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Select item 61396461.

Cytosolic phosphoenolpyruvate carboxykinase as a cataplerotic pathway in the small intestine

Austin Potts, Aki Uchida, Stanislaw Deja, Eric D. Berglund, Blanka Kucejova, Joao A. Duarte, Xiaorong Fu, Jeffrey D. Browning, Mark A. Magnuson, Shawn C. Burgess

Am J Physiol Gastrointest Liver Physiol. 2018 Aug 1; 315(2): G249–G258. Published online 2018 Apr 6. doi: 10.1152/ajpgi.00039.2018

PMCID:: PMC6139646

Article

Select item 46298272.

Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors

Yong Li, Shunqun Luo, Ruihua Ma, Jing Liu, Pingwei Xu, Huafeng Zhang, Ke Tang, Junwei Ma, Yi Zhang, Xiaoyu Liang, Yanling Sun, Tiantian Ji, Ning Wang, Bo Huang

Cancer Res. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Cancer Res. 2015 Apr 1; 75(7): 1191–1196. Published online 2015 Feb 24. doi: 10.1158/0008-5472.CAN-14-2615

PMCID:: PMC4629827

Article PDF–858K

Select item 44846203.

Overexpression of the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) in Skeletal Muscle Repatterns Energy Metabolism in the Mouse

Parvin Hakimi, Jianqi Yang, Gemma Casadesus, Duna Massillon, Fatima Tolentino-Silva, Colleen K. Nye, Marco E. Cabrera, David R. Hagen, Christopher B. Utter, Yacoub Baghdy, David H. Johnson, David L. Wilson, John P. Kirwan, Satish C. Kalhan, Richard W. Hanson

J Biol Chem. Author manuscript; available in PMC 2015 Jun 29.

Published in final edited form as: J Biol Chem. 2007 Nov 9; 282(45): 32844–32855. Published online 2007 Aug 23. doi: 10.1074/jbc.M706127200

PMCID:: PMC4484620

Article PDF–3.1M

Select item 32234704.

Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized ¹³C magnetic resonance

Matthew E. Merritt, Crystal Harrison, A. Dean Sherry, Craig R. Malloy, Shawn C. Burgess

Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47): 19084–19089. Published online 2011 Nov 7. doi: 10.1073/pnas.1111247108

PMCID:: PMC3223470

Article PDF–455K

Select item 30355085.

Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice

Carrie A. Millward, David DeSantis, Chang-Wen Hsieh, Jason D. Heaney, Sorana Pisano, Yael Olswang, Lea Reshef, Michelle Beidelschies, Michelle Puchowicz, Colleen M. Croniger

J Lipid Res. 2010 Jun; 51(6): 1452–1463. doi: 10.1194/jlr.M005363

PMCID:: PMC3035508

Article PDF–938K

Select item 27774746.

Reduced Milk Triglycerides in Mice Lacking Phosphoenolpyruvate Carboxykinase in Mammary Gland Adipocytes and White Adipose Tissue Contribute to the Development of Insulin Resistance in Pups

Chang-Wen Hsieh, Carrie A. Millward, David DeSantis, Sorana Pisano, Jana Machova, Jose C. Perales, Colleen M. Croniger

J Nutr. 2009 Dec; 139(12): 2257–2265. doi: 10.3945/jn.109.113092

PMCID:: PMC2777474

Article PDF–970K

Select item 26800897.

Cytosolic Phosphoenolpyruvate Carboxykinase Does Not Solely Control the Rate of Hepatic Gluconeogenesis in the Intact Mouse Liver

Shawn C. Burgess, Tian Teng He, Zheng Yan, Jill Lindner, A. Dean Sherry, Craig R. Malloy, Jeffrey D. Browning, Mark A. Magnuson

Cell Metab. Author manuscript; available in PMC 2009 May 11.

Published in final edited form as: Cell Metab. 2007 Apr; 5(4): 313–320. doi: 10.1016/j.cmet.2007.03.004

PMCID:: PMC2680089

Article PDF–980K

Select item 13252338.

Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism

Parvin Hakimi, Mark T Johnson, Jianqi Yang, David F Lepage, Ronald A Conlon, Satish C Kalhan, Lea Reshef, Shirley M Tilghman, Richard W Hanson

Nutr Metab (Lond) 2005; 2: 33. Published online 2005 Nov 21. doi: 10.1186/1743-7075-2-33

PMCID:: PMC1325233

Article PDF–1.3M

Select item 447659.

Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.

A Valera, A Pujol, M Pelegrin, F Bosch

Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19): 9151–9154. doi: 10.1073/pnas.91.19.9151

PMCID:: PMC44765

Summary Page Browse PDF–981K

Select item 1068335410.

hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner

Weijie Hao, Zhimin Chen, Jingzhi Tang, Ru Yang, Wei-Qiang Gao, Huiming Xu

J Transl Med. 2023; 21: 861. Published online 2023 Nov 28. doi: 10.1186/s12967-023-04704-4

PMCID:: PMC10683354

Article PDF–4.8M

Select item 1031336211.

Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression

Dongmei Gou, Rui Liu, Xiaoqun Shan, Haijun Deng, Chang Chen, Jin Xiang, Yi Liu, Qingzhu Gao, Zhi Li, Ailong Huang, Kai Wang, Ni Tang

J Clin Invest. 2023 Jul 3; 133(13): e161713. Published online 2023 Jul 3. doi: 10.1172/JCI161713

PMCID:: PMC10313362

Article PDF–26M

Select item 1001509512.

Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Qian Ye, Yi Liu, Guiji Zhang, Haijun Deng, Xiaojun Wang, Lin Tuo, Chang Chen, Xuanming Pan, Kang Wu, Jiangao Fan, Qin Pan, Kai Wang, Ailong Huang, Ni Tang

Nat Commun. 2023; 14: 1402. Published online 2023 Mar 14. doi: 10.1038/s41467-023-37142-3

PMCID:: PMC10015095

Article PDF–4.2M

Select item 979914313.

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice

Ferrol I. Rome, Gregory L. Shobert, William C. Voigt, David B. Stagg, Patrycja Puchalska, Shawn C. Burgess, Peter A. Crawford, Curtis C. Hughey

Am J Physiol Endocrinol Metab. 2023 Jan 1; 324(1): E9–E23. Published online 2022 Nov 9. doi: 10.1152/ajpendo.00222.2022

PMCID:: PMC9799143

Article

Select item 826247914.

Multitissue ²H/¹³C flux analysis reveals reciprocal upregulation of renal gluconeogenesis in hepatic PEPCK-C–knockout mice

Mohsin Rahim, Clinton M. Hasenour, Tomasz K. Bednarski, Curtis C. Hughey, David H. Wasserman, Jamey D. Young

JCI Insight. 2021 Jun 22; 6(12): e149278. Published online 2021 Jun 22. doi: 10.1172/jci.insight.149278

PMCID:: PMC8262479

Article PDF–1.3M

Select item 583610915.

Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype

Chih-Wei Ko, Daniel Counihan, Jing Wu, Maria Hatzoglou, Michelle A. Puchowicz, Colleen M. Croniger

J Biol Chem. 2018 Mar 2; 293(9): 3399–3409. Published online 2018 Jan 9. doi: 10.1074/jbc.M117.819136

PMCID:: PMC5836109

Article PDF–595K

Select item 466580016.

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

Santhosh Satapati, Blanka Kucejova, Joao A.G. Duarte, Justin A. Fletcher, Lacy Reynolds, Nishanth E. Sunny, Tianteng He, L. Arya Nair, Kenneth Livingston, Xiaorong Fu, Matthew E. Merritt, A. Dean Sherry, Craig R. Malloy, John M. Shelton, Jennifer Lambert, Elizabeth J. Parks, Ian Corbin, Mark A. Magnuson, Jeffrey D. Browning, Shawn C. Burgess

J Clin Invest. 2015 Dec 1; 125(12): 4447–4462. Published online 2015 Nov 16. doi: 10.1172/JCI82204