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Items: 1 to 20 of 72

1.
Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
Manjeera Gowravaram, Juliane Schwarz, Sana K. Khilji, Henning Urlaub, Sutapa Chakrabarti
Nat Commun. 2019; 10: 5054. Published online 2019 Nov 7. doi: 10.1038/s41467-019-13080-x
PMCID:
PMC6838198
ArticlePDF–2.1M
2.
Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2
Marcello Clerici, Aurélien Deniaud, Volker Boehm, Niels H. Gehring, Christiane Schaffitzel, Stephen Cusack
Nucleic Acids Res. 2014 Feb; 42(4): 2673–2686. Published online 2013 Nov 23. doi: 10.1093/nar/gkt1197
PMCID:
PMC3936715
ArticlePDF–11M
3.
hUPF2 Silencing Identifies Physiologic Substrates of Mammalian Nonsense-Mediated mRNA Decay
Jürgen Wittmann, Elly M. Hol, Hans-Martin Jäck
Mol Cell Biol. 2006 Feb; 26(4): 1272–1287. doi: 10.1128/MCB.26.4.1272-1287.2006
PMCID:
PMC1367210
ArticlePDF–565K
4.
Modulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2
Guangpu Xue, Vincent D. Maciej, Alexandrina Machado de Amorim, Melis Pak, Uma Jayachandran, Sutapa Chakrabarti
RNA. 2023 Feb; 29(2): 178–187. doi: 10.1261/rna.079188.122
PMCID:
PMC9891255
ArticlePDF–4.1M
5.
Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex
Andrés López-Perrote, Raquel Castaño, Roberto Melero, Teresa Zamarro, Hitomi Kurosawa, Tetsuo Ohnishi, Akiko Uchiyama, Kyoko Aoyagi, Gretel Buchwald, Naoyuki Kataoka, Akio Yamashita, Oscar Llorca
Nucleic Acids Res. 2016 Feb 29; 44(4): 1909–1923. Published online 2016 Jan 5. doi: 10.1093/nar/gkv1527
PMCID:
PMC4770235
ArticlePDF–5.0M
6.
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2
Marcello Clerici, André Mourão, Irina Gutsche, Niels H Gehring, Matthias W Hentze, Andreas Kulozik, Jan Kadlec, Michael Sattler, Stephen Cusack
EMBO J. 2009 Aug 5; 28(15): 2293–2306. Published online 2009 Jun 25. doi: 10.1038/emboj.2009.175
PMCID:
PMC2726699
ArticlePDF–2.3M
7.
Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation
Joshua C Bufton, Kyle T Powers, Jenn-Yeu A Szeto, Christine Toelzer, Imre Berger, Christiane Schaffitzel
Nucleic Acids Res. 2022 Jun 10; 50(10): 5934–5947. Published online 2022 May 31. doi: 10.1093/nar/gkac421
PMCID:
PMC9177958
ArticlePDF–2.7M
8.
Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response
Jennifer L. Johnson, Loredana Stoica, Yuwei Liu, Ping Jun Zhu, Abhisek Bhattacharya, Shelly A. Buffington, Redwan Huq, N. Tony Eissa, Ola Larsson, Bo T. Porse, Deepti Domingo, Urwah Nawaz, Renee Carroll, Lachlan Jolly, Tom S. Scerri, Hyung-Goo Kim, Amanda Brignell, Matthew J. Coleman, Ruth Braden, Usha Kini, Victoria Jackson, Anne Baxter, Melanie Bahlo, Ingrid E. Scheffer, David J. Amor, Michael S. Hildebrand, Penelope E. Bonnen, Christine Beeton, Jozef Gecz, Angela T. Morgan, Mauro Costa-Mattioli
Neuron. Author manuscript; available in PMC 2020 Jun 24.
Published in final edited form as: Neuron. 2019 Nov 20; 104(4): 665–679.e8. Published online 2019 Oct 1. doi: 10.1016/j.neuron.2019.08.027
PMCID:
PMC7312756
ArticlePDF–2.5M
9.
Identification and Characterization of Human Orthologues to Saccharomyces cerevisiae Upf2 Protein and Upf3 Protein (Caenorhabditis elegans SMG-4)
Guillaume Serin, Anand Gersappe, Jennifer D. Black, Rachel Aronoff, Lynne E. Maquat
Mol Cell Biol. 2001 Jan; 21(1): 209–223. doi: 10.1128/MCB.21.1.209-223.2001
PMCID:
PMC88795
ArticlePDF–5.8M
10.
Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells.
Thomas Schell, Thomas Köcher, Matthias Wilm, Bertrand Seraphin, Andreas E Kulozik, Matthias W Hentze
Biochem J. 2003 Aug 1; 373(Pt 3): 775–783. doi: 10.1042/BJ20021920
PMCID:
PMC1223536
SummaryPDF–300K
11.
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
Akio Yamashita, Tetsuo Ohnishi, Isao Kashima, Yoichi Taya, Shigeo Ohno
Genes Dev. 2001 Sep 1; 15(17): 2215–2228. doi: 10.1101/gad.913001
PMCID:
PMC312771
ArticlePDF–1.3M
12.
Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes
Joshua T. Mendell, Susan M. Medghalchi, Ross G. Lake, Erick N. Noensie, Harry C. Dietz
Mol Cell Biol. 2000 Dec; 20(23): 8944–8957. doi: 10.1128/mcb.20.23.8944-8957.2000
PMCID:
PMC86549
ArticlePDF–3.6M
13.
Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.
Gretel Buchwald, Judith Ebert, Claire Basquin, Jerome Sauliere, Uma Jayachandran, Fulvia Bono, Hervé Le Hir, Elena Conti
Proc Natl Acad Sci U S A. 2010 Jun 1; 107(22): 10050–10055. Published online 2010 May 17. doi: 10.1073/pnas.1000993107
PMCID:
PMC2890422
ArticlePDF–1.5M
14.
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways
Pavel V Ivanov, Niels H Gehring, Joachim B Kunz, Matthias W Hentze, Andreas E Kulozik
EMBO J. 2008 Mar 5; 27(5): 736–747. Published online 2008 Feb 7. doi: 10.1038/emboj.2008.17
PMCID:
PMC2265754
ArticlePDF–4.5M
15.
Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1
SHANG-YI CHIU, GUILLAUME SERIN, OSAMU OHARA, LYNNE E. MAQUAT
RNA. 2003 Jan; 9(1): 77–87. doi: 10.1261/rna.2137903
PMCID:
PMC1370372
ArticlePDF–507K
16.
Identification of a Human Decapping Complex Associated with hUpf Proteins in Nonsense-Mediated Decay
Jens Lykke-Andersen
Mol Cell Biol. 2002 Dec; 22(23): 8114–8121. doi: 10.1128/MCB.22.23.8114-8121.2002
PMCID:
PMC134073
ArticlePDF–329K
17.
The Hierarchy of Exon-Junction Complex Assembly by the Spliceosome Explains Key Features of Mammalian Nonsense-Mediated mRNA Decay
Niels H. Gehring, Styliani Lamprinaki, Matthias W. Hentze, Andreas E. Kulozik
PLoS Biol. 2009 May; 7(5): e1000120. Published online 2009 May 26. doi: 10.1371/journal.pbio.1000120
PMCID:
PMC2682485
ArticlePDF–1.3M
18.
Human INT6/eIF3e is required for nonsense-mediated mRNA decay
Christelle Morris, Jürgen Wittmann, Hans-Martin Jäck, Pierre Jalinot
EMBO Rep. 2007 Jun; 8(6): 596–602. Published online 2007 Apr 20. doi: 10.1038/sj.embor.7400955
PMCID:
PMC2002529
ArticlePDF–160K
19.
A Yeast Model of FUS/TLS-Dependent Cytotoxicity
Shulin Ju, Daniel F. Tardiff, Haesun Han, Kanneganti Divya, Quan Zhong, Lynne E. Maquat, Daryl A. Bosco, Lawrence J. Hayward, Robert H. Brown, Jr., Susan Lindquist, Dagmar Ringe, Gregory A. Petsko
PLoS Biol. 2011 Apr; 9(4): e1001052. Published online 2011 Apr 26. doi: 10.1371/journal.pbio.1001052
PMCID:
PMC3082520
ArticlePDF–837K
20.
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA
Collynn F Woeller, Martina Gaspari, Olaf Isken, Lynne E Maquat
EMBO Rep. 2008 May; 9(5): 446–451. Published online 2008 Mar 28. doi: 10.1038/embor.2008.36
PMCID:
PMC2373368
ArticlePDF–210K

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