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Select item 82322591.

(-)-Englerin-A Has Analgesic and Anti-Inflammatory Effects Independent of TRPC4 and 5

João de Sousa Valente, Khadija M Alawi, Sabah Bharde, Ali A. Zarban, Xenia Kodji, Dibesh Thapa, Fulye Argunhan, Brentton Barrett, Istvan Nagy, Susan D. Brain

Int J Mol Sci. 2021 Jun; 22(12): 6380. Published online 2021 Jun 15. doi: 10.3390/ijms22126380

PMCID:: PMC8232259

Article PDF–2.3M

Select item 66726192.

Induction of Calcium Influx through TRPC5 Channels by Cross-Linking of GM1 Ganglioside Associated with α5β1 Integrin Initiates Neurite Outgrowth

Gusheng Wu, Zi-Hua Lu, Alexander G. Obukhov, Martha C. Nowycky, Robert W. Ledeen

J Neurosci. 2007 Jul 11; 27(28): 7447–7458. doi: 10.1523/JNEUROSCI.4266-06.2007

PMCID:: PMC6672619

Article PDF–696K

Select item 66565363.

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

Jingjing Duan, Jian Li, Gui-Lan Chen, Yan Ge, Jieyu Liu, Kechen Xie, Xiaogang Peng, Wei Zhou, Jianing Zhong, Yixing Zhang, Jie Xu, Changhu Xue, Bo Liang, Lan Zhu, Wei Liu, Cheng Zhang, Xiao-Li Tian, Jianbin Wang, David E. Clapham, Bo Zeng, Zongli Li, Jin Zhang

Sci Adv. 2019 Jul; 5(7): eaaw7935. Published online 2019 Jul 24. doi: 10.1126/sciadv.aaw7935

PMCID:: PMC6656536

Article PDF–7.2M

Select item 64597974.

Contribution of Zinc-Dependent Delayed Calcium Influx via TRPC5 in Oxidative Neuronal Death and its Prevention by Novel TRPC Antagonist

Sang Eun Park, Ji Hoon Song, Chansik Hong, Dong Eun Kim, Jee-Won Sul, Tae-Youn Kim, Bo-Ra Seo, Insuk So, Sang-Yeob Kim, Dong-Jun Bae, Mi-Ha Park, Hye Min Lim, In-Jeoung Baek, Antonio Riccio, Joo-Yong Lee, Woo Hyun Shim, Bumwoo Park, Jae-Young Koh, Jung Jin Hwang

Mol Neurobiol. 2019; 56(4): 2822–2835. Published online 2018 Jul 31. doi: 10.1007/s12035-018-1258-7

Correction in:: Mol Neurobiol. 2019; 56(4): 2836–2837.

PMCID:: PMC6459797

Article PDF–7.4M

Select item 63498755.

TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice

Baptiste Rode, Nadira Y. Yuldasheva, Paul D. Baxter, Alicia Sedo, Justin F. Ainscough, Michael Shires, Mark T. Kearney, Marc A. Bailey, Stephen B. Wheatcroft, David J. Beech

Sci Rep. 2019; 9: 773. Published online 2019 Jan 28. doi: 10.1038/s41598-018-37299-8

PMCID:: PMC6349875

Article PDF–4.0M

Select item 63228786.

The TRPC5 channel regulates angiogenesis and promotes recovery from ischemic injury in mice

Yifei Zhu, Mengru Gao, Tingting Zhou, Mingxu Xie, Aiqin Mao, Lei Feng, Xiaoqiang Yao, Wing Tak Wong, Xin Ma

J Biol Chem. 2019 Jan 4; 294(1): 28–37. Published online 2018 Nov 9. doi: 10.1074/jbc.RA118.005392

PMCID:: PMC6322878

Article PDF–2.7M

Select item 58651447.

Correspondence: Challenging a proposed role for TRPC5 in aortic baroreceptor pressure-sensing

Pratish Thakore, Susan D. Brain, David J. Beech

Nat Commun. 2018; 9: 1245. Published online 2018 Mar 23. doi: 10.1038/s41467-017-02703-w

PMCID:: PMC5865144

Article PDF–337K

Select item 57910758.

TRPC5 Does Not Cause or Aggravate Glomerular Disease

Xuexiang Wang, Ranadheer R. Dande, Hao Yu, Beata Samelko, Rachel E. Miller, Mehmet M. Altintas, Jochen Reiser

J Am Soc Nephrol. 2018 Feb; 29(2): 409–415. Published online 2017 Oct 23. doi: 10.1681/ASN.2017060682

PMCID:: PMC5791075

Article

Select item 54437559.

Transient receptor potential canonical 5 channels plays an essential role in hepatic dyslipidemia associated with cholestasis

Khadija M. Alawi, David Tandio, Jin Xu, Pratish Thakore, Georgia Papacleovoulou, Elizabeth S. Fernandes, Cristina Legido-Quigley, Catherine Williamson, Susan D. Brain

Sci Rep. 2017; 7: 2338. Published online 2017 May 24. doi: 10.1038/s41598-017-02439-z

PMCID:: PMC5443755

Article PDF–2.4M

Select item 532478010.

