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Select item 28950681.

Population robustness arising from cellular heterogeneity

Pawel Paszek, Sheila Ryan, Louise Ashall, Kate Sillitoe, Claire V. Harper, David G. Spiller, David A. Rand, Michael R. H. White

Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25): 11644–11649. Published online 2010 Jun 7. doi: 10.1073/pnas.0913798107

PMCID:: PMC2895068

Abstract Article PDF–966K

Select item 249822.

Cloning and functional characterization of mouse IκBɛ

Simos Simeonidis, Stanley Liang, Guoying Chen, Dimitris Thanos

Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26): 14372–14377. doi: 10.1073/pnas.94.26.14372

PMCID:: PMC24982

Abstract Article PDF–395K

Select item 64433373.

Proteasome activator REGγ promotes inflammation in Leydig cells via IkBε signaling

Tiancheng Xie, Hui Chen, Shihui Shen, Tingmei Huang, Bisheng Huang, Guanghui Hu, Lei Li, Yunfei Xu

Int J Mol Med. 2019 May; 43(5): 1961–1968. Published online 2019 Feb 27. doi: 10.3892/ijmm.2019.4115

PMCID:: PMC6443337

Abstract Article PDF–1.6M

Select item 31678474.

Inhibitor of Kappa B Epsilon (IκBε) Is a Non-Redundant Regulator of c-Rel-Dependent Gene Expression in Murine T and B Cells

Joanna M. Clark, Karolina Aleksiyadis, Alex Martin, Kay McNamee, Tharsana Tharmalingam, Richard O. Williams, Sylvie Mémet, Andrew P. Cope

PLoS One. 2011; 6(9): e24504. Published online 2011 Sep 6. doi: 10.1371/journal.pone.0024504

PMCID:: PMC3167847

Abstract Article PDF–1.8M

Select item 3076485.

IκBα/IκBε deficiency reveals that a critical NF-κB dosage is required for lymphocyte survival

Bertrand Goudeau, François Huetz, Sandrine Samson, James P. Di Santo, Ana Cumano, Amer Beg, Alain Israël, Sylvie Mémet

Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26): 15800–15805. Published online 2003 Dec 9. doi: 10.1073/pnas.2535880100

PMCID:: PMC307648

Abstract Article PDF–765K

Select item 50340636.

The Nuclear Protein IκBζ Forms a Transcriptionally Active Complex with Nuclear Factor-κB (NF-κB) p50 and the Lcn2 Promoter via the N- and C-terminal Ankyrin Repeat Motifs

Akira Kohda, Soh Yamazaki, Hideki Sumimoto

J Biol Chem. 2016 Sep 23; 291(39): 20739–20752. Published online 2016 Aug 3. doi: 10.1074/jbc.M116.719302

PMCID:: PMC5034063

Abstract Article PDF–6.2M

Select item 47648997.

The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

Jinjin Xu, Lei Zhou, Lei Ji, Fengyuan Chen, Karen Fortmann, Kun Zhang, Qingwu Liu, Ke Li, Weicang Wang, Hao Wang, Wei Xie, Qingwei Wang, Jiang Liu, Biao Zheng, Pei Zhang, Shixia Huang, Tieliu Shi, Biaohong Zhang, Yongyan Dang, Jiwu Chen, Bert W. O'Malley, Robb E. Moses, Ping Wang, Lei Li, Jianru Xiao, Alexander Hoffmann, Xiaotao Li

Nat Commun. 2016; 7: 10761. Published online 2016 Feb 22. doi: 10.1038/ncomms10761

PMCID:: PMC4764899

Abstract Article PDF–2.9M

Select item 26737088.

A homeostatic model of IκB metabolism to control constitutive NF-κB activity

Ellen L O'Dea, Derren Barken, Raechel Q Peralta, Kim T Tran, Shannon L Werner, Jeffrey D Kearns, Andre Levchenko, Alexander Hoffmann

Mol Syst Biol. 2007; 3: 111. Published online 2007 May 8. doi: 10.1038/msb4100148

PMCID:: PMC2673708

Abstract Article PDF–216K

Select item 81841279.

Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses

Adewunmi Adelaja, Brooks Taylor, Katherine M. Sheu, Yi Liu, Stefanie Luecke, Alexander Hoffmann

Immunity. Author manuscript; available in PMC 2021 Jun 7.

Published in final edited form as: Immunity. 2021 May 11; 54(5): 916–930.e7. doi: 10.1016/j.immuni.2021.04.011

PMCID:: PMC8184127

Abstract Article PDF–3.0M

Select item 727164910.

IκBα deficiency imposes a fetal phenotype to intestinal stem cells

Laura Marruecos, Joan Bertran, Yolanda Guillén, Jéssica González, Raquel Batlle, Erika López‐Arribillaga, Marta Garrido, Cristina Ruiz‐Herguido, Dominique Lisiero, Mónica González‐Farré, Sara Arce‐Gallego, Mar Iglesias, Angel R Nebreda, Shigeki Miyamoto, Anna Bigas, Lluís Espinosa

EMBO Rep. 2020 Jun 4; 21(6): e49708. Published online 2020 Apr 9. doi: 10.15252/embr.201949708

PMCID:: PMC7271649

Abstract Article PDF–12M

Select item 396564211.

