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Select item 94991711.

Loss of Serpina1 in Mice Leads to Altered Gene Expression in Inflammatory and Metabolic Pathways

Sri Harsha Meghadri, Beatriz Martinez-Delgado, Lena Ostermann, Gema Gomez-Mariano, Sara Perez-Luz, Srinu Tumpara, Sabine Wrenger, David S. DeLuca, Ulrich A. Maus, Tobias Welte, Sabina Janciauskiene

Int J Mol Sci. 2022 Sep; 23(18): 10425. Published online 2022 Sep 9. doi: 10.3390/ijms231810425

PMCID:: PMC9499171

Article PDF–1.8M

Select item 78613542.

Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury

Kyle Stearns, Monica Goldklang, Rui Xiao, Tina Zelonina, Keith Blomenkamp, Jeffery Teckman, Jeanine M. D’Armiento

PLoS One. 2021; 16(2): e0246040. Published online 2021 Feb 4. doi: 10.1371/journal.pone.0246040

PMCID:: PMC7861354

Article PDF–1.0M

Select item 65224763.

A combined in silico and in vitro study on mouse Serpina1a antitrypsin-deficiency mutants

Reto Eggenschwiler, Atanas Patronov, Jan Hegermann, Mariane Fráguas-Eggenschwiler, Guangming Wu, Leon Cortnumme, Matthias Ochs, Iris Antes, Tobias Cantz

Sci Rep. 2019; 9: 7486. Published online 2019 May 16. doi: 10.1038/s41598-019-44043-3

PMCID:: PMC6522476

Article PDF–1.9M

Select item 45488144.

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α₁-antitrypsin while allowing its antiproteinase activity

Adriana Ordóñez, Juan Pérez, Lu Tan, Jennifer A. Dickens, Neda Motamedi-Shad, James A. Irving, Imran Haq, Ugo Ekeowa, Stefan J. Marciniak, Elena Miranda, David A. Lomas

FASEB J. 2015 Jun; 29(6): 2667–2678. Published online 2015 Mar 10. doi: 10.1096/fj.14-267351

PMCID:: PMC4548814

Article

Select item 35109805.

Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency

Nancy Y Marcus, Keith Blomenkamp, Muneeb Ahmad, Jeffrey H Teckman

Exp Biol Med (Maywood) Author manuscript; available in PMC 2013 Oct 26.

Published in final edited form as: Exp Biol Med (Maywood). 2012 Oct 1; 237(10): 1163–1172. Published online 2012 Oct 26. doi: 10.1258/ebm.2012.012106

PMCID:: PMC3510980

Article PDF–1.6M

Select item 34583866.

Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival

Maria Koulmanda, Manoj Bhasin, Zhigang Fan, Dusan Hanidziar, Nipun Goel, Prabhakar Putheti, Babak Movahedi, Towia A. Libermann, Terry B. Strom

Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38): 15443–15448. Published online 2012 Sep 4. doi: 10.1073/pnas.1018366109

PMCID:: PMC3458386

Article PDF–863K

Select item 34173647.

Alpha-1 Antitrypsin is Markedly Decreased Following Pulmonary F. tularensis Challenge

James P. Chambers, Jieh-Juen Yu, Madhulika Jupelli, Susan T. Weintraub, Jose L. Lopez-Ribot, James J. Valdes, Bernard P. Arulanandam

Front Cell Infect Microbiol. 2011; 1: 20. Published online 2011 Dec 26. doi: 10.3389/fcimb.2011.00020

PMCID:: PMC3417364

Article PDF–1.2M

Select item 40299788.

Rapid Renal Alpha-1 Antitrypsin Gene Induction in Experimental and Clinical Acute Kidney Injury

Richard A. Zager, Ali C. M. Johnson, Kirsten B. Frostad

PLoS One. 2014; 9(5): e98380. Published online 2014 May 21. doi: 10.1371/journal.pone.0098380

PMCID:: PMC4029978

Article PDF–1.9M

Select item 32586039.

Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation

Isao Tawara, Yaping Sun, Eli C. Lewis, Tomomi Toubai, Rebecca Evers, Evelyn Nieves, Tania Azam, Charles A. Dinarello, Pavan Reddy

Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2): 564–569. Published online 2011 Dec 27. doi: 10.1073/pnas.1117665109

PMCID:: PMC3258603

Article PDF–820K

Select item 318886410.

α-1-Antitrypsin Gene Delivery Reduces Inflammation, Increases T-Regulatory Cell Population Size and Prevents Islet Allograft Rejection

Galit Shahaf, Hadas Moser, Eyal Ozeri, Mark Mizrahi, Avishag Abecassis, Eli C Lewis

Mol Med. 2011 Sep-Oct; 17(9-10): 1000–1011. Published online 2011 Jun 9. doi: 10.2119/molmed.2011.00145

PMCID:: PMC3188864

Article PDF–2.5M

Select item 308376811.

Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes

Jianqiang Ding, Govardhana R. Yannam, Namita Roy-Chowdhury, Tunda Hidvegi, Hesham Basma, Stephen I. Rennard, Ronald J. Wong, Yesim Avsar, Chandan Guha, David H. Perlmutter, Ira J. Fox, Jayanta Roy-Chowdhury

J Clin Invest. 2011 May 2; 121(5): 1930–1934. Published online 2011 Apr 18. doi: 10.1172/JCI45260

PMCID:: PMC3083768

Article PDF–3.7M

Select item 136056812.

Serpina1 is a potent inhibitor of IL-8-induced hematopoietic stem cell mobilization

Melissa van Pel, Ronald van Os, Gerjo A. Velders, Henny Hagoort, Peter M. H. Heegaard, Ivan J. D. Lindley, Roel Willemze, Willem E. Fibbe

Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5): 1469–1474. Published online 2006 Jan 23. doi: 10.1073/pnas.0510192103

PMCID:: PMC1360568

Article PDF–498K

Select item 488375813.

Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus

Ahmed S. Elshikha, Yuanqing Lu, Mong-Jen Chen, Mohammad Akbar, Leilani Zeumer, Andrea Ritter, Hanaa Elghamry, Mahmoud A. Mahdi, Laurence Morel, Sihong Song

PLoS One. 2016; 11(5): e0156583. Published online 2016 May 27. doi: 10.1371/journal.pone.0156583

PMCID:: PMC4883758

Article PDF–3.8M

Select item 399057214.

Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium

Angelia D. Lockett, Mary Beth Brown, Nieves Santos-Falcon, Natalia I. Rush, Houssam Oueini, Amber J. Oberle, Esther Bolanis, Miryam A. Fragoso, Daniela N. Petrusca, Karina A. Serban, Kelly S. Schweitzer, Robert G. Presson Jr., Michael Campos, Irina Petrache

PLoS One. 2014; 9(4): e93979. Published online 2014 Apr 17. doi: 10.1371/journal.pone.0093979

PMCID:: PMC3990572

Article PDF–1.1M

Select item 1083008615.

Sirtuin3 promotes the degradation of hepatic Z alpha-1 antitrypsin through lipophagy

Brittney Poole, Regina Oshins, Zhiguang Huo, Alek Aranyos, Jesse West, Sergio Duarte, Virginia C. Clark, Thiago Beduschi, Ali Zarrinpar, Mark Brantly, Nazli Khodayari

Hepatol Commun. 2024 Feb; 8(2): e0370. Published online 2024 Jan 29. doi: 10.1097/HC9.0000000000000370

PMCID:: PMC10830086

Article PDF–1.4M

Select item 906947316.

Placental HTRA1 cleaves α₁-antitrypsin to generate a NET-inhibitory peptide

Robert A. Campbell, Heather D. Campbell, J. Samuel Bircher, Claudia Valeria de Araujo, Frederik Denorme, Jacob L. Crandell, John L. Rustad, Josh Monts, Mark J. Cody, Yasuhiro Kosaka, Christian C. Yost

Blood. 2021 Sep 16; 138(11): 977–988. Prepublished online 2021 Jun 30. doi: 10.1182/blood.2020009021

PMCID:: PMC9069473

Article

Select item 510711817.

Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation

Andrea Di Francesco, Clara Di Germanio, Amaresh C. Panda, Phu Huynh, Robert Peaden, Ignacio Navas-Enamorado, Paul Bastian, Elin Lehrmann, Alberto Diaz-Ruiz, David Ross, David Siegel, Jennifer L. Martindale, Michel Bernier, Myriam Gorospe, Kotb Abdelmohsen, Rafael de Cabo

Free Radic Biol Med. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Free Radic Biol Med. 2016 Oct; 99: 225–233. Published online 2016 Aug 8. doi: 10.1016/j.freeradbiomed.2016.08.005

PMCID:: PMC5107118

Article PDF–787K

Select item 538821818.

Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/α-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy

Lijie Feng, Jin Zhang, Na Zhu, Qian Ding, Xiaojie Zhang, Jishuang Yu, Weimin Qiang, Zhetao Zhang, Yuyang Ma, Dake Huang, Yujun Shen, Shengyun Fang, Yifan Yu, Haiping Wang, Yuxian Shen

Autophagy. 2017; 13(4): 686–702. Published online 2017 Jan 25. doi: 10.1080/15548627.2017.1280207