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Select item 78812681.

Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes

Montserrat A. de la Rosa Rodriguez, Lei Deng, Anne Gemmink, Michel van Weeghel, Marie Louise Aoun, Christina Warnecke, Rajat Singh, Jan Willem Borst, Sander Kersten

Mol Metab. 2021 May; 47: 101168. Published online 2021 Jan 16. doi: 10.1016/j.molmet.2021.101168

PMCID:: PMC7881268

Abstract Article PDF–4.4M

Select item 78435142.

Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir

Klaus Wunderling, Christina Leopold, Isabell Jamitzky, Mohamed Yaghmour, Fabian Zink, Dagmar Kratky, Christoph Thiele

Mol Metab. 2021 Mar; 45: 101150. Published online 2020 Dec 23. doi: 10.1016/j.molmet.2020.101150

PMCID:: PMC7843514

Abstract Article PDF–3.1M

Select item 71162653.

Intestine-specific DGAT1 deficiency improves atherosclerosis in apolipoprotein E knockout mice by reducing systemic cholesterol burden

Nemanja Vujić, Melanie Korbelius, Vinay Sachdev, Silvia Rainer, Andreas Zimmer, Anton Huber, Branislav Radović, Dagmar Kratky

Atherosclerosis. Author manuscript; available in PMC 2020 Oct 27.

Published in final edited form as: Atherosclerosis. 2020 Oct 1; 310: 26–36. Published online 2020 Aug 10. doi: 10.1016/j.atherosclerosis.2020.07.030

PMCID:: PMC7116265

Abstract Article PDF–1.6M

Select item 70245684.

DGAT1 DEFICIENCY DISRUPTS LYSOSOME FUNCTION IN ENTEROCYTES DURING DIETARY FAT ABSORPTION

Yu-Han Hung, Kimberly K. Buhman

Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2020 Apr 1.

Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr; 1864(4): 587–595. Published online 2018 Oct 17. doi: 10.1016/j.bbalip.2018.10.007

PMCID:: PMC7024568

Abstract Article PDF–1.8M

Select item 63866565.

DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis

Kareem L. Graham, Bonnie J. Werner, Kimberly M. Moyer, Alycia K. Patton, Charles R. Krois, Hong Sik Yoo, Maria Tverskoy, Melissa LaJevic, Joseph L. Napoli, Raymond A. Sobel, Brian A. Zabel, Eugene C. Butcher

Proc Natl Acad Sci U S A. 2019 Feb 19; 116(8): 3126–3135. Published online 2019 Feb 4. doi: 10.1073/pnas.1817669116

PMCID:: PMC6386656

Abstract Article PDF–1.4M

Select item 55536136.

DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy

Truc B. Nguyen, Sharon M. Louie, Joseph R. Daniele, Quan Tran, Andrew Dillin, Roberto Zoncu, Daniel K. Nomura, James A. Olzmann

Dev Cell. Author manuscript; available in PMC 2018 Jul 10.

Published in final edited form as: Dev Cell. 2017 Jul 10; 42(1): 9–21.e5. doi: 10.1016/j.devcel.2017.06.003

PMCID:: PMC5553613

Abstract Article PDF–2.2M

Select item 53667567.

Analysis of Differentially Expressed Genes in Gastrocnemius Muscle between DGAT1 Transgenic Mice and Wild-Type Mice

Fei Ying, Hao Gu, Yuanzhu Xiong, Bo Zuo

Biomed Res Int. 2017; 2017: 5404682. Published online 2017 Mar 13. doi: 10.1155/2017/5404682

PMCID:: PMC5366756

Abstract Article PDF–957K

Select item 49457608.

Palmitic Acid and DGAT1 Deficiency Enhance Osteoclastogenesis, while Oleic Acid-Induced Triglyceride Formation Prevents It

Zoi Drosatos-Tampakaki, Konstantinos Drosatos, Yasemin Siegelin, Shan Gong, Salmiyeh Khan, Thomas Van Dyke, Ira J Goldberg, P Christian Schulze, Ulrike Schulze-Späte

J Bone Miner Res. Author manuscript; available in PMC 2016 Jul 15.

Published in final edited form as: J Bone Miner Res. 2014; 29(5): 1183–1195. doi: 10.1002/jbmr.2150

PMCID:: PMC4945760

Abstract Article PDF–1.1M

Select item 42079999.

Cardiomyocyte-specific Loss of Diacylglycerol Acyltransferase 1 (DGAT1) Reproduces the Abnormalities in Lipids Found in Severe Heart Failure

Li Liu, Chad M. Trent, Xiang Fang, Ni-Huiping Son, HongFeng Jiang, William S. Blaner, Yunying Hu, Yu-Xin Yin, Robert V. Farese, Jr., Shunichi Homma, Andrew V. Turnbull, Jan W. Eriksson, Shi-Lian Hu, Henry N. Ginsberg, Li-Shin Huang, Ira J. Goldberg

J Biol Chem. 2014 Oct 24; 289(43): 29881–29891. Published online 2014 Aug 25. doi: 10.1074/jbc.M114.601864

PMCID:: PMC4207999

Abstract Article PDF–1.7M

Select item 367124310.

Upregulation of triglyceride synthesis in skeletal muscle overexpressing DGAT1

Feifei Yang, Zhuying Wei, Xiangbin Ding, Xinfeng Liu, Xiuguo Ge, Guimin Song, Guangpeng Li, Hong Guo

Lipids Health Dis. 2013; 12: 63. Published online 2013 May 4. doi: 10.1186/1476-511X-12-63

PMCID:: PMC3671243

Abstract Article PDF–543K

Select item 354595611.

