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Select item 77218961.

The E3 ligase UBR2 regulates cell death under caspase deficiency via Erk/MAPK pathway

Elodie Villa, Rachel Paul, Ophélie Meynet, Sophie Volturo, Guillaume Pinna, Jean-Ehrland Ricci

Cell Death Dis. 2020 Dec; 11(12): 1041. Published online 2020 Dec 8. doi: 10.1038/s41419-020-03258-3

PMCID:: PMC7721896

Abstract Article PDF–1.9M

Select item 31701122.

Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest

Toshinobu Miyamoto, Akira Tsujimura, Yasushi Miyagawa, Eitetsu Koh, Mikio Namiki, Michiharu Horikawa, Yasuaki Saijo, Kazuo Sengoku

J Assist Reprod Genet. 2011 Aug; 28(8): 743–746. Published online 2011 May 4. doi: 10.1007/s10815-011-9576-y

PMCID:: PMC3170112

Abstract Article PDF–97K

Select item 107897583.

The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling

Ying-Chun Shih, Hsueh-Fen Chen, Chia-Ying Wu, Yi-Ru Ciou, Chia-Wen Wang, Huai-Chia Chuang, Tse-Hua Tan

Nat Commun. 2024; 15: 532. Published online 2024 Jan 15. doi: 10.1038/s41467-024-44843-w

PMCID:: PMC10789758

Abstract Article PDF–5.3M

Select item 66002684.

The N‐end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin

Hao Xu, Jianjin Shi, Hang Gao, Ying Liu, Zhenxiao Yang, Feng Shao, Na Dong

EMBO J. 2019 Jul 1; 38(13): e101996. Published online 2019 May 6. doi: 10.15252/embj.2019101996

PMCID:: PMC6600268

Abstract Article PDF–1.8M

Select item 33551315.

UBR2 of the N-End Rule Pathway Is Required for Chromosome Stability via Histone Ubiquitylation in Spermatocytes and Somatic Cells

Jee Young An, Euna Kim, Adriana Zakrzewska, Young Dong Yoo, Jun Min Jang, Dong Hoon Han, Min Jae Lee, Jai Wha Seo, Yong Jun Lee, Tae-You Kim, Dirk G. de Rooij, Bo Yeon Kim, Yong Tae Kwon

PLoS One. 2012; 7(5): e37414. Published online 2012 May 17. doi: 10.1371/journal.pone.0037414

PMCID:: PMC3355131

Abstract Article PDF–1.5M

Select item 76698216.

The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway

Tri T. M. Vu, Alexander Varshavsky

Biochemistry. Author manuscript; available in PMC 2020 Nov 17.

Published in final edited form as: Biochemistry. 2020 Aug 4; 59(30): 2796–2812. Published online 2020 Jul 21. doi: 10.1021/acs.biochem.0c00514

PMCID:: PMC7669821

Abstract Article PDF–1.9M

Select item 31514877.

Alternative Ubiquitin Activation/Conjugation Cascades Interact with N-end rule Ubiquitin Ligases to Control Degradation of RGS Proteins

Peter C.W. Lee, Mathew E. Sowa, Steven P. Gygi, J. Wade Harper

Mol Cell. Author manuscript; available in PMC 2012 Aug 5.

Published in final edited form as: Mol Cell. 2011 Aug 5; 43(3): 392–405. doi: 10.1016/j.molcel.2011.05.034

PMCID:: PMC3151487

Abstract Article PDF–2.6M

Select item 2624018.

Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway

Yong Tae Kwon, Zanxian Xia, Jee Young An, Takafumi Tasaki, Ilia V. Davydov, Jai Wha Seo, Jun Sheng, Youming Xie, Alexander Varshavsky

Mol Cell Biol. 2003 Nov; 23(22): 8255–8271. doi: 10.1128/MCB.23.22.8255-8271.2003

PMCID:: PMC262401

Abstract Article PDF–1.8M

Select item 22244379.

