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Items: 1 to 20 of 56

1.
Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study
Yu Shimizu, Kiminori Nakamura, Mani Kikuchi, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Akihiro Imae, Takafumi Nakagawa, Ryodai Yamamura, Akiko Tamakoshi, Tokiyoshi Ayabe
GeroScience. 2022 Apr; 44(2): 997–1009. Published online 2021 Jun 8. doi: 10.1007/s11357-021-00398-y
PMCID:
PMC9135951
ArticlePDF–927K
2.
Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn’s colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease
Tanu Rana, Olga Y. Korolkova, Girish Rachakonda, Amanda D. Williams, Alexander T. Hawkins, Samuel D. James, Amos M. Sakwe, Nian Hui, Li Wang, Chang Yu, Jeffrey S. Goodwin, Michael G. Izban, Regina S. Offodile, Mary K. Washington, Billy R. Ballard, Duane T. Smoot, Xuan-Zheng Shi, Digna S. Forbes, Anil Shanker, Amosy E. M’Koma
PLoS One. 2021; 16(3): e0246393. Published online 2021 Mar 9. doi: 10.1371/journal.pone.0246393
PMCID:
PMC7942995
ArticlePDF–2.0M
3.
An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease
Armin Rashidi, Adam Herman, Antonio LC Gomes, Jonathan U. Peled, Robert R. Jenq, Daniel G. Brereton, Christopher Staley, Bruce R. Blazar, Daniel J. Weisdorf
Br J Haematol. Author manuscript; available in PMC 2021 Jun 1.
Published in final edited form as: Br J Haematol. 2020 Jun; 189(5): 926–930. Published online 2020 Feb 21. doi: 10.1111/bjh.16458
PMCID:
PMC7536617
ArticlePDF–344K
4.
Human Enteric Defensin 5 Promotes Shigella Infection of Macrophages
Dan Xu, Chongbing Liao, Jiu Xiao, Kun Fang, Wei Zhang, Weirong Yuan, Wuyuan Lu
Infect Immun. 2020 Jan; 88(1): e00769-19. Prepublished online 2019 Oct 14. Published online 2019 Dec 17. doi: 10.1128/IAI.00769-19
PMCID:
PMC6921650
ArticlePDF–2.0M
5.
Age-of-Diagnosis Dependent Ileal Immune Intensification and Reduced Alpha-Defensin in Older versus Younger Pediatric Crohn Disease Patients despite Already Established Dysbiosis
Yael Haberman, Melanie Schirmer, Phillip J. Dexheimer, Rebekah Karns, Tzipi Braun, Mi-Ok Kim, Thomas D. Walters, Robert N. Baldassano, Joshua D Noe, Joel Rosh, James Markowitz, Wallace V. Crandall, David R. Mack, Anne M. Griffiths, Melvin B. Heyman, Susan S. Baker, Richard Kellermayer, Dedrick Moulton, Ashish S. Patel, Ajay S. Gulati, Steven J Steiner, Neal LeLeiko, Anthony Otley, Maria Oliva-Hemker, David Ziring, Barbara S Kirschner, David J Keljo, Stephen L. Guthery, Stanley A Cohen, Scott Snapper, Jonathan Evans, Marla Dubinsky, Bruce Aronow, Jeffrey S. Hyams, Subra Kugathasan, Curtis Huttenhower, Ramnik J. Xavier, Lee A. Denson
Mucosal Immunol. Author manuscript; available in PMC 2019 Jun 12.
Published in final edited form as: Mucosal Immunol. 2019 Mar; 12(2): 491–502. Published online 2018 Dec 12. doi: 10.1038/s41385-018-0114-4
PMCID:
PMC6375755
ArticlePDF–2.0M
6.
Alpha‐defensins (α‐Defs) in Crohn's disease: decrease of ileal α‐Def 5 via permanent methylation and increase in plasma α‐Def 1‐3 concentrations offering biomarker utility
E. Cerrillo, I. Moret, M. Iborra, D. Ramos, E. Busó, L. Tortosa, E. Sáez‐González, P. Nos, B. Beltrán
Clin Exp Immunol. 2018 Apr; 192(1): 120–128. Published online 2018 Jan 10. doi: 10.1111/cei.13085
PMCID:
PMC5842403
ArticlePDF–511K
7.
Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease
Amanda D. Williams, Olga Y. Korolkova, Amos M. Sakwe, Timothy M. Geiger, Samuel D. James, Roberta L. Muldoon, Alan J. Herline, J. Shawn Goodwin, Michael G. Izban, Mary K. Washington, Duane T. Smoot, Billy R. Ballard, Maria Gazouli, Amosy E. M'Koma
PLoS One. 2017; 12(8): e0179710. Published online 2017 Aug 17. doi: 10.1371/journal.pone.0179710
Correction in:
PLoS One. 2017; 12(12): e0189551.
PMCID:
PMC5560519
ArticlePDF–24M
8.
Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy
Charles Vragniau, Jens-Martin Hübner, Peter Beidler, Sucheol Gil, Kamola Saydaminova, Zhuo-Zhuang Lu, Roma Yumul, Hongjie Wang, Maximilian Richter, Pavel Sova, Charles Drescher, Pascal Fender, André Lieber
J Virol. 2017 Mar 15; 91(6): e02030-16. Prepublished online 2017 Jan 11. Published online 2017 Feb 28. doi: 10.1128/JVI.02030-16
PMCID:
PMC5331826
ArticlePDF–2.9M
9.