Diacylglycerol Acyltransferase-1 (DGAT1) Inhibition Perturbs Postprandial Gut Hormone Release

Hua V. Lin, Dunlu Chen, Zhu Shen, Lei Zhu, Xuesong Ouyang, Aurawan Vongs, Yanqing Kan, John M. Levorse, Edward J. Kowalik, Jr, Daphne M. Szeto, Xiaorui Yao, Jianying Xiao, Shirley Chen, Jinqi Liu, Marga Garcia-Calvo, Myung K. Shin, Shirly Pinto

PLoS One. 2013; 8(1): e54480. Published online 2013 Jan 15. doi: 10.1371/journal.pone.0054480

PMCID:: PMC3545956

Abstract Article PDF–830K

Select item 346600512.

Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying

Gene P. Ables, Kryscilla Jian Zhang Yang, Silke Vogel, Antonio Hernandez-Ono, Shuiqing Yu, Jason J. Yuen, Susan Birtles, Linda K. Buckett, Andrew V. Turnbull, Ira J. Goldberg, William S. Blaner, Li-Shin Huang, Henry N. Ginsberg

J Lipid Res. 2012 Nov; 53(11): 2364–2379. doi: 10.1194/jlr.M029041

PMCID:: PMC3466005

Abstract Article PDF–755K

Select item 329290213.

Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice

Ryan S. Streeper, Carrie A. Grueter, Nathan Salomonis, Sylvaine Cases, Malin C. Levin, Suneil K. Koliwad, Ping Zhou, Matthew D. Hirschey, Eric Verdin, Robert V. Farese, Jr.

Aging (Albany NY) 2012 Jan; 4(1): 13–27. Published online 2012 Jan 29. doi: 10.18632/aging.100424

PMCID:: PMC3292902

Abstract Article PDF–2.4M

Select item 328416514.

DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle

Li Liu, Shuiqing Yu, Raffay S. Khan, Gene P. Ables, Kalyani G. Bharadwaj, Yunying Hu, Lesley A. Huggins, Jan W. Eriksson, Linda K. Buckett, Andrew V. Turnbull, Henry N. Ginsberg, William S. Blaner, Li-Shin Huang, Ira J. Goldberg

J Lipid Res. 2011 Apr; 52(4): 732–744. doi: 10.1194/jlr.M011395

PMCID:: PMC3284165

Abstract Article PDF–1.3M

Select item 309713515.

A Specific Role for Dgat1 in Hepatic Steatosis Due to Exogenous Fatty Acids

Claudio J. Villanueva, Mara Monetti, Michelle Shih, Ping Zhou, Steve M. Watkins, Sanjay Bhanot, Robert V. Farese, Jr.

Hepatology. Author manuscript; available in PMC 2011 May 18.

Published in final edited form as: Hepatology. 2009 Aug; 50(2): 434–442. doi: 10.1002/hep.22980

PMCID:: PMC3097135

Abstract Article PDF–1.5M

Select item 298834316.

Topological Orientation of Acyl-CoA:Diacylglycerol Acyltransferase-1 (DGAT1) and Identification of a Putative Active Site Histidine and the Role of the N Terminus in Dimer/Tetramer Formation

Pamela J. McFie, Sandra L. Stone, Shanna L. Banman, Scot J. Stone

J Biol Chem. 2010 Nov 26; 285(48): 37377–37387. Published online 2010 Sep 27. doi: 10.1074/jbc.M110.163691

PMCID:: PMC2988343

Abstract Article PDF–3.9M

Select item 288275117.

Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1^−/− mice

Bonggi Lee, Angela M. Fast, Jiabin Zhu, Ji-Xin Cheng, Kimberly K. Buhman

J Lipid Res. 2010 Jul; 51(7): 1770–1780. doi: 10.1194/jlr.M002311

PMCID:: PMC2882751

Abstract Article PDF–1.2M

Select item 279474718.

DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity

Li Liu, XiaoJing Shi, Kalyani G. Bharadwaj, Shota Ikeda, Haruyo Yamashita, Hiroaki Yagyu, Jean E. Schaffer, Yi-Hao Yu, Ira J. Goldberg

J Biol Chem. 2009 Dec 25; 284(52): 36312–36323. Published online 2009 Sep 24. doi: 10.1074/jbc.M109.049817

PMCID:: PMC2794747

Abstract Article PDF–3.3M

Select item 277544319.

Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues

Sylvaine Cases, Ping Zhou, Jonathan M. Shillingford, Bryony S. Wiseman, Jo Dee Fish, Christina S. Angle, Lothar Hennighausen, Zena Werb, Robert V. Farese, Jr

Development. Author manuscript; available in PMC 2009 Nov 10.

Published in final edited form as: Development. 2004 Jul; 131(13): 3047–3055. Published online 2004 May 26. doi: 10.1242/dev.01158

PMCID:: PMC2775443

Abstract Article PDF–2.2M

Select item 276816520.

Paradoxical Coupling of Triglyceride Synthesis and Fatty Acid Oxidation in Skeletal Muscle Overexpressing DGAT1

Li Liu, Xiaojing Shi, Cheol Soo Choi, Gerald I. Shulman, Katherine Klaus, K. Sreekumaran Nair, Gary J. Schwartz, Yiying Zhang, Ira J. Goldberg, Yi-Hao Yu

Diabetes. 2009 Nov; 58(11): 2516–2524. Published online 2009 Aug 12. doi: 10.2337/db08-1096