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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 84928752.

Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes

Hyeon-Ji Kang, Byong-Keol Min, Won-Il Choi, Jae-Han Jeon, Dong Wook Kim, Sungmi Park, Yun-Kyung Lee, Hwa-jin Kim, Ju-Eun Byeon, Younghoon Go, Hye Jin Ham, Yong Hyun Jeon, Mi-Jin Kim, Jung Yi Lee, Adam R. Wende, Sung Hee Choi, Robert A. Harris, In-Kyu Lee

Exp Mol Med. 2021 Sep; 53(9): 1390–1401. Published online 2021 Sep 22. doi: 10.1038/s12276-021-00672-1

PMCID:: PMC8492875

Article PDF–5.5M

Select item 67888073.

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function

Nora Yucel, Yu Xin Wang, Thach Mai, Ermelinda Porpiglia, Peder J. Lund, Glenn Markov, Benjamin A. Garcia, Sean C. Bendall, Michael Angelo, Helen M. Blau

Cell Rep. Author manuscript; available in PMC 2019 Oct 11.

Published in final edited form as: Cell Rep. 2019 Jun 25; 27(13): 3939–3955.e6. doi: 10.1016/j.celrep.2019.05.092

PMCID:: PMC6788807

Article PDF–2.3M

Select item 66054204.

Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis

Mithilesh Kumar Jha, Gyun Jee Song, Maan Gee Lee, Nam Ho Jeoung, Younghoon Go, Robert A. Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Suk

J Neurosci. 2015 Oct 21; 35(42): 14353–14369. doi: 10.1523/JNEUROSCI.1910-15.2015

PMCID:: PMC6605420

Article PDF–5.5M

Select item 65145285.

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype

Byong-Keol Min, Sungmi Park, Hyeon-Ji Kang, Dong Wook Kim, Hye Jin Ham, Chae-Myeong Ha, Byung-Jun Choi, Jung Yi Lee, Chang Joo Oh, Eun Kyung Yoo, Hui Eon Kim, Byung-Gyu Kim, Jae-Han Jeon, Do Young Hyeon, Daehee Hwang, Yong-Hoon Kim, Chul-Ho Lee, Taeho Lee, Jung-whan Kim, Yeon-Kyung Choi, Keun-Gyu Park, Ajay Chawla, Jongsoon Lee, Robert A. Harris, In-Kyu Lee

Front Immunol. 2019; 10: 944. Published online 2019 May 7. doi: 10.3389/fimmu.2019.00944

PMCID:: PMC6514528

Article PDF–9.8M

Select item 42463376.

Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance

Yasmeen Rahimi, João-Paulo G. Camporez, Max C. Petersen, Dominik Pesta, Rachel J. Perry, Michael J. Jurczak, Gary W. Cline, Gerald I. Shulman

Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46): 16508–16513. Published online 2014 Nov 3. doi: 10.1073/pnas.1419104111

PMCID:: PMC4246337

Article PDF–814K

Select item 40894527.

Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

Peter C. Harris, Vicente E. Torres

J Clin Invest. 2014 Jun 2; 124(6): 2315–2324. Published online 2014 Jun 2. doi: 10.1172/JCI72272

PMCID:: PMC4089452

Article PDF–1.5M

Select item 39243058.

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Ingrid Wernstedt-Asterholm, Lorraine K. Morlock, Kyle R. Owens, Philipp E. Scherer, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn, David T. Chuang

J Biol Chem. 2014 Feb 14; 289(7): 4432–4443. Published online 2013 Dec 19. doi: 10.1074/jbc.M113.533885

PMCID:: PMC3924305

Article PDF–2.8M

Select item 65928229.

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

Keiyo Takubo, Go Nagamatsu, Chiharu I. Kobayashi, Ayako Nakamura-Ishizu, Hiroshi Kobayashi, Eiji Ikeda, Nobuhito Goda, Yasmeen Rahimi, Randall S. Johnson, Tomoyoshi Soga, Atsushi Hirao, Makoto Suematsu, Toshio Suda

Cell Stem Cell. Author manuscript; available in PMC 2019 Jun 25.

Published in final edited form as: Cell Stem Cell. 2013 Jan 3; 12(1): 49–61. doi: 10.1016/j.stem.2012.10.011

PMCID:: PMC6592822

Article PDF–2.5M

Select item 634140310.

Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex

Alla Klyuyeva, Alina Tuganova, Natalia Kedishvili, Kirill M. Popov

J Biol Chem. 2019 Jan 18; 294(3): 838–851. Published online 2018 Nov 27. doi: 10.1074/jbc.RA118.006433

PMCID:: PMC6341403

Article PDF–2.7M

Select item 478673311.

Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy

Md Habibur Rahman, Mithilesh Kumar Jha, Jong-Heon Kim, Youngpyo Nam, Maan Gee Lee, Younghoon Go, Robert A. Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Suk

J Biol Chem. 2016 Mar 11; 291(11): 6011–6025. Published online 2016 Jan 14. doi: 10.1074/jbc.M115.699215

PMCID:: PMC4786733

Article PDF–3.1M

Select item 451084612.

Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation

Xiaojing Hou, Liang Zhang, Longsen Han, Juan Ge, Rujun Ma, Xuesen Zhang, Kelle Moley, Tim Schedl, Qiang Wang

J Cell Sci. 2015 Jul 1; 128(13): 2319–2329. doi: 10.1242/jcs.167049

PMCID:: PMC4510846

Article

Select item 432316113.

Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice

Nam Ho Jeoung, Yasmeen Rahimi, Pengfei Wu, W. N. Paul Lee, Robert A. Harris

Biochem J. Author manuscript; available in PMC 2015 Feb 10.

Published in final edited form as: Biochem J. 2012 May 1; 443(3): 829–839. doi: 10.1042/BJ20112197

PMCID:: PMC4323161

Article PDF–437K

Select item 272912614.

Mitochondrial mutations contribute to HIF1α accumulation via increased reactive oxygen species and upregulated PDK2 in head and neck squamous cell carcinoma

Wenyue Sun, Shaoyu Zhou, Steven S. Chang, Thomas McFate, Ajay Verma, Joseph A. Califano

Clin Cancer Res. Author manuscript; available in PMC 2010 Jan 15.

Published in final edited form as: Clin Cancer Res. 2009 Jan 15; 15(2): 476–484. doi: 10.1158/1078-0432.CCR-08-0930

PMCID:: PMC2729126

Article PDF–1.5M

Select item 373384715.

Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes

Rongya Tao, Xiwen Xiong, Robert A. Harris, Morris F. White, Xiaocheng C. Dong

PLoS One. 2013; 8(8): e71997. Published online 2013 Aug 5. doi: 10.1371/journal.pone.0071997

PMCID:: PMC3733847

Article PDF–1.1M

Select item 371111516.

Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2

Satoko Yoshiba, Hidetaka Shiratori, Ivana Y. Kuo, Aiko Kawasumi, Kyosuke Shinohara, Shigenori Nonaka, Yasuko Asai, Genta Sasaki, Jose Antonio Belo, Hiroshi Sasaki, Junichi Nakai, Bernd Dworniczak, Barbara E. Ehrlich, Petra Pennekamp, Hiroshi Hamada

Science. Author manuscript; available in PMC 2013 Jul 15.

Published in final edited form as: Science. 2012 Oct 12; 338(6104): 226–231. Published online 2012 Sep 13. doi: 10.1126/science.1222538

PMCID:: PMC3711115

Article PDF–2.0M

Select item 1019220817.

Genome-wide analysis of sex-specific differences in the mother–child PELAGIE cohort exposed to organophosphate metabolites

Martina Capriati, Chunxiang Hao, Shereen Cynthia D’Cruz, Christine Monfort, Cecile Chevrier, Charline Warembourg, Fatima Smagulova

Sci Rep. 2023; 13: 8003. Published online 2023 May 17. doi: 10.1038/s41598-023-35113-8

PMCID:: PMC10192208

Article PDF–3.0M

Select item 519349218.

PEG3 binds to H19-ICR as a transcriptional repressor

An Ye, Hongzhi He, Joomyeong Kim

Epigenetics. 2016; 11(12): 889–900. Published online 2016 Nov 8. doi: 10.1080/15592294.2016.1255385

PMCID:: PMC5193492

Article PDF–1.2M

Select item 768101219.

GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism

Lisha Wei, Yan-Yan Zheng, Jie Sun, Pei Wang, Tao Tao, Yeqiong Li, Xin Chen, Yongjuan Sang, Danyang Chong, Wei Zhao, Yuwei Zhou, Ye Wang, Zhihui Jiang, Tiantian Qiu, Chao-Jun Li, Min-Sheng Zhu, Xuena Zhang

J Biol Chem. 2020 Nov 20; 295(47): 15988–16001. Published online 2020 Sep 10. doi: 10.1074/jbc.RA120.015020

PMCID:: PMC7681012

Article PDF–3.6M

Select item 494642720.

Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series

Caitlyn E. Bowman, Liang Zhao, Thomas Hartung, Michael J. Wolfgang

Mol Cell Biol. 2016 Aug 1; 36(15): 2089–2104. Prepublished online 2016 May 23. Published online 2016 Jul 14. doi: 10.1128/MCB.00166-16

PMCID:: PMC4946427

Article PDF–3.4M

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