.1074/jbc.M117.785154

PMCID:: PMC5473215

Article PDF–2.6M

Select item 475947317.

Role of Kir2.1 in human monocyte‐derived foam cell maturation

Wei Zhang, Xin‐Jun Lei, Yi‐Fan Wang, Dong‐Qi Wang, Zu‐Yi Yuan

J Cell Mol Med. 2016 Mar; 20(3): 403–412. Published online 2015 Dec 22. doi: 10.1111/jcmm.12705

PMCID:: PMC4759473

Article PDF–595K

Select item 437312818.

Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway

Huanxin Liu, Jie Huang, Juan Peng, Xiaoxia Wu, Yan Zhang, Weiliang Zhu, Linlang Guo

Mol Cancer. 2015; 14: 59. Published online 2015 Mar 12. doi: 10.1186/s12943-015-0298-0

PMCID:: PMC4373128

Article PDF–3.5M

Select item 425747819.

KCNJ2 Mutation Causes an Adrenergic-Dependent Rectification Abnormality with Calcium Sensitivity and Ventricular Arrhythmia

Matthew M. Kalscheur, Ravi Vaidyanathan, Kate M. Orland, Sara Abozeid, Nicholas Fabry, Kathleen R. Maginot, Craig T. January, Jonathan C. Makielski, Lee L. Eckhardt

Heart Rhythm. Author manuscript; available in PMC 2014 Dec 5.

Published in final edited form as: Heart Rhythm. 2014 May; 11(5): 885–894. Published online 2014 Feb 21. doi: 10.1016/j.hrthm.2014.02.015

PMCID:: PMC4257478

Article PDF–2.3M

Select item 414046720.

Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism–epilepsy phenotype

Elena Ambrosini, Federico Sicca, Maria S. Brignone, Maria C. D'Adamo, Carlo Napolitano, Ilenio Servettini, Francesca Moro, Yanfei Ruan, Luca Guglielmi, Stefania Pieroni, Giuseppe Servillo, Angela Lanciotti, Giulia Valvo, Luigi Catacuzzeno, Fabio Franciolini, Paola Molinari, Maria Marchese, Alessandro Grottesi, Renzo Guerrini, Filippo M. Santorelli, Silvia Priori, Mauro Pessia

Hum Mol Genet. 2014 Sep 15; 23(18): 4875–4886. Published online 2014 May 2. doi: 10.1093/hmg/ddu201

PMCID:: PMC4140467

Article PDF–857K

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