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Select item 100520891.

Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling

John Grayson Evans, Laura A. Novotny, Eric G. Meissner

Viruses. 2023 Mar; 15(3): 632. Published online 2023 Feb 25. doi: 10.3390/v15030632

PMCID:: PMC10052089

Article PDF–3.5M

Select item 40109152.

IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies

Francois H.T. Duong, Gaia Trincucci, Tujana Boldanova, Diego Calabrese, Benedetta Campana, Ilona Krol, Sarah C. Durand, Laura Heydmann, Mirjam B. Zeisel, Thomas F. Baumert, Markus H. Heim

J Exp Med. 2014 May 5; 211(5): 857–868. doi: 10.1084/jem.20131557

PMCID:: PMC4010915

Article PDF–3.7M

Select item 38836423.

Epigenetic Reprogramming of the Type III Interferon Response Potentiates Antiviral Activity and Suppresses Tumor Growth

Siyuan Ding, William Khoury-Hanold, Akiko Iwasaki, Michael D. Robek

PLoS Biol. 2014 Jan; 12(1): e1001758. Published online 2014 Jan 7. doi: 10.1371/journal.pbio.1001758

PMCID:: PMC3883642

Article PDF–1.8M

Select item 12232074.

Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3.

Laure Dumoutier, Diane Lejeune, Simon Hor, Helmut Fickenscher, Jean-Christophe Renauld

Biochem J. 2003 Mar 1; 370(Pt 2): 391–396. doi: 10.1042/BJ20021935

PMCID:: PMC1223207

Summary PDF–187K

Select item 72174875.

Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells

Deanna M. Santer, Gillian E. S. Minty, Dominic P. Golec, Julia Lu, Julia May, Afshin Namdar, Juhi Shah, Shokrollah Elahi, David Proud, Michael Joyce, D. Lorne Tyrrell, Michael Houghton

PLoS Pathog. 2020 Apr; 16(4): e1008515. Published online 2020 Apr 30. doi: 10.1371/journal.ppat.1008515

PMCID:: PMC7217487

Article PDF–2.7M

Select item 62888116.

Crystal structure of a complex of the intracellular domain of interferon λ receptor 1 (IFNLR1) and the FERM/SH2 domains of human JAK1

Di Zhang, Alexander Wlodawer, Jacek Lubkowski

J Mol Biol. Author manuscript; available in PMC 2018 Dec 11.

Published in final edited form as: J Mol Biol. 2016 Nov 20; 428(23): 4651–4668. Published online 2016 Oct 7. doi: 10.1016/j.jmb.2016.10.005

PMCID:: PMC6288811

Article PDF–3.5M

Select item 29915167.

Crystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1

Zachary J. Miknis, Eugenia Magracheva, Wei Li, Alexander Zdanov, Sergei V. Kotenko, Alexander Wlodawer

J Mol Biol. 2010 Dec 10; 404(4): 650–664. Published online 2010 Oct 8. doi: 10.1016/j.jmb.2010.09.068

PMCID:: PMC2991516

Article PDF–2.0M

Select item 28191908.

Genome-wide Association Study of Suicidal Ideation Emerging During Citalopram Treatment of Depressed Outpatients

Gonzalo Laje, Andrew S. Allen, Nirmala Akula, Husseini Manji, A. John Rush, Francis J. McMahon

Pharmacogenet Genomics. Author manuscript; available in PMC 2010 Sep 1.

Published in final edited form as: Pharmacogenet Genomics. 2009 Sep; 19(9): 666. doi: 10.1097/FPC.0b013e32832e4bcd

PMCID:: PMC2819190

Article PDF–760K

Select item 28055399.

Purification, crystallization and preliminary crystallographic studies of the complex of interferon-λ1 with its receptor

Eugenia Magracheva, Sergei Pletnev, Sergei Kotenko, Wei Li, Alexander Wlodawer, Alexander Zdanov

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1; 66(Pt 1): 61–63. Published online 2009 Dec 25. doi: 10.1107/S1744309109048817

PMCID:: PMC2805539

Article PDF–132K

Select item 628668410.

IFN‐λ4 inhibits HIV infection of macrophages through signalling of IFN‐λR1/IL‐10R2 receptor complex

Qi‐Jian Su, Xu Wang, Run‐Hong Zhou, Le Guo, Hang Liu, Jie‐Liang Li, Wen‐Zhe Ho

Scand J Immunol. 2018 Nov; 88(5): e12717. Published online 2018 Oct 10. doi: 10.1111/sji.12717

PMCID:: PMC6286684

Article PDF–385K

Select item 489926911.

The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

Ryan Ferrao, Heidi J.A. Wallweber, Hoangdung Ho, Christine Tam, Yvonne Franke, John Quinn, Patrick J. Lupardus

Structure. Author manuscript; available in PMC 2017 Jun 7.

Published in final edited form as: Structure. 2016 Jun 7; 24(6): 897–905. Published online 2016 Apr 28. doi: 10.1016/j.str.2016.03.023

PMCID:: PMC4899269

Article PDF–933K

Select item 357950312.

Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells

Zhiwei Yin, Jihong Dai, Jing Deng, Faruk Sheikh, Mahwish Natalia, Tiffany Shih, Anita Lewis-Antes, Sheela B. Amrute, Ursula Garrigues, Sean Doyle, Raymond P Donnelly, Sergei V Kotenko, Patricia Fitzgerald-Bocarsly

J Immunol. Author manuscript; available in PMC 2013 Sep 15.

