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Select item 85492761.

Cytotoxic lymphocytes-related gene ITK from a systematic CRISPR screen could predict prognosis of ovarian cancer patients with distant metastasis

Mengyao Xu, Shan Huang, Jiahui Chen, Wanxue Xu, Rong Xiang, Yongjun Piao, Shuangtao Zhao

J Transl Med. 2021; 19: 447. Published online 2021 Oct 26. doi: 10.1186/s12967-021-03119-3

PMCID:: PMC8549276

Abstract Article PDF–7.6M

Select item 83516952.

Interleukin-2 inducible T-cell kinase: a potential prognostic biomarker and tumor microenvironment remodeling indicator for hepatocellular carcinoma

Binhua Pan, Modan Yang, Xuyong Wei, Wangyao Li, Kun Wang, Mengfan Yang, Di Lu, Rui Wang, Beini Cen, Xiao Xu

Aging (Albany NY) 2021 Jul 31; 13(14): 18620–18644. Published online 2021 Jul 19. doi: 10.18632/aging.203306

PMCID:: PMC8351695

Abstract Article PDF–5.2M

Select item 77796613.

ITK deficiency presenting as Autoimmune Lymphoproliferative Syndrome

Jacqueline G Wallace, Mohammed Alosaimi, Claudia Djambas Khayat, Faris Jaber, Abduarahman Almutairi, Sarah Beaussant-Cohen, Geraldine Pinkus, Mark Fleming, Cybel Mehawej, Janet Chou, Raif S Geha

J Allergy Clin Immunol. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: J Allergy Clin Immunol. 2021 Feb; 147(2): 743–745.e1. Published online 2020 Jul 4. doi: 10.1016/j.jaci.2020.06.019

PMCID:: PMC7779661

Abstract Article PDF–777K

Select item 73172794.

Inherited Interleukin 2–Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma

Leila Youssefian, Hassan Vahidnezhad, Mehdi Yousefi, Amir Hossein Saeidian, Arghavan Azizpour, Andrew Touati, Neda Nikbakht, Kambiz Kamyab- Hesari, Mohammad Mahdi Adib-Sereshki, Sirous Zeinali, Behzad Mansoori, Ali Jazayeri, Razieh Karamzadeh, Paolo Fortina, Emmanuelle Jouanguy, Jean-Laurent Casanova, Jouni Uitto

Clin Infect Dis. 2019 Jun 1; 68(11): 1938–1941. Published online 2019 Feb 19. doi: 10.1093/cid/ciy942

PMCID:: PMC7317279

Abstract Article PDF–9.0M

Select item 64832015.

A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3⁺ T_REG differentiation

Polina Mamontov, Ryan A. Eberwine, Jackie Perrigoue, Anuk Das, Joshua R. Friedman, J. Rodrigo Mora

PLoS One. 2019; 14(4): e0215963. Published online 2019 Apr 25. doi: 10.1371/journal.pone.0215963

PMCID:: PMC6483201

Abstract Article PDF–1.6M

Select item 61549936.

Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma

Sami Mamand, Rebecca L. Allchin, Matthew J. Ahearne, Simon D. Wagner

Sci Rep. 2018; 8: 14216. Published online 2018 Sep 21. doi: 10.1038/s41598-018-32634-5

PMCID:: PMC6154993

Abstract Article PDF–2.5M

Select item 58166327.

IL-2 Inducible Kinase ITK is Critical for HIV-1 Infection of Jurkat T-cells

Anika Hain, Melanie Krämer, René M. Linka, Saeideh Nakhaei-Rad, Mohammad Reza Ahmadian, Dieter Häussinger, Arndt Borkhardt, Carsten Münk

Sci Rep. 2018; 8: 3217. Published online 2018 Feb 16. doi: 10.1038/s41598-018-21344-7

PMCID:: PMC5816632

Abstract Article PDF–2.4M

Select item 44180298.

