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Select item 96812101.

Mcm2 promotes stem cell differentiation via its ability to bind H3-H4

Xiaowei Xu, Xu Hua, Kyle Brown, Xiaojun Ren, Zhiguo Zhang

eLife. 2022; 11: e80917. Published online 2022 Nov 10. doi: 10.7554/eLife.80917

PMCID:: PMC9681210

Article PDF–12M

Select item 93771542.

Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context

Toshihiro Matsukawa, Mianmian Yin, Timour Baslan, Yang Jo Chung, Dengchao Cao, Ryan Bertoli, Yuelin J. Zhu, Robert L. Walker, Amy Freeland, Erik Knudsen, Scott W. Lowe, Paul S. Meltzer, Peter D. Aplan

FASEB J. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: FASEB J. 2022 Sep; 36(9): e22430. doi: 10.1096/fj.202200061RR

PMCID:: PMC9377154

Article PDF–2.6M

Select item 69620243.

A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia

Mianmian Yin, Timour Baslan, Robert L. Walker, Yuelin J. Zhu, Amy Freeland, Toshihiro Matsukawa, Sriram Sridharan, André Nussenzweig, Steven C. Pruitt, Scott W. Lowe, Paul S. Meltzer, Peter D. Aplan

JCI Insight. 2019 Dec 5; 4(23): e131434. Published online 2019 Dec 5. doi: 10.1172/jci.insight.131434

PMCID:: PMC6962024

Article PDF–23M

Select item 52425454.

A Signature of Genomic Instability Resulting from Deficient Replication Licensing

Steven C. Pruitt, Maochun Qin, Jianmin Wang, Dimiter Kunnev, Amy Freeland

PLoS Genet. 2017 Jan; 13(1): e1006547. Published online 2017 Jan 3. doi: 10.1371/journal.pgen.1006547

PMCID:: PMC5242545

Article PDF–2.6M

Select item 47131005.

Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation

Gongshi Bai, Marcus B. Smolka, John C. Schimenti

PLoS Genet. 2016 Jan; 12(1): e1005787. Published online 2016 Jan 14. doi: 10.1371/journal.pgen.1005787

PMCID:: PMC4713100

Article PDF–4.3M

Select item 43815276.

Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins

Dimiter Kunnev, Amy Freeland, Maochun Qin, Robert W. Leach, Jianmin Wang, Rajani M. Shenoy, Steven C. Pruitt

Genome Res. 2015 Apr; 25(4): 558–569. doi: 10.1101/gr.176099.114

PMCID:: PMC4381527

Article PDF–1.5M

Select item 33870037.

Minichromosome Maintenance 2 Bound with Retroviral Gp70 Is Localized to Cytoplasm and Enhances DNA-Damage-Induced Apoptosis

Shinya Abe, Morito Kurata, Shiho Suzuki, Kouhei Yamamoto, Ken-ichi Aisaki, Jun Kanno, Masanobu Kitagawa

PLoS One. 2012; 7(6): e40129. Published online 2012 Jun 29. doi: 10.1371/journal.pone.0040129

PMCID:: PMC3387003

Article PDF–4.1M

Select item 33091118.

Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma

Michael E. Rusiniak, Dimiter Kunnev, Amy Freeland, Gillian K. Cady, Steven C. Pruitt

Oncogene. Author manuscript; available in PMC 2013 Mar 6.

Published in final edited form as: Oncogene. 2012 Sep 6; 31(36): 4034–4044. Published online 2011 Dec 12. doi: 10.1038/onc.2011.566

PMCID:: PMC3309111

Article PDF–2.5M

Select item 33672059.

Post-transcriptional homeostasis and regulation of MCM2–7 in mammalian cells

Chen-Hua Chuang, Dian Yang, Gongshi Bai, Amy Freeland, Steven C. Pruitt, John C. Schimenti

Nucleic Acids Res. 2012 Jun; 40(11): 4914–4924. Published online 2012 Feb 22. doi: 10.1093/nar/gks176

PMCID:: PMC3367205

Article PDF–3.5M

Select item 678293210.