Published in final edited form as: J Immunol. 2012 Sep 15; 189(6): 2735–2745. Published online 2012 Aug 13. doi: 10.4049/jimmunol.1102038

PMCID:: PMC3579503

Article PDF–3.8M

Select item 974758613.

The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection

MuChun Tsai, Wissam Osman, Jessica Adair, Rabab ElMergawy, Lexie Chafin, Finny Johns, Daniela Farkas, Ajit Elhance, James Londino, Rama K. Mallampalli

J Biol Chem. 2022 Dec; 298(12): 102698. Published online 2022 Nov 13. doi: 10.1016/j.jbc.2022.102698

PMCID:: PMC9747586

Article PDF–2.6M

Select item 593124114.

Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal-dominant non-syndromic hearing loss

Xue Gao, Yong-Yi Yuan, Qiong-Fen Lin, Jin-Cao Xu, Wei-Qian Wang, Yue-Hua Qiao, Dong-Yang Kang, Dan Bai, Feng Xin, Sha-Sha Huang, Shi-Wei Qiu, Li-Ping Guan, Yu Su, Guo-Jian Wang, Ming-Yu Han, Yi Jiang, Han-Kui Liu, Pu Dai

J Med Genet. 2018 May; 55(5): 298–306. Published online 2018 Feb 16. doi: 10.1136/jmedgenet-2017-104954

PMCID:: PMC5931241

Article PDF–2.7M

Select item 337014715.

Genome-wide Meta-analysis Identifies Variants Associated with Platinating Agent Susceptibility Across Populations

Heather E. Wheeler, Eric R. Gamazon, Amy L. Stark, Peter H. O’Donnell, Lidija K. Gorsic, R. Stephanie Huang, Nancy J. Cox, M. Eileen Dolan

Pharmacogenomics J. Author manuscript; available in PMC 2013 Aug 1.

Published in final edited form as: Pharmacogenomics J. 2013 Feb; 13(1): 35–43. Published online 2011 Aug 16. doi: 10.1038/tpj.2011.38

PMCID:: PMC3370147

Article PDF–621K

Select item 374973016.

Genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

Amy Strange, Francesca Capon, Chris CA Spencer, Jo Knight, Michael E Weale, Michael H Allen, Anne Barton, Gavin Band, Céline Bellenguez, Judith GM Bergboer, Jenefer M Blackwell, Elvira Bramon, Suzannah J Bumpstead, Juan P Casas, Michael J Cork, Aiden Corvin, Panos Deloukas, Alexander Dilthey, Audrey Duncanson, Sarah Edkins, Xavier Estivill, Oliver Fitzgerald, Colin Freeman, Emiliano Giardina, Emma Gray, Angelika Hofer, Ulrike Hüffmeier, Sarah E Hunt, Alan D Irvine, Janusz Jankowski, Brian Kirby, Cordelia Langford, Jesús Lascorz, Joyce Leman, Stephen Leslie, Lotus Mallbris, Hugh S Markus, Christopher G Mathew, WH Irwin McLean, Ross McManus, Rotraut Mössner, Loukas Moutsianas, Åsa T Naluai, Frank O Nestle, Giuseppe Novelli, Alexandros Onoufriadis, Colin NA Palmer, Carlo Perricone, Matti Pirinen, Robert Plomin, Simon C Potter, Ramon M Pujol, Anna Rautanen, Eva Riveira-Munoz, Anthony W Ryan, Wolfgang Salmhofer, Lena Samuelsson, Stephen J Sawcer, Joost Schalkwijk, Catherine H Smith, Mona Ståhle, Zhan Su, Rachid Tazi-Ahnini, Heiko Traupe, Ananth C Viswanathan, Richard B Warren, Wolfgang Weger, Katarina Wolk, Nicholas Wood, Jane Worthington, Helen S Young, Patrick LJM Zeeuwen, Adrian Hayday, A David Burden, Christopher EM Griffiths, Juha Kere, André Reis, Gilean McVean, David M Evans, Matthew A Brown, Jonathan N Barker, Leena Peltonen, Peter Donnelly, Richard C Trembath

Nat Genet. Author manuscript; available in PMC 2013 Aug 22.

Published in final edited form as: Nat Genet. 2010 Nov; 42(11): 985–990. Published online 2010 Oct 17. doi: 10.1038/ng.694

PMCID:: PMC3749730

Article PDF–1.1M

Select item 655402417.

Decoding type I and III interferon signalling during viral infection

Emily V. Mesev, Robert A. LeDesma, Alexander Ploss

Nat Microbiol. 2019; 4(6): 914–924. Published online 2019 Apr 1. doi: 10.1038/s41564-019-0421-x

PMCID:: PMC6554024

Article PDF–1.4M

Select item 44214718.

A Protein Interaction Framework for Human mRNA Degradation

Ben Lehner, Christopher M. Sanderson

Genome Res. 2004 Jul; 14(7): 1315–1323. doi: 10.1101/gr.2122004

PMCID:: PMC442147

Article PDF–272K

Select item 926261419.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Article PDF–3.6M

Select item 716998320.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Article PDF–5.4M

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