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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 82063772.

Fatty acids suppress the steroidogenesis of the MA-10 mouse Leydig cell line by downregulating CYP11A1 and inhibiting late-stage autophagy

Chien Huang, Hsiu-Ju Hsu, Mu-En Wang, Meng-Chieh Hsu, Leang-Shin Wu, De-Shien Jong, Yi-Fan Jiang, Chih-Hsien Chiu

Sci Rep. 2021; 11: 12561. Published online 2021 Jun 15. doi: 10.1038/s41598-021-92008-2

PMCID:: PMC8206377

Article PDF–1.9M

Select item 73680573.

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann

Nat Commun. 2020; 11: 3588. Published online 2020 Jul 17. doi: 10.1038/s41467-020-17339-6

PMCID:: PMC7368057

Article PDF–2.0M

Select item 38648744.

The Steroidogenic Enzyme Cyp11a1 is Essential for Development of Peanut-Induced Intestinal Anaphylaxis

Meiqin Wang, Julita Ramirez, Junyan Han, Yi Jia, Joanne Domenico, Max Seibold, James Hagman, Erwin W. Gelfand

J Allergy Clin Immunol. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: J Allergy Clin Immunol. 2013 Nov; 132(5): 10.1016/j.jaci.2013.05.027. Published online 2013 Jul 16. doi: 10.1016/j.jaci.2013.05.027

PMCID:: PMC3864874

Article PDF–621K

Select item 104875155.

FXR Maintains the Intestinal Barrier and Stemness by Regulating CYP11A1-Mediated Corticosterone Synthesis in Biliary Obstruction Diseases

Zequn Li, Haijiang Dong, Suchen Bian, Hao Wu, Wenfeng Song, Xing Jia, Jian Chen, Xingxin Zhu, Long Zhao, Zefeng Xuan, Cheng Jin, Mengqiao Zhou, Shusen Zheng, Penghong Song

Int J Mol Sci. 2023 Sep; 24(17): 13494. Published online 2023 Aug 30. doi: 10.3390/ijms241713494

PMCID:: PMC10487515

Article PDF–4.4M

Select item 77170726.

Antifibrogenic Activities of CYP11A1-derived Vitamin D3-hydroxyderivatives Are Dependent on RORγ

Zorica Janjetovic, Arnold Postlethwaite, Hong Soon Kang, Tae-Kang Kim, Robert C Tuckey, David K Crossman, Shariq Qayyum, Anton M Jetten, Andrzej T Slominski

Endocrinology. 2021 Jan; 162(1): bqaa198. Published online 2020 Oct 27. doi: 10.1210/endocr/bqaa198

PMCID:: PMC7717072

Article

Select item 57445597.

NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice

E Meimaridou, M Goldsworthy, V Chortis, E Fragouli, P A Foster, W Arlt, R Cox, L A Metherell

J Endocrinol. 2018 Jan; 236(1): 13–28. Published online 2017 Oct 18. doi: 10.1530/JOE-16-0638

PMCID:: PMC5744559

Article PDF–2.3M

Select item 54195508.

Mutation of Mouse Cyp11a1 Promoter Caused Tissue-Specific Reduction of Gene Expression and Blunted Stress Response without Affecting Reproduction

Meng-Chun Shih, Nai-Chi Hsu, Chen-Che Huang, Tzong-Shoon Wu, Pao-Yen Lai, Bon-chu Chung

Mol Endocrinol. April 1, 2008; 22(4): 915–923. doi: 10.1210/me.2007-0222

PMCID:: PMC5419550

Article

Select item 36577759.

Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8⁺ T cell skewing in allergic lung disease

Yi Jia, Joanne Domenico, Katsuyuki Takeda, Junyan Han, Meiqin Wang, Michael Armstrong, Nichole Reisdorph, Brian P. O’Connor, Joseph J. Lucas, Erwin W. Gelfand

Proc Natl Acad Sci U S A. 2013 May 14; 110(20): 8152–8157. Published online 2013 Apr 29. doi: 10.1073/pnas.1216671110

PMCID:: PMC3657775

Article PDF–573K

Select item 216891210.

Histone Deacetylase Inhibitors Reduce Steroidogenesis through SCF-Mediated Ubiquitination and Degradation of Steroidogenic Factor 1 (NR5A1)

Wei-Yi Chen, Jui-Hsia Weng, Chen-Che Huang, Bon-chu Chung

Mol Cell Biol. 2007 Oct; 27(20): 7284–7290. Published online 2007 Aug 20. doi: 10.1128/MCB.00476-07

PMCID:: PMC2168912

Article PDF–271K

Select item 677343411.

Tissue-Specific Ablation of ACSL4 Results in Disturbed Steroidogenesis

Wei Wang, Xiao Hao, Lina Han, Zhe Yan, Wen-Jun Shen, Dachuan Dong, Kathrin Hasbargen, Stefanie Bittner, Yuan Cortez, Andrew S Greenberg, Salman Azhar, Fredric B Kraemer

Endocrinology. 2019 Nov; 160(11): 2517–2528. Published online 2019 Aug 27. doi: 10.1210/en.2019-00464

PMCID:: PMC6773434

Article

Select item 557802712.