Human Immunodeficiency Virus Type 1 Vpr Links Proteasomal Degradation and Checkpoint Activation

Jason L. DeHart, Vicente Planelles

J Virol. 2008 Feb; 82(3): 1066–1072. Published online 2007 Sep 12. doi: 10.1128/JVI.01628-07

PMCID:: PMC2224437

Article PDF–222K

Select item 283662310.

UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination

Jee Young An, Eun-A. Kim, Yonghua Jiang, Adriana Zakrzewska, Dong Eun Kim, Min Jae Lee, Inhee Mook-Jung, Yi Zhang, Yong Tae Kwon

Proc Natl Acad Sci U S A. 2010 Feb 2; 107(5): 1912–1917. Published online 2010 Jan 11. doi: 10.1073/pnas.0910267107

PMCID:: PMC2836623

Abstract Article PDF–1.4M

Select item 724509611.

Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling

Jang-Hyun Oh, Ju-Yeon Hyun, Shun-Jia Chen, Alexander Varshavsky

Proc Natl Acad Sci U S A. 2020 May 19; 117(20): 10778–10788. Published online 2020 May 4. doi: 10.1073/pnas.2003043117

PMCID:: PMC7245096

Abstract Article PDF–1.7M

Select item 182072012.

HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1

Bärbel Schröfelbauer, Yoshiyuki Hakata, Nathaniel R. Landau

Proc Natl Acad Sci U S A. 2007 Mar 6; 104(10): 4130–4135. Published online 2007 Feb 28. doi: 10.1073/pnas.0610167104

PMCID:: PMC1820720

Abstract Article PDF–500K

Select item 410402713.

Cytosolic Quality Control of Mislocalized Proteins Requires RNF126 Recruitment to Bag6

Monica C. Rodrigo-Brenni, Erik Gutierrez, Ramanujan S. Hegde

Mol Cell. 2014 Jul 17; 55(2): 227–237. doi: 10.1016/j.molcel.2014.05.025

PMCID:: PMC4104027

Abstract Article

Select item 331091014.

Vif hijacks CBF – β to degrade APOBEC3G and promote HIV–1 infection

Stefanie Jäger, Dong Young Kim, Judd F. Hultquist, Keisuke Shindo, Rebecca S. LaRue, Eunju Kwon, Ming Li, Brett D. Anderson, Linda Yen, David Stanley, Cathal Mahon, Joshua Kane, Kathy Franks-Skiba, Peter Cimermancic, Alma Burlingame, Andrej Sali, Charles S. Craik, Reuben S. Harris, John D. Gross, Nevan J. Krogan

Nature. Author manuscript; available in PMC 2013 Jan 19.

Published in final edited form as: Nature. 2011 Dec 21; 481(7381): 371–375. Published online 2011 Dec 21. doi: 10.1038/nature10693

PMCID:: PMC3310910

Abstract Article PDF–928K

Select item 434998615.

KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and Lysosome-Mediated Degradation

Jenny H. Hong, Lilia Kaustov, Etienne Coyaud, Tharan Srikumar, Janet Wan, Cheryl Arrowsmith, Brian Raught

Mol Cell Proteomics. 2015 Mar; 14(3): 674–685. Published online 2015 Jan 12. doi: 10.1074/mcp.M114.042168

PMCID:: PMC4349986

Abstract Article PDF–3.4M

Select item 412618916.

Genome-wide association study of smoking behaviors among Bangladeshi adults

Maria Argos, Lin Tong, Brandon L. Pierce, Muhammad Rakibuz-Zaman, Alauddin Ahmed, Tariqul Islam, Mahfuzar Rahman, Rachelle Paul-Brutus, Ronald Rahaman, Shantanu Roy, Farzana Jasmine, Muhammad G. Kibriya, Habibul Ahsan

J Med Genet. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: J Med Genet. 2014 May; 51(5): 327–333. Published online 2014 Mar 24. doi: 10.1136/jmedgenet-2013-102151