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Select item 58248551.

Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age-associated obesity

Geun Hyang Kim, Guojun Shi, Diane R.M. Somlo, Leena Haataja, Soobin Song, Qiaoming Long, Eduardo A. Nillni, Malcolm J. Low, Peter Arvan, Martin G. Myers, Jr., Ling Qi

J Clin Invest. 2018 Mar 1; 128(3): 1125–1140. Published online 2018 Feb 19. doi: 10.1172/JCI96420

PMCID:: PMC5824855

Article PDF–21M

Select item 56176492.

Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus

Daniel G. Bichet, Yoann Lussier

J Clin Invest. 2017 Oct 2; 127(10): 3591–3593. Published online 2017 Sep 18. doi: 10.1172/JCI96839

PMCID:: PMC5617649

Article PDF–1.8M

Select item 47515993.

Epithelial Sel1L is required for the maintenance of intestinal homeostasis

Shengyi Sun, Rohan Lourie, Sara B. Cohen, Yewei Ji, Julia K. Goodrich, Angela C. Poole, Ruth E. Ley, Eric Y. Denkers, Michael A. McGuckin, Qiaoming Long, Gerald E. Duhamel, Kenneth W. Simpson, Ling Qi

Mol Biol Cell. 2016 Feb 1; 27(3): 483–490. doi: 10.1091/mbc.E15-10-0724

PMCID:: PMC4751599

Article PDF–2.1M

Select item 47467014.

Crystal structure of SEL1L: Insight into the roles of SLR motifs in ERAD pathway

Hanbin Jeong, Hyo Jung Sim, Eun Kyung Song, Hakbong Lee, Sung Chul Ha, Youngsoo Jun, Tae Joo Park, Changwook Lee

Sci Rep. 2016; 6: 20261. Published online 2016 Feb 9. doi: 10.1038/srep20261

PMCID:: PMC4746701

Article PDF–2.3M

Select item 31213735.

Haploid Insufficiency of Suppressor Enhancer Lin12 1-like (SEL1L) Protein Predisposes Mice to High Fat Diet-induced Hyperglycemia

Adam B. Francisco, Rajni Singh, Haibo Sha, Xi Yan, Ling Qi, Xingen Lei, Qiaoming Long

J Biol Chem. 2011 Jun 24; 286(25): 22275–22282. Published online 2011 May 2. doi: 10.1074/jbc.M111.239418

PMCID:: PMC3121373

Article PDF–1.6M

Select item 30996886.

mSEL-1L (Suppressor/Enhancer Lin12-like) Protein Levels Influence Murine Neural Stem Cell Self-renewal and Lineage Commitment

Marina Cardano, Giuseppe R. Diaferia, Monica Cattaneo, Sara S. Dessì, Qiaoming Long, Luciano Conti, Pasquale DeBlasio, Elena Cattaneo, Ida Biunno

J Biol Chem. 2011 May 27; 286(21): 18708–18719. Published online 2011 Mar 31. doi: 10.1074/jbc.M110.210740

PMCID:: PMC3099688

Article PDF–3.4M

Select item 108733447.

SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex

Liangguang Leo Lin, Huilun Helen Wang, Brent Pederson, Xiaoqiong Wei, Mauricio Torres, You Lu, Zexin Jason Li, Xiaodan Liu, Hancheng Mao, Hui Wang, Linyao Elina Zhou, Zhen Zhao, Shengyi Sun, Ling Qi

Nat Commun. 2024; 15: 1440. Published online 2024 Feb 16. doi: 10.1038/s41467-024-45633-0

Correction in:: Nat Commun. 2024; 15: 3241.

PMCID:: PMC10873344

Article PDF–7.3M

Select item 58606968.

Inflammation arising from obesity reduces taste bud abundance and inhibits renewal

Andrew Kaufman, Ezen Choo, Anna Koh, Robin Dando

PLoS Biol. 2018 Mar; 16(3): e2001959. Published online 2018 Mar 20. doi: 10.1371/journal.pbio.2001959

PMCID:: PMC5860696

Article PDF–5.1M

Select item 39188159.

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

Shengyi Sun, Guojun Shi, Xuemei Han, Adam B. Francisco, Yewei Ji, Nuno Mendonça, Xiaojing Liu, Jason W. Locasale, Kenneth W. Simpson, Gerald E. Duhamel, Sander Kersten, John R. Yates, III, Qiaoming Long, Ling Qi

Proc Natl Acad Sci U S A. 2014 Feb 4; 111(5): E582–E591. Published online 2014 Jan 22. doi: 10.1073/pnas.1318114111

Correction in:: Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16): 6115.

PMCID:: PMC3918815

Article PDF–2.0M

Select item 1018547110.

SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool

Yewei Ji, Yuan Luo, Yating Wu, Yao Sun, Lianfeng Zhao, Zhen Xue, Mengqi Sun, Xiaoqiong Wei, Zinan He, Shuangcheng Alivia Wu, Liangguang Leo Lin, You Lu, Lei Chang, Fei Chen, Siyu Chen, Wei Qian, Xiaoxi Xu, Shengnuo Chen, Dongli Pan, Zhangsen Zhou, Sheng Xia, Chih-Chi Andrew Hu, Tingbo Liang, Ling Qi

Nat Cell Biol. 2023; 25(5): 726–739. Published online 2023 May 4. doi: 10.1038/s41556-023-01138-4

PMCID:: PMC10185471

Article PDF–22M

Select item 955061011.

SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer

Asmita Bhattacharya, Juncheng Wei, Wenxin Song, Beixue Gao, Chunyan Tian, Shuangcheng Alivia Wu, Jian Wang, Ligong Chen, Deyu Fang, Ling Qi

iScience. 2022 Oct 21; 25(10): 105183. Published online 2022 Sep 24. doi: 10.1016/j.isci.2022.105183

PMCID:: PMC9550610

Article PDF–6.4M

Select item 561765912.

ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis

Guojun Shi, Diane R.M. Somlo, Geun Hyang Kim, Cristina Prescianotto-Baschong, Shengyi Sun, Nicole Beuret, Qiaoming Long, Jonas Rutishauser, Peter Arvan, Martin Spiess, Ling Qi

J Clin Invest. 2017 Oct 2; 127(10): 3897–3912. Published online 2017 Sep 18. doi: 10.1172/JCI94771

PMCID:: PMC5617659

Article PDF–19M

Select item 979734113.

Integration of ER protein quality control mechanisms defines β cell function and ER architecture

Neha Shrestha, Mauricio Torres, Jason Zhang, You Lu, Leena Haataja, Rachel B. Reinert, Jeffrey Knupp, Yu-Jie Chen, Gunes Parlakgul, Ana Paula Arruda, Billy Tsai, Peter Arvan, Ling Qi

J Clin Invest. 2023 Jan 3; 133(1): e163584. Published online 2023 Jan 3. doi: 10.1172/JCI163584

PMCID:: PMC9797341

Article PDF–5.5M

Select item 623633114.

Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH

Asmita Bhattacharya, Shengyi Sun, Heting Wang, Ming Liu, Qiaoming Long, Lei Yin, Sander Kersten, Kezhong Zhang, Ling Qi

EMBO J. 2018 Nov 15; 37(22): e99277. Published online 2018 Nov 2. doi: 10.15252/embj.201899277

PMCID:: PMC6236331

Article PDF–4.1M

Select item 501458215.

The Sel1L-Hrd1 endoplasmic reticulum-associated degradation complex manages a key checkpoint in B cell development

Yewei Ji, Hana Kim, Liu Yang, Haibo Sha, Christopher A. Roman, Qiaoming Long, Ling Qi

Cell Rep. Author manuscript; available in PMC 2016 Sep 7.

Published in final edited form as: Cell Rep. 2016 Sep 6; 16(10): 2630–2640. Published online 2016 Aug 25. doi: 10.1016/j.celrep.2016.08.003

PMCID:: PMC5014582

Article PDF–1.3M

Select item 831579516.

Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

Xia Liu, Jingjing Yu, Longyong Xu, Katharine Umphred-Wilson, Fanglue Peng, Yao Ding, Brendan M Barton, Xiangdong Lv, Michael Y Zhao, Shengyi Sun, Yuning Hong, Ling Qi, Stanley Adoro, Xi Chen

eLife. 2021; 10: e69975. Published online 2021 Jul 9. doi: 10.7554/eLife.69975

PMCID:: PMC8315795

Article PDF–3.1M

Select item 788853817.

Protein Quality Control Through Endoplasmic Reticulum-Associated Degradation Maintains Hematopoietic Stem Cell Identity and Niche Interactions

Longyong Xu, Xia Liu, Fanglue Peng, Weijie Zhang, Liting Zheng, Yao Ding, Tianpeng Gu, Kaosheng Lv, Jin Wang, Laura Ortinau, Tianyuan Hu, Xiangguo Shi, Guojun Shi, Ge Shang, Shengyi Sun, Takao Iwawaki, Yewei Ji, Wei Li, Jeffrey M. Rosen, Xiang H.-F. Zhang, Dongsu Park, Stanley Adoro, Andre Catic, Wei Tong, Ling Qi, Daisuke Nakada, Xi Chen

Nat Cell Biol. Author manuscript; available in PMC 2021 Mar 21.

Published in final edited form as: Nat Cell Biol. 2020 Oct; 22(10): 1162–1169. Published online 2020 Sep 21. doi: 10.1038/s41556-020-00581-x

PMCID:: PMC7888538

Article PDF–2.7M

Select item 777056318.

ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

Lu Liu, Ayaka Inoki, Kelly Fan, Fengbiao Mao, Guojun Shi, Xi Jin, Meiling Zhao, Gina Ney, Morgan Jones, Shengyi Sun, Yali Dou, Ken Inoki, Ling Qi, Qing Li

Blood. 2020 Dec 24; 136(26): 2975–2986. Prepublished online 2020 Nov 4. doi: 10.1182/blood.2020007975

PMCID:: PMC7770563

Article

Select item 415653919.

The ER-Associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism

Haibo Sha, Shengyi Sun, Adams Francisco, Nicole Ehrhardt, Zhen Xue, Lei Liu, Peter Lawrence, Frits Mattijssen, Robert Guber, Muhammad S. Panhwar, J. Thomas Brenna, Hang Shi, Bingzhong Xue, Sander Kersten, André Bensadoun, Miklós Péterfy, Qiaoming Long, Ling Qi

Cell Metab. Author manuscript; available in PMC 2015 Sep 2.

Published in final edited form as: Cell Metab. 2014 Sep 2; 20(3): 458–470. Published online 2014 Jul 24. doi: 10.1016/j.cmet.2014.06.015

PMCID:: PMC4156539

Article PDF–1.7M

Select item 732419120.

Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling

Neha Shrestha, Tongyu Liu, Yewei Ji, Rachel B. Reinert, Mauricio Torres, Xin Li, Maria Zhang, Chih-Hang Anthony Tang, Chih-Chi Andrew Hu, Chengyang Liu, Ali Naji, Ming Liu, Jiandie D. Lin, Sander Kersten, Peter Arvan, Ling Qi

J Clin Invest. 2020 Jul 1; 130(7): 3499–3510. Published online 2020 May 26. doi: 10.1172/JCI134874

PMCID:: PMC7324191

Article PDF–18M

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