A_2A Adenosine Receptor Deficiency Attenuates Brain Injury Induced by Transient Focal Ischemia in Mice

Jiang-Fan Chen, Zhihong Huang, Jianya Ma, JinMin Zhu, Rosario Moratalla, David Standaert, Michael A. Moskowitz, J. Stephen Fink, Michael A. Schwarzschild

J Neurosci. 1999 Nov 1; 19(21): 9192–9200. doi: 10.1523/JNEUROSCI.19-21-09192.1999

PMCID:: PMC6782932

Article PDF–290K

Select item 289201911.

DNA Damage Response and Tumorigenesis in Mcm2 Deficient Mice

Dimiter Kunnev, Michael E. Rusiniak, Angela Kudla, Amy Freeland, Gillian K. Cady, Steven C. Pruitt

Oncogene. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Oncogene. 2010 Jun 24; 29(25): 3630–3638. Published online 2010 May 3. doi: 10.1038/onc.2010.125

PMCID:: PMC2892019

Article PDF–1.3M

Select item 1001835212.

The importance of nuclear RAGE–Mcm2 axis in diabetes or cancer-associated replication stress

Zhe Han, Martin Andrš, Bindhu K Madhavan, Serap Kaymak, Alba Sulaj, Zoltan Kender, Stefan Kopf, Lars Kihm, Rainer Pepperkok, Pavel Janscak, Peter Nawroth, Varun Kumar

Nucleic Acids Res. 2023 Mar 21; 51(5): 2298–2318. Published online 2023 Feb 21. doi: 10.1093/nar/gkad085

PMCID:: PMC10018352

Article PDF–8.2M

Select item 352870013.

GFAPδ Expression in Glia of the Developmental and Adolescent Mouse Brain

Carlyn Mamber, Willem Kamphuis, Nina L. Haring, Nuzrat Peprah, Jinte Middeldorp, Elly M. Hol

PLoS One. 2012; 7(12): e52659. Published online 2012 Dec 21. doi: 10.1371/journal.pone.0052659

PMCID:: PMC3528700

Article PDF–6.9M

Select item 293822714.

Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2–7 complex

Lena R. Kundu, Yuji Kumata, Naoko Kakusho, Saori Watanabe, Asako Furukohri, Shou Waga, Masayuki Seki, Hisao Masai, Takemi Enomoto, Shusuke Tada

Nucleic Acids Res. 2010 Sep; 38(16): 5409–5418. Published online 2010 Apr 26. doi: 10.1093/nar/gkq262

PMCID:: PMC2938227

Article PDF–3.2M

Select item 649694615.

A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

Daniel A. Berg, Yijing Su, Dennisse Jimenez-Cyrus, Aneek Patel, Nancy Huang, David Morizet, Stephanie Lee, Reeti Shah, Francisca Rojas Ringeling, Rajan Jain, Jonathan A. Epstein, Qing-Feng Wu, Stefan Canzar, Guo-li Ming, Hongjun Song, Allison M. Bond

Cell. Author manuscript; available in PMC 2020 Apr 18.

Published in final edited form as: Cell. 2019 Apr 18; 177(3): 654–668.e15. Published online 2019 Mar 28. doi: 10.1016/j.cell.2019.02.010

PMCID:: PMC6496946

Article PDF–4.4M

Select item 293653916.

Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress

Chen-Hua Chuang, Marsha D. Wallace, Christian Abratte, Teresa Southard, John C. Schimenti

PLoS Genet. 2010 Sep; 6(9): e1001110. Published online 2010 Sep 9. doi: 10.1371/journal.pgen.1001110

PMCID:: PMC2936539

Article PDF–2.6M

Select item 301954917.

Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload

Marjorie A. Kuipers, Timothy J. Stasevich, Takayo Sasaki, Korey A. Wilson, Kristin L. Hazelwood, James G. McNally, Michael W. Davidson, David M. Gilbert

J Cell Biol. 2011 Jan 10; 192(1): 29–41. doi: 10.1083/jcb.201007111