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Select item 83733531.

Silencing of the CrkL gene reverses the doxorubicin resistance of K562/ADR cells through regulating PI3K/Akt/MRP1 signaling

Jiang Yu, Wen‐XU Chen, Wen‐Jing Xie, Rong‐Wei Chen, Dan‐Qi Lin, Wei‐Wei You, Wei‐Lin Ye, Hong‐Qin Zhang, Dong‐Hong Lin, Jian‐Ping Xu

J Clin Lab Anal. 2021 Aug; 35(8): e23817. Published online 2021 Jun 11. doi: 10.1002/jcla.23817

PMCID:: PMC8373353

Article PDF–880K

Select item 82690692.

Bifunctional Role of CrkL during Bone Remodeling

Jung Ha Kim, Kabsun Kim, Inyoung Kim, Semun Seong, Hyun Kook, Kyung Keun Kim, Jeong-Tae Koh, Nacksung Kim

Int J Mol Sci. 2021 Jul; 22(13): 7007. Published online 2021 Jun 29. doi: 10.3390/ijms22137007

PMCID:: PMC8269069

Article PDF–2.2M

Select item 79339663.

CRKL promotes hepatocarcinoma through enhancing glucose metabolism of cancer cells via activating PI3K/Akt

Chunmei Guo, Chao Gao, Xinxin Lv, Dongting Zhao, Frederick T. Greenaway, Lihong Hao, Yuxiang Tian, Shuqing Liu, Ming‐Zhong Sun

J Cell Mol Med. 2021 Mar; 25(5): 2714–2724. Published online 2021 Feb 1. doi: 10.1111/jcmm.16303

PMCID:: PMC7933966

Article PDF–1.5M

Select item 69492824.

Copy number gains of the putative CRKL oncogene in laryngeal squamous cell carcinoma result in strong nuclear expression of the protein and influence cell proliferation and migration

Magdalena Kostrzewska-Poczekaj, Kinga Bednarek, Malgorzata Jarmuz-Szymczak, Magdalena Bodnar, Violeta Filas, Andrzej Marszalek, Anna Bartochowska, Reidar Grenman, Katarzyna Kiwerska, Krzysztof Szyfter, Maciej Giefing

Sci Rep. 2020; 10: 24. Published online 2020 Jan 8. doi: 10.1038/s41598-019-56870-5

PMCID:: PMC6949282

Article PDF–1.7M

Select item 65373095.

CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell

Qingling Song, Fengtao Yi, Yuhong Zhang, Daniel K. Jun Li, Yaxun Wei, Han Yu, Yi Zhang

BMC Cancer. 2019; 19: 499. Published online 2019 May 27. doi: 10.1186/s12885-019-5671-8

PMCID:: PMC6537309

Article PDF–2.3M

Select item 50453896.

CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma

Rong An, Yisong Wang, Donna Voeller, Arjan Gower, In-Kyu Kim, Yu-Wen Zhang, Giuseppe Giaccone

Oncotarget. 2016 May 17; 7(20): 29199–29210. Published online 2016 Apr 7. doi: 10.18632/oncotarget.8638

PMCID:: PMC5045389

Article PDF–6.1M

Select item 33884587.

The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer

Hiroko Natsume, Kazuya Shinmura, Hong Tao, Hisaki Igarashi, Masaya Suzuki, Kiyoko Nagura, Masanori Goto, Hidetaka Yamada, Matsuyoshi Maeda, Hiroyuki Konno, Satoki Nakamura, Haruhiko Sugimura

J Transl Med. 2012; 10: 97. Published online 2012 Jul 3. doi: 10.1186/1479-5876-10-97

PMCID:: PMC3388458

Article PDF–1.3M

Select item 33537208.

Amplification of CRKL induces transformation and EGFR inhibitor resistance in human non small cell lung cancers

Hiu Wing Cheung, Jinyan Du, Jesse S. Boehm, Frank He, Barbara A. Weir, Xiaoxing Wang, Mohit Butaney, Lecia V. Sequist, Biao Luo, Jeffrey A. Engelman, David E. Root, Matthew Meyerson, Todd R. Golub, Pasi A. Jänne, William C. Hahn

Cancer Discov. Author manuscript; available in PMC 2012 Jun 1.

Published in final edited form as: Cancer Discov. 2011 Dec; 1(7): 608–625. Published online 2011 Oct 17. doi: 10.1158/2159-8290.CD-11-0046

PMCID:: PMC3353720

Article PDF–2.9M

Select item 33205689.

Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer

Young H. Kim, Kevin A. Kwei, Luc Girard, Keyan Salari, Jessica Kao, Manuela Pacyna-Gengelbach, Pei Wang, Tina Hernandez-Boussard, Adi F. Gazdar, Iver Petersen, John D. Minna, Jonathan R. Pollack

Oncogene. Author manuscript; available in PMC 2012 Apr 5.

Published in final edited form as: Oncogene. 2010 Mar 11; 29(10): 1421–1430. Published online 2009 Dec 7. doi: 10.1038/onc.2009.437

PMCID:: PMC3320568

Article PDF–707K

Select item 870581810.

Experimental Characterization of the Interaction between the N-Terminal SH3 Domain of Crkl and C3G

Livia Pagano, Francesca Malagrinò, Caterina Nardella, Stefano Gianni, Angelo Toto

Int J Mol Sci. 2021 Dec; 22(24): 13174. Published online 2021 Dec 7. doi: 10.3390/ijms222413174

PMCID:: PMC8705818

Article PDF–2.7M

Select item 837922911.

Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction

Armando Estrada, III, Alejandro C. Rodriguez, Georgialina Rodriguez, Alice H. Grant, Yoshira M. Ayala-Marin, Amy J. Arrieta, Robert A. Kirken

Sci Rep. 2021; 11: 16951. Published online 2021 Aug 20. doi: 10.1038/s41598-021-96428-y

PMCID:: PMC8379229

Article PDF–1.8M

Select item 796110512.

Quantitative assessment of glioblastoma phenotypes in vitro establishes cell migration as a robust readout of Crk and CrkL activity

Taeju Park, Neka Large, Tom Curran

J Biol Chem. 2021 Jan-Jun; 296: 100390. Published online 2021 Feb 6. doi: 10.1016/j.jbc.2021.100390

PMCID:: PMC7961105

Article PDF–2.9M

Select item 784464413.

MicroRNA-379 Suppresses Cervical Cancer Cell Proliferation and Invasion by Directly Targeting V-crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like (CRKL)

Xi Shi, Xiao Xiao, Na Yuan, Shili Zhang, Fukang Yuan, Xiaohong Wang

Oncol Res. 2018; 26(7): 987–996. Published online 2018 Aug 23. doi: 10.3727/096504017X15140534417184

PMCID:: PMC7844644

Article PDF–22M

Select item 733947814.

Downregulated miR-29a promotes B cell overactivation by upregulating Crk-like protein in systemic lupus erythematosus

Xinyu Shi, Lulu Ye, Shuqi Xu, Gangqiang Guo, Ziyi Zuo, Mengke Ye, Lejiang Zhu, Baoqing Li, Xiangyang Xue, Qiaoai Lin, Xiaokai Ding

Mol Med Rep. 2020 Aug; 22(2): 841–849. Published online 2020 May 21. doi: 10.3892/mmr.2020.11166

PMCID:: PMC7339478

Article PDF–775K

Select item 579924815.

miR-429 suppresses tumor migration and invasion by targeting CRKL in hepatocellular carcinoma via inhibiting Raf/MEK/ERK pathway and epithelial-mesenchymal transition

Chunmei Guo, Dongting Zhao, Qiuling Zhang, Shuqing Liu, Ming-Zhong Sun

Sci Rep. 2018; 8: 2375. Published online 2018 Feb 5. doi: 10.1038/s41598-018-20258-8

PMCID:: PMC5799248

Article PDF–15M

Select item 535490616.

ABCG2 confers promotion in gastric cancer through modulating downstream CRKL in vitro combining with biostatistics mining

Junqing Wang, Zhou Yunyun, Lu Wang, Xuehua Chen, Zhenggang Zhu

Oncotarget. 2017 Jan 17; 8(3): 5256–5267. Published online 2016 Dec 23. doi: 10.18632/oncotarget.14128

PMCID:: PMC5354906

Article PDF–3.2M

Select item 511278717.

SLC7A5 Functions as a Downstream Target Modulated by CRKL in Metastasis Process of Gastric Cancer SGC-7901 Cells

Junqing Wang, Xiaochun Fei, Weize Wu, Xuehua Chen, Liping Su, Zhenggang Zhu, Yunyun Zhou

PLoS One. 2016; 11(11): e0166147. Published online 2016 Nov 15. doi: 10.1371/journal.pone.0166147

PMCID:: PMC5112787

Article PDF–3.1M

Select item 417062418.

LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia

Jochen J. Frietsch, Carolin Kastner, Thomas G. P. Grunewald, Hardy Schweigel, Peter Nollau, Janine Ziermann, Joachim H. Clement, Paul La Rosée, Andreas Hochhaus, Elke Butt

Oncotarget. 2014 Jul; 5(14): 5257–5271. Published online 2014 Jun 7. doi: 10.18632/oncotarget.2072