IL-2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

Craig C. Carson, Stergios J. Moschos, Sharon N. Edmiston, David B. Darr, Nana Nikolaishvili-Feinberg, Pamela A. Groben, Xin Zhou, Pei Fen Kuan, Shaily Pandey, Keefe T. Chan, Jamie L. Jordan, Honglin Hao, Jill S. Frank, Dennis A. Hopkinson, David C. Gibbs, Virginia D. Alldredge, Eloise Parrish, Sara C. Hanna, Paula Berkowitz, David S. Rubenstein, C. Ryan Miller, James E. Bear, David W. Ollila, Norman E. Sharpless, Kathleen Conway, Nancy E. Thomas

Clin Cancer Res. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Clin Cancer Res. 2015 May 1; 21(9): 2167–2176. doi: 10.1158/1078-0432.CCR-14-1826

PMCID:: PMC4418029

Abstract Article PDF–904K

Select item 42032289.

Angioimmunoblastic T-cell lymphoma in Taiwan shows a frequent gain of ITK gene

Peir-In Liang, Sheng-Tsung Chang, Ming-Yen Lin, Yen-Chuan Hsieh, Pei-Yi Chu, Chih-Jung Chen, Kai-Jen Lin, Yun-Chih Jung, Wei-Shou Hwang, Wen-Tsung Huang, Wei-Chin Chang, Hongtao Ye, Shih-Sung Chuang

Int J Clin Exp Pathol. 2014; 7(9): 6097–6107. Published online 2014 Aug 15.

PMCID:: PMC4203228

Abstract Article PDF–2.1M

Select item 411066510.

Identification of ITK deficiency as a novel genetic cause of idiopathic CD4⁺ T-cell lymphopenia

Nina Kathrin Serwas, Deniz Cagdas, Sol A. Ban, Kirsten Bienemann, Elisabeth Salzer, İlhan Tezcan, Arndt Borkhardt, Ozden Sanal, Kaan Boztug

Blood. 2014 Jul 24; 124(4): 655–657. doi: 10.1182/blood-2014-03-564930

PMCID:: PMC4110665

Article

Select item 278561811.

The Tec Family Kinase Itk Exists as a Folded Monomer in Vivo

Qian Qi, Avery August

J Biol Chem. 2009 Oct 23; 284(43): 29882–29892. Published online 2009 Aug 28. doi: 10.1074/jbc.M109.003129

PMCID:: PMC2785618

Abstract Article PDF–2.9M

Select item 275320412.

Mechanism and functional significance of Itk autophosphorylation

Raji E. Joseph, D. Bruce Fulton, Amy H. Andreotti

J Mol Biol. Author manuscript; available in PMC 2009 Sep 28.

Published in final edited form as: J Mol Biol. 2007 Nov 9; 373(5): 1281–1292. Published online 2007 Aug 31. doi: 10.1016/j.jmb.2007.08.060

PMCID:: PMC2753204

Abstract Article PDF–2.1M

Select item 272294913.

SH2 dependent autophosphorylation within the Tec family kinase Itk

Raji E. Joseph, Andrew Severin, Lie Min, D. Bruce Fulton, Amy H. Andreotti

J Mol Biol. Author manuscript; available in PMC 2010 Aug 7.

Published in final edited form as: J Mol Biol. 2009 Aug 7; 391(1): 164–177. Published online 2009 Jun 11. doi: 10.1016/j.jmb.2009.06.023

PMCID:: PMC2722949

Abstract Article PDF–4.9M

Select item 267387214.

Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation

Kirsten Huck, Oliver Feyen, Tim Niehues, Franz Rüschendorf, Norbert Hübner, Hans-Jürgen Laws, Tanja Telieps, Stefan Knapp, Hans-Heinrich Wacker, Alfons Meindl, Hassan Jumaa, Arndt Borkhardt

J Clin Invest. 2009 May 1; 119(5): 1350–1358. Published online 2009 Apr 1. doi: 10.1172/JCI37901

PMCID:: PMC2673872

Abstract Article PDF–1.8M

Select item 8877015.

Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation

Xiaochuan Shan, Michael J. Czar, Stephen C. Bunnell, Pinghu Liu, Yusen Liu, Pamela L. Schwartzberg, Ronald L. Wange

Mol Cell Biol. 2000 Sep; 20(18): 6945–6957. doi: 10.1128/mcb.20.18.6945-6957.2000

PMCID:: PMC88770

Abstract Article PDF–1.7M

Select item 4101416.

Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.

S A Langhans-Rajasekaran, Y Wan, X Y Huang

Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19): 8601–8605. doi: 10.1073/pnas.92.19.8601

PMCID:: PMC41014

Summary Page Browse PDF–1.6M

Select item 964131217.

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis

Masato Ogishi, Rui Yang, Rémy Rodriguez, Dominic P. Golec, Emmanuel Martin, Quentin Philippot, Jonathan Bohlen, Simon J. Pelham, Andrés Augusto Arias, Taushif Khan, Manar Ata, Fatima Al Ali, Flore Rozenberg, Xiao-Fei Kong, Maya Chrabieh, Candice Laine, Wei-Te Lei, Ji Eun Han, Yoann Seeleuthner, Zenia Kaul, Emmanuelle Jouanguy, Vivien Béziat, Leila Youssefian, Hassan Vahidnezhad, V. Koneti Rao, Bénédicte Neven, Claire Fieschi, Davood Mansouri, Mohammad Shahrooei, Sevgi Pekcan, Gulsum Alkan, Melike Emiroğlu, Hüseyin Tokgöz, Jouni Uitto, Fabian Hauck, Jacinta Bustamante, Laurent Abel, Sevgi Keles, Nima Parvaneh, Nico Marr, Pamela L. Schwartzberg, Sylvain Latour, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis

J Exp Med. 2023 Jan 2; 220(1): e20220484. Published online 2022 Nov 3. doi: 10.1084/jem.20220484

PMCID:: PMC9641312

Abstract Article PDF–7.9M

Select item 811308818.

Itk promotes the integration of TCR and CD28 costimulation, through its direct substrates, SLP-76 and Gads

Enas Hallumi, Rose Shalah, Wan-Lin Lo, Jasmin Corso, Ilana Oz, Dvora Beach, Samuel Wittman, Amy Isenberg, Meirav Sela, Henning Urlaub, Arthur Weiss, Deborah Yablonski

J Immunol. Author manuscript; available in PMC 2022 May 15.

Published in final edited form as: J Immunol. 2021 May 15; 206(10): 2322–2337. Published online 2021 Apr 30. doi: 10.4049/jimmunol.2001053

PMCID:: PMC8113088

Abstract Article PDF–2.7M

Select item 736155019.

BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy

Michael C McGee, Avery August, Weishan Huang

J Leukoc Biol. 2021 Jan; 109(1): 49–53. Published online 2020 Jul 8. doi: 10.1002/JLB.5COVR0620-306R

PMCID:: PMC7361550

Abstract Article PDF–567K

Select item 540501220.

T-cell receptor signaling activates an ITK/NF-κB/GATA-3 axis in T-cell lymphomas facilitating resistance to chemotherapy

Tianjiao Wang, Ye Lu, Avery Polk, Pinki Chowdhury, Carlos Murga Zamalloa, Hiroshi Fujiwara, Koichiro Suemori, Niklas Beyersdorf, Alexandra C. Hristov, Megan S. Lim, Nathanael G. Bailey, Ryan A. Wilcox

Clin Cancer Res. Author manuscript; available in PMC 2018 May 15.

Published in final edited form as: Clin Cancer Res. 2017 May 15; 23(10): 2506–2515. Published online 2016 Oct 25. doi: 10.1158/1078-0432.CCR-16-1996

Correction in:: Clin Cancer Res. 2017 Oct 1; 23(19): 5995.

PMCID:: PMC5405012

Abstract Article PDF–2.0M

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