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Select item 75279221.

The structure of the MICU1‐MICU2 complex unveils the regulation of the mitochondrial calcium uniporter

Wenping Wu, Qingya Shen, Ruiling Zhang, Zhiyu Qiu, Youjun Wang, Jimin Zheng, Zongchao Jia

EMBO J. 2020 Oct 1; 39(19): e104285. Published online 2020 Aug 13. doi: 10.15252/embj.2019104285

PMCID:: PMC7527922

Abstract Article PDF–4.0M

Select item 70553702.

Structure of the MICU1–MICU2 heterodimer provides insights into the gatekeeping threshold shift

Jongseo Park, Youngjin Lee, Taein Park, Jung Youn Kang, Sang A Mun, Minwoo Jin, Jihyeong Yang, Soo Hyun Eom

IUCrJ. 2020 Mar 1; 7(Pt 2): 355–365. Published online 2020 Feb 27. doi: 10.1107/S2052252520001840

PMCID:: PMC7055370

Abstract Article PDF–1.8M

Select item 67269063.

The crystal structure of MICU2 provides insight into Ca²⁺ binding and MICU1‐MICU2 heterodimer formation

Wenping Wu, Qingya Shen, Zhen Lei, Zhiyu Qiu, Dan Li, Hairun Pei, Jimin Zheng, Zongchao Jia

EMBO Rep. 2019 Sep; 20(9): e47488. Published online 2019 Aug 9. doi: 10.15252/embr.201847488

PMCID:: PMC6726906

Abstract Article PDF–4.1M

Select item 56645354.

Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter

Alexander G. Bick, Hiroko Wakimoto, Kimberli J. Kamer, Yasemin Sancak, Olga Goldberger, Anna Axelsson, Daniel M. DeLaughter, Joshua M. Gorham, Vamsi K. Mootha, J. G. Seidman, Christine E. Seidman

Proc Natl Acad Sci U S A. 2017 Oct 24; 114(43): E9096–E9104. Published online 2017 Oct 9. doi: 10.1073/pnas.1711303114

PMCID:: PMC5664535

Abstract Article PDF–1.0M

Select item 55384265.

High‐affinity cooperative Ca²⁺ binding by MICU1–MICU2 serves as an on–off switch for the uniporter

Kimberli J Kamer, Zenon Grabarek, Vamsi K Mootha

EMBO Rep. 2017 Aug; 18(8): 1397–1411. Published online 2017 Jun 14. doi: 10.15252/embr.201643748

PMCID:: PMC5538426

Abstract Article PDF–804K

Select item 39896966.

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter

Kimberli J Kamer, Vamsi K Mootha

EMBO Rep. 2014 Mar; 15(3): 299–307. Published online 2014 Feb 6. doi: 10.1002/embr.201337946

PMCID:: PMC3989696

Abstract Article PDF–1.2M

Select item 81639867.

Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

N. Vishnu, A. Hamilton, A. Bagge, A. Wernersson, E. Cowan, H. Barnard, Y. Sancak, K.J. Kamer, P. Spégel, M. Fex, A. Tengholm, V.K. Mootha, D.G. Nicholls, H. Mulder

Mol Metab. 2021 Sep; 51: 101239. Published online 2021 Apr 28. doi: 10.1016/j.molmet.2021.101239

PMCID:: PMC8163986

Abstract Article PDF–2.2M

Select item 74344458.

Structures reveal gatekeeping of the mitochondrial Ca²⁺ uniporter by MICU1-MICU2

Chongyuan Wang, Agata Jacewicz, Bryce D Delgado, Rozbeh Baradaran, Stephen Barstow Long

eLife. 2020; 9: e59991. Published online 2020 Jul 15. doi: 10.7554/eLife.59991

PMCID:: PMC7434445

Abstract Article PDF–2.9M

Select item 78958719.

Structure of intact human MCU supercomplex with the auxiliary MICU subunits

Wei Zhuo, Heng Zhou, Runyu Guo, Jingbo Yi, Laixing Zhang, Lei Yu, Yinqiang Sui, Wenwen Zeng, Peiyi Wang, Maojun Yang

Protein Cell. 2021 Mar; 12(3): 220–229. Published online 2020 Aug 30. doi: 10.1007/s13238-020-00776-w

PMCID:: PMC7895871

Article PDF–2.5M

Select item 754443110.

Structure and mechanism of the mitochondrial Ca²⁺ uniporter holocomplex

Minrui Fan, Jinru Zhang, Chen-Wei Tsai, Benjamin J. Orlando, Madison Rodriguez, Yan Xu, Maofu Liao, Ming-Feng Tsai, Liang Feng

Nature. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nature. 2020 Jun; 582(7810): 129–133. Published online 2020 May 20. doi: 10.1038/s41586-020-2309-6

PMCID:: PMC7544431

Abstract Article PDF–7.2M

Select item 744249011.

