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Select item 106308881.

Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2

Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale, Riccardo Parra, Antonia Gurgone, Daniela Lecca, Anna Cavaccini, Cezar M Tigaret, Alfredo Cagnotto, Kimberley Jones, Simon Brooks, Gian Michele Ratto, Nicholas D Allen, Mariah J Lelos, Silvia Middei, Maurizio Giustetto, Anna R Carta, Raffaella Tonini, Mario Salmona, Jeremy Hall, Kerrie Thomas, Riccardo Brambilla, Stefania Fasano

EMBO Mol Med. 2023 Nov; 15(11): e15984. Published online 2023 Oct 4. doi: 10.15252/emmm.202215984

PMCID:: PMC10630888

Article PDF–4.2M

Select item 103382372.

Loss of the importin Kpna2 causes infertility in male mice by disrupting the translocation of testis-specific transcription factors

Paula Navarrete-López, María Maroto, Eva Pericuesta, Raúl Fernández-González, Marta Lombó, Priscila Ramos-Ibeas, Alfonso Gutiérrez-Adán

iScience. 2023 Jul 21; 26(7): 107134. Published online 2023 Jun 16. doi: 10.1016/j.isci.2023.107134

PMCID:: PMC10338237

Article PDF–6.9M

Select item 65072653.

Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice

Satoshi Okano, Akira Yasui, Shin-ichiro Kanno, Kennichi Satoh, Masahiko Igarashi, Osamu Nakajima

J Diabetes Res. 2019; 2019: 7234549. Published online 2019 Apr 24. doi: 10.1155/2019/7234549

PMCID:: PMC6507265

Article PDF–12M

Select item 3944354.

In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import.

N Imamoto, T Shimamoto, T Takao, T Tachibana, S Kose, M Matsubae, T Sekimoto, Y Shimonishi, Y Yoneda

EMBO J. 1995 Aug 1; 14(15): 3617–3626. doi: 10.1002/j.1460-2075.1995.tb00031.x

PMCID:: PMC394435

Summary Page Browse PDF–3.3M

Select item 97986055.

KPNA2 promotes angiogenesis by regulating STAT3 phosphorylation

Yujie Jia, Qi Wang, Minglu Liang, Kai Huang

J Transl Med. 2022; 20: 627. Published online 2022 Dec 28. doi: 10.1186/s12967-022-03841-6

PMCID:: PMC9798605

Article PDF–8.8M

Select item 68793486.

NLRP3 negatively regulates Treg differentiation through Kpna2-mediated nuclear translocation

Su-Ho Park, Sunyoung Ham, Arim Lee, Andreas Möller, Tae Sung Kim

J Biol Chem. 2019 Nov 22; 294(47): 17951–17961. Published online 2019 Oct 9. doi: 10.1074/jbc.RA119.010545

PMCID:: PMC6879348

Article PDF–3.0M

Select item 46010147.

Structure of importin-α bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein

Ryohei Nakada, Hidemi Hirano, Yoshiyuki Matsuura

Sci Rep. 2015; 5: 15055. Published online 2015 Oct 12. doi: 10.1038/srep15055

PMCID:: PMC4601014

Article PDF–1.4M

Select item 43951338.

Specific interaction with the nuclear transporter importin α2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles

Andrew T. Major, Cathryn A. Hogarth, Yoichi Miyamoto, Mai A. Sarraj, Catherine L. Smith, Peter Koopman, Yasuyuki Kurihara, David A. Jans, Kate L. Loveland

Mol Biol Cell. 2015 Apr 15; 26(8): 1543–1558. doi: 10.1091/mbc.E14-01-0678

PMCID:: PMC4395133

Article PDF–3.5M

Select item 31563289.

Distinct roles for classical nuclear import receptors in the growth of multinucleated muscle cells

Monica N. Hall, Christine A. Griffin, Adriana Simionescu, Anita H. Corbett, Grace K. Pavlath

Dev Biol. Author manuscript; available in PMC 2012 Sep 1.

Published in final edited form as: Dev Biol. 2011 Sep 1; 357(1): 248–258. Published online 2011 Jun 30. doi: 10.1016/j.ydbio.2011.06.032

PMCID:: PMC3156328

Article PDF–4.2M

Select item 325257310.

Nuclear retention of importin α coordinates cell fate through changes in gene expression

Yoshinari Yasuda, Yoichi Miyamoto, Tomoko Yamashiro, Munehiro Asally, Ayumi Masui, Chin Wong, Kate L Loveland, Yoshihiro Yoneda

EMBO J. 2012 Jan 4; 31(1): 83–94. Published online 2011 Sep 30. doi: 10.1038/emboj.2011.360

PMCID:: PMC3252573

Article PDF–1.2M

Select item 288840511.

Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin-α Using Oriented Peptide Library Screening

Sundy N. Y. Yang, Agnes A. S. Takeda, Marcos R. M. Fontes, Jonathan M. Harris, David A. Jans, Boštjan Kobe

J Biol Chem. 2010 Jun 25; 285(26): 19935–19946. Published online 2010 Apr 20. doi: 10.1074/jbc.M109.079574

PMCID:: PMC2888405

Article PDF–2.1M

Select item 483519412.

MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation

Yuntao Lu, Limin Xiao, Yawei Liu, Hai Wang, Hong Li, Qiang Zhou, Jun Pan, Bingxi Lei, Annie Huang, Songtao Qi

Autophagy. 2015 Dec; 11(12): 2213–2232. Published online 2015 Nov 9. doi: 10.1080/15548627.2015.1108507

Correction in:: Autophagy. 2016 Feb; 12(2): 445–448.

Correction in:: Autophagy. 2019; 15(6): 1125–1127.

PMCID:: PMC4835194

Article PDF–2.9M

Select item 425011513.

Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells

Yasuhiro Umemura, Nobuya Koike, Tsuguhiro Matsumoto, Seung-Hee Yoo, Zheng Chen, Noriko Yasuhara, Joseph S. Takahashi, Kazuhiro Yagita

Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47): E5039–E5048. Published online 2014 Nov 11. doi: 10.1073/pnas.1419272111

PMCID:: PMC4250115

Article PDF–3.0M

Select item 269183114.

A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein–protein interactions

Radhashree Maitra, Moshe J. Sadofsky

Nucleic Acids Res. 2009 Jun; 37(10): 3301–3309. Published online 2009 Mar 25. doi: 10.1093/nar/gkp192

PMCID:: PMC2691831

Article PDF–3.4M

Select item 268964815.

Interferon γ is recognised by importin α/β: Enhanced nuclear localising and transactivation activities of an interferon γ mimetic

Alex J. Fulcher, Chulbul M.I. Ahmed, Ezra N. Noon-Song, Rain Y.Q. Kwan, Prem S. Subramaniam, Howard M. Johnson, David A. Jans

FEBS Lett. Author manuscript; available in PMC 2009 Jun 2.

Published in final edited form as: FEBS Lett. 2008 May 14; 582(11): 1569–1574. Published online 2008 Apr 9. doi: 10.1016/j.febslet.2008.03.054

PMCID:: PMC2689648

Article PDF–395K

Select item 268200016.

Masking of a Nuclear Signal Motif by Monoubiquitination Leads to Mislocalization and Degradation of the Regulatory Enzyme Cytidylyltransferase

Bill B. Chen, Rama K. Mallampalli

Mol Cell Biol. 2009 Jun; 29(11): 3062–3075. Published online 2009 Mar 30. doi: 10.1128/MCB.01824-08

PMCID:: PMC2682000

Article PDF–3.4M

Select item 122256217.

Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells.

Ghislaine Guillemain, Maria J Muñoz-Alonso, Aurélia Cassany, Martine Loizeau, Anne-Marie Faussat, Anne-Françoise Burnol, Armelle Leturque

Biochem J. 2002 May 15; 364(Pt 1): 201–209. doi: 10.1042/bj3640201

PMCID:: PMC1222562

Summary PDF–243K

Select item 491410118.

Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3

Joon Kyu Park, Tanuza Das, Eun Joo Song, Eunice EunKyeong Kim

Nucleic Acids Res. 2016 Jun 20; 44(11): 5424–5437. Published online 2016 Apr 7. doi: 10.1093/nar/gkw218

PMCID:: PMC4914101

Article PDF–7.7M

Select item 476149919.

Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling

Sumitra Miriyala, Chadinee Thippakorn, Luksana Chaiswing, Yong Xu, Teresa Noel, Artak Tovmasyan, Ines Batinic-Haberle, Craig W. Vander Kooi, Wang Chi, Ahmed Abdel Latif, Manikandan Panchatcharam, Virapong Prachayasittikul, D. Allan Butterfield, Mary Vore, Jeffrey Moscow, Daret K. St. Clair

Free Radic Biol Med. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Free Radic Biol Med. 2016 Feb; 91: 68–80. Published online 2015 Dec 9. doi: 10.1016/j.freeradbiomed.2015.12.002

PMCID:: PMC4761499

Article PDF–2.4M

Select item 434619420.

Molecular determinants for nuclear import of Influenza A PB2 by importin α isoforms 3 and 7

Ruth A. Pumroy, Song Ke, Darren J. Hart, Ulrich Zachariae, Gino Cingolani

Structure. Author manuscript; available in PMC 2016 Feb 3.

Published in final edited form as: Structure. 2015 Feb 3; 23(2): 374–384. Published online 2015 Jan 15. doi: 10.1016/j.str.2014.11.015

PMCID:: PMC4346194

Article PDF–3.0M

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