Visualizing Attack of Escherichia coli by the Antimicrobial Peptide Human Defensin 5
Haritha R. Chileveru, Shion A. Lim, Phoom Chairatana, Andrew J. Wommack, I-Ling Chiang, Elizabeth M. Nolan
Biochemistry. Author manuscript; available in PMC 2017 Jan 27.
Published in final edited form as: Biochemistry. 2015 Mar 10; 54(9): 1767–1777. Published online 2015 Mar 2. doi: 10.1021/bi501483q
PMCID:
PMC5270551
ArticlePDF–1.7M
10.
α-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome
Mayim E. Wiens, Jason G. Smith
mBio. 2017 Jan-Feb; 8(1): e02304-16. Published online 2017 Jan 24. doi: 10.1128/mBio.02304-16
PMCID:
PMC5263252
ArticlePDF–2.6M
11.
Conformational landscape and pathway of disulfide bond reduction of human alpha defensin
Joost Snijder, Michiel van de Waterbeemd, Matthew S Glover, Liuqing Shi, David E Clemmer, Albert J R Heck
Protein Sci. 2015 Aug; 24(8): 1264–1271. Published online 2015 May 27. doi: 10.1002/pro.2694
PMCID:
PMC4534177
ArticlePDF–518K
12.
A Bacterial Mutant Library as a Tool to Study the Attack of a Defensin Peptide
Simone Moser, Haritha R. Chileveru, Jill Tomaras, Elizabeth M. Nolan
Chembiochem. Author manuscript; available in PMC 2015 Dec 15.
Published in final edited form as: Chembiochem. 2014 Dec 15; 15(18): 2684–2688. Published online 2014 Nov 27. doi: 10.1002/cbic.201402354
PMCID:
PMC4341900
ArticlePDF–1.1M
13.
The Human Alpha Defensin HD5 Neutralizes JC Polyomavirus Infection by Reducing Endoplasmic Reticulum Traffic and Stabilizing the Viral Capsid
Stephen R. Zins, Christian D. S. Nelson, Melissa S. Maginnis, Rahul Banerjee, Bethany A. O'Hara, Walter J. Atwood
J Virol. 2014 Jan; 88(2): 948–960. doi: 10.1128/JVI.02766-13
PMCID:
PMC3911681
ArticlePDF–2.0M
14.
Reduction of Human Defensin 5 Affords a High-Affinity Zinc-Chelating Peptide
Yunfei Zhang, Fabien B. L. Cougnon, Yoshitha A. Wanniarachchi, Joshua A. Hayden, Elizabeth M. Nolan
ACS Chem Biol. Author manuscript; available in PMC 2014 Sep 20.
Published in final edited form as: ACS Chem Biol. 2013 Sep 20; 8(9): 1907–1911. Published online 2013 Jul 10. doi: 10.1021/cb400340k
PMCID:
PMC3783636
ArticlePDF–2.1M
15.
An Intrinsically Disordered Region of the Adenovirus Capsid Is Implicated in Neutralization by Human Alpha Defensin 5
Justin W. Flatt, Robert Kim, Jason G. Smith, Glen R. Nemerow, Phoebe L. Stewart
PLoS One. 2013; 8(4): e61571. Published online 2013 Apr 19. doi: 10.1371/journal.pone.0061571
PMCID:
PMC3631211
ArticlePDF–2.6M
16.
NMR Solution Structure and Condition-Dependent Oligomerization of the Antimicrobial Peptide Human Defensin 5
Andrew J. Wommack, Scott A. Robson, Yoshitha A. Wanniarachchi, Andrea Wan, Christopher J. Turner, Gerhard Wagner, Elizabeth M. Nolan
Biochemistry. Author manuscript; available in PMC 2013 Dec 4.
Published in final edited form as: Biochemistry. 2012 Dec 4; 51(48): 9624–9637. Published online 2012 Nov 19. doi: 10.1021/bi301255u
PMCID:
PMC3579768
ArticlePDF–1.2M
17.
Functional Determinants of Human Enteric α-Defensin HD5: CRUCIAL ROLE FOR HYDROPHOBICITY AT DIMER INTERFACE
Mohsen Rajabi, Bryan Ericksen, Xueji Wu, Erik de Leeuw, Le Zhao, Marzena Pazgier, Wuyuan Lu
J Biol Chem. 2012 Jun 22; 287(26): 21615–21627. Published online 2012 May 9. doi: 10.1074/jbc.M112.367995
PMCID:
PMC3381126
ArticlePDF–4.3M
18.
Direct Evidence from Single-Cell Analysis that Human α-Defensins Block Adenovirus Uncoating To Neutralize Infection
Emily K. Nguyen, Glen R. Nemerow, Jason G. Smith
J Virol. 2010 Apr; 84(8): 4041–4049. Published online 2010 Feb 3. doi: 10.1128/JVI.02471-09
PMCID:
PMC2849482
ArticlePDF–1.0M
19.
The Conserved Salt Bridge in Human α-Defensin 5 Is Required for Its Precursor Processing and Proteolytic Stability
Mohsen Rajabi, Erik de Leeuw, Marzena Pazgier, Jing Li, Jacek Lubkowski, Wuyuan Lu
J Biol Chem. 2008 Aug 1; 283(31): 21509–21518. doi: 10.1074/jbc.M801851200
PMCID:
PMC2490794
ArticlePDF–587K
20.
Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract.
A. J. Quayle, E. M. Porter, A. A. Nussbaum, Y. M. Wang, C. Brabec, K. P. Yip, S. C. Mok
Am J Pathol. 1998 May; 152(5): 1247–1258.
PMCID:
PMC1858596
SummaryPage BrowsePDF–3.8M

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