Structural insights into the Ca²⁺-dependent gating of the human mitochondrial calcium uniporter

Yan Wang, Yan Han, Ji She, Nam X Nguyen, Vamsi K Mootha, Xiao-chen Bai, Youxing Jiang

eLife. 2020; 9: e60513. Published online 2020 Aug 7. doi: 10.7554/eLife.60513

PMCID:: PMC7442490

Abstract Article PDF–5.7M

Select item 573410312.

MICU2 Restricts Spatial Crosstalk Between InsP₃R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU

Riley Payne, Henry Hoff, Anne Roskowski, J. Kevin Foskett

Cell Rep. Author manuscript; available in PMC 2017 Dec 18.

Published in final edited form as: Cell Rep. 2017 Dec 12; 21(11): 3141–3154. doi: 10.1016/j.celrep.2017.11.064

PMCID:: PMC5734103

Abstract Article PDF–2.1M

Select item 776445113.

Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex

Anna M. Van Keuren, Chen-Wei Tsai, Enrique Balderas, Madison X. Rodriguez, Dipayan Chaudhuri, Ming-Feng Tsai

Cell Rep. Author manuscript; available in PMC 2020 Dec 26.

Published in final edited form as: Cell Rep. 2020 Dec 8; 33(10): 108486. doi: 10.1016/j.celrep.2020.108486

PMCID:: PMC7764451

Abstract Article PDF–1.3M

Select item 699656014.

MCUB regulates the molecular composition of the mitochondrial calcium uniporter channel to limit mitochondrial calcium overload during stress

Jonathan P. Lambert, Timothy S. Luongo, Dhanendra Tomar, Pooja Jadiya, Erhe Gao, Xueqian Zhang, Anna Maria Lucchese, Devin W. Kolmetzky, Neil S. Shah, John W. Elrod

Circulation. Author manuscript; available in PMC 2020 Nov 19.

Published in final edited form as: Circulation. 2019 Nov 19; 140(21): 1720–1733. Published online 2019 Sep 19. doi: 10.1161/CIRCULATIONAHA.118.037968

PMCID:: PMC6996560

Abstract Article PDF–1.6M

Select item 634745115.

The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

Charles B Phillips, Chen-Wei Tsai, Ming-Feng Tsai

eLife. 2019; 8: e41112. Published online 2019 Jan 15. doi: 10.7554/eLife.41112

PMCID:: PMC6347451

Abstract Article PDF–2.0M

Select item 677303016.

DCAMKL1 Encodes a Protein Kinase with Homology to Doublecortin that Regulates Microtubule Polymerization

Peter T. Lin, Joseph G. Gleeson, Joseph C. Corbo, Lisa Flanagan, Christopher A. Walsh

J Neurosci. 2000 Dec 15; 20(24): 9152–9161. doi: 10.1523/JNEUROSCI.20-24-09152.2000

PMCID:: PMC6773030

Abstract Article PDF–926K

Select item 398889117.

MICU1 and MICU2 Finely Tune the Mitochondrial Ca²⁺ Uniporter by Exerting Opposite Effects on MCU Activity

Maria Patron, Vanessa Checchetto, Anna Raffaello, Enrico Teardo, Denis Vecellio Reane, Maura Mantoan, Veronica Granatiero, Ildikò Szabò, Diego De Stefani, Rosario Rizzuto

Mol Cell. 2014 Mar 6; 53(5): 726–737. doi: 10.1016/j.molcel.2014.01.013

PMCID:: PMC3988891

Abstract Article

Select item 356711218.

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

Molly Plovanich, Roman L. Bogorad, Yasemin Sancak, Kimberli J. Kamer, Laura Strittmatter, Andrew A. Li, Hany S. Girgis, Satya Kuchimanchi, Jack De Groot, Lauren Speciner, Nathan Taneja, Jonathan OShea, Victor Koteliansky, Vamsi K. Mootha

PLoS One. 2013; 8(2): e55785. Published online 2013 Feb 7. doi: 10.1371/journal.pone.0055785

PMCID:: PMC3567112

Abstract Article PDF–1.0M

Select item 346731419.

Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay

Li-Chun Lisa Tsai, Guy Chiu-Kai Chan, Shannon N. Nangle, Masami Shimizu-Albergine, Graham Jones, Daniel R. Storm, Joseph A. Beavo, Larry S. Zweifel

Genes Brain Behav. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: Genes Brain Behav. 2012 Oct; 11(7): 837–847. Published online 2012 Sep 4. doi: 10.1111/j.1601-183X.2012.00836.x

PMCID:: PMC3467314

Abstract Article PDF–1.5M

Select item 409162920.

EMRE is an essential component of the mitochondrial calcium uniporter complex

Yasemin Sancak, Andrew L. Markhard, Toshi Kitami, Erika Kovács-Bogdán, Kimberli J. Kamer, Namrata D. Udeshi, Steven A. Carr, Dipayan Chaudhuri, David E. Clapham, Andrew A. Li, Sarah E. Calvo, Olga Goldberger, Vamsi K. Mootha

Science. Author manuscript; available in PMC 2014 Jul 10.

Published in final edited form as: Science. 2013 Dec 13; 342(6164): 1379–1382. Published online 2013 Nov 14. doi: 10.1126/science.1242993