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Select item 108160631.

Acetyltransferase P300 Regulates Glucose Metabolic Reprogramming through Catalyzing Succinylation in Lung Cancer

Qingzhi Ma, Qingmei Zeng, Kun Wang, Meirui Qian, Jingzhuo Li, Hao Wang, Huijie Zhang, Jianli Jiang, Zhinan Chen, Wan Huang

Int J Mol Sci. 2024 Jan; 25(2): 1057. Published online 2024 Jan 15. doi: 10.3390/ijms25021057

PMCID:: PMC10816063

Abstract Article PDF–9.3M

Select item 104960812.

Novel heterozygous variants in the EP300 gene cause Rubinstein–Taybi syndrome 2: Reports from two Chinese children

Caiqi Du, Zhuoguang Li, Biao Zou, Xuesong Li, Fan Chen, Yan Liang, Xiaoping Luo, Sainan Shu

Mol Genet Genomic Med. 2023 Sep; 11(9): e2192. Published online 2023 May 10. doi: 10.1002/mgg3.2192

PMCID:: PMC10496081

Abstract Article PDF–952K

Select item 104750753.

TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition

Longxia Xu, Hongwen Xuan, Wei He, Liang Zhang, Mengying Huang, Kuai Li, Hong Wen, Han Xu, Xiaobing Shi

Nat Commun. 2023; 14: 5362. Published online 2023 Sep 2. doi: 10.1038/s41467-023-41245-2

PMCID:: PMC10475075

Abstract Article PDF–2.7M

Select item 104186474.

EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs

Karla Rubio, Alejandro Molina-Herrera, Andrea Pérez-González, Hury Viridiana Hernández-Galdámez, Carolina Piña-Vázquez, Tania Araujo-Ramos, Indrabahadur Singh

Int J Mol Sci. 2023 Aug; 24(15): 12302. Published online 2023 Aug 1. doi: 10.3390/ijms241512302

PMCID:: PMC10418647

Abstract Article PDF–1.4M

Select item 103348085.

EP300 facilitates human trophoblast stem cell differentiation

A. Jantine van Voorden, Remco Keijser, Geertruda J. M. Veenboer, Solange A. Lopes Cardozo, Dina Diek, Jennifer A. Vlaardingerbroek, Marie van Dijk, Carrie Ris-Stalpers, Ans M. M. van Pelt, Gijs B. Afink

Proc Natl Acad Sci U S A. 2023 Jul 11; 120(28): e2217405120. Published online 2023 Jul 5. doi: 10.1073/pnas.2217405120

PMCID:: PMC10334808

Abstract Article PDF–4.5M

Select item 101201446.

De novo variation in EP300 gene cause Rubinstein-Taybi syndrome 2 in a Chinese family with severe early-onset high myopia

Xiaoyu Huang, Xue Rui, Shuang Zhang, Xiaolong Qi, Weining Rong, Xunlun Sheng

BMC Med Genomics. 2023; 16: 84. Published online 2023 Apr 21. doi: 10.1186/s12920-023-01516-9

PMCID:: PMC10120144

Abstract Article PDF–1.5M

Select item 101191597.

Familial risk for depression is associated with reduced P300 and late positive potential to affective stimuli and prolonged cardiac deceleration to unpleasant stimuli

Tania Moretta, Simone Messerotti Benvenuti

Sci Rep. 2023; 13: 6432. Published online 2023 Apr 20. doi: 10.1038/s41598-023-33534-z

PMCID:: PMC10119159

Abstract Article PDF–1.4M

Select item 100466018.

Effects of the Acetyltransferase p300 on Tumour Regulation from the Novel Perspective of Posttranslational Protein Modification

Qingmei Zeng, Kun Wang, Yongxiang Zhao, Qingzhi Ma, Zhinan Chen, Wan Huang

Biomolecules. 2023 Mar; 13(3): 417. Published online 2023 Feb 22. doi: 10.3390/biom13030417

PMCID:: PMC10046601

Abstract Article PDF–2.1M

Select item 99141449.

Diabetes and Its Cardiovascular Complications: Potential Role of the Acetyltransferase p300

Nadia Di Pietrantonio, Pamela Di Tomo, Domitilla Mandatori, Gloria Formoso, Assunta Pandolfi

Cells. 2023 Feb; 12(3): 431. Published online 2023 Jan 28. doi: 10.3390/cells12030431

PMCID:: PMC9914144

Abstract Article PDF–1.1M

Select item 984398310.

Experimental analysis of bladder cancer-associated mutations in EP300 identifies EP300-R1627W as a driver mutation

Mayao Luo, Yifan Zhang, Zhuofan Xu, Shidong Lv, Qiang Wei, Qiang Dang

Mol Med. 2023; 29: 7. Published online 2023 Jan 16. doi: 10.1186/s10020-023-00608-7

PMCID:: PMC9843983

Abstract Article PDF–3.3M

Select item 866593611.

Mapping the residue specificities of epigenome enzymes by yeast surface display

Alison C. Waldman, Balaji M. Rao, Albert J. Keung

Cell Chem Biol. Author manuscript; available in PMC 2022 Dec 16.