IκBε is a key regulator of B-cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner

Bryce N. Alves, Rachel Tsui, Jon Almaden, Maxim N. Shokhirev, Jeremy Davis-Turak, Jessica Fujimoto, Harry Birnbaum, Julia Ponomarenko, Alexander Hoffmann

J Immunol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: J Immunol. 2014 Apr 1; 192(7): 3121–3132. Published online 2014 Mar 3. doi: 10.4049/jimmunol.1302351

PMCID:: PMC3965642

Abstract Article PDF–3.2M

Select item 848985512.

NFκB Dynamics Determine the Stimulus-Specificity of Epigenomic Reprogramming in Macrophages

Quen J. Cheng, Sho Ohta, Katherine M. Sheu, Roberto Spreafico, Adewunmi Adelaja, Brooks Taylor, Alexander Hoffmann

Science. Author manuscript; available in PMC 2021 Oct 4.

Published in final edited form as: Science. 2021 Jun 18; 372(6548): 1349–1353. doi: 10.1126/science.abc0269

PMCID:: PMC8489855

Abstract Article PDF–1.4M

Select item 363461113.

Control of RelB during dendritic cell activation integrates canonical and non-canonical NF-?B pathways

Vincent F.-S. Shih, Jeremy Davis-Turak, Monica Macal, Jenny Q. Huang, Julia Ponomarenko, Jeffrey D. Kearns, Tony Yu, Riku Fagerlund, Masataka Asagiri, Elina I. Zuniga, Alexander Hoffmann

Nat Immunol. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: Nat Immunol. 2012 Dec; 13(12): 1162–1170. Published online 2012 Oct 21. doi: 10.1038/ni.2446

PMCID:: PMC3634611

Abstract Article PDF–1.3M

Select item 40366714.

Comparative Analysis of Apoptosis and Inflammation Genes of Mice and Humans

John C. Reed, Kutbuddin Doctor, Ana Rojas, Juan M. Zapata, Christian Stehlik, Loredana Fiorentino, Jason Damiano, Wilfried Roth, Shu-ichi Matsuzawa, Ruchi Newman, Shinichi Takayama, Hiroyuki Marusawa, Famming Xu, Guy Salvesen, RIKEN GER Group, GSL Members, Adam Godzik

Genome Res. 2003 Jun; 13(6b): 1376–1388. doi: 10.1101/gr.1053803

PMCID:: PMC403667

Abstract Article PDF–157K

Select item 343984515.

A Genome-Wide Screen to Identify Transcription Factors Expressed in Pelvic Ganglia of the Lower Urinary Tract

Carrie B. Wiese, Sara Ireland, Nicole L. Fleming, Jing Yu, M. Todd Valerius, Kylie Georgas, Han Sheng Chiu, Jane Brennan, Jane Armstrong, Melissa H. Little, Andrew P. McMahon, E. Michelle Southard-Smith

Front Neurosci. 2012; 6: 130. Published online 2012 Sep 12. doi: 10.3389/fnins.2012.00130

PMCID:: PMC3439845

Abstract Article PDF–1.4M

Select item 574645516.

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals Molecular Determinants of Redox Homeostasis and NF-κB Signaling

Ramy H. Malty, Hiroyuki Aoki, Ashwani Kumar, Sadhna Phanse, Shahreen Amin, Qingzhou Zhang, Zoran Minic, Florian Goebels, Gabriel Musso, Zhuoran Wu, Hosam Abou-tok, Michael Meyer, Viktor Deineko, Sandy Kassir, Vishaldeep Sidhu, Matthew Jessulat, Nichollas E. Scott, Xuejian Xiong, James Vlasblom, Bhanu Prasad, Leonard J. Foster, Tiziana Alberio, Barbara Garavaglia, Haiyuan Yu, Gary D. Bader, Ken Nakamura, John Parkinson, Mohan Babu

Cell Syst. Author manuscript; available in PMC 2018 Dec 27.

Published in final edited form as: Cell Syst. 2017 Dec 27; 5(6): 564–577.e12. Published online 2017 Nov 8. doi: 10.1016/j.cels.2017.10.010

PMCID:: PMC5746455

Abstract Article PDF–3.3M

Select item 311015117.

A Systems Approach Reveals that the Myogenesis Genome Network Is Regulated by the Transcriptional Repressor RP58

Shigetoshi Yokoyama, Yoshiaki Ito, Hiroe Ueno-Kudoh, Hirohito Shimizu, Kenta Uchibe, Sonia Albini, Kazuhiko Mitsuoka, Shigeru Miyaki, Minako Kiso, Akane Nagai, Tomohiro Hikata, Tadahiro Osada, Noritsugu Fukuda, Satoshi Yamashita, Daisuke Harada, Valeria Mezzano, Masataka Kasai, Pier Lorenzo Puri, Yoshihide Hayashizaki, Haruo Okado, Megumi Hashimoto, Hiroshi Asahara

Dev Cell. Author manuscript; available in PMC 2011 Jun 7.

Published in final edited form as: Dev Cell. 2009 Dec; 17(6): 836–848. doi: 10.1016/j.devcel.2009.10.011

PMCID:: PMC3110151

Abstract Article PDF–2.0M

Select item 431955918.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 141356819.

BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System

Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M Batten, Christopher Eden, Shannon M Norland, Dennis S Rice, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran

PLoS Biol. 2006 Apr; 4(4): e86. Published online 2006 Mar 28. doi: 10.1371/journal.pbio.0040086

PMCID:: PMC1413568

Article PDF–99K

Select item 357241020.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

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