TrpC5 mediates acute leptin and serotonin effects via Pomc neurons

Yong Gao, Ting Yao, Zhuo Deng, Jong-Woo Sohn, Jia Sun, Yiru Huang, Xingxing Kong, Kai-jiang Yu, Rui-tao Wang, Hong Chen, Hongbo Guo, Jianqun Yan, Kathryn A. Cunningham, Yongsheng Chang, Tiemin Liu, Kevin W. Williams

Cell Rep. Author manuscript; available in PMC 2018 Jan 17.

Published in final edited form as: Cell Rep. 2017 Jan 17; 18(3): 583–592. doi: 10.1016/j.celrep.2016.12.072

PMCID:: PMC5324780

Article PDF–1.1M

Select item 379060911.

Cocaine self-administration in mice with forebrain knock-down of trpc5 ion channels

Matthew B Pomrenze, Michael V Baratta, Kristin C Rasmus, Brian A Cadle, Shinya Nakamura, Lutz Birnbaumer, Donald C Cooper

Version 1. F1000Res. 2013; 2: 53. Published online 2013 Feb 15. doi: 10.12688/f1000research.2-53.v1

PMCID:: PMC3790609

Article PDF–906K

Select item 311873812.

Involvement of TRP channels in the CO₂ chemosensitivity of locus coeruleus neurons

Ningren Cui, Xiaoli Zhang, Jyothirmayee S. Tadepalli, Lei Yu, Hongyu Gai, James Petit, Ravi T. Pamulapati, Xin Jin, Chun Jiang

J Neurophysiol. 2011 Jun; 105(6): 2791–2801. Published online 2011 Mar 23. doi: 10.1152/jn.00759.2010

PMCID:: PMC3118738

Article

Select item 271995413.

Essential role for TRPC5 in amygdala function and fear-related behavior

Antonio Riccio, Yan Li, Jisook Moon, Kwang-Soo Kim, Kiersten S. Smith, Uwe Rudolph, Svetlana Gapon, Gui Lan Yao, Evgeny Tsvetkov, Scott J. Rodig, Ashlee Van’t Veer, Edward G. Meloni, William A. Carlezon, Jr, Vadim Y. Bolshakov, David E. Clapham

Cell. Author manuscript; available in PMC 2009 Nov 15.

Published in final edited form as: Cell. 2009 May 15; 137(4): 761–772. doi: 10.1016/j.cell.2009.03.039

PMCID:: PMC2719954

Article PDF–6.9M

Select item 271297314.

Intracellular calcium strongly potentiates agonist-activated TRPC5 channels

Nathaniel T. Blair, J. Stefan Kaczmarek, David E. Clapham

J Gen Physiol. 2009 May; 133(5): 525–546. doi: 10.1085/jgp.200810153

PMCID:: PMC2712973

Article PDF–6.5M

Select item 265539215.

Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels

Ana Gomis, Sergio Soriano, Carlos Belmonte, Félix Viana

J Physiol. 2008 Dec 1; 586(Pt 23): 5633–5649. Published online 2008 Oct 2. doi: 10.1113/jphysiol.2008.161257

PMCID:: PMC2655392

Article PDF–1.5M

Select item 1021799416.

The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels

Zhong-Jiao Jiang, Liang-Wei Gong

J Neurosci. 2023 May 24; 43(21): 3807–3824. doi: 10.1523/JNEUROSCI.1494-22.2023

PMCID:: PMC10217994

Article PDF–5.5M

Select item 826078317.

Lactate sensing mechanisms in arterial chemoreceptor cells

Hortensia Torres-Torrelo, Patricia Ortega-Sáenz, Lin Gao, José López-Barneo

Nat Commun. 2021; 12: 4166. Published online 2021 Jul 6. doi: 10.1038/s41467-021-24444-7

PMCID:: PMC8260783

Article PDF–6.1M

Select item 707221618.

Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells

Alberto Arboit, Antonio Reboreda, Motoharu Yoshida

Cells. 2020 Feb; 9(2): 365. Published online 2020 Feb 5. doi: 10.3390/cells9020365

PMCID:: PMC7072216

Article PDF–1.9M

Select item 672596419.

A Cytosolic Residue Mediates Mg²⁺ Block and Regulates Inward Current Amplitude of a Transient Receptor Potential Channel

Alexander G. Obukhov, Martha C. Nowycky

J Neurosci. 2005 Feb 2; 25(5): 1234–1239. doi: 10.1523/JNEUROSCI.4451-04.2005

PMCID:: PMC6725964

Article PDF–815K

Select item 604985920.

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A

Sin Ying Cheung, Matthias Henrot, Mohammad Al-Saad, Matthias Baumann, Heiko Muller, Anke Unger, Hussein N. Rubaiy, Ilka Mathar, Klaus Dinkel, Peter Nussbaumer, Bert Klebl, Marc Freichel, Baptiste Rode, Sebastian Trainor, Steven J. Clapcote, Mathias Christmann, Herbert Waldmann, Syed Khawar Abbas, David J. Beech, Naveen S. Vasudev

Oncotarget. 2018 Jul 3; 9(51): 29634–29643. Published online 2018 Jul 3. doi: 10.18632/oncotarget.25659