Effects of Melatonin on Early Pregnancy in Mouse: Involving the Regulation of StAR, Cyp11a1, and Ihh Expression

Shengyu Guan, Lu Xie, Teng Ma, Dongying Lv, Wang Jing, Xiuzhi Tian, Yukun Song, Zhiping Liu, Xianghong Xiao, Guoshi Liu

Int J Mol Sci. 2017 Aug; 18(8): 1637. Published online 2017 Jul 27. doi: 10.3390/ijms18081637

PMCID:: PMC5578027

Article PDF–5.7M

Select item 673573913.

Sex Differences in Adrenal Bmal1 Deletion–Induced Augmentation of Glucocorticoid Responses to Stress and ACTH in Mice

William C Engeland, Logan Massman, Lauren Miller, Sining Leng, Emanuele Pignatti, Lorena Pantano, Diana L Carlone, Paulo Kofuji, David T Breault

Endocrinology. 2019 Oct; 160(10): 2215–2229. Published online 2019 Jul 29. doi: 10.1210/en.2019-00357

PMCID:: PMC6735739

Article

Select item 639732314.

Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders

Anne-Louise Gannon, Laura O’Hara, J. Ian Mason, Diane Rebourcet, Sarah Smith, Adriana Traveres, Carlos Jose Alcaide-Corral, Hanne Frederiksen, Anne Jørgensen, Laura Milne, Rod T. Mitchell, Lee B. Smith

Sci Rep. 2019; 9: 3250. Published online 2019 Mar 1. doi: 10.1038/s41598-019-39867-y

PMCID:: PMC6397323

Article PDF–9.2M

Select item 388031015.

Targeting of GFP-Cre to the Mouse Cyp11a1 Locus Both Drives Cre Recombinase Expression in Steroidogenic Cells and Permits Generation of Cyp11a1 Knock Out Mice

Laura O'Hara, Jean Philippe York, Pumin Zhang, Lee B. Smith

PLoS One. 2014; 9(1): e84541. Published online 2014 Jan 3. doi: 10.1371/journal.pone.0084541

PMCID:: PMC3880310

Article PDF–5.1M

Select item 328535916.

Death-associated Protein 6 (Daxx) Mediates cAMP-dependent Stimulation of Cyp11a1 (P450scc) Transcription

Hsin-Chieh Lan, Chih-Feng Wu, Hsiu-Ming Shih, Bon-chu Chung

J Biol Chem. 2012 Feb 17; 287(8): 5910–5916. Published online 2011 Dec 24. doi: 10.1074/jbc.M111.307603

PMCID:: PMC3285359

Article PDF–1.3M

Select item 281868917.

Transgenic Expression of Ad4BP/SF-1 in Fetal Adrenal Progenitor Cells Leads to Ectopic Adrenal Formation

Mohamad Zubair, Sanae Oka, Keith L. Parker, Ken-ichirou Morohashi

Mol Endocrinol. 2009 Oct; 23(10): 1657–1667. Published online 2009 Jul 23. doi: 10.1210/me.2009-0055

PMCID:: PMC2818689

Article

Select item 768280518.

Endogenous glucocorticoid signaling regulates effector differentiation and development of dysfunction in CD8⁺ T cells in the tumor microenvironment

Nandini Acharya, Asaf Madi, Huiyuan Zhang, Max Klapholz, Giulia Escobar, Shai Dulberg, Elena Christian, Michelle Ferreira, Karen O. Dixon, Geoffrey Fell, Katherine Tooley, Davide Mangani, Junrong Xia, Meromit Singer, Marcus Bosenberg, Donna Neuberg, Orit Rozenblatt-Rosen, Aviv Regev, Vijay K. Kuchroo, Ana C. Anderson

Immunity. Author manuscript; available in PMC 2021 Sep 15.

Published in final edited form as: Immunity. 2020 Sep 15; 53(3): 658–671.e6. doi: 10.1016/j.immuni.2020.08.005

PMCID:: PMC7682805

Article PDF–3.6M

Select item 4054619.

Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids.

Y Sadovsky, P A Crawford, K G Woodson, J A Polish, M A Clements, L M Tourtellotte, K Simburger, J Milbrandt

Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24): 10939–10943. doi: 10.1073/pnas.92.24.10939

PMCID:: PMC40546

Summary Page Browse PDF–1.8M

Select item 857083120.

Sexually Dimorphic Neurosteroid Synthesis Regulates Neuronal Activity in the Murine Brain

Philipp Wartenberg, Imre Farkas, Veronika Csillag, William H. Colledge, Erik Hrabovszky, Ulrich Boehm

J Neurosci. 2021 Nov 3; 41(44): 9177–9191. doi: 10.1523/JNEUROSCI.0885-21.2021

PMCID:: PMC8570831

Article PDF–9.6M

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