Published in final edited form as: Cell Chem Biol. 2021 Dec 16; 28(12): 1772–1779.e4. Published online 2021 Jun 28. doi: 10.1016/j.chembiol.2021.05.022

PMCID:: PMC8665936

Abstract Article PDF–1.7M

Select item 862155812.

Hyperinsulinism in an individual with an EP300 variant of Rubinstein-Taybi syndrome

K. Taylor Wild, Tomoki T. Nomakuchi, Sarah E. Sheppard, Karla F. Leavens, Diva D. De León, Elaine H. Zackai

Am J Med Genet A. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Am J Med Genet A. 2021 Apr; 185(4): 1251–1255. Published online 2021 Jan 14. doi: 10.1002/ajmg.a.62085

PMCID:: PMC8621558

Abstract Article PDF–262K

Select item 840284413.

Beta-Genus Human Papillomavirus 8 E6 Destabilizes the Host Genome by Promoting p300 Degradation

Dalton Dacus, Nicholas A. Wallace

Viruses. 2021 Aug; 13(8): 1662. Published online 2021 Aug 21. doi: 10.3390/v13081662

PMCID:: PMC8402844

Abstract Article PDF–1.5M

Select item 832215614.

Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity

Yi Zhang, Kyle Brown, Yucong Yu, Ziad Ibrahim, Mohamad Zandian, Hongwen Xuan, Steven Ingersoll, Thomas Lee, Christopher C. Ebmeier, Jiuyang Liu, Daniel Panne, Xiaobing Shi, Xiaojun Ren, Tatiana G. Kutateladze

Nat Commun. 2021; 12: 4618. Published online 2021 Jul 29. doi: 10.1038/s41467-021-24950-8

PMCID:: PMC8322156

Abstract Article PDF–3.5M

Select item 765386615.

EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer

Alexander Ring, Pushpinder Kaur, Julie E. Lang

BMC Cancer. 2020; 20: 1076. Published online 2020 Nov 10. doi: 10.1186/s12885-020-07573-y

PMCID:: PMC7653866

Abstract Article PDF–3.1M

Select item 728705216.

In silico analysis reveals EP300 as a panCancer inhibitor of anti-tumor immune response via metabolic modulation

Rosemarie Krupar, Christian Watermann, Christian Idel, Julika Ribbat-Idel, Anne Offermann, Helen Pasternack, Jutta Kirfel, Andrew G. Sikora, Sven Perner

Sci Rep. 2020; 10: 9389. Published online 2020 Jun 10. doi: 10.1038/s41598-020-66329-7

PMCID:: PMC7287052

Abstract Article PDF–5.8M

Select item 704176517.

EP300 mutation is associated with tumor mutation burden and promotes antitumor immunity in bladder cancer patients

Gongmin Zhu, Lijiao Pei, Yuan Li, Xin Gou

Aging (Albany NY) 2020 Feb 15; 12(3): 2132–2141. Published online 2020 Feb 3. doi: 10.18632/aging.102728

PMCID:: PMC7041765

Abstract Article PDF–1.3M

Select item 691438418.

Transcription factor dimerization activates the p300 acetyltransferase

Esther Ortega, Srinivasan Rengachari, Ziad Ibrahim, Naghmeh Hoghoughi, Jonathan Gaucher, Alex S. Holehouse, Saadi Khochbin, Daniel Panne

Nature. Author manuscript; available in PMC 2019 Dec 16.

Published in final edited form as: Nature. 2019 Dec 9; 562(7728): 538–544. Published online 2018 Oct 15. doi: 10.1038/s41586-018-0621-1

PMCID:: PMC6914384

Abstract Article PDF–6.0M

Select item 681875519.

Metabolic regulation of gene expression by histone lactylation

Di Zhang, Zhanyun Tang, He Huang, Guolin Zhou, Chang Cui, Yejing Weng, Wenchao Liu, Sunjoo Kim, Sangkyu Lee, Mathew Perez-Neut, Daniel Czyz, Rong Hu, Zhen Ye, Maomao He, Y. George Zheng, Howard Shuman, Jun Ding, Lunzhi Dai, Bing Ren, Robert G. Roeder, Lev Becker, Yingming Zhao

Nature. Author manuscript; available in PMC 2020 Apr 23.

Published in final edited form as: Nature. 2019 Oct; 574(7779): 575–580. Published online 2019 Oct 23. doi: 10.1038/s41586-019-1678-1

PMCID:: PMC6818755

Abstract Article PDF–4.0M

Select item 668847920.

Histone acetyltransferase p300 induces de novo super-enhancers to drive cellular senescence

Payel Sen, Yemin Lan, Catherine Y. Li, Simone Sidoli, Greg Donahue, Zhixun Dou, Brian Frederick, Qijun Chen, Lacey J. Luense, Benjamin A. Garcia, Weiwei Dang, F. Bradley Johnson, Peter D. Adams, David C. Schultz, Shelley L. Berger

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 684–698.e8. Published online 2019 Feb 14. doi: 10.1016/j.molcel.2019.01.021