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Select item 107742931.

FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models

Kristianne J. C. Galpin, Galaxia M. Rodriguez, Vincent Maranda, David P. Cook, Elizabeth Macdonald, Humaira Murshed, Shan Zhao, Curtis W. McCloskey, Andrzej Chruscinski, Gary A. Levy, Michele Ardolino, Barbara C. Vanderhyden

Sci Rep. 2024; 14: 787. Published online 2024 Jan 8. doi: 10.1038/s41598-024-51217-1

PMCID:: PMC10774293

Article PDF–2.3M

Select item 107118772.

Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells

Lei Wu, Xudong Liu, Juan Lei, Nan Zhang, Huakan Zhao, Jiangang Zhang, Huan Deng, Yongsheng Li

J Immunother Cancer. 2023; 11(12): e008081. Published online 2023 Dec 6. doi: 10.1136/jitc-2023-008081

PMCID:: PMC10711877

Article PDF–8.5M

Select item 102040713.

Fibrinogen-like protein 2: its biological function across cell types and the potential to serve as an immunotherapy target for brain tumors

Sheng Zhang, Ganesh Rao, Amy Heimberger, Shulin Li

Cytokine Growth Factor Rev. Author manuscript; available in PMC 2023 May 23.

Published in final edited form as: Cytokine Growth Factor Rev. 2023 Feb; 69: 73–79. Published online 2022 Sep 2. doi: 10.1016/j.cytogfr.2022.08.004

PMCID:: PMC10204071

Article PDF–977K

Select item 100833194.

FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-κB mediated endothelial oxidative stress

Lianjing Huang, Di Zhan, Ying Xing, Yaqin Yan, Qing Li, Jingyi Zhang, Sujuan Li, Qin Ning, Cai Zhang, Xiaoping Luo

Front Immunol. 2023; 14: 1157027. Published online 2023 Mar 27. doi: 10.3389/fimmu.2023.1157027

PMCID:: PMC10083319

Article PDF–14M

Select item 87905575.

Fibrinogen-like protein 2 deficiency inhibits virus-induced fulminant hepatitis through abrogating inflammatory macrophage activation

Fang Xiao, Hong-Wu Wang, Jun-Jian Hu, Ran Tao, Xin-Xin Weng, Peng Wang, Di Wu, Xiao-Jing Wang, Wei-Ming Yan, Dong Xi, Xiao-Ping Luo, Xiao-Yang Wan, Qin Ning

World J Gastroenterol. 2022 Jan 28; 28(4): 479–496. Published online 2022 Jan 28. doi: 10.3748/wjg.v28.i4.479

PMCID:: PMC8790557

Article PDF–16M

Select item 82492366.

Intrauterine inflammation induced white matter injury protection by fibrinogen-like protein 2 deficiency in perinatal mice

Di Zhan, Cai Zhang, Wenjun Long, Lan Wei, Shengjuan Jin, Caiqi Du, Zhuxi Li, Shusen Guo, Lianjing Huang, Qin Ning, Xiaoping Luo

Pediatr Res. 2021; 89(7): 1706–1714. Published online 2020 Oct 19. doi: 10.1038/s41390-020-01211-w

PMCID:: PMC8249236

Article PDF–3.7M

Select item 71232987.

Identification of the Receptor for FGL2 and Implications for Susceptibility to Mouse Hepatitis Virus (MHV-3)-Induced Fulminant Hepatitis

Hao Liu, Li Zhang, Myron Cybulsky, Reg Gorczynski, Jennifer Crookshank, Justin Manuel, David Grant, Gary Levy

The Nidoviruses. 2006; 581: 421–425. doi: 10.1007/978-0-387-33012-9_76

PMCID:: PMC7123298

Article PDF–1.3M

Select item 57975848.

Control of Intestinal Inflammation, Colitis-Associated Tumorigenesis, and Macrophage Polarization by Fibrinogen-Like Protein 2

Ying Zhu, Jie Zhou, Yi Feng, Liying Chen, Longhui Zhang, Fei Yang, Haoran Zha, Xinxin Wang, Xiao Han, Chi Shu, Yisong Y. Wan, Qi-Jing Li, Bo Guo, Bo Zhu

Front Immunol. 2018; 9: 87. Published online 2018 Jan 30. doi: 10.3389/fimmu.2018.00087

PMCID:: PMC5797584

Article PDF–6.8M

Select item 57002719.

Adenovirus-mediated artificial miRNA targetting fibrinogen-like protein 2 attenuates the severity of acute pancreatitis in mice

Xiaohua Ye, Jin Ding, Yanping Chen, Jiayue Dong

Biosci Rep. 2017 Dec 22; 37(6): BSR20170964. Prepublished online 2017 Oct 20. Published online 2017 Nov 23. doi: 10.1042/BSR20170964

PMCID:: PMC5700271

Article PDF–1.7M

Select item 540374610.

Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis

Agata Bartczak, Jianhua Zhang, Oyedele Adeyi, Achiya Amir, David Grant, Reginald Gorczynski, Nazia Selzner, Andrzej Chruscinski, Gary A Levy

World J Gastroenterol. 2017 Apr 21; 23(15): 2673–2684. Published online 2017 Apr 21. doi: 10.3748/wjg.v23.i15.2673

PMCID:: PMC5403746

Article PDF–4.1M

Select item 442549511.

Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4⁺ CD25⁺ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice

Junhua Wang, Dominique A. Vuitton, Norbert Müller, Andrew Hemphill, Markus Spiliotis, Oleg Blagosklonov, Denis Grandgirard, Stephen L. Leib, Itay Shalev, Gary Levy, Xiaomei Lu, Renyong Lin, Hao Wen, Bruno Gottstein

PLoS Negl Trop Dis. 2015 May; 9(5): e0003755. Published online 2015 May 8. doi: 10.1371/journal.pntd.0003755

PMCID:: PMC4425495

Article PDF–5.4M

Select item 426491312.

The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts

Peter Urbanellis, Wendy Shyu, Ramzi Khattar, Jihong Wang, Anna Zakharova, Wei He, Hassan Sadozai, Achiya Z Amir, Itay Shalev, M James Phillips, Oyedele Adeyi, Heather Ross, David Grant, Gary A Levy, Andrzej Chruscinski

Immunology. 2015 Jan; 144(1): 91–106. Published online 2014 Dec 8. doi: 10.1111/imm.12354

PMCID:: PMC4264913

Article PDF–1.4M

Select item 379567913.

Targeted Deletion of FGL2 Leads to Increased Early Viral Replication and Enhanced Adaptive Immunity in a Murine Model of Acute Viral Hepatitis Caused by LCMV WE

Ramzi Khattar, Olga Luft, Nataliya Yavorska, Itay Shalev, M. James Phillips, Oyedele Adeyi, Darrin Gao, Agata Bartczak, Peter Urbanellis, Wendy Shyu, Jianhua Zhang, Justin Manuel, Gary A. Levy, Nazia Selzner

PLoS One. 2013; 8(10): e72309. Published online 2013 Oct 11. doi: 10.1371/journal.pone.0072309

PMCID:: PMC3795679

Article PDF–2.0M

Select item 30448514.

Structure of a cytotoxic T-lymphocyte-specific gene shows a strong homology to fibrinogen beta and gamma chains.

T Koyama, L R Hall, W G Haser, S Tonegawa, H Saito

Proc Natl Acad Sci U S A. 1987 Mar; 84(6): 1609–1613. doi: 10.1073/pnas.84.6.1609

PMCID:: PMC304485

Summary Page Browse PDF–1.0M

Select item 16229315.

The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis

Philip A. Marsden, Qin Ning, Laisum S. Fung, Xioping Luo, Yue Chen, Michael Mendicino, Anand Ghanekar, Jeremy A. Scott, Teresa Miller, Camie W.Y. Chan, Mathew W.C. Chan, Wei He, Reginald M. Gorczynski, David R. Grant, David A. Clark, M. James Phillips, Gary A. Levy

J Clin Invest. 2003 Jul 1; 112(1): 58–66. doi: 10.1172/JCI18114

PMCID:: PMC162293

Article PDF–2.4M

Select item 800986116.

FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells

Jun Yan, Qingnan Zhao, Jian Wang, Xiangjun Tian, Jing Wang, Xueqing Xia, Martina Ott, Ganesh Rao, Amy B. Heimberger, Shulin Li

Cancer Lett. Author manuscript; available in PMC 2022 May 28.

Published in final edited form as: Cancer Lett. 2021 May 28; 506: 83–94. Published online 2021 Mar 4. doi: 10.1016/j.canlet.2021.02.021

PMCID:: PMC8009861

Article PDF–2.5M

Select item 630049217.

Clara Cell 10 kDa Protein Alleviates Murine Hepatitis Virus Strain 3-Induced Fulminant Hepatitis by Inhibiting Fibrinogen-Like Protein 2 Expression

Haijing Yu, Yang Liu, Hongwu Wang, Xiaoyang Wan, Jiaquan Huang, Weiming Yan, Dong Xi, Xiaoping Luo, Guanxin Shen, Qin Ning

Front Immunol. 2018; 9: 2935. Published online 2018 Dec 13. doi: 10.3389/fimmu.2018.02935

PMCID:: PMC6300492

Article PDF–2.1M

Select item 600223618.

Inhibition of the Fibrinogen‐Like Protein 2:FcγRIIB/RIII immunosuppressive pathway enhances antiviral T‐cell and B‐cell responses leading to clearance of lymphocytic choriomeningitis virus clone 13

Olga Luft, Ramzi Khattar, Kaveh Farrokhi, Dario Ferri, Nataliya Yavorska, Jianhua Zhang, Hassan Sadozai, Oyedele Adeyi, Andrzej Chruscinski, Gary A. Levy, Nazia Selzner

Immunology. 2018 Jul; 154(3): 476–489. Published online 2018 Feb 20. doi: 10.1111/imm.12897