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Select item 107167801.

The multistep oxidation of cholesterol to pregnenolone by human cytochrome P450 11A1 is highly processive

Kevin D. McCarty, Lu Liu, Yasuhiro Tateishi, Hannah L. Wapshott-Stehli, F. Peter Guengerich

J Biol Chem. 2024 Jan; 300(1): 105495. Published online 2023 Nov 24. doi: 10.1016/j.jbc.2023.105495

PMCID:: PMC10716780

Article PDF–1.3M

Select item 93175582.

In-Silico Investigation of Effects of Single-Nucleotide Polymorphisms in PCOS-Associated CYP11A1 Gene on Mutated Proteins

Fatima Muccee, Osama Bijou, Steve Harakeh, Rabi’atul Adawiyah, R. Z. Sayyed, Leila Haghshenas, Dikhnah Alshehri, Mohammad Javed Ansari, Shakira Ghazanfar

Genes (Basel) 2022 Jul; 13(7): 1231. Published online 2022 Jul 12. doi: 10.3390/genes13071231

PMCID:: PMC9317558

Article PDF–7.2M

Select item 82052653.

The significance of CYP11A1 expression in skin physiology and pathology

RM Slominski, C Raman, C Elmets, AM Jetten, AT Slominski, RC Tuckey

Mol Cell Endocrinol. Author manuscript; available in PMC 2022 Jun 15.

Published in final edited form as: Mol Cell Endocrinol. 2021 Jun 15; 530: 111238. Published online 2021 Mar 12. doi: 10.1016/j.mce.2021.111238

PMCID:: PMC8205265

Article PDF–1.6M

Select item 72720764.

Expression and activation of the steroidogenic enzyme CYP11A1 is associated with IL-13 production in T cells from peanut allergic children

Meiqin Wang, Matthew J. Strand, Bruce J. Lanser, Carah Santos, Kreso Bendelja, Jennifer Fish, Elizabeth A. Esterl, Shigeru Ashino, Jordan K. Abbott, Vijaya Knight, Erwin W. Gelfand

PLoS One. 2020; 15(6): e0233563. Published online 2020 Jun 4. doi: 10.1371/journal.pone.0233563

PMCID:: PMC7272076

Article PDF–1.3M

Select item 66079625.

Characterization of the CYP11A1 Nonsynonymous Variant p.E314K in Children Presenting With Adrenal Insufficiency

Vipula Kolli, Hannah Kim, Ahmed Torky, Qizong Lao, Christina Tatsi, Ashwini Mallappa, Deborah P Merke

J Clin Endocrinol Metab. 2019 Feb; 104(2): 269–276. Published online 2018 Oct 8. doi: 10.1210/jc.2018-01661

PMCID:: PMC6607962

Article

Select item 47325176.

Evidence that Compound I is the active species in both the hydroxylase and lyase steps by which P450scc converts cholesterol to pregnenolone: EPR/ENDOR/cryoreduction/annealing studies

Roman Davydov, Natallia Strushkevich, David Smil, Aliaksei Yantsevich, Andrey Gilep, Sergey Usanov, Brian M. Hoffman

Biochemistry. Author manuscript; available in PMC 2016 Dec 8.

Published in final edited form as: Biochemistry. 2015 Dec 8; 54(48): 7089–7097. Published online 2015 Nov 25. doi: 10.1021/acs.biochem.5b00903

PMCID:: PMC4732517

Article PDF–1.6M

Select item 40968857.

CYP11A1 microsatellite (tttta)_n polymorphism in PCOS women from South India

K. Ranjith Reddy, M. L. N. Deepika, K. Supriya, K. Prasanna Latha, S. S. Lakshmana Rao, V. Usha Rani, P. Jahan

J Assist Reprod Genet. 2014 Jul; 31(7): 857–863. Published online 2014 May 4. doi: 10.1007/s10815-014-0236-x

PMCID:: PMC4096885

Article PDF–540K

Select item 36901828.

Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas

Misu Lee, Ilaria Marinoni, Martin Irmler, Tsambika Psaras, Jürgen B. Honegger, Rudi Beschorner, Natasa Anastasov, Johannes Beckers, Marily Theodoropoulou, Federico Roncaroli, Natalia S. Pellegata

Acta Neuropathol. 2013; 126(1): 137–150. Published online 2013 Jun 12. doi: 10.1007/s00401-013-1132-7

PMCID:: PMC3690182

Article PDF–1.3M

Select item 36120869.

Abnormal Apoptosis of Trophoblastic Cells Is Related to the Up-Regulation of CYP11A Gene in Placenta of Preeclampsia Patients

Guolin He, Wenming Xu, Yan Chen, Xinghui Liu, Mingrong Xi

PLoS One. 2013; 8(3): e59609. Published online 2013 Mar 29. doi: 10.1371/journal.pone.0059609

PMCID:: PMC3612086

Article PDF–4.2M

Select item 356511510.

Varied Clinical Presentations of Seven Patients With Mutations in CYP11A1 Encoding the Cholesterol Side-Chain Cleavage Enzyme, P450scc

Meng Kian Tee, Michal Abramsohn, Neta Loewenthal, Mark Harris, Sudeep Siwach, Ana Kaplinsky, Barak Markus, Ohad Birk, Val C. Sheffield, Ruti Pavari, Eli Hershkovitz, Walter L. Miller

J Clin Endocrinol Metab. 2013 Feb; 98(2): 713–720. Published online 2013 Jan 21. doi: 10.1210/jc.2012-2828

Correction in:: J Clin Endocrinol Metab. 2013 Oct; 98(10): 4213.

PMCID:: PMC3565115

Article

Select item 345543511.

No Association Between the Microsatellite Polymorphism (TTTTA)_n in the Promoter of the CYP11A Gene and Ovarian Hyperstimulation Syndrome

Polonca Ferk, Ksenija Gersak, Natasa Teran

J Assist Reprod Genet. 2006 Jan; 23(1): 29–32. Published online 2006 Jan 4. doi: 10.1007/s10815-005-9009-x

PMCID:: PMC3455435

Article PDF–180K

Select item 334425412.

Risk-Association of CYP11A1 Polymorphisms and Breast Cancer Among Han Chinese Women in Southern China

Minying Sun, Xuexi Yang, Changsheng Ye, Weiwen Xu, Guangyu Yao, Jun Chen, Ming Li

Int J Mol Sci. 2012; 13(4): 4896–4905. Published online 2012 Apr 18. doi: 10.3390/ijms13044896

PMCID:: PMC3344254

Article PDF–183K

Select item 304722813.

Partial Defect in the Cholesterol Side-Chain Cleavage Enzyme P450scc (CYP11A1) Resembling Nonclassic Congenital Lipoid Adrenal Hyperplasia

Taninee Sahakitrungruang, Meng Kian Tee, Piers R. Blackett, Walter L. Miller

J Clin Endocrinol Metab. 2011 Mar; 96(3): 792–798. Published online 2010 Dec 15. doi: 10.1210/jc.2010-1828

PMCID:: PMC3047228

Article

Select item 257483714.

20-Hydroxyvitamin D3, a Product of Vitamin D3 Hydroxylation by Cytochrome P450scc, Stimulates Keratinocyte Differentiation

Blazej Zbytek, Zorica Janjetovic, Robert C. Tuckey, Michal A. Zmijewski, Trevor W. Sweatman, Emily Jones, Minh N. Nguyen, Andrzej T. Slominski

J Invest Dermatol. Author manuscript; available in PMC 2009 Sep 1.

Published in final edited form as: J Invest Dermatol. 2008 Sep; 128(9): 2271–2280. Published online 2008 Mar 27. doi: 10.1038/jid.2008.62

PMCID:: PMC2574837

Article PDF–904K

Select item 114998315.

Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein.

M C Hu, I C Guo, J H Lin, B C Chung

Biochem J. 1991 Mar 15; 274(Pt 3): 813–817. doi: 10.1042/bj2740813

PMCID:: PMC1149983

Summary Page Browse PDF–1.0M

Select item 38705416.

Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta.

B C Chung, K J Matteson, R Voutilainen, T K Mohandas, W L Miller

Proc Natl Acad Sci U S A. 1986 Dec; 83(23): 8962–8966. doi: 10.1073/pnas.83.23.8962

PMCID:: PMC387054

Summary Page Browse PDF–1.2M

Select item 705502717.

CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study

Ning Gao, Hong Tang, Ling Gao, Guolong Tu, Han Luo, Ying Xia

BMC Neurol. 2020; 20: 77. Published online 2020 Mar 4. doi: 10.1186/s12883-020-1628-4

PMCID:: PMC7055027

Article PDF–631K

Select item 654192618.

Active site structures of CYP11A1 in the presence of its physiological substrates and alterations upon binding of Adrenodoxin

Qianhong Zhu, Piotr J. Mak, Robert C. Tuckey, James R. Kincaid

Biochemistry. Author manuscript; available in PMC 2019 May 30.

Published in final edited form as: Biochemistry. 2017 Oct 31; 56(43): 5786–5797. Published online 2017 Oct 20. doi: 10.1021/acs.biochem.7b00766

PMCID:: PMC6541926

Article PDF–864K

Select item 425261319.

Lumisterol is metabolized by CYP11A1: discovery of a new pathway

Robert C. Tuckey, Andrzej T. Slominski, Chloe Y. S. Cheng, Jianjun Chen, Tae-Kang Kim, Min Xiao, Wei Li

Int J Biochem Cell Biol. Author manuscript; available in PMC 2015 Oct 1.

Published in final edited form as: Int J Biochem Cell Biol. 2014 Oct; 55: 24–34. Published online 2014 Aug 13. doi: 10.1016/j.biocel.2014.08.004

PMCID:: PMC4252613

Article PDF–2.4M

Select item 352009920.

Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes

Andrzej T. Slominski, Tae-Kang Kim, Jianjun Chen, Minh N. Nguyen, Wei Li, Charles R. Yates, Trevor Sweatman, Zorica Janjetovic, Robert C. Tuckey

Int J Biochem Cell Biol. Author manuscript; available in PMC 2013 Nov 1.

Published in final edited form as: Int J Biochem Cell Biol. 2012 Nov; 44(11): 2003–2018. Published online 2012 Aug 2. doi: 10.1016/j.biocel